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ProSy: API-Based Synthesis with Probabilistic Model

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Journal of Computer Science & Technology 2020年第6期35卷 1234-1257页

作者： Bin-Bin Liu Wei dong Jia-Xin Liu Ya-ting zhang Dai-Yan Wang College of Computer Science National University of Defense TechnologyChangsha 410072China Key Laboratory of Software Engineering for Complex Systems College of Computer ScienceNational University of Defense TechnologyChangsha 410072China

Program synthesis is an exciting topic that desires to generate programs satisfying user intent automatically. But in most cases, only small programs for simple or domain-specific tasks can be synthesized. The major obstacle of synthesis lies in the huge search space. A common practice in addressing this problem is using a domain-specific language, while many approaches still wish to synthesize programs in general programming languages. With the rapid growth of reusable libraries, component-based synthesis provides a promising way, such as synthesizing Java programs which are only composed of APIs (application programming interfaces). However, the efficiency of searching for proper solutions for complex tasks is still a challenge. Given an unfamiliar programming task, programmers would search for API usage knowledge from various coding resources to reduce the search space. Considering this, we propose a novel approach named ProSy to synthesize API-based programs in Java. The key novelty is to retrieve related knowledge from Javadoc and Stack Overflow and then construct a probabilistic reachability graph. It assigns higher probabilities to APIs that are more likely to be used in implementing the given task. In the synthesis process, the program sketch with a higher probability will be considered first;thus, the number of explored reachable paths would be decreased. Some extension and optimization strategies are further studied in the paper. We implement our approach and conduct several experiments on it. We compare ProSy with SyPet and other state-of-the-art API-based synthesis approaches. The experimental results show that ProSy reduces the synthesis time of SyPet by up to 80%.

关键词： application programming interface(API)-based program Petri net probabilistic reachability graph program synthesis

Transfer RNA-derived small RNA serves as potential non-invasive diagnostic marker and a novel therapeutic target for acute pancreatitis

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World Journal of Gastroenterology 2025年第1期31卷 152-156页

作者： Jing zhang Chun-Lin Ou Department of Immunology School of Basic MedicineCentral South UniversityChangsha 410000Hunan ProvinceChina Department of Pathology Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina

Transfer RNA(tRNA)-derived fragments,a new type of tRNA-derived small RNA(tsRNA),can be cleaved from tRNA by enzymes to regulate target gene expression at the transcriptional and translational *** are not only degradation fragments but also have biological functions,including those in immune inflammation,metabolic disorders,and cell *** dysregulation is closely associated with multiple diseases,including various cancers and acute pancreatitis(AP).AP is a common gastrointestinal disease,and its incidence increases *** development is associated with tsRNAs,which regulate cell injury and induce inflammation,especially pyroptosis and ***,serum tRF36 has the potential to serve as a non-invasive diagnostic biomarker and leads to pancreatic acinar cell ferroptosis causing inflammation to promote *** show the characteristics of tsRNAs and their diagnostic value and function in AP,and discuss the potential opportunities and challenges of using tsRNAs in clinical applications and research.

关键词： Transfer RNA derived small RNAs Acute pancreatitis Liquid biopsy Biomarker Cell pyroptosis Ferroptosis

Targeting Epac2 and GluA3-containing AMPARs:a novel therapeutic strategy for Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3223-3224页

作者： Tong zhang Martina Schmidt Department of Molecular Pharmacology Groningen Research Institute of PharmacyUniversity of GroningenGroningenThe Netherlands School of Pharmacy Tianjin Medical UniversityTianjinChina

Alzheimer's disease(AD)is a neurodegenerative disease that manifests progressive decline in memory and *** the early stage of AD,memory retrieval is impaired preceding memory acquisition and consolidation(Roy et al.,2016).Prior to the onset of symptoms,pathological amyloid-β(Aβ)plagues and tau protein tangles accumulate in extracellular and intracellular spaces,respectively,leading to *** these hallmark pathologies,Aβ is proposed to be the primary etiology by triggering a cascade of pathogenic events,including neuroinflammation,oxidative stress,tau hyperphosphorylation,synaptic/neuronal dysfunction,and neuronal death(zhang et al.,2023b).

关键词： Alzheimer impaired Aβ

Synergistic Brønsted Base/Photoredox-Catalyzed Three-Component Coupling with Malonates to Synthesize δ-Hydroxy Esters and δ-Keto Esters

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Chinese Journal of Chemistry 2024年第9期42卷 957-962页

作者： ting Li Wei Wang Ming dong Zhije zhang Sha Yu Zhengchu Chen Siping Wei dong Yi Green Pharmaceutical Technology Key Laboratory of Luzhou City Central Nervous System Drug Key Laboratory of Sichuan ProvinceSchoolof PharmacySouthwestMedicalUniversityLuzhouSichuan 646000China Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province LuzhouSichuan 646000China

