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World Journal of Gastroenterology 2024年第8期30卷 843-854页

作者： Hong-Xiao Wu Xiao-yan ding Ya-Wen Xu Ming-Hua Yu Xiao-Mi Li Na Deng Jing-Long Chen Cancer Center Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

BACKGROUND Hepatocellular carcinoma(HCC)patients complicated with portal vein tumor thrombus(PVTT)exhibit poor prognoses and treatment *** To investigate efficacies and safety of the combination of PD-1 inhibitor,transcatheter arterial chemoembolization(TACE)and Lenvatinib in HCC subjects comorbid with *** From January 2019 to December 2020,HCC patients with PVTT types Ⅰ-Ⅳ were retrospectively enrolled at Beijing Ditan *** were distributed to either the PTL or TACE/Lenvatinib(TL)*** median progression-free survival(mPFS)was set as the primary endpoint,while parameters like median overall survival,objective response rate,disease control rate(DCR),and toxicity level served as secondary *** Forty-one eligible patients were finally recruited for this study and divided into the PTL(n=18)and TL(n=23)*** a median follow-up of 21.8 months,the DCRs were 88.9%and 60.9%in the PTL and TL groups(P=0.046),***,mPFS indicated significant improvement(HR=0.25;P<0.001)in PTL-treated patients(5.4 months)compared to TL-treated(2.7 months)*** were no treatment-related deaths or differences in adverse events in either *** A triplet regimen of PTL was safe and well-tolerated as well as exhibited favorable efficacy over the TL regimen for advanced-stage HCC patients with PVTT types Ⅰ-Ⅳ.

关键词： Hepatocellular carcinoma Transcatheter arterial chemoembolization Lenvatinib PD-1 inhibitor Portal vein tumor thrombus

Nphos:Database and Predictor of Protein N-phosphorylation

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Genomics, Proteomics & Bioinformatics 2024年第3期22卷 139-151页

作者： Ming-Xiao Zhao Ruo-Fan ding Qiang Chen Junhua Meng Fulai Li Songsen Fu Biling Huang yan Liu Zhi-Liang Ji Yufen Zhao Institute of Drug Discovery Technology Ningbo UniversityNingbo 315211China Department of Chemical Biology Key Laboratory for Chemical Biology of Fujian ProvinceCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China State Key Laboratory of Cellular Stress Biology School of Life SciencesFaculty of Medicine and Life SciencesXiamen UniversityXiamen 361102China Zhejiang Key Laboratory of Pathophysiology Department of Biochemistry and Molecular BiologyHealth Science CenterNingbo UniversityNingbo 315211China BGI Genomics BGI-ShenzhenShenzhen 518083China Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084China

Protein N-phosphorylation is widely present in nature and participates in various biological ***,current knowledge on N-phosphorylation is extremely limited compared to that on *** this study,we collected 11,710 experimentally verified N-phosphosites of 7344 proteins from 39 species and subsequently constructed the database Nphos to share up-to-date information on protein *** these substantial data,we characterized the sequential and structural features of protein ***,after comparing hundreds of learning models,we chose and optimized gradient boosting decision tree(GBDT)models to predict three types of human N-phosphorylation,achieving mean area under the receiver operating characteristic curve(AUC)values of 90.56%,91.24%,and 92.01%for pHis,pLys,and pArg,***,we discovered 488,825 distinct N-phosphosites in the human *** models were also deployed in Nphos for interactive N-phosphosite *** summary,this work provides new insights and points for both flexible and focused investigations of *** will also facilitate a deeper and more systematic understanding of protein N-phosphorylation modification by providing a data and technical *** is freely available at http://***/Nphos/and http://***/Nphos/.

