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Effects of physical rehabilitation interventions in COVID-19 patients following discharge from hospital:A systematic review

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Journal of Integrative Medicine 2023年第2期21卷 149-158页

作者： Masoud Rahmati Mahdieh Molanouri Shamsi Wongi woo Ai Koyanagi Seung Won Lee dong Keon Yon Jae Il Shin Lee Smith Department of Physical Education and Sport Sciences Faculty of Literature and Human SciencesLorestan University*** KhoramabadIran Department of Physical Education&Sport Sciences Faculty of HumanitiesTarbiat Modares University*** TehranIran Department of Thoracic and Cardiovascular Surgery Yonsei University College of MedicineGangnam Severance HospitalGangnam-guSeoul 06273Republic of Korea Research and Development Unit Parc Sanitari Sant Joan de DéuSant Boi de Llobregat08830 BarcelonaSpain Catalan Institution for Research and Advanced Studies(ICREA) Barcelona 08010Spain Department of Precision Medicine Sungkyunkwan University School of MedicineSuwon 16419Republic of Korea Medical Science Research Institute Kyung Hee UniversitySeoul 02447Republic of Korea Department of Pediatrics Kyung Hee University Medical CenterKyung Hee UniversitySeoul 02447Republic of Korea Department of Pediatrics College of MedicineYonsei UniversitySeoul 03722Republic of Korea Centre for Health Performanceand WellbeingAnglia Ruskin UniversityCambridge CB11PTUK

Background:Hospitalized patients recovering from coronavirus disease 2019(COVID-19)may experience disability and suffer from significant physical and mental impairment requiring physical rehabilitation following their ***,to date,no attempt has been made to collate and synthesize literature in this ***:This systematic review examines the outcomes of different physical rehabilitation interventions tested in COVID-19 patients who were discharged from *** strategy:A systematic search of MEDLINE/PubMed,CINAHL,Scopus and medRxiv was conducted to identify articles published up to March *** criteria:This systematic review included studies of outpatient rehabilitation programs for people recovering from COVID-19 who received physical activity,exercise,or breathing training to enhance or restore functional capacity,pulmonary function,quality of life,and mental health or *** extraction and analysis:Selection of included articles,data extraction,and methodological quality assessments were conducted by two review authors respectively,and consensus was reached through discussion and consultation with a third ***,we review the outcomes of studies based on four categories including:(1)functional capacity,(2)pulmonary function,(3)quality of life,and(4)mental health ***:A total of 7534 titles and abstracts were screened;10 cohort studies,4 randomized controlled trials and 13 other prospective studies involving 1583 patients were included in our *** physical rehabilitation interventions applied in COVID-19 patients who were discharged from the hospital improved multiple parameters related to functional capacity,pulmonary function,quality of life and mental health ***:Physical rehabilitation interventions may be safe,feasible and effective in COVID-19 patients discharged from the hospital,and can improve a variety of clinically relevant *** studies are warranted to det

关键词： COVID-19 Physical activity Exercise Rehabilitation Systematic review

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3D cell-printing of gradient multi-tissue interfaces for rotator cuff regeneration

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Bioactive Materials 2023年第1期19卷 611-625页

作者： Suhun Chae Uijung Yong Wonbin Park Yoo-mi Choi In-Ho Jeon Homan Kang Jinah Jang Hak Soo Choi dong-woo Cho Department of Mechanical Engineering Pohang University of Science and Technology77 Cheongam-roNam-guGyeongsangbuk-doPohang37673South Korea EDmicBio Inc. 111 Hoegi-roDongdaemun-guSeoul 02445South Korea Institute for Convergence Research and Education in Advanced Technology Yonsei University50 Yonsei-roSeodaemun-guSeoul03722South Korea Gordon Center for Medical Imaging Department of RadiologyMassachusetts General Hospital&Harvard Medical School14913th StreetBostonMA02114USA Department of Convergence IT Engineering Pohang University of Science and Technology77 Cheongam-roNam-guGyeongsangbuk-doPohang37673South Korea School of Interdisciplinary Bioscience and Bioengineering Pohang University of Science and Technology77 Cheongam-roNam-guGyeongsangbuk-doPohang37673South Korea Department of Orthopaedic Surgery Asan Medical CenterCollege of MedicineUniversity of Ulsan86 Asanbyeongwon-gilSongpa-guSeoul05505South Korea