Multicomponent alkene 1,2-dicarbofunctionalizations(DCFs)have emerged as a powerful strategy to rapidly incorporate both two carbon subunits across one C-C double bond in one step for enhancing molecular complexity and *** the best of our knowledge,there is only one report on photoredox-catalyzed three-component DCFs with malonates through the radical−radical cross-coupling,while photoredox-catalyzed radical-polar crossover(RPC)-type DCFs with malonates were still ***,we describe a redox-neutral RPC-type 1,2-dialkylation of styrenes with malonates and aldehydes through the synergistic Brønsted base/photoredox catalysis *** transition-metal-free strategy provides an efficient and clean approach to a broad variety ofδ-hydroxy esters and also features exceptionally mild conditions,wide compatibility of substrate scope and functional groups,and high atomic ***,three-component 1,2-alkylacylation from the same starting materials was achieved in one-pot manner through such RPC-type coupling and subsequent two-electron oxidation process,providing a set ofδ-keto esters of interest in pharmaceutical research.

关键词： Alkene difunctionalization Photoredox catalysis Malonates Radical reactions C-C coupling Synthetic methods Aldehydes Alkylation Multicomponentreactions

Refractive Index Engineering as a Novel Strategy toward Highly Transparent and Tough Sustainable Polymer Blends

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Chinese Journal of Polymer Science 2020年第12期38卷 1335-1344页

作者： Si-ting Sun Hang Wang dong Huang Ying-Li Ding Yang zhang dong-Po Song Kun-Yu zhang Li Pan Yue-Sheng Li Department of Polymer Science and Engineering School ofChemical Engineering and TechnologyTianjin UniversityTianin 300350China Department of Chemical Engineering Xiamen UniversityXiamen 361005China Tianjin Key Laboratory ofComposite and Functional Materials School ofMaterials Science and EngineeringTianjin UniversityTlanin 300350 China Cllaborotive lovation Center ofChemical Science and Engineering(injin) Tianjin 300072 China

High transparency and toughness are prerequisites for sustainable polymers if they are to find wide application as alternatives to petroleum-based ***,the utility of sustainable polymers such as commercially available polylactide(PLA)is limited by their inherent brittleness and high ***,toughening PLA-based materials via cost-effective blending strategies without sacrificing transparency remains a ***,we report a novel strategy involving active refractive index matching for creation of highly transparent and tough PLA ***,we engineered the refractive index of a promising renewable poly(epichlorohydrin-co-ethylene oxide)elastomer by introducing polar ionic moieties via a simple chemical method,and we blended the resulting ionomers with *** best blend showed an impact strength of>80 kJ/m2,an elongation at break of 400%,and high transparency(90%).These characteristics are of great importance for potential applications such as *** strategy offers a versatile new way to prepare high-performance sustainable polymer materials with excellent transparency.

关键词： Polylactide Blending strategies Refraaive index matching Poly(epichlorohydrin-co-ethylene oxide) Ionomers

Ammonia pyrolysis oxidation excited by nanosecond pulsed discharge:Global/fluid models hybrid solution

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Journal of Energy Chemistry 2025年第1期100卷 385-396页

作者： Mingming zhang Hanyu Wu Qi Chen Jiaxin Yang Bonan Liu School of Mechanical Electronic and Control Engineering Beijing Jiaotong University China University of Petroleum

The kinetic characteristics of plasma-assisted oxidative pyrolysis of ammonia are studied by using the global/fluid models hybrid solution ***,the stable products of plasma-assisted oxidative pyrolysis of ammonia are *** results show that the consumption of NH3/O2and the production of N2/H2change linearly with the increase of voltage,which indicates the decoupling of nonequilibrium molecular excitation and oxidative pyrolysis of ammonia at low ***,the detailed reaction kinetics mechanism of ammonia oxidative pyrolysis stimulated by a nanosecond pulse voltage at low pressure and room temperature is *** on the reaction path analysis,the simplified mechanism is *** detailed and simplified mechanism simulation results are compared with experimental data to verify the accuracy of the simplified ***,based on the simplified mechanism,the fluid model of ammonia oxidative pyrolysis stimulated by the nanosecond pulse plasma is established to study the pre-sheath/sheath behavior and the resultant consumption and formation of key *** results show that the generation,development,and propagation of the pre-sheath have a great influence on the formation and consumption of *** consumption of NH3by the cathode pre-sheath is greater than that by the anode pre-sheath,but the opposite is true for OH and O（1S）.However,within the sheath,almost all reactions do not ***,by changing the parameters of nanosecond pulse power supply voltage,it is found that the electron number density,electron current density,and applied peak voltages are not the direct reasons for the structural changes of the sheath and ***,the discharge interval has little effect on the sheath structure and gas mixture *** research results of this paper not only help to understand the kinetic promotion of non-equilibrium excitation in the process of oxidative pyrolysis but also help to explore th

关键词： Nanosecond pulsed discharge Ammonia Oxidative pyrolysis Fluid model Global model

Co/Co_(7)Fe_(3)heterostructures with controllable alloying degree on carbon spheres as bifunctional electrocatalyst forrechargeable zinc-air batteries

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 476-487页

作者： Junkang Chen Yongyue Zhuang Yanxin Qiao Yu zhang Aihua Yuan Hu Zhou School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

