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Neuroprotective Effect and Mechanism of Tanreqing Injection on Ischemic Stroke:Insights from Network Pharmacology and in vivo Experiments

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Chinese Journal of Integrative Medicine 2024年第8期30卷 713-720页

作者： LI Zhong-hao PU Xiao-qi LI Sha-sha dong Xiao-ke ZHANG Guo-qiang WANG yu LIU Jin-min Department of Emergency China-Japan Friendship HospitalBeijing100029China Department of Neurology Beijing University of Chinese Medicine Dongfang HospitalBeijing100078China Department of Radiology China-Japan Friendship HospitalBeijing100029China Graduate School Beijing University of Chinese MedicineBeijing100029China

Objective To explore the neuroprotective effects and mechanism of Tanreqing Injection(TRQ)on treating ischemic stroke based on network pharmacology and in vivo experimental *** The chemical compounds of TRQ were retrieved based on published data,with targets retrieved from PubChem,Therapeutic Target Database and *** visualization and analysis were performed using Cytoscape,with protein-protein interaction networks derived from the STRING *** analysis was performed using Kyoto Encyclopedia of Genes Genomes pathway and Gene Ontology *** in vivo experiments,the middle cerebral artery occlusion(MCAO)model was *** volume was determined by 2,3,5-triphenyltetrazolium hydrochloride staining and protein expressions were analyzed by Western *** docking was performed to predict ligand-receptor *** We screened 81 chemical compounds in TRQ and retrieved their therapeutic *** the targets,116 were therapeutic targets for *** enrichment analysis showed that the apelin signaling pathway was a key pathway for ischemic ***,in in vivo experiment we found that administering with intraperitoneal injection of 2.5 mL/kg TRQ every 6 h could significantly reduce the infarct volume of MCAO rats(P<0.05).In addition,protein levels of the apelin receptor(APJ)/phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)pathway were increased by TRQ(P<0.05).In addition,41 chemical compounds in TRQ could bind to *** The neuroprotective effect of TRQ may be related to the APJ/PI3K/AKT signaling ***,further studies are needed to confirm the findings.

关键词： Tanreqing Injection Chinese medicine ischemic stroke middle cerebral artery occlusion quantitative estimate of drug-likeness

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基于第三方认证的公平电子商务技术体系研究

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计算机集成制造系统 2005年第4期11卷 592-596页

作者：董玉民帅典勋华东理工大学信息工程学院

在电子商务中,为了防止交易抵赖,保证买卖双方在交易时的公平性,提出了基于第三方认证的公平电子商务技术体系。该系统借助可信第三方技术、数字签名和加密等技术,确保电子交易的安全性和可靠性。同时,结合信誉评估系统,通过历史交易,... 详细信息

在电子商务中,为了防止交易抵赖,保证买卖双方在交易时的公平性,提出了基于第三方认证的公平电子商务技术体系。该系统借助可信第三方技术、数字签名和加密等技术,确保电子交易的安全性和可靠性。同时,结合信誉评估系统,通过历史交易,给出参与交易的不同商家和客户的信誉值,为未来的交易方确定潜在的交易伙伴提供参考。

关键词：电子商务可信第三方数字签名加密管理信誉评估系统

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Macrocyclic peptides:up-and-coming weapons to combat antimicrobial resistance

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1786-1787页

作者： Wen-Jing Wang Xiang-min dong Guo-Bo L Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuanChina Key Laboratory of Drug Targeting and Drug Delivery System of ministry of Education Department of Medicinal ChemistryWest China School of PharmacySichuan UniversityChengduSichuanChina

Recently,two companion papers published in Nature reported a first-in-class tethered macrocyclic peptide antibiotic targeting carbapenem-resistant ***(CRAB)and unveiled their unique antibacterial mechanism,which invol... 详细信息

关键词： outer macrocyclic Macrocyclic

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Synergetic PVA degradation and H2 evolution in photocatalytic fuel cells using Ag@Fe_(2)O_(3) cathode

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Frontiers of Chemical Science and Engineering 2024年第1期18卷 85-93页

作者： Likun Sun Kesi Xiong Baoning Zhang Jinghong Fang Yingchao He min Wang Zhixing Gan Fanglin Du Qiong Sun Liyan yu Lifeng dong College of Materials Science and Engineering Qingdao University of Science and TechnologyQingdao 266042China Center for Future Optoelectronic Functional Materials School of Computer and Electronic InformationNanjing Normal UniversityNanjing 210023China Department of Physics Hamline UniversitySt.Paul 55104USA

In a dual-chamber photocatalytic fuel cell device,polyvinyl alcohol degradation and H2 evolution were concurrently *** setup involved commercial P25 as the photoanode and Ag@Fe_(2)O_(3) nanoparticles as the ***,the feasibility of a Fentonlike reaction in the cathode,utilizing Fe^(2+)ions and pumped O_(2),was *** cathode materials,polyvinyl alcohol types,and pH values’effects were assessed on device *** tests highlighted photoinduced holes(h+)and OH·radicals as pivotal contributions to polyvinyl alcohol ***-term stability of the device was established through cycling experiments.

关键词： photocatalytic fuel cell PVA Ag@Fe_(2)O_(3) cathode materials Fenton-like reaction

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Intelligent representation method of image flatness for cold rolled strip

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Journal of Iron and Steel Research International 2024年第5期31卷 1177-1195页

作者： Yang-huan Xu dong-cheng Wang Hong-min Liu Bo-wei Duan National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan UniversityQinhuangdao066004HebeiChina National Key Laboratory of Metal Forming Technology and Heavy Equipment China National Heavy Machinery Research Institute Co.Ltd.Xi’an710018ShaanxiChina State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao066004HebeiChina

Real flatness images are the bases for flatness detection based on machine vision of cold rolled *** characteristics of a real flatness image are analyzed,and a lightweight strip location detection(SLD)model with deep semantic segmentation networks is *** interference areas in the real flatness image can be eliminated by the SLD model,and valid information can be *** this basis,the concept of image flatness is proposed for the first *** image flatness representation(IFAR)model is established on the basis of an autoencoder with a new *** optimal structure of the bottleneck layer is 16×16×4,and the IFAR model exhibits a good representation ***,interpretability analysis of the representation factors is carried out,and the difference and physical meaning of the representation factors for image flatness with different categories are *** flatness with new defect morphologies(bilateral quarter waves and large middle waves)that are not present in the original dataset are generated by modifying the representation factors of the no wave ***,the SLD and IFAR models are used to detect and represent all the real flatness images on the test *** average processing time for a single image is 11.42 ms,which is suitable for industrial *** research results provide effective methods and ideas for intelligent flatness detection technology based on machine vision.

关键词： Cold rolled strip Image flatness Location detection Representation learning Bottleneck layer

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Surface decoration of mesocarbon microbeads with multifunctional TiNbO_(4-x)@C coating layer as high rate and stable anode of Li-ion batteries

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Rare Metals 2024年第5期43卷 2053-2066页

作者： Jia-Mei Lai Zhi-min Zou yu Bai yu-Tao Xing Chun-Hai Jiang Fujian Provincial Key Laboratory of Functional Materials and Applications Institute of Advanced Energy MaterialsSchool of Materials Science and EngineeringXiamen University of TechnologyXiamen 361024China Shanghai XFH Science and Technology Development Co. Ltd.Shanghai 200949China Fujian XFH New Energy Materials Co. Ltd.Yong'an 366000China Shenzhen XFH Science and Technology Co. Ltd.Shenzhen 518071China Laboratorio de Microscopia Eletronica de Alta Resolucao Centro de Caracterizagao Avangada Para a Industria de Petroleo(LaMAR/CAIPE)Universidade Federal FluminenseNiteroiRJ 24210-346Brazil