Owing to the prevalence of rotator cuff(RC)injuries and suboptimal healing outcome,rapid and functional regeneration of the tendon-bone interface(TBI)after RC repair continues to be a major clinical *** the essential role of the RC in shoulder movement,the engineering of biomimetic multi-tissue constructs presents an opportunity for complex TBI reconstruction after RC ***,we propose a gradient cell-laden multi-tissue construct combined with compositional gradient TBI-specific bioinks via 3D cell-printing *** vitro studies demonstrated the capability of a gradient scaffold system in zone-specific inducibility and multi-tissue formation mimicking *** regenerative performance of the gradient scaffold on RC regeneration was determined using a rat RC repair *** particular,we adopted nondestructive,consecutive,and tissue-targeted near-infrared fluorescence imaging to visualize the direct anatomical change and the intricate RC regeneration progression in real time in ***,the 3D cell-printed implant promotes effective restoration of shoulder locomotion function and accelerates TBI healing in *** summary,this study identifies the therapeutic contribution of cell-printed constructs towards functional RC regeneration,demonstrating the translational potential of biomimetic gradient constructs for the clinical repair of multi-tissue interfaces.

关键词： 3D cell-printing Tissue-specific bioink Gradient tissue scaffolds Near-infrared fluorophores Rotator cuff repair

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Creep and tensile properties of press molding joined GMT-sheets

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 170-174页

作者： Jin-woo KIM dong-Gi LEE Center for NDE Iowa State University Department of Mechatronics Engineering Chosun University

GMT-sheet is used in automobile bumper with high rigidity and strength, and its joining strength is influenced by lap length, one of the joined molding conditions. Fracture strength was calculated by dividing fracture load with cross-sectional area. Total five repeated measurements were made to obtain the average value. Tensile test was conducted at room temperature for 10 specimens. In addition, the effect of compression ratio on creep and tensile performance during lap joined molding was discussed. With increasing lap length, the lap joining efficiency of GMT-sheet was increased. However, higher compression ratio reduced the joining efficiency. Creep test on GMT-sheet showed abrupt fracture without tertiary creep. This can be explained by the weak thermal resistance of the resin. If GMT-sheet was exposed to high temperature for a long time, it was easily failed by external force.

关键词：蠕变试验拉伸性能冲压成型时间表标准格林断裂强度搭接长度

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Calculation of the Transition Temperature for Partitioned Growth of Proeutectoid Ferrite in Fe-C Base Multicomponent Alloys

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Journal of Iron and Steel Research(International) 2011年第S1期18卷 530-534页

作者： SUH dong-woo Graduate Institute of Ferrous Technology Pohang University of Science and TechnologyPohang 790-784Republic of Korea

According to the local equilibrium theory,the ferrite growth from alloyed austenite could be divided into the partition local equilibrium (PLE) mode and negligible partition local equilibrium (NPLE) mode.A graphical construction method proposed earlier by Hillert using in Fe-C-X ternary alloys was extended into Fe-C base multicomponent alloys to calculate the PLE/NPLE transition *** method utilize the carbon component ray,in which the substitutional alloy elements content is constant,to determine PLE/NPLE transition *** the method,the PLE/NPLE transition temperature in several alloy systems are calculated and compared with the formerly reported results.

关键词： phase transformation local equilibrium kinetics ferrite PLE/NPLE transition

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Preclinical Long-term Magnetic Resonance Imaging Study of Silymarin Liver-protective Effects

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Journal of Clinical and Translational Hepatology 2022年第6期10卷 1167-1175页

作者： Yeon Ji Chae Hwon Heo Chul-woong woo Sang-Tae Kim Jae-Im Kwon Monica Young Choi Yu Sub Sung Kyung Won Kim Jeong Kon Kim Yoonseok Choi dong-Cheol woo Department of Convergence Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea Convergence Medicine Research Center Asan Institute for Life SciencesAsan Medical CenterSeoulRepublic of Korea Clinical Research Center Asan Medical CenterSeoulRepublic of Korea Department of Radiology Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea Medical Research Institute Gangneung Asan HospitalGangneung-siGangwon-doRepublic of Korea

Background and Aims:Efficacy evaluations with preclini-cal magnetic resonance imaging(MRI)are uncommon,but MRI in the preclinical phase of drug development provides information that is useful for longitudinal *** study aim was to monitor the protective effectiveness of silymarin with multiparameter MRI and biomarkers in a thioacetamide(TAA)-induced model of liver injury in *** analysis was conducted to assess compare the monitoring of liver function by MRI and ***-ods:TAA was injected three times a week for 8 weeks to generate a disease model(TAA group).In the TAA and sily-marin-treated(TAA-SY)groups,silymarin was administered three times weekly from week *** images were acquired at 0,2,4,6,and 8 weeks in the control,TAA,and TAA-SY ***:The area under the curve to maximum time(AUCtmax)and T_(2)*values of the TAA group decreased over the study period,but the serological markers of liver abnormality increased significantly more than those in the control *** the TAA-SY group,MRI and serological biomarkers indicated attenuation of liver function as in the TAA ***,pattern changes were observed from week 6 to comparable levels in the control group with si-lymarin *** correlations between either AUCtmax or T_(2)*values and the serological biomarkers were ***:Silymarin had hepatoprotective effects on TAA-induced liver injury and demonstrated the usefulness of multiparametric MRI to evaluate efficacy in preclinical studies of liver drug development.

