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Current Use of Oral Anticoagulants and Prognostic Analysis in Patients with Atrial Fibrillation Undergoing Coronary Stenting

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Chinese Medical Journal 2017年第12期130卷 1418-1423页

作者： Heng-Bo Zhai Jun Liu Zhi-Chao dong dong-xia wang Bo Zhang Department of Cardiology The First Affiliated Hospital of Dalian Medical University Dalian Liaoning 116011 China Department of Cardiology The General Hospital of Shenyang Military Shenyang Liaoning 110016 China

Background： It is currently believed that triple oral antithrombotic therapy in patients with atrial fibrillation （AF） after percutaneous coronary intervention （PCI） should be recommended if there are no contraindications. However, selecting triple therapy for AF patients undergoing PCI is still challenging when bleeding risk is considered. This study aimed to investigate the current use of oral anticoagulants （Vitamin K antagonists [VKA]） and perform prognostic analysis in real-world patients with AF undergoing coronary stenting. Methods： A total of 276 consecutive coronary artery disease （CAD） patients with or without AF undergoing coronary stenting were retrospectively evaluated and analyzed. The univariate and multivariate analyses were conducted to explore the current use of VKA and prognosis of patients with AF undergoing coronary stenting. The primary end-point was composite of all-cause death, nonfatal recurrent myocardial infarction, stroke, serious bleeding events, unplanned repeat revascularization, and worsening heart failure at 12-month follow-up after coronary stenting. Results： AF patients undergoing coronary stenting have more clinical concomitant diseases. Only 9.0% AF patients after coronary stenting received triple antithrombotic therapy （VKA, aspirin, and clopidogrel） at discharge. AF was independently associated with increased risk of the 12-month composite end-points （relative risk = 5.732, 95% confidence interval 1.786-18.396, P = 0.003）. Conclusions： In real-life AF patients undergoing coronary stenting, guideline-recommended VKA was less used. AF patients had adjusted worse prognosis during 12-month follow-up after discharge. It is of utmost importance to improve the current status of oral anticoagulants use.

关键词： Antithrombotic Therapy Atrial Fibrillation Coronary Artery Disease Percutaneous Coronary Intervention Prognosis

CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng wang Guo-Cui Mao Hui-Lin Jiang Bao-xia dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： Metal hydride Ni catalysts Carbonate Metal-carbonate interface

New conversion of Friendlnder reaction of 3-amino-1H-benzo[f]chromene-2-carbonitriles with cyclohexanone

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Chinese Chemical Letters 2008年第1期19卷 15-18页

作者： Jia Rong Li Li Jun Zhang Xi Quan Yang Qing Li dong wang Chun xia wang Da Xin Shi Qi Zhang School of Chemical Engineering and Environment Beijing Institute of Technology Beijing 100081 China

Two different skeletons of heterocyclic compounds, quinoline and quinazolinone analogs could be obtained by a novel one-pot synthesis from substituted 3-amino- 1H-benzo[f]chromene-2-carbonitrile derivatives and cyclohexanone in DMF in the catalyst of anhydrous Zinc chloride under reflux. A plausible mechanism was proposed. 2007 Jia Rong Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： Friedlander cyclocondensation Quinoline and quinazolinone analogs New conversion

冷藏秋刀鱼的菌相分析及其优势腐败菌的分离鉴定

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现代食品科技 2016年第11期32卷 139-145,221页

作者：董文霞王欣上海理工大学食品质量与安全研究所上海200093

冷藏秋刀鱼优势腐败菌的研究可为靶向抑菌,延长货架期提供一定的参考。论文利用传统培养的方法研究了冷藏(4℃)秋刀鱼的菌相变化、分离与鉴定优势腐败菌并验证了其腐败能力。结果表明,秋刀鱼冷藏6 d后达到其货架期终点,冷藏过程中共分... 详细信息

冷藏秋刀鱼优势腐败菌的研究可为靶向抑菌,延长货架期提供一定的参考。论文利用传统培养的方法研究了冷藏(4℃)秋刀鱼的菌相变化、分离与鉴定优势腐败菌并验证了其腐败能力。结果表明,秋刀鱼冷藏6 d后达到其货架期终点,冷藏过程中共分离、鉴定出13株细菌,革兰氏阳性菌7株,革兰氏阴性菌6株,分属7个菌属。根据各菌株在菌相中的比例变化及对灭菌鱼汁TVB-N值的影响,可以确定菌株13(肠杆菌),12(希瓦氏菌),7、9(不动杆菌)为冷藏秋刀鱼的优势腐败菌。各株优势腐败菌对秋刀鱼挥发性盐基氮(total volatile base nitrogen,TVB-N)、三甲胺(trimethylamine,TMA)、硫代巴比妥酸(the 2-2-thiobarbituric acid,TBA)的影响不同,12号菌株(希瓦氏菌)会加速样品TMA的产生,13号菌株(肠杆菌)对样品的TVB-N值影响最大,7号菌株(不动杆菌)则会促使样品的TBA值显著增大,9号菌株(不动杆菌)对以上各指标也均具有一定的影响,证明所确定的4株菌对冷藏秋刀鱼具有较强的腐败能力。

关键词：秋刀鱼冷藏菌相分析优势腐败菌腐败能力

Enteromorpha prolifera polysaccharide-Fe(Ⅲ) complex promotes intestinal development as a new iron supplement

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Science China Life Sciences 2025年第1期 219-231页

作者： Yingying Feng Yuying Wu Jialu wang Zhenglin dong Qian Yu Shuangshuang xia Chunxue Liu Haihua wang Xin Wu Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences CAS Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical AgricultureChinese Academy of Sciences ANYOU Biotechnology Group Co.Ltd Qingdao Seawin Biotech Group Co. LTD

