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Conditioned medium from human dental pulp stem cells treats spinal cord injury by inhibiting microglial pyroptosis

Neural Regeneration Research 2024年第5期19卷 1105-1111页

作者： Tao Liu Ziqian Ma Liang Liu Yilun Pei Qichao Wu Songjie Xu Yadong Liu Nan ding Yun Guan yan Zhang Xueming Chen Department of Orthopedic Surgery Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Orthopedic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina Department of Stomatology Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Anesthesiology and Critical Care Medicine School of MedicineJohns Hopkins UniversityBaltimoreMDUSA Department of Neurological Surgery School of MedicineJohns Hopkins UniversityBaltimoreMDUSA

Human dental pulp stem cell transplantation has been shown to be an effective therapeutic strategy for spinal cord ***,whether the human dental pulp stem cell secretome can contribute to functional recovery after spinal cord injury remains *** the present study,we established a rat model of spinal cord injury based on impact injury from a dropped weight and then intraperitoneally injected the rats with conditioned medium from human dental pulp stem *** found that the conditioned medium effectively promoted the recovery of sensory and motor functions in rats with spinal cord injury,decreased expression of the microglial pyroptosis markers NLRP3,GSDMD,caspase-1,and interleukin-1β,promoted axonal and myelin regeneration,and inhibited the formation of glial *** addition,in a lipopolysaccharide-induced BV2 microglia model,conditioned medium from human dental pulp stem cells protected cells from pyroptosis by inhibiting the NLRP3/caspase-1/interleukin-1β*** results indicate that conditioned medium from human dental pulp stem cells can reduce microglial pyroptosis by inhibiting the NLRP3/caspase-1/interleukin-1βpathway,thereby promoting the recovery of neurological function after spinal cord ***,conditioned medium from human dental pulp stem cells may become an alternative therapy for spinal cord injury.

关键词： BV2 conditioned medium dental pulp stem cells GSDMD microglia neuroinflammation NLRP3 pyroptosis spinal cord injury

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A brand new green coating technology for realizing the regulation of spherical propellant energy release process

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Defence Technology（防务技术） 2024年第6期36卷 78-94页

作者： Wenhao Fan Yajun ding Zhongliang Xiao School of Chemistry and Chemical Engineering Nanjing University of Science and TechnologyNanjing210094China Key Laboratory of Special Energy Materials Nanjing University of Science and TechnologyMinistry of EducationNanjing 210094China

To achieve the controllable release of energy of nitrocellulose-based propellants,this paper combines the cellulose-based nanocomposites aqueous coating(Surelease®-NC)with fluidized bed coating equipment to successfully prepare the coated spherical propellant for the first *** effects of fluidized bed coating temperature,air velocity,flow speed and atomization pressure on the adhesion rate,coating integrity and coating uniformity of the coated spherical propellant were investigated,and the preparation of coated spherical propellant with homogeneous size and structural integrity was achieved for the first *** microscopic morphology,chemical structure,water vapor adsorption behavior,combustion performance,and ageing resistance property of the coated spherical propellant were systematically investigated by,Fourier transforms infrared spectroscopy(FTIR),Micro confocal raman spectrometer,field scanning electron microscopy(SEM),dynamic vapor adsorption techniques,and closed bomb test,confirming the surface core-shell structure and the tightly bonded interfacial structure of coated spherical ***,the coated spherical propellant has good hygroscopic,excellent progressive burning and long storage stability.

关键词： Nanocomposites aqueous coating Fluidized bed coating equipment Coated spherical propellant Controllable release of energy Long storage stability

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Niduenes A-F,six functionalized sesterterpenoids with a pentacyclic 5/5/5/5/6 skeleton from endophytic fungus Aspergillus nidulans

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Chinese Chemical Letters 2024年第9期35卷 202-205页

作者： Aimin Fu Chunmei Chen Qin Li Nanjin ding Jiaxin dong Yu Chen Mengsha Wei Weiguang Sun Hucheng Zhu Yonghui Zhang Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation School of PharmacyTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Niduenes A-F(1-6),six novel sesterterpenoids with unprecedented 5/5/5/5/6 pentacyclic ring skeleton were isolated from endophytic fungus Aspergillus *** 1 and 2 represent the first examples of aromatic pentacyclic *** structures and configurations were elucidated by spectroscopic data and single-crystal X-ray diffraction *** 4 demonstrated potent resensitization of SW620/AD300 cells to paclitaxel(PTX).Rhodamine 123 accumulation assay and docking analysis further support that 4 inhibitory the efflux function of P-glycoprotein(P-gp).

