检索结果-南通市图书馆

A pilot exome-wide association study of age-related cataract in Koreans

在线全文

学校读者我要写书评

暂无评论

The Journal of Biomedical Research 2016年第3期30卷 186-190页

作者： Sang-Yong Eom dong-Hyuk Yim Jung-Hyun Kim Joo-Byung chae Yong-Dae Kim Heon Kim Center for Farmer's Safety and Health Chungbuk National University Hospital Department of Preventive Medicine College of MedicineChungbuk National University Department of Optometry Daejeon Health Science College Department of Ophthalmology College of MedicineChungbuk National University

Age-related cataract （ARC） is the most common cause of visual impairment and blindness worldwide. A previous study reported that genetic factors could explain approximately 50% of the heritability of cataract. However, a genetic predisposition to ARC and the contributing factors have not yet been elucidated in the Korean population. In this study, we assessed the influence of genetic polymorphisms on the risk of ARC in Koreans, including 156 cataract cases and 138 healthy adults. We conducted an exome-wide association study using Illumina Human Exome-12v1.2 platform to screen 244,770 single nucleotide polymorphisms （SNPs）. No SNPs reached exome-wide significance level of association （P 〈 l x 10 6）. B3GNT4 rs7136356 showed the most significant association with ARC （P = 6.54x 10 5）. Two loci （MUC16 and P2RY2） among the top 20 ARC-associated SNPs were recognized as probably linked to cata- ractogenesis. Functions of these genes were potentially related to regulating dehydration or homeostasis of the eyes, and showed a potential association with dry eye disease. This finding suggests that mucin- and dry eye disease-related genes may play a significant role in cataractogenesis. Our study provides insight into the genetic predisposition of ARC in Koreans. Additional studies with larger sample sizes are required to confirm the results of this study.

关键词： age-related cataract exome-wide association study single nucleotide polymorphism genetic predispo-sition dry eye disease

COMPARATIVE ANALYSIS OF MUSCLE ACTIVITIES DURING RESISTANCE EXERCISES USING VARIABLE AND ELASTIC LOADS

在线全文

学校读者我要写书评

暂无评论

COMPARATIVE ANALYSIS OF MUSCLE ACTIVITIES DURING RESISTANCE ...

Hybrid algorithm for modeling of fluid-structure interaction in incompressible, viscous flows

第23届国际运动生物力学学术年会

作者： Young-Tae Lim Woen-sik chae Division of Sport Science Konkuk University Department of Physical Education Kyungpook National University

＜正＞INTRODUCTION:Over the last few decades,many resistance training devices and methods have been developed for the purpose of increasing *** of the most popular devices being used is variable resistance training（VRT）device（Baechle＆Groves,1992）.This type of exercise machines has a major advantage that,by altering the shapes of cams,

关键词： dynamic variable resistance rubber band surgical tubing exercise

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2012年第4期28卷 1030-1041页

作者： Eun Jung chae Deniz Tolga Akcabay Department of Naval Architecture and Marine Engineering University of Michigan

The objective of this paper is to present and to validate a new hybrid coupling （HC） algorithm for modeling of fluid-structure interaction （FSI） in incompressible, viscous flows. The HC algorithm is able to avoid numerical instability issues associated with artificial added mass effects, which are often encountered by standard loosely coupled （LC） and tightly coupled （TC） algorithms, when modeling the FSI response of flexible structures in incompressible flow. The artificial added mass effect is caused by the lag in exchange of interfacial displacements and forces between the fluid and solid solvers in partitioned algorithms. The artificial added mass effect is much more prominent for light/flexible struc- tures moving in water, because the fluid forces are in the same order of magnitude as the solid forces, and because the speed at which numerical errors propagate in an incom- pressible fluid. The new HC algorithm avoids numerical instability issues associated with artificial added mass effects by embedding Theodorsen＇s analytical approximation of the hydroelastic forces in the solution process to obtain better initial estimates of the displacements. Details of the new HC algorithm are presented. