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盐亭县食管癌高发区危险因素聚集性的相关分析

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中国胸心血管外科临床杂志 2024年第3期31卷 385-391页

作者：罗瑞武黄桁程豪倪思语付思怡钱钦春杨俊杰陈鑫龙黄涵禹宗正东赵玉娟秦宇鹤何城诚吴野文红英田东四川大学华西医院胸外科成都610041 川北医学院临床医学系四川南充637000 川北医学院护理学院四川南充637000 川北医学院附属医院心胸外科四川南充637000

目的基于对食管癌高发区饮食模式现状的调查,探究与高发特征相关的危险因素聚集性及其影响因素。方法2021年7—8月采用特制结构式问卷对四川省盐亭县农村居民饮食模式开展入户调查,单因素和多因素logistic回归模型用于分析食管癌危险因... 详细信息

目的基于对食管癌高发区饮食模式现状的调查,探究与高发特征相关的危险因素聚集性及其影响因素。方法2021年7—8月采用特制结构式问卷对四川省盐亭县农村居民饮食模式开展入户调查,单因素和多因素logistic回归模型用于分析食管癌危险因素聚集的影响因素。结果共有838份有效问卷纳入分析,使用自来水等清洁水的农村居民共占90.8%。近1年,对水果蔬菜、豆制品和葱蒜食用频率高的农村居民分别占69.5%、32.8%和74.5%;对泡菜、腌菜、酸菜、烧烤、烫热食物和霉变食物食用频率较低的农村居民分别占59.2%、79.6%、68.2%、90.3%、80.9%和90.3%。73.3%居民存在食管癌危险因素聚集,同时具有2种危险因素的聚集模式最常见(28.2%),其中肿瘤史+腌制食品是主要的聚集模式(4.6%)。Logistic回归模型显示,性别、年龄、婚姻状况和职业是食管癌危险因素聚集的影响因素(P<0.05)。结论大部分盐亭县食管癌高发区农村居民具有较好的饮食习惯,但仍存在高水平的危险因素聚集性,性别、年龄、婚姻状况和职业是食管癌危险因素聚集的影响因素。

关键词：食管癌高发区饮食习惯危险因素聚集性

Role of long noncoding RNA-mediated competing endogenous RNA regulatory network in hepatocellular carcinoma

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World Journal of Gastroenterology 2020年第29期26卷 4240-4260页

作者： zhao-Shan Niu Wen-Hong Wang Xian-Ning dong Li-Mei-Li Tian Laboratory of Micromorphology School of Basic MedicineMedical Department of Qingdao UniversityQingdao 266071Shandong ProvinceChina Department of Pathology School of Basic MedicineMedical Department of Qingdao UniversityQingdao 266071Shandong ProvinceChina Department of Pathology the Affiliated Hospital of Qingdao UniversityQingdao 266061Shandong ProvinceChina School of Basic Medicine Medical Department of Qingdao UniversityQingdao 266071Shandong ProvinceChina

Long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) are noncodingRNAs (ncRNAs) that occupy over 90% of the human genome, and their mainfunction is to directly or indirectly regulate messenger RNA (mRNA) expressionand participate in the tumorigenesis and progression of malignances. Inparticular, some lncRNAs can interact with miRNAs as competing endogenousRNAs (ceRNAs) to modulate mRNA expression. Accordingly, these RNAmolecules are interrelated and coordinate to form a dynamic lncRNA-mediatedceRNA regulatory network. Mounting evidence has revealed that lncRNAs thatact as ceRNAs are closely related to tumorigenesis. To date, numerous studieshave established many different regulatory networks in hepatocellular carcinoma(HCC), and perturbations in these ceRNA interactions may result in the initiationand progression of HCC. Herein, we emphasize recent advances concerning thebiological function of lncRNAs as ceRNAs in HCC, with the aim of elucidating themolecular mechanism underlying these HCC-related RNA molecules andproviding novel insights into the diagnosis and treatment of HCC.