关键词： Liver fibrosis Magnetic resonance imaging Silymarin T1-weight-ed dynamic contrast-enhanced T_(2)*

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Improvement in Background Error Covariances Using Ensemble Forecasts for Assimilation of High-Resolution Satellite Data

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Advances in Atmospheric Sciences 2011年第4期28卷 758-774页

作者： Seung-woo LEE dong-Kyou LEE School of Earth and Environmental Sciences Seoul National University

Satellite data obtained over synoptic data-sparse regions such as an ocean contribute toward improving the quality of the initial state of limited-area models. Background error covariances are crucial to the proper distribution of satellite-observed information in variational data assimilation. In the NMC （National Meteorological Center） method, background error covariances are underestimated over data-sparse regions such as an ocean because of small differences between different forecast times. Thus, it is necessary to reconstruct and tune the background error covariances so as to maximize the usefulness of the satellite data for the initial state of limited-area models, especially over an ocean where there is a lack of conventional data. In this study, we attempted to estimate background error covariances so as to provide adequate error statistics for data-sparse regions by using ensemble forecasts of optimal perturbations using bred vectors. The background error covariances estimated by the ensemble method reduced the overestimation of error amplitude obtained by the NMC method. By employing an appropriate horizontal length scale to exclude spurious correlations, the ensemble method produced better results than the NMC method in the assimilation of retrieved satellite data. Because the ensemble method distributes observed information over a limited local area, it would be more useful in the analysis of high-resolution satellite data. Accordingly, the performance of forecast models can be improved over the area where the satellite data are assimilated.

关键词： 3DVAR background error covariances retrieved satellite data assimilation ensemble forecasts.

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Beach stabilization by the laying of a drainage layer

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Science China(Technological Sciences) 2012年第9期55卷 2625-2639页

作者： HUR dong-Soo LEE woo-dong CHO Won-Chul Department of Ocean Civil Engineering(Institute of Marine Industry) Gyeongsang National University445 Inpyeong-dongTongyeong 650-160Korea Department of Ocean Civil Engineering Gyeongsang National University445 Inpyeong-dongTongyeong 650-160Korea Department of Civil and Environmental Engineering Chung-Ang University221 Heuksuk-dong Dongjak-guSeoul 156-756Korea

In the present study,the stabilization effects of the laying of a drainage layer in a sandy beach were *** numerical model developed by Hur et al.(2011) was used to examine the characteristics of wave-sandy beach interaction with/without a drainage *** numerical model directly simulates Wave-Structure-Seabed/Sandy(WASS) beach interaction by considering flow through a porous medium with inertia,laminar and turbulent resistances,and determines the eddy viscosity with the Large Eddy Simulation(LES) turbulent model in a 3-D wave field(LES-WASS-3D).Based on the numerical results,it appears that the installation of a drainage layer in the beach results in a decrease in both the mean groundwater level around the foreshore and the flow moving offshore on the beach *** distributions of the mean groundwater level and wave setup around the foreshore with various arrangements of the drainage layer and conditions of the incident wave are also discussed in this paper.

关键词：排水层海滩铺设稳定数值模型湍流模型地下水位多孔介质

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Impact of Horizontal Resolution and Cumulus Parameterization Scheme on the Simulation of Heavy Rainfall Events over the Korean Peninsula

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Advances in Atmospheric Sciences 2011年第1期28卷 1-15页

作者： Seung-woo LEE dong-Kyou LEE dong-Eon CHANG School of Earth and Environmental Sciences Seoul National University National Institute of Meteorological Research Korea Meteorological Administration

In this paper, we present the results from high-resolution numerical simulations of three heavy rainfall events over the Korean Peninsula. The numerical results show that the prediction accuracy for heavy rainfall events improved as horizontal resolution increased. The fine-grid precipitation fields were much closer to the real precipitation fields in the case of large synoptic forcing over the Korean Peninsula. In the case of large convective available potential energy and weak synoptic forcing, it seems that even when using a high resolution, the models still showed poor performance in reproducing the observed high precipitation amounts. However, activation of the cumulus parameterization scheme in the intermediate resolution of 9 km, even at a grid spacing of 3 km, had a positive impact on the simulation of the heavy rainfall event.