Iron is a crucial micronutrient, and its deficiency can have detrimental effects on the health of infants. Dietary polysaccharide-iron(Ⅲ) complexes(PICs) are promising for addressing iron deficiency due to their minimal adverse reactions and high iron absorption rate. This study aimed to investigate the effects of dietary Enteromorpha prolifera polysaccharide-Fe(Ⅲ) complex(EP-Fe) on newborns, using 3-day weaned piglets as the iron-deficiency model. Results showed that EP-Fe improved iron levels and promoted intestinal development in piglets. Transcriptome sequencing revealed that EP-Fe increased the survival of intestinal epithelial cells under hypoxia by upregulating the expression of genes that promote the development of the vascular system. Additionally, EP-Fe enhanced the mucosal barrier functions by inhibiting myosin light chain kinase(MLCK)/phosphorylated myosin light chain(p-MLC) signaling pathway to increase the expression of intestinal tight junction proteins. Furthermore, the 16S r RNA gene sequencing of gut microbiota showed that EP-Fe promoted the enrichment of Bacteroides＿fragilis and other gut microbes that can metabolize carbohydrates. In conclusion, EP-Fe is an effective iron supplement for newborns, and it can be developed as a comprehensive nutritional supplement.

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大气污染对北京冬季城市和郊区辐射收支影响的观测分析

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地球物理学报 2016年第11期59卷 3996-4006页

作者：王昕然苗世光窦军霞董璠王京丽中国气象科学研究院北京100081 中国气象局北京城市气象研究所北京100089 中国气象局京津冀环境气象预报预警中心北京100089

近年来城市化和大气污染对辐射收支的影响日益显著.本研究利用2013—2014年中国科学院大气物理研究所325m铁塔、南郊观象台、密云气象塔、上甸子区域大气本底站四个观测站点的辐射及自动站气象要素数据,采用南郊观象台的能见度资料将观... 详细信息

近年来城市化和大气污染对辐射收支的影响日益显著.本研究利用2013—2014年中国科学院大气物理研究所325m铁塔、南郊观象台、密云气象塔、上甸子区域大气本底站四个观测站点的辐射及自动站气象要素数据,采用南郊观象台的能见度资料将观测数据分为清洁天和污染天,并进行类比分析,以1月份为例,研究了北京地区大气污染和城郊差异对辐射收支的影响.结果表明:(1)从月平均值来看,各站污染天入射短波辐射均小于清洁天,衰减最大可达55.8W·m^(-2),直接辐射亦然,衰减最大可达161.1W·m^(-2),散射辐射相反,增加最大值为72.2W·m^(-2);长波辐射污染天大于清洁天,向下向上长波辐射增加最大值分别为85.0 W·m^2和70.0 W·m^(-2),且长波辐射的衰减与污染物浓度和大气温度相关;净辐射白天污染天小于清洁天,夜间相反.(2)从各站的对比可知,大气污染对入射短波辐射的衰减,南部郊区(13.2%)大于北部城区(7.4%),与北京地区"南北两重天"的污染物分布特征一致;且污染物对长短波辐射的影响呈现了从城区到郊区衰减率依次减小的现象.本研究为大气污染与气象条件的相互作用研究提供了观测基础.

关键词：大气污染辐射收支城市郊区北京

Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

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Science China Chemistry 2025年第01期 201-208页

作者： Hui-Feng wang Wen-Jie Shi Yu-Xin Yang Bao-xia dong Tong-Bu Lu Di-Chang Zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

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EXPERIMENTAL STUDY ON PREVENTING FLOOD OF 1% FREQUENCY IN HUAIHE RIVER

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Journal of Hydrodynamics 1999年第4期11卷 2-9页

作者： Chen xian pu, Liang Bin, Shao dong chao, wang xia Anhui & Huaihe River Water Resources Research Institute, Bengbu 233000, P.R.China Duan Hong dong, Chen Biao Huaihe River Planning & Design Institute, Bengbu 233001, P.R.China

After having completed river regulation work in recent years, the dike distance up the reach of Lutaizi has been extended to 1.5 2.0 km in the Huaihe river. When the middle flood happened,such as those in 1956, 1982 and 1991, flood can pass through safely. If the flood of 1% frequency happens, the flood discharge at Lutaizi will be larger than safe flood discharge 10000 m 3/s in downstream Lutaizi. By storing flood with the Linhuaigang sluice, the discharge of Lutaizi will not be over 10000 m 3/s. Cities in downstream Lutaizi will be free from flood.

关键词： flood control model the flood of 1% frequency Linhuaigang flood control project Huaihe river

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DNA步行者分子机器研究新进展

中国科学：化学 2019年第5期49卷 776-786页

作者：汪晶王东霞马嘉懿孔德明南开大学化学学院分析科学研究中心天津300071 天津市生物传感与分子识别重点实验室天津300071

作为人类向大自然学习过程中迈出的重要一步,人工分子机器的研究越来越受到人们的重视.由于具有碱基配对的精确性、序列的可编程性、二级结构的多样性和可控性等一系列优势, DNA被认为是最有前途的一类分子机器构筑材料之一.本综述依据... 详细信息

作为人类向大自然学习过程中迈出的重要一步,人工分子机器的研究越来越受到人们的重视.由于具有碱基配对的精确性、序列的可编程性、二级结构的多样性和可控性等一系列优势, DNA被认为是最有前途的一类分子机器构筑材料之一.本综述依据驱动力的不同,对一类重要的分子机器——DNA步行者分子机器的最新研究进展进行了介绍,并对该类分子机器的未来发展进行了展望.

关键词：分子机器 DNA步行者生物传感生物成像纳米探针