关键词： Hepatocellular carcinoma Long noncoding RNA MicroRNA Competing endogenous RNA Function Mechanism

Can kissing cause paraquat poisoning: A case report and review of literature

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World Journal of Clinical Cases 2021年第20期9卷 5588-5593页

作者： Bing Lv dong-Feng Han Jing Chen Hai-Bin zhao Xiao-Liang Liu Emergency Department First Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Endocrinology and Nephrology Central Hospital of TonghuaTonghua 134000Jilin ProvinceChina

BACKGROUND Paraquat is an effective,broad-spectrum,highly toxic quaternary ammonium *** poisoning has been reported frequently in recent *** has severe lung,kidney,liver,and nervous system toxicity,and there is currently no specific *** poisoning may follow ingestion,inhalation,and skin *** have been no previous reports of paraquat poisoning that resulted from *** rare case provides a new reference for the prevention of paraquat *** SUMMARY A 27-year-old man came to the emergency department complaining that he had come into contact with paraquat by kissing his girlfriend,who had taken 80-120 mL 20%*** admission,his lung computed tomography(CT)showed increased lung *** and a burning sensation developed on his tongue,which progressed to painful erosions and coalescent *** final diagnosis was mild paraquat ***-inflammatory,antioxidant,and symptomatic treatment were initiated and continued for 7 *** did not occur,subsequent lung CT showed no significant changes,and the tongue pain was slightly *** month after discharge,the tongue injury was *** This case indicated that the tongue and lung tissues are particularly vulnerable to paraquat toxicity,even after a limited exposure.

关键词： Paraquat Poisoning Pesticides Tongue Lung Case report

Fundamental studies for high temperature processing of tungsten leaching residues for alloy formation

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Tungsten 2020年第4期2卷 362-370页

作者： Xu Wang Xiao‑dong Ma Kun Su Chun‑Fa Liao Bao‑Jun zhao Faculty of Materials Metallurgy and ChemistryJiangxi University of Science and TechnologyGanzhouChina The University of Queensland BrisbaneAustralia

The first step in the production of tungsten is to enrich tungsten from two minerals wolframite((Fe,Mn)WO_(4))and scheelite(CaWO_(4))through the leaching *** leaching residue usually contains a certain amount(2-5 wt%)of WO_(3) which is higher than that in the tungsten ore(generally less than 1 wt%).In addition,the leaching residue may also consist of other valuable elements such as Cu,Ta,Nb,Sn,Sc,Mn and *** the phases and their compositions present in the residue is one of the key steps for the efficient *** typical residue sample is carefully analysed by electron probe X-ray microanalysis and X-ray fluorescence.A high-temperature process,which includes pre-reduction at 1000-1100℃and smelting reduction at 1450-1500℃,is proposed to efficiently recover the valuable *** work and thermo-dynamic calculations confirmed that most of the valuable elements can be economically recovered with optimum conditions.

关键词： Tungsten Leaching residue Valuable elements Liquidus temperature Slag

胆囊癌根治性目的切除术达到教科书式结局对远期预后影响的全国多中心队列研究

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中华消化外科杂志 2024年第7期23卷 926-933页

作者：刘智鹏李子沐罗宇乐赵小林白洁江艳李云峰喻超黄帆吴兆平周进学尹大龙丁睿郭伟朱沂陈伟林科灿岳平程遥戴海粟张东陈志宇陆军军医大学第一附属医院肝胆外科全军肝胆外科研究所重庆400038 湖南省人民医院肝胆胰外科长沙410002 贵州医科大学附属医院肝胆外科贵阳550004 安徽医科大学第一附属医院普通外科合肥230022 九江市第一人民医院肝胆胰外科九江332001 郑州大学附属肿瘤医院肝胆胰外科郑州450003 中国科学技术大学附属第一医院肝胆外科合肥230002 空军军医大学第一附属医院肝胆胰外科西安710032 首都医科大学附属北京友谊医院普通外科北京100050 浙江大学医学院附属第二医院肝胆胰外科杭州310003 中山大学第一附属医院肝胆胰外科中山510080 福建医科大学孟超肝胆医院肝病中心福州350025 兰州大学第一医院普通外科兰州730013 重庆医科大学附属第二医院肝胆外科重庆400010 西安交通大学第一附属医院肝胆外科西安710061

目的探讨胆囊癌根治性目的切除术后达到肝脏外科中教科书式结局(TOLS)对远期预后的影响。方法采用回顾性队列研究方法。收集2014年1月至2021年1月中华消化外科菁英荟胆道外科学组全国多中心数据库15家医学中心收治的824例胆囊癌患者的... 详细信息