Surface modification of graphite anode with electroactive matters has been proven of a more practical strategy in enhancing the performance of Li-ion batteries than exploring alternative novel anode ***,rutile TiNbO_(4-x) nanoparticles with a tunnel structure are employed as multifunctional decoration substances in combination with a carbon coating layer to improve the rate and cycle properties of mesocarbon microbeads(MCMBs).As compared to pristine MCMB,the Li^(+)diffusion coefficients of the composite anodes are enhanced due to the synergistic effect of TiNbO_(4-x)@***,the overcharge and voltage polarization of the composite anodes at high rate are obviously minimized due to the current sharing effect of the high-potential TiNbO_(4-x).Moreover,the amorphous Li_(y)TiNbO_(4-x) converted from TiNbO_(4-x) in the initial lithiation process can deliver pseudocapacitive capacity to the composite anodes from the second *** of these functions of TiNbO_(4-x)@Ccoating layer have directly contributed to the improved rate and cycle performance of the MCMB/TiNbO_(4-x)@C composite *** one containing 12.0 wt%TiNbO_(4-x) exhibits a high reversible specific capacity of 118 m Ah·g^(-1)at 10C(1C=372 m A·g^(-1)),together with a high capacity retention of 90.9%after 300 cycles at 3C,which are all much superior to those of pristine MCMB.

关键词： Li-ion batteries MCMB TiNbO_(4-x)@C Surface decoration Rate capability

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Cu,N codoped carbon nanosheets encapsulating ultrasmall Cu nanoparticles for enhancing selective 1,2-propanediol oxidation

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Journal of Energy Chemistry 2024年第4期91卷 27-35页

作者： Yonghai Feng min yu minjia Meng Lei Liu Dewei Rao Institute for Advanced Materials School of Materials Science and EngineeringJiangsu UniversityZhenjiang 212013JiangsuChina School of Chemistry and Chemical Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina

In the selective oxidation of biomass-based 1,2-propanediol(PDO)with oxygen as the terminal oxidant,it is challenging to improve the lactic acid(LA)selectivity for nonnoble metal nanoparticles(NPs)due to their limited oxygen reduction rate and easy C-C *** the high economic feasibility of nonnoble metals,i.e.,Cu,in this work,copper and nitrogen codoped porous carbon nanosheets encapsulating ultrafine Cu nanoparticles(Cu@Cu-N-C)were developed to realize highly selective of PDO oxidation to *** carbon-encapsulated ultrasmall Cu^(0)NPs in Cu@Cu-N-C have high PDO dehydrogenation activity while N-coordinated Cu(Cu-N)sites are responsible for the high oxygen reduction ***,the performance of catalytic PDO conversion to LA is optimized by a proposed pathway of PDO→hydroxylacetone→lactaldehyde→***,the enhanced LA selectivity is 88.5%,and the PDO conversion is up to 75.1%in an O_(2)-pressurized reaction system(1.0 MPa O_(2)),superior to other Cu-based catalysts,while in a milder nonpressurized system(O_(2)flow rate of 100 mL min-1),a remarkable LA selectivity(94.2%)is obtained with 39.8%PDO conversion,2.2 times higher than that of supported Au nanoparticles(1%Au/C).Moreover,carbon encapsulation offers Cu@Cu-N-C with strong leaching resistance for better recycling.

关键词： Selective oxidation Copper and nitrogen doped carbon 1,2-Propanediol Ultrasmall Cu nanoparticles Lactic acid

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One-pot synthesis of a giant twisted double-layer chiral macrocycle via [4+8] imine condensation and its X-ray structure

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Chinese Chemical Letters 2024年第10期35卷 241-243页

作者： yu Pang min Wang Ning-Hua Yang min Xue Yong Yang School of Science Department of PhysicsKey Laboratory of Optical Field Manipulation of Zhejiang ProvinceZhejiang Sci-Tech UniversityHangzhou 310018China School of Chemistry and Chemical Engineering Key Laboratory of Surface&Interface Science of Polymer Materials of Zhejiang ProvinceZhejiang Sci-Tech UniversityHangzhou310018China

Trifluoroacetic acid(TFA)catalyzed condensation reaction between tetraaminooxacalix[4]arene and N-alkylcarbazole-3,6-dicarbaldehyde in CH_(2)Cl2afforded a single product in 87%–89%***-defined yet undissolvable1H NMR spectra suggested formation of robust and discrete structures in solution.X-ray single crystal analysis further revealed a giant twisted double-layer chiral macrocycle in the solid state,which was formed from[4+8]condensation of the two reactants via 16 imine *** calculations discovered that only the[4+8]twisted product is thermodynamically favorable,which accounts for its highly selective and efficient formation out of a library of many other combinations.