关键词： N-phosphorylation Post-translational modification Machine learning Database Benchmark dataset

Cleaning of two mirrors in the first mirror unit using radiofrequency capacitively coupled plasma

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Plasma Science and Technology 2024年第9期26卷 165-171页

作者： Chenxue WANG Rong yan Yuming LIU Su XU Lei MU Wei ZHENG Rui ding Junling CHEN Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People’s Republic of China University of Science and Technology of China Hefei 230026People’s Republic of China School of Computer Engineering Anhui Sanlian UniversityHefei 230601People’s Republic of China

First mirror(FM)cleaning,using radio frequency(RF)plasma,has been proposed to recover FM reflectivity in nuclear fusion reactors such as the International Thermonuclear Experimental Reactor(ITER).To investigate the influence of simultaneous cleaning of two mirrors on mirror cleaning efficiency and uniformity,experiments involving single-mirror cleaning and dual-mirror cleaning were conducted using RF capacitively coupled plasma in the *** the test and simultaneous cleaning of two mirrors,the FM and second mirror(SM),both measuring 110 mm×80 mm,were placed inside the first mirror unit(FMU).They were composed of 16 mirror samples,each with a dimension of 27.5 mm×20 *** mirror samples consist of a titanium-zirconium-molybdenum alloy substrate,a 500 nm Mo intermediate layer and a 30 nm Al_(2)O_(3) surface coating as a proxy for Be *** cleaning of a single first mirror(SFM)and the simultaneous cleaning of the FM and SM(DFM and DSM)lasted for 9 h using Ar plasma at a pressure of 1 *** total reflectivity of mirror samples on the DSM did not fully recover and varied with location,with a self-bias of−140 *** a self-bias of−300 V,the total reflectivity of mirror samples on the SFM and DFM was fully *** energy dispersive spectrometer results demonstrated that the Al_(2)O_(3) coating had been completely removed from these mirror ***,the mass loss of each mirror sample on the SFM and DFM before and after cleaning varied depending on its location,with higher mass loss observed for mirror samples located in the corners and lower loss for those in the *** with SM cleaning,the simultaneous cleaning of two mirrors reduced the difference between the highest and lowest mass ***,this mass loss for the mirror samples of the DFM facing the DSM was *** indicated that mirror samples cleaned face to face in the FMU simultaneously could influence each other,highlighting the need for special attention in

关键词： first mirror unit dual-mirror cleaning reflectivity sputtering rate

Does the continuous wetting of the Tibetan Plateau contribute to the accelerated degradation of permafrost?

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Science China Earth Sciences 2024年第5期67卷 1714-1718页

作者： Yuyang WANG Jinzhi ding Shilong PIAO Sino-French Institute for Earth System Science College of Urban and Environmental SciencesPeking UniversityBeijing 100871China State Key Laboratory of Tibetan Plateau Earth System Environment and ResourcesInstitute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China

Global warming is causing the Tibetan permafrost to degrade, as evidenced by rising ground temperatures, thicker active layer thickness, thinner permafrost layer, and melting underground ice, etc.(Ran et al., 2018;Wang et al., 2020).The degradation of permafrost not only profoundly alters the carbon cycling processes in high-altitude ecosystems,thereby influencing the regional climate system, but also affects landscape hydrological connectivity。

关键词： Tibetan landscape altitude

Analytical model for predicting time-dependent lateral deformation of geosynthetics-reinforced soil walls with modular block facing

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 711-725页

作者： Luqiang ding Chengzhi Xiao Feilong Cui School of Civil and Transportation Engineering Hebei University of TechnologyTianjin300401China

To date,few models are available in the literature to consider the creep behavior of geosynthetics when predicting the lateral deformation(d)of geosynthetics-reinforced soil(GRS)retaining *** this study,a general hyperbolic creep model was first introduced to describe the long-term deformation of geosynthetics,which is a function of elapsed time and two empirical parameters a and *** conventional creep tests with three different tensile loads(Pr)were conducted on two uniaxial geogrids to determine their creep behavior,as well as the a-Pr and b-Pr *** test results show that increasing Pr accelerates the development of creep deformation for both ***,a and b respectively show exponential and negatively linear relationships with Pr,which were confirmed by abundant experimental data available in other *** on the above creep model and relationships,an accurate and reliable analytical model was then proposed for predicting the time-dependent d of GRS walls with modular block facing,which was further validated using a relevant numerical investigation from the previous *** evaluation and comparison of the proposed model with six available prediction models were *** a parametric study was carried out to evaluate the effects of wall height,vertical spacing of geogrids,unit weight and internal friction angle of backfills,and factor of safety against pullout on d at the end of construction and 5 years *** findings show that the creep effect not only promotes d but also raises the elevation of the maximum d along the wall ***,the limitations and application prospects of the proposed model were discussed and analyzed.