关键词： Aspergillus nidulans Sesterterpenoids Aromatic sesterterpenoids Structure elucidation Single-crystal X-ray diffraction Biosynthetic pathways

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Prediction of favorable geological storage areas based on sedimentary characteristics:A case study on the northeastern Ordos Basin,China

Energy Geoscience

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Energy Geoscience 2024年第4期5卷 187-197页

作者： Yue Zhao Qiang Xu Song Du yang Zhang Tengzhuo Zhang Yinglin Fan yan ding Sitong Song Xinxin Feng General Prospecting Institute China National Administration of Coal GeologyBeijing100039China China Coal Weikun(Beijing)Energy Saving and Environmental Protection Technology Co. Ltd.Beijing102488China China University of Mining and Technology(Beijing) Beijing100083China Shaanxi Tiancheng Petroleum Technology Co. Ltd.Xi'an710000China

The Ordos Basin is a large cratonic basin with stable deposition in Northwest *** its mostly stable subsidence background and the urgent need for saline water disposal and carbon dioxide storage in the coal mining and coal chemical industries,the Ordos Basin has been chosen as a pilot demonstration site for carbon dioxide and saline water storage in ***,few studies have been made to evaluate the sedimentary and sequence stratigraphy characteristics of this region,as well as their influence on carbon dioxide and saline water storage *** address this research gap,we conducted a sedimentary study of the Lower Triassic Liujiagou Formation in the northeastern Ordos Basin utilizing the stratigraphy theory,laboratory test analysis,and pilot project demonstration,to evaluate the area's viability for the deep geological storage of gas and liquid *** studied the tectonic setting,petrological features,and sedimentary characteristics of the favorable strata and predicted favorable areas based on sequence stratigraphy *** lithology predominantly consists of feldspathic graywacke,with a fine grain size and mostly fine-to-medium-grained *** distribution of thick-grained sandstone and fine-grained sediment was identified by dividing the sequence,and a favorable reservoir-cap assemblage configuration was ***'s concluded that the Lower Triassic Liujiagou Formation exhibits suitable characteristics for the deep geological storage of carbon dioxide and saline *** study demonstrates the importance of basic theory in guiding practical applications and provides a reference for the scientific selection of favorable areas for deep basin storage.

关键词： Ordos Basin Liujiagou Formation Sedimentary facies Sequence stratigraphy Geological storage

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Upconversion luminescence and temperature sensing performance of Er^(3+) ions doped self-activated KYb(MoO_(4))_(2) phosphors

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Journal of Rare Earths 2024年第8期42卷 1507-1513,I0004页

作者： Ye Tong Wenpeng Liu Shoujun ding School of Microelectronics and Data Science Anhui University of TechnologyMaanshan243002China Advanced Laser Technology Laboratory of Anhui Province Hefei230037China Anhui Institute of Optics and Fine Mechanics Chinese Academy of SciencesHefei230031China

