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Enhanced Oxidation Resistance of Iron Nanoparticles via Surface Modification in Chemical Vapor Condensation Process

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Journal of Materials Science & Technology 2010年第4期26卷 367-370页

作者： dong-won lee Ji-Hun Yu Taesuk Jang Byoung-Kee Kim Korea Institute of Materials Science Changwon 641-831 Korea Department of Electronic Materials Sunmoon University Asan 336-708 Korea 不详

In order to prevent the oxide formation on the surface of nano-size iron particles and thereby to improve the oxidation resistance in ordinary condition, iron nanoparticles synthesized by a chemical vapor condensation method were directly soaked in hexadecanethiol solution to coat them with a polymer layer. Oxygen content in the polymer-coated iron nanoparticles was significantly lower than that in usual air-passivated particles possessing iron-core/oxide-shell structure. Accordingly, oxidation resistance of the polymer-coated particles at an elevated temperature below 130℃ in air was 10-40 times higher than that of the normally passivated particles.

关键词： Powder technology Nano materials Iron Chemical vapor condensation

Effect of focal laser photocoagulation in eyes with mild to moderate non-proliferative diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2016年第10期9卷 1439-1443页

作者： Seong Hun Jeong Jung Il Han Sung won Cho dong won lee Chul Gu Kim Tae Gon lee Jong Woo Kim Department of Ophthalmology Kim's Eye HospitalMyung-Gok Eye Research InstituteKonyang University College of Medicine

AIM：To report the effect of focal laser photocoagulation on both the severity of hard exudates（HEs） and the rate of disease progression in eyes with mild to moderate non-proliferative diabetic retinopathy（NPDR）.METHODS： We retrospectively reviewed the medical records of 33 patients（60 eyes） who had been diagnosed with mild to moderate NPDR between January 2006 and December *** patients were divided into 2 groups：Group A（38 eyes in 20 patients treated using focal laser photocoagulation） and Group B（treated without laser photocoagulation）.We also reviewed the best corrected visual acuity measurements,and the fundus photographs taken at both baseline and follow-up visits. RESULTS： In Group A,HE severity grade had decreased significantly from baseline to the final visit（P 〈0.05）,but this was not the case in Group B（P =0.662）.The cumulative probabilities of retinopathy progression at 5y were 26% in Group A and 30% in Group *** survival curves showed no significant difference between the groups with regard to retinopathy progression（P =0.805）.CONCLUSION： Focal laser photocoagulation reduced the levels of HEs in eyes with mild to moderate ***,the treatment was not able to decelerate the progression of DR.

关键词： focal laser diabetic retinopathy retina non-proliferative diabetic retinopathy

Abrupt visual loss during anti-vascular endothelial growth factor treatment for type 3 neovascularization

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International Journal of Ophthalmology(English edition) 2019年第3期12卷 480-487页

作者： Jae Hui Kim Young Suk Chang Jong Woo Kim Chul Gu Kim dong won lee Department of Ophthalmology Kim's Eye Hospital Konyang University College of Medicine Department of Ophthalmology Konyang University College of Medicine

AIM: To investigate the incidence of abrupt visual loss and its associated factors, during anti-vascular endothelial growth factor(VEGF) treatment for type 3 ***: This retrospective study included 137 eyes that were newly diagnosed with type 3 neovascularization. All eyes were treated with anti-VEGF therapy. Abrupt visual loss was defined as loss of 5 or more lines in best-corrected visual acuity(BCVA) in comparison to the previous visit. The incidence and timing of abrupt visual loss as well as the factors associated with it, were determined. In addition, the BCVA at the final follow-up was compared between the eyes with and those without abrupt visual ***: The mean follow-up period was 42.4±18.9 mo after diagnosis, and abrupt visual loss was noted in 22 eyes(16.1%) at a mean of 19.6±13.9 mo. Abrupt visual loss was found to be associated with subretinal hemorrhage in 11 eyes(50.0%), development of or increase in the height of pigment epithelial detachment with fluid in 8 eyes(36.4%), and tears in the retinal pigment epithelium in 3 eyes(13.6%). The logarithm of minimum angle of resolution(logMAR) mean BCVA at the final follow-up was 2.07±0.67(Snellen equivalents: 20/2349) and 1.00±0.55(20/200) in eyes with and without abrupt visual loss, respectively. BCVA was significantly worse in the eyes with abrupt visual loss(P<0.001).CONCLUSION: Abrupt visual loss is noted in 16.1% of patients with type 3 neovascularization and is associated with poor visual outcome. Additional studies are needed to determine how abrupt visual loss can be prevented.