关键词： high resolution cumulus parameterization scheme heavy rainfall numerical simulation

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Utilizing hybrid faradaic mechanism via catalytic and surface interactions for high-performance flexible energy storage system

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能源化学:英文版 2023年第8期83卷 541-548,I0013页

作者： dong-Gyu Lee Hyeonggeun Choi Yeonsu Park Min-Cheol Kim Jong Bae Park Suok Lee Younghyun Cho wook Ahn A-Rang Jang Jung Inn Sohn john Hong Young-woo Lee Department of Energy Engineering Soonchunhyang UniversityAsan 31538Republic of Korea Division of Physics and Semiconductor Science Dongguk University-SeoulSeoul 04620Republic of Korea Jeonju Centre Korea Basic Science InstituteJeonju 54907Republic of Korea Division of Electrical Electronic and Control EngineeringKongju National UniversityCheonan 31080Republic of Korea School of Materials Science and Engineering Kookmin UniversitySeoul 02707Republic of Korea

Improving the capacitance and energy density is a significant challenge while developing practical and flexible energy storage system(ESS).Redox mediators(RMs),as redox-active electrolyte additives,can provide additional energy storing capability via electrochemical faradaic contribution on electrodes for high-performance flexible ***,determining effective material combinations between electrodes and RMs is essential for maximizing surface faradaic redox reactions for energy-storage *** this study,an electrode-RM system comprising heterostructured hybrid(carbon fiber(CF)/MnO_(2)) faradaic electrodes and iodine RMs(I-RMs) in a redox-active electrolyte is *** CF/MnO_(2)with the 1-RMs(CF/MnO_(2)-I) induces dominant catalytic faradaic interaction with the I-RMs,significantly enhancing the surface faradaic kinetics and increasing the overall energy-storage *** CF/MnO_(2)-I ESSs show a 12.6-fold(or higher) increased volumetric energy density of 793.81 mWh L^(-1)at a current of 10 μA relative to ESSs using CF/MnO_(2)without I-RMs(CF/MnO_(2)).Moreover,the CF/MnO_(2)-I retains 93.1% of its initial capacitance after 10,000 cycles,validating the excellent ***,the flexibility of the ESSs is tested at different bending angles(180° to 0°),demonstrating its feasibility for flexible and high-wear ***,CF/MnO_(2)electrodes present a practical material combination for high-performance flexible energy-storage devices owing to the catalytic faradaic interaction with I-RMs.

关键词： Energy storage system Redox mediators Faradaic electrodes Catalytic interactions Mechanical stability

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Effect of molybdenum on interfacial properties of titanium carbide reinforced Fe composite

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Journal of Materials Science & Technology 2022年第12期107卷 252-258页

作者： Seungchan Cho Junghwan Kim Ilguk Jo Jae Hyun Park Jaekwang Lee Hyun-Uk Hong Bong Ho Lee wook Ryol Hwang dong-woo Suh Sang-Kwan Lee Sang-Bok Lee Composites Research Division Korea Institute of Materials Science(KIMS)Changwon 51508South Korea Advanced Materials Engineering Dong-Eui UniversityBusan 47340South Korea Department of Aerospace and Software Engineering Gyeongsang National UniversityJinju 52828South Korea Department of Physics Pusan National UniversityBusan 46241South Korea Department of Materials Convergence and System Engineering Changwon National UniversityChangwon 51140South Korea Center for Core Research Facilities Daegu Gyeongbuk Institute of Science and TechnologyDaegu 42988South Korea School of Mechanical Engineering Gyeongsang National UniversityJinju 52828South Korea Graduate Institute of Ferrous Technology Pohang University of Science and TechnologyGyeongbuk 37673South Korea

This study shows that the mechanical strength of the composite of Fe matrix and titanium carbide(Ti C)ceramic particles is significantly enhanced with addition of molybdenum(Mo) atoms. Ti C reinforced Fe(Fe-0.2C-7Mn) composites with and without Mo were fabricated by a liquid pressing infiltration(LPI)process and the effect of Mo on interfacial properties of TiC–Fe composite was investigated using atomic probe tomography(APT) analysis, molecular dynamics(MD) simulations, first-principle density functional theory(DFT), and thermodynamic calculations. First, DFT calculations showed that total energies of the Mo-doped Ti C–Fe superlattices strongly depend on the position of Mo defects, and are minimized when the Mo atom is located at the TiC/Fe interface, supporting the probable formation of MoC-like interphase at the TiC/Fe interface region. Then, APT analysis confirmed the DFT predictions by finding that about6.5 wt.% Mo is incorporated in the Ti C–Fe(Mo) composite and that sub-micrometer thick(Ti,Mo)C interphase is indeed formed near the interface. The MD simulations show that Mo atoms migrate to the Mo-free TiC–Fe interface at elevated temperatures and the mechanical strength of the interface is considerably enhanced, which is in good agreement with experimental observations.

关键词： Metal matrix composites(MMCs) Titanium carbide Fe matrix composite Infiltration Molybdenum Interfacial property

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