In this work,a series of self-activated KYb(MoO_(4))_(2) phosphors with various x at% Er^(3+) doping concentrations(x=0.5,1,3,5,8,10,15) was synthesized by the solid-state reaction *** phase structure of the as-prepared samples was analyzed by X-ray diffraction(XRD),XRD Rietveld refinement and Fourier transform infrared(FT-IR) *** as-prepared samples retain the orthorhombic structure with space group of Pbcn even Er^(3+) doping concentration up to 15 at%.High-purity upconversion(UC) green emission with green to red intensity ratio of 55 is observed from the as-prepared samples upon the excitation of 980 nm semiconductor laser and the optimum doping concentration of Er^(3+) ions in the self-activated KYb(MoO_(4))_(2) host is revealed as 3 at%.The strong green UC emission is confirmed as a two-photon process based on the power-dependent UC *** addition,the fluorescence intensity ratios(FIRs) of the two thermally-coupled energy levels,namely ^(2)H_(11/2) and ^(4)S_(3/2).of Er^(3+) ions were investigated in the temperature region 300-570 K to evaluate the optical temperature sensor behavior of the *** maximum relative sensitivity(S_(R)) is determined to be 0.0069 K^(-1) at300 K and the absolute sensitivity(S_(A)) is determined to be 0.0126 K^(-1) at 300 *** S_(A) of self-activated KYb(MoO_(4))2:Er^(3+)is almost twice that of traditional KY(MoO_(4))2:Er^(3+)/Yb^(3+)codoping *** results demonstrate that Er^(3+) ions doped self-activated KYb(MoO_(4))2 phosphor has promising application in visible display,trademark security and optical temperature sensors.

关键词： Er^(3+)ions doped KYb(MoO_(4))_(2) Self-activated phosphors Upconversion luminescence Solid-state reaction method Optical temperature sensors Rare earths

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Optimization of resource allocation in FDD massive MIMO systems

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Digital Communications and Networks 2024年第1期10卷 117-125页

作者： Jun Cai Chuan Yin Youwei ding School of Artificial Intelligence and Information Technology Nanjing University of Chinese MedicineNanjing 210046China School of Electronic and Information Hangzhou Dianzi UniversityHangzhou 310018ZhejiangChina

The performance of massive MIMO systems relies heavily on the availability of Channel State Information at the Transmitter(CSIT).A large amount of work has been devoted to reducing the CSIT acquisition overhead at the pilot training and/or CsI feedback *** fact,the downlink communication generally includes three stages,i.e.,pilot training,CsI feedback,and data *** three stages are mutually related and jointly determine the overall system ***,there exist few studies on the reduction of csIT acquisition overhead from the global point of *** this paper,we integrate the Minimum Mean Square Error(MMSE)channel estimation,Random Vector Quantization(RVQ)based limited feedback and Maximal Ratio Combining(MRC)precoding into a unified framework for investigating the resource allocation *** particular,we first approximate the covariance matrix of the quantization error with a simple expression and derive an analytical expression of the received Signal-to-Noise Ratio(SNR)based on the deterministic equivalence *** the three performance metrics(the spectral efficiency,energy efficiency,and total energy consumption)oriented problems are formulated *** practical system requirements,these three metrics can be collaboratively ***,we propose an optimization solver to derive the optimal partition of channel coherence *** results verify the benefits of the proposed resource allocation schemes under three different scenarios and illustrate the tradeoff of resource allocation between three stages.

关键词： Massive MIMO FDD CSIT Resource allocation

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Modification of LiMn_(0.6)Fe_(0.4)PO_(4)lithium-ion battery cathode materials with a fluorine-doped carbon coating

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Particuology 2024年第9期92卷 278-287页

作者： Debao Pan Ziyuan Liu Chengping Li Rundong Wan Jinsong Wang Jiangzhao Chen ding Wang Jinkun Liu Yingjie Zhang Jianhong Yi Rui Bao Zhengfu Zhang Peng dong Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming 650093China Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming 650093China

In this study,glucose and NH4F were utilized as sources of carbon and fluorine,respectively,for the synthesis of LiMn_(0.6)Fe_(0.4)PO_(4)(LMFP)*** nanoscales were subsequently modified with varying levels of fluorine-doped carbon through co-precipitation and mechanical ball milling *** LMFP,incorporating carbon and varying levels of fluoride ions,exhibit higher specific discharge capacities at 0.2 Cand electrochemical characteristics compared to the original LMFP coated solely with *** inclusion of fluorine-doped carbon in the composite material creates numerous pathways for expeditious electron ***,the partial formation of metal fluoride at the interface between the surface of LMFP and the layer of carbon coating doped with fluorine enhances the reduction in the charge-transfer *** modified ferromanganese phosphate cathode material reveals an outstanding discharge capacity displaying a reversible discharge specific capacity value of 131.73 mA h g^(−1)at 10C and 154.6 mA h g^(−1)at 0.2C,due to its unique structure.