关键词： age-related macular degeneration type 3 neovascularization retinal angiomatous proliferation hemorrhage tear in retinal pigment epithelium pigment epithelial detachment

Autoimmune hepatitis in a patient with immunoglobulin A nephropathy:A case report

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World Journal of Clinical Cases 2020年第17期8卷 3828-3834页

作者： You Hyun Jeon Da Woon Kim So Jeong lee Young Joo Park Hyo Jin Kim Miyeun Han Il Young Kim dong won lee Sang Heon Song Soo Bong lee Eun Young Seong Department of Internal Medicine Pusan National University School of MedicineBusan 49241South Korea Department of Pathology Pusan National University HospitalBusan 49241South Korea Division of Gastroenterology Department of Internal MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea Division of Nephrology Department of Internal MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea Division of Nephrology Department of Internal MedicinePusan National University Yangsan HospitalYangsan 626-770South Korea

BACKGROUND Immunoglobulin A nephropathy(IgAN)is the most commonly encountered glomerular disease in Asian *** has a broad clinical presentation,and it is frequently associated with other *** liver disease is well recognized as the leading cause of secondary ***,cases of IgAN associated with autoimmune hepatitis(AIH)have seldom been *** SUMMARY A 63-year-old Korean woman was admitted to Pusan National University Hospital for an evaluation of abdominal pain and elevated liver *** weeks prior,she had presented to our hospital with proteinuria of approximately 1350 mg/d and hematuria and was diagnosed with *** profiles were highly positive for antinuclear antibodies,and symptoms related to portal hypertension including ascites and peripheral edema were present.A diagnosis of AIH was made according to the simplified scoring system of the International Autoimmune Hepatitis *** immunosuppression with prednisolone and azathioprine,rapid deterioration of liver function led to end-stage liver *** a living-donor liver transplantation,liver function gradually improved,and she had maintained stable liver and kidney function at the six months *** Cases of secondary IgAN with chronic liver disease have been frequently reported in the literature but are rarely associated with *** encountered an IgAN patient with concurrent progressive liver failure due to AIH.

关键词： Immunoglobulin A nephropathy Secondary immunoglobulin A nephropathy Autoimmune hepatitis Liver transplantation Case report

Diagnostic delay in inflammatory bowel disease increases the risk of intestinal surgery

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World Journal of Gastroenterology 2017年第35期23卷 6474-6481页

作者： dong-won lee Ja Seol Koo Jung Wan Choe Sang Jun Suh Seung Young Kim Jong Jin Hyun Sung Woo Jung Young Kul Jung Hyung Joon Yim Sang Woo lee Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University Ansan Hospital

AIM To investigate the factors affecting diagnostic delay and outcomes of diagnostic delay in inflammatory bowel disease(IBD) METHODS We retrospectively studied 165 patients with Crohn's disease(CD) and 130 patients with ulcerative colitis(UC) who were diagnosed and had follow up durations > 6 mo at Korea University Ansan Hospital from January 2000 to December 2015. A diagnostic delay was defined as the time interval between the first symptom onset and IBD diagnosis in which the 76^(th) to 100^(th) percentiles of patients were *** The median diagnostic time interval was 6.2 and 2.4 mo in the patients with CD and UC, respectively. Among the initial symptoms, perianal discomfort before diagnosis(OR = 10.2, 95%CI: 1.93-54.3, P = 0.006) was associated with diagnostic delays in patients with CD; however, no clinical factor was associated with diagnostic delays in patients with UC. Diagnostic delays, stricturing type, and penetrating type were associated with increased intestinal surgery risks in CD(OR = 2.54, 95%CI: 1.06-6.09; OR = 4.44, 95%CI: 1.67-11.8; OR = 3.79, 95%CI: 1.14-12.6, respectively). In UC, a diagnostic delay was the only factor associated increased intestinal surgery risks(OR = 6.81, 95%CI: 1.12-41.4).CONCLUSION A diagnostic delay was associated with poor outcomes, such as increased intestinal surgery risks in patients with CD and UC.