关键词： Geosynthetics Creep behavior Geosynthetics-reinforced soil(GRS)walls Lateral deformation Analytical model

Optimization for epitaxial fabrication of infinite-layer nickelate superconductors

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Frontiers of physics 2024年第3期19卷 61-69页

作者： Minghui Xu yan Zhao Xiang ding Huaqian Leng Shu Zhang Jie Gong Haiyan Xiao Xiaotao Zu Huiqian Luo Ke-Jin Zhou Bing Huang Liang Qiao School of Physics University of Electronic Science and Technology of ChinaChengdu 610054China Beijing Computational Science Research Center Beijing 100193China Diamond Light Source Harwell CampusDidcot OX110DEUnited Kingdom Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China

The discovery of nickelates superconductor creates exciting opportunities to unconventional superconductivity. However, its synthesis is challenging and only a few groups worldwide can obtain samples with zero-resistance. This problem becomes the major barrier for this field. From plume dynamics perspective, we found the synthesis of superconducting nickelates is a complex process and the challenge is twofold, i.e., how to stabilize an ideal infinite-layer structure Nd_(0.8)Sr_(0.2)NiO_(2), and then how to make Nd_(0.8)Sr_(0.2)NiO_(2) superconducting? The competition between perovskite Nd_(0.8)Sr_(0.2)NiO_(3) and Ruddlesden−Popper defect phase is crucial for obtaining infinite-layer structure. Due to inequivalent angular distributions of condensate during laser ablation, the laser energy density is critical to obtain phase-pure Nd_(0.8)Sr_(0.2)NiO_(3). However, for obtaining superconductivity, both laser energy density and substrate temperature are very important. We also demonstrate the superconducting Nd_(0.8)Sr_(0.2)NiO_(2) epitaxial film is very stable in ambient conditions up to 512 days. Our results provide important insights for fabrication of superconducting infinite-layer nickelates towards future device applications.

关键词： nickelate superconductivity infinite-layer plasma condensate plume dynamics

Harnessing bacteria for tumor therapy:Current advances and challenges

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Chinese Chemical Letters 2024年第2期35卷 97-106页

作者： Lina Guo Jinsong ding Wenhu Zhou Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China Changsha Medical University Academician WorkstationChangsha 410219China Key Laboratory of Biological Nanotechnology of National Health Commission Changsha 410008China

After a century of standstill,bacteria-based tumor therapy has resurged recently benefiting from the revolution of tumor immunotherapy,which provides unique solutions to tackle the obstacles of traditional tumor *** and facultative anaerobes with active tropism can selectively colonize at tumor sites and suppress tumor growth via different mechanisms,serving as attractive tools for tumor treatment either as a monotherapy or combining with other therapies for synergistic anti-tumor *** this critical review,we introduce the recent advances of bacteria-based tumor therapy from the following ***,the general properties of bacteria are reviewed emphasizing on their structural components related to tumor immunotherapy,and the main bacteria that have been used in tumor therapy are ***,the benefits of bacteria for tumor therapy are illustrated,such as tumor targetability,deep penetration,and facile genetic engineering for attenuation,enhanced efficacy,as well as ***,anti-tumor mechanisms of bacteria are summarized,which refer to intrinsic tumoricidal activities,immune activation,bacteria metabolism,and their capability to regulate gut microbiota ***,bacteria could act as carriers to deliver various types of therapeutics to achieve combination therapy with improved *** addition,several challenges for anti-tumor applications of bacteria are discussed regarding the delivery,efficacy and safety issues,and potential solutions are also ***,the possible improvements and perspectives are discussed in the end,which provide a guideline for the design of advanced bacteria-based tumor therapeutics in the future.