目的探讨胆囊癌根治性目的切除术后达到肝脏外科中教科书式结局(TOLS)对远期预后的影响。方法采用回顾性队列研究方法。收集2014年1月至2021年1月中华消化外科菁英荟胆道外科学组全国多中心数据库15家医学中心收治的824例胆囊癌患者的临床病理资料;男285例,女539例;年龄为(62±11)岁。根据TOLS评价标准,将患者分为达到TOLS和未达到TOLS。正态分布的计量资料以x±s表示,组间比较采用独立样本t检验;偏态分布的计量资料以M(Q1,Q3)表示,组间比较采用Mann‑Whitney U检验。计数资料以绝对数表示,组间比较采用χ^(2)检验。等级资料比较采用Mann‑Whitney U检验。采用Kaplan‑Meier法计算生存率和绘制生存曲线,Log‑rank检验进行生存分析。单因素分析和多因素分析采用COX逐步回归模型向后Wald法。结果(1)TOLS情况。824例行胆囊癌根治性目的切除术患者中,510例达到TOLS,314例未达到TOLS。(2)随访情况。824例行胆囊癌根治性目的切除术患者,排除出院后90 d内死亡的112例,712例患者纳入生存分析。510例达到TOLS患者的中位随访时间为22.1(11.4,30.1)个月,中位总生存时间为47.6(30.6,64.6)个月,5年总生存率为47.5%。202例未达到TOLS患者的中位随访时间为14.0(6.8,25.5)个月,中位总生存时间为24.3(20.0,28.6)个月,5年总生存率为21.0%。两者总生存情况比较,差异有统计学意义(χ^(2)=58.491,P<0.05)。(3)影响患者生存情况的因素分析。多因素分析结果显示:TOLS、癌胚抗原、CA19‑9、肿瘤分化程度为低分化、第八版美国癌症联合委员会(AJCC)T2期、第八版AJCC T3期和T4期、第八版AJCC N1期、第八版AJCC N2期、辅助治疗是胆囊癌根治性目的切除术后患者总生存时间的独立影响因素(风险比=0.452,1.479,1.373,1.612,1.455,1.481,1.835,1.978,0.538,95%可信区间为0.352~0.581,1.141~1.964,1.052~1.791,1.259~2.063,1.102~1.920,1.022~2.147,1.380~2.441,1.342~2.915,0.382~0.758,P<0.05)。结论达到TOLS的胆囊癌根治性目的切除术患者能够获得更好的远期预后。

关键词：胆道肿瘤肝切除教科书式结局影响因素分析预后

Meeting report:the 4^(th) symposium on animal models of non-human primates in Kunming,Yunnan,China

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Zoological Research 2016年第6期37卷 361-365页

作者： Jia-Li LI Yong-Tang ZHENG Xu-dong zhao Xin-Tian HU Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province Kunming Institute of ZoologyChinese Academy of Sciences Kunming Primate Research Center Kunming Institute of ZoologyChinese Academy of Sciences

From 2 to 4 November, 2016, the 4th Symposium on Animal Models of Non-Human Primates （NHP） was held in Kunming, Yunnan, China. This meeting was organized by the Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences （CAS）＆ Yunnan Province Kunming Primate Research Center （KPRC）, Zoological Research, and Kunming Institute of Zoology （KIZ）, CAS.

关键词： Meeting report symposium on animal models of non-human primates in Kunming,Yunnan,China th

考虑作动器输出饱合的光电平台终端滑模神经网络控制

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振动与冲击 2022年第21期41卷 161-167页

作者：朱志忠袁鑫赵丰董登峰中国科学院微电子研究所北京100049 北京航天控制仪器研究所北京100854

光电惯性稳定平台被广泛的应用于无人系统移动载体上,针对两轴光电平台系统参数不确定与外界扰动问题,提出自适应终端滑模神经网络控制算法对光电平台伺服系统进行稳定跟踪控制。利用径向基神经网络估计平台动力学系统中的未知非线性函... 详细信息