关键词： Diagnostic delay Intestinal surgery Inflammatory bowel disease Crohn’s disease Ulcerative colitis

Fabrication and characterization of the Ti-Ca-P composites by vacuum sintering

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Journal of Biomedical Science and Engineering 2011年第9期4卷 583-590页

作者： Dibakar Mondal Swapan Kumar Sarkar dong-won lee Young-Seon lee Byong-Taek lee 不详

Using Ti and biphasic calcium phosphate (BCP) pow-ders, Ti-Ca-P composites which contained 0 - 30 vol.% BCP powders initially, were fabricated by vac-uum sintering at two different sintering temperatures, 1300°C and 1400°C. Detailed microstructural char-acteristics of the resulting composites were investi-gated. Mechanical properties like compressive strength, Vickers hardness were evaluated and they showed decreasing trend with the increasing initial BCP content. The x-ray diffraction (XRD) profiles revealed that extensive chemical reaction occurred and the initial BCP was degraded and formed CaO, TiO2, TiP, CaTiO3. However, the cell viability by MTT assay and cell proliferation behavior through one cell morphology analysis showed excellent in-creasing trend in biocompatibility which makes this materials suitable for hard tissue aid *** the composite containing 30 vol.% BCP content with Ti sintered at 1400°C showed excellent biocompati-bility with the Vickers Hardness value 108.8 HV and the compressive strength value 303.7 MPa.

关键词： Ti Calcium Phosphate Biocompatibility Bio-ceramic

PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 1993-1994页

作者： Anup Bhusal won-Ha lee Kyoungho Suk Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU Biomedical Convergence Program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea School of Life Sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea Brain Science and Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.

关键词： inflammation considerably

Oxidation Behavior of Fe-36Ni and Fe-46Ni Alloy Scraps

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Journal of Electrical Engineering 2014年第1期2卷 49-53页

作者： Jung-Yeul Yun Da-Hee Park dong-won lee Shun-Myung Shin Young-Ho Kim Jei-Pil Wang Powder Technology Research Group KIMS (Korea Institute of Materials Science) Changwon Kyungnam 641-010 Korea Titanium Department KIMS (Korea Institute of Materials Science) Changwon Kyungnam 641-010 Korea Extractive Metallurgy Group KIGAM (Korea Institute of Geoscience & Mineral Resources) Deajeon 305-530 Korea Department of Metallurgical Engineering Pukyong National University Busan 608-739 Korea

Oxidation study of Fe-36Ni and Fe-46Ni alloys was conducted on the effect of temperature under a 0.2 atm oxygen partial pressure. The weight of both specimens was continuously measured by TGA （thermogravimetric apparatus） at various temperatures and it was found that the weigh was gained with an increase of temperature. The oxidation behavior of Fe-36/46Ni alloys was found to be followed by parabolic rate law and the rate constants were linearly proportional to the temperature. In addition, activation energies of Fe-36Ni and Fe-46Ni alloys were calculated to be 106.49 kJ/mol and 58.99 kJ/mol, respectively. The cross sectional area of oxide scale was examined by SEM （scanning electron microscopy） and analyzed by XRD （X-ray diffraction） and EDX （energy-dispersive X-ray spectroscopy）.

关键词： Oxidation Fe-36Ni Fe-46Ni thermogravimetric apparatus parabolic rate law activation energy

Aligned Ion Conduction Pathway of Polyrotaxane‑Based Electrolyte with Dispersed Hydrophobic Chains for Solid‑State Lithium–Oxygen Batteries

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Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram Kim Myeong‑Chang Sung Gwang‑Hee lee Byoungjoon Hwang Sojung Seo Ji‑Hun Seo dong‑Wan Kim Department of Materials Science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea School of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials Science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves ***-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： Solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity Hydrophobic chain