关键词： One-pot synthesis Oxacalixarene Dynamic covalent chemistry Chiral macrocycle X-ray single crystal

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A Multilayered Magnetoelectric Transmitter with Suppressed Nonlinearity for Portable VLF Communication

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Research 2024年第2期2023卷 553-563页

作者： Zhaoqiang Chu Zhineng Mao Kaixin Song Shizhan Jiang Shugang min Wei Dan Chenyuan yu Meiyu Wu Yinghui Ren Zhichao Lu Jie Jiao Tianxiang Nan Shuxiang dong Qingdao Innovation and Development Base Harbin Engineering UniversityQingdao 266071China College of Underwater Acoustics Engineering Harbin Engineering UniversityHarbin 150001China Songshan Lake Materials Laboratory DongguanGuangdong 523808 China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 201800China School of Integrated Circuits and Beijing National Research Center for Information Science and Technology(BNRist) Tsinghua UniversityBeijing 100084China College of Engineering Peking UniversityBeijing 100871China

Acoustically actuated magnetoelectric(ME)antenna based on the efficient oscillation of magnetic dipoles has recently been considered as a promising solution for portable very-low-frequency ***,the severe nonlinear dynamic behavior in the case of strong-field excitation results in insufficient radiation capability and poor communication performance for a conventional ME *** this work,we propose to suppress the nonlinearity of an ME antenna by neutralizing the spring-hardening effect in amorphous Metglas and the spring-softening effect in piezoelectric ceramics through an ME multilayered transmitter(ME-MLTx)*** a driving voltage of 50 V_(pp)at the resonance frequency of 21.2 kHz,a magnetic flux density as high as 108 fT at a distance of 100 m is produced from a single *** addition,ME-MLTx performs a decreased mechanical quality factor(Q_(m))less than 40.65,and,thus,a broadened bandwidth of 500 Hz is ***,a communication link transmitting binary American Standard Code for Information Interchange-coded message is built,which allows for an error-free communication with a distance of 18 m and a data rate of 300 bit/s in the presence of heavy environment *** communication distance can be further estimated over 100 m when using a femtotesla-class-inductive magnetic field *** obtained results are believed to bring ME antennas one step closer to being applicable in very-low-frequency communications.

关键词： closer nonlinearity inductive

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Modeling Method of Multi-Energy Systems Based on LSTM Algorithm

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1701-1709页

作者： Di Qiu Fei Chen dong Liu min Cao Siyang Liu Shanghai Jiao Tong University Shanghai 200240China yunnan Power Grid Co. Ltd

The development of the Energy Internet has improved the efficiency of energy utilization and promoted sustainable development of power and energy *** multi-energy system modeling considering the dynamic process of transmission line is one of the key research points of Energy Internet operation *** the energy circuit theory,the lumped parameter model of natural gas pipelines is built and the dynamic characteristic parameters under the control instruction are *** with dynamic characteristic parameters,the long short-term memory(LSTM)neural network is designed to fit the natural gas pipeline dynamic process into discrete linear time-varying(LTV)*** with the equations,an energy hub method is used to build a control model of industrial parks with multi-energy distribution *** the rolling optimal control strategy given in this paper,the model is solved by the Matlab-Yalmip solver and rolling control instructions of each energy conversion unit are ***,the case study demonstrates that the LSTM neural network-based modeling method presented in this paper can accurately fit the dynamic process of a natural gas pipeline *** rolling control model of the multi-energy system can improve the efficiency of energy utilization,exhibit the transmission line status constraints during the optimization control process and improve reliability of the multi-energy system operation.

关键词： Energy hub LSTM multi-energy supply system pipeline system modeling

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