关键词： Lithium manganese iron phosphate Anode Electrochemical Fluorine-doped carbon

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Frictional contact analysis of a rigid solid with periodic surface sliding on the thermoelectric material

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Applied Mathematics and Mechanics(English Edition) 2024年第1期45卷 179-196页

作者： Yali ZHANG Yueting ZHOU Shenghu ding School of Mathematics and Statistics Ningxia UniversityYinchuan 750021China School of Aerospace Engineering and Applied Mechanics Tongji UniversityShanghai 200092China

Understanding and characterizing rough contact and wavy surfaces are essential for developing effective strategies to mitigate wear,optimize lubrication,and enhance the overall performance and durability of mechanical *** sliding friction contact problem between a thermoelectric(TE)half-plane and a rigid solid with a periodic wavy surface is the focus of this *** simplify the problem,we utilize mixed boundary conditions,leading to a set of singular integral equations(SIEs)with the Hilbert *** analytical solutions for the energy flux and electric current density are obtained by the variable transform method in the context of the electric and temperature *** contact problem for the elastic field is transformed into the second-kind SIE and solved by the Jacobi ***,the smoothness of the wavy contact surface ensures that there are no singularities in the surface contact stress,and ensures that it remains free at the contact *** on the plane strain theory of elasticity,the analysis primarily examines the correlation between the applied load and the effective contact *** distribution of the normal stress on the surface with or without TE loads is discussed in detail for various friction ***,the obtained results indicate that the in-plane stress decreases behind the trailing edge,while it increases ahead of the trailing edge when subjected to TE loads.

关键词： wavy surface periodic contact thermoelectric(TE)material Hilbert integral kernel

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Prescribed-Time Fully Distributed Nash Equilibrium Seeking Strategy in Networked Games

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 261-263页

作者： Cheng Qian Lei ding the Institute of Advanced Technology for Carbon Neutrality College of Automation&the College of Artificial Intelligence Nanjing University of Posts and TelecommunicationsNanjing 210023China IEEE

Dear Editor, This letter is concerned with prescribed-time fully distributed Nash equilibrium seeking for networked games under directed graphs. An adaptive algorithm is proposed to ensure the convergence of all players to the Nash equilibrium without requiring any knowledge of global parameters. Moreover, it is theoretically proved that the convergence time of the proposed seeking strategy can be predefined based on practical requirements. Finally, a numerical example is presented to validate the effectiveness of the proposed method.

关键词： parameters seeking prescribed

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Single-atom catalysts: controlled synthesis and dynamic mechanism in electrochemical oxygen evolution substitution reactions

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Rare Metals 2024年第10期43卷 4903-4920页

作者： Qin Zhao Rong Gan Yi-Ling Ran Quan-Lei Ma Wen-Wen Chen Yue-Xin Guo yan Zhang ding-Sheng Wang School of Chemistry Southwest Jiaotong University School of Life Science and Engineering Southwest Jiaotong University Engineering Research Center of Advanced Rare Earth Materials Department of ChemistryTsinghua University

Single-atom catalysts(SACs) have attracted much attention in the field of electrocatalysis due to their100% atomic utilization efficiency, clear active center and adjustable support. The application of SACs to anodic oxygen evolution substitution reactions with high conversion efficiency and selectivity is undoubtedly ***, a full understanding of the interactions between metal single-atom active sites and supports, and an in-depth understanding of the active centers and catalytic mechanisms of SACs in the electro-oxidation of small molecules are the keys to the development of high-performance catalysts. This review focuses on the synthesis of different support SACs and the interactions between single atoms and supports at the inter-face, and introduces the reaction mechanism of SACs in the electro-oxidation of different small-molecule substrates, such as ethanol, urea and hydrazine, with the aim of providing insights and ideas for the design of more efficient and ideal catalysts. Finally, we discuss the current challenges and future opportunities in the field.

关键词： Synthesis (chemical)

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