Exploring efficient and nonprecious metal electrocatalysts of oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)is crucial for developing rechargeable zinc-air batteries(ZABs).Herein,an alloying-degree control strategy was employed to fabricate nitrogen-doped carbon sphere(NCS)decorated with dual-phase Co/Co_(7)Fe_(3)heterojunctions(CoFe@NCS).The phase composition of materials has been adjusted by controlling the alloying *** optimal CoFe_(0.08)@NCS electrocatalyst displays a half-wave potential of 0.80 V for ORR and an overpotential of 283 mV at 10 mA·cm^(-2)for OER in an alkaline *** intriguing bifunctional electrocatalytic activity and durability is attributed to the hierarchically porous structure and interfacial electron coupling of highly-active Co_(7)Fe_(3)alloy and metallic Co *** the CoFe_(0.08)@NCS material is used as air-cathode catalyst of rechargeable liquid-state zinc-air battery(ZAB),the device shows a high peak power-density(157 mW·cm^(-2))and maintains a stable voltage gap over 150 h,outperforming those of the benchmark(Pt/C+RuO_(2))-based *** particular,the as-fabricated solid-state flexible ZAB delivers a reliable compatibility under different bending *** work provides a promising strategy to develop metal/alloy-based electrocatalysts for the application in renewable energy conversion technologies.

关键词： bifunctional electrocatalysts oxygen reduction reaction oxygen evolution reaction zinc-air battery metal/alloy carbon sphere

Reassessing the Lewis Turning Point in China： Evidence from 70,000 Rural Households

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China & World Economy 2018年第1期26卷 4-17页

作者： Yuan zhang ting Shao Qi dong China Center for Economic Studies Fudan University China Development Research Center of the State Council China. Hanqing Advanced Institute of Economics and and Finance Renmin University China

There is no convincing evidence to prove that China＇s Lewis turning point （LTP） arrived in 2004-2005, as suggested in some of the existing literature. Employing data from the National Bureau of Statistics of China for 70,000 rural households and following the method proposed by Minami （1968） to identify the Lewis turning point in Japan, the present study reassessed the reaching of the LTP in China and found that China＇s economy reached the LTP around 2010. From a regional perspective, China ＂s eastern region reached the LTP in 2010 and its central and western regions are now approaching the turning point. After arriving at the LTP, China＇s rural economy will face three key tasks.＂ safeguarding grain security, promoting economic restructuring and realizing agricultural modernization. To cope with the shortage of human capital in agriculture production and the challenge of the tight balance between grain supply and demand, the Chinese Government should improve the human capital training system, accelerate agricultural modernization and guarantee national grain security.

关键词： grain security Lewis turning point marginal labor productivity rural household data

T29C genotype polymorphism of estrogen receptor alpha is associated with initial response to interferon-alpha therapy in chronic hepatitis B patients

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Hepatobiliary & Pancreatic Diseases International 2010年第3期9卷 275-279页

作者： zhang, ting-ting zhang, Zhen-Hua Gao, Yu-Feng zhang, Ya-Fei Yang, dong-Liang Li, Xu Anhui Med Coll Affiliated Hosp 1 Dept Infect Dis Hefei 230022 Peoples R China Huazhong Univ Sci & Technol Tongji Med Coll Tongji Hosp Div Clin Immunol Wuhan 430030 Peoples R China

BACKGROUND: Virological clearance, delayed progression to cirrhosis or liver cancer, and increased survival are the long-term goals of antiviral therapy in chronic hepatitis B patients. Identification of host factors correlated with therapeutic response may contribute greatly to individual treatment. This study aimed at investigating whether T29C genotype polymorphism of estrogen receptor alpha (ESR1) is associated with the initial response to interferon-alpha (IFN-alpha) therapy in chronic hepatitis B patients. METHODS: The initial responses of 100 patients to IFN-alpha therapy were evaluated and compared by classifying them into three groups according to T29C genotype polymorphism of ESR1: T/T, TIC, and C/C genotype groups. Polymerase chain reaction-restriction fragment length polymorphism was used to analyze the genotype polymorphism in T29C. RESULTS: The frequency of initially combined response was markedly higher in both the T/T and TIC groups than in the C/C group (Z=10.326, P=0.006 and Z=26.247, P=0.000, respectively). In addition, the initial virological response was higher in the T/T and T/C groups than the C/C group (chi(2)=5.674, P=0.017 and chi(2)=4.980, P=0.026, respectively). In 78 initially HBeAg-positive patients, however, the frequency of initial e-antigen disappearance or seroconversion among the T/T, T/C, and C/C genotype groups was 34.15%, 27.78% and 15.79%, respectively, which were not significantly different. CONCLUSION. The T29C genotype polymorphism of ESR1 is associated with the initial response to IFN-alpha in patients with chronic hepatitis B, and might be a significant marker for predicting the initial response to IFN-alpha, at least in this study population. (Hepatobiliary Pancreat Dis Int 2010; 9: 275-279)

关键词： estrogen receptor polymorphism chronic hepatitis B initial response interferon-alpha