关键词： Bacteria Tumor targeting Immunotherapy Combination therapy Genetic engineering Surface decoration

A noval iron-capturing nanocomposites against biofilms for disrupting bacterial nutritional balance

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Science China Chemistry 2024年第6期67卷 1760-1761页

作者： Jinying Lin Qihang ding Yao Sun Department of Oral Implantology Jilin Provincial Key Laboratory of Tooth Development and Bone RemodelingSchool of StomatologyJilin UniversityChangchun130021China Department of Chemistry Korea UniversitySeoul02841Korea National Key Laboratory of Green Pesticide International Joint Research Center for Intelligent Biosensor Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan430079China

Currently,the escalating crisis of bacterial infections and antibiotic resistance poses a significant global public health challenge[1-3].This situation has driven the search for novel antimicrobial ***,a crucial micr... 详细信息

关键词： metabolism resistance balance

Dynamic impact properties of deep sandstone under thermal-hydraulicmechanical coupling loads

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Journal of Mountain Science 2024年第6期21卷 2113-2129页

作者： CAO Chunhui ding Haonan ZOU Baoping School of Civil Engineering and Architecture Zhejiang University of Science and TechnologyHangzhou 310023China Zhejiang-Singapore Joint Laboratory for Urban Renewal and Future City Hangzhou 310023China

The deep rock mass within coal mines situated in a challenging environment are characterized by high ground stress,high geotemperature,high osmotic water pressure,and dynamic disturbances from mechanical *** investigate the impact of this complex mechanical environment on the dynamic characteristics of roof sandstone in self-formed roadways without coal pillars,standard specimens of deep sandstone from the 2611 upper tunnel working face of the Yongmei Company within the Henan Coal Chemical Industry Group in Henan,China were prepared,and an orthogonal test was *** a self-developed geotechnical dynamic impact mechanics test system,triaxial dynamic impact tests under thermal-hydraulicmechanical coupling conditions were conducted on deep *** results indicate that under high confining pressure,deep sandstone exhibits pronounced brittle failure at low temperatures,with peak strength gradually decreasing as temperature and osmotic water pressure ***,under low confining pressure and low temperature,the brittleness of deep sandstone weakens gradually,while ductility ***,sandstone demonstrates higher peak strength at low temperatures under high axial pressure conditions,lower peak strength at high temperatures,and greater strain under low axial pressure and high osmotic water *** in impact air pressure and osmotic water pressure have proportionally greater effects on peak stress and peak *** 50%of the input strain energy is utilized as effective energy driving the sandstone fracture *** analysis identifies the optimal combination of factors affecting the peak stress and peak strain of *** the coupling effect,intergranular and transgranular fractures occur within the *** images illustrate that the damage forms range from minor damage with multiple fissures to extensive fractures and severe *** study elucidates the varied dynamic impact me

关键词： Deep sandstone Thermal-hydraulicmechanical coupling Dynamic impact Stress-strain Failure Modes Polar analysis

Targeted nanostrategies eliminate pre-metastatic niche of cancer

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Nano Research 2024年第6期17卷 5358-5373页

作者： Juan Wang Ning Zhang Xiuping ding Chengrui Fu Xiaodong Li Baosheng Li Jianxun ding Tianmeng Sun Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education Institute of ImmunologyThe First HospitalJilin University1 Xinmin StreetChangchun 130061China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of Sciences5625 Renmin StreetChangchun 130022China Department of Radiation Oncology Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical Sciences440 Jiyan RoadJinan 250117China Department of orthopaedics The Second Hospital of Shandong UniversityShandong University247 Beiyuan StreetJinan 250033China State Key Laboratory of Molecular Engineering of Polymers Fudan University220 Handan RoadShanghai 200433China

Establishing a pre-metastatic niche(PMN)in secondary organs is a prerequisite for cancer *** advances in cancer therapy,the efficient inhibition of PMN formation remains a clinical *** advances in understanding the specific characteristics of PMN and advances in nanotechnology have provided hope for manipulating their microenvironments.A series of nanostrategies have been designed to eliminate the PMN,including the removal of pro-metastatic exosomes from the bloodstream for excretion via the intestines,the targeting and scavenging of myeloid-derived suppressor cells,fibroblasts,and critical extracellular matrix components,and the elimination of circulating tumor cells prior to colonization in distant *** review summarizes the underlying mechanisms of PMN formation,highlights the anti-PMN efficacy of currently reported nanostrategies,and underlines the unresolved questions.

关键词： nanoparticle controlled drug delivery pre-metastatic niche elimination metastasis suppression cancer therapy