光电惯性稳定平台被广泛的应用于无人系统移动载体上,针对两轴光电平台系统参数不确定与外界扰动问题,提出自适应终端滑模神经网络控制算法对光电平台伺服系统进行稳定跟踪控制。利用径向基神经网络估计平台动力学系统中的未知非线性函数,同时,考虑无刷直流力矩电机在实际应用中的输出饱和特性,引入辅助函数用以补偿理想控制力矩和实际输出力矩之间的误差,提高了光电负载图像的稳定性与动态目标跟踪的快速性。最后,通过李亚普诺夫原理验证了闭环系统的稳定性与渐进收敛性。外界随机振动试验结果表明,提出的终端滑模神经网络控制算法减振效果陀螺均方根值为4.7 mrad/s,比传统的滑模控制的减振效果提升了8%,相比于传统的PID控制提高了13.3%。所提出的控制方法能够较好抑制移动载体对光电设备的扰动,抗干扰能力强。

关键词：惯性稳定终端滑模作动器饱和神经网络控制

Myocardial bridge-related coronary heart disease:Independent influencing factors and their predicting value

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World Journal of Clinical Cases 2019年第15期7卷 1986-1995页

作者： dong-Hui zhao Qian Fan Jun-Xia Ning Xin Wang Jia-Yu Tian Department of Cardiology Beijing Anzhen Hospital Affiliated to Capital Medical UniversityBeijing 100029China Department of Cardiology The First People's Hospital of Pingyuan CountyDezhou 253100Shandong ProvinceChina

BACKGROUND Myocardial bridge(MB)will compress the mural coronary artery(MCA)during the systole and cause myocardial *** the diagnosis of coronary heart disease(CHD),because the structure of MB is difficult to be observed by coronary angiography(CAG),the clinical study of the influence of MB on CHD is *** the advancement of computed tomography coronary angiography technology,detailed observations of the MB anatomy have *** To explore the main influencing factors of MB-related CHD and to find potential indicators for predicting MB-related *** A total of 1718 patients with suspected CHD due to the symptoms of myocardial ischemia were enrolled as *** diagnosed with CHD were included in a CHD group,and patients with no significant abnormalities were included in a control *** the CHD group,patients were divided into an MB-CHD subgroup if MB-related CHD was *** the control group,patients were divided into a simple MB subgroup if MB was *** patient's clinical data and MB-related indicators,including the branch of MB,MB type(superficial/deep type),MB length,MB thickness,systolic and diastolic compression of the MCA,and MCA systolic stenosis rate were recorded and *** regression analysis was used to explore the independent influencing factors of MD-related *** curve was used to analyze the diagnostic efficacy of potential indicators for MB-related *** There were 1060 cases in the CHD group and 658 cases in the control group,and there were 236 cases in the MB-CHD subgroup and 52 cases in the simple MB *** logistic regression analysis showed that the combined MB had a significant effect on the occurrence of CHD(P<0.05).MB thickness,systolic compression,diastolic compression,and MCA systolic stenosis rate had significant effects on the occurrence of MB-related CHD(P<0.05).The area under the curve(AUC)of the combination of these influencing factors for the diagnosis of MB-r

关键词： Myocardial bridge Coronary heart disease Mural coronary artery Computed tomography coronary angiography Independent influencing factor

基于自调整测量基准图的直线电机动子位置测量累积误差消减

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光学学报 2023年第11期43卷 84-95页

作者：赵静朱龙吴震宇董菲安徽大学电气工程与自动化学院安徽合肥230601

为解决直线电机动子位置测量中多帧图像位移叠加而产生的误差累积问题,提出一种加阈值变换基准图(TTBM)的机器视觉累积误差消减算法。首先,根据直线电机动子的一维刚体平动特点,生成并优选灰度变化更加平滑的一维散斑图像作为目标拍摄... 详细信息

为解决直线电机动子位置测量中多帧图像位移叠加而产生的误差累积问题,提出一种加阈值变换基准图(TTBM)的机器视觉累积误差消减算法。首先,根据直线电机动子的一维刚体平动特点,生成并优选灰度变化更加平滑的一维散斑图像作为目标拍摄图。其次,采用相位相关算法(PCA)改进灰度梯度方法,对配准图像进行整像素平移后再计算亚像素位移,以增大基准图像与配准图像之间的位移测量范围。最后,提出自调整基准图方法,根据图像位移的测量范围设定基准图像变换阈值,降低位移叠加次数,减小累积误差,实现直线电机长行程精密位移测量。同时,研究了基准图像变换阈值对测量精度的影响,给出了基准图变换的最佳阈值选取范围。仿真和实验表明,所提方法可以有效地减小直线电机动子测量中叠加而产生的累积误差。

关键词：直线电机精密位移测量阈值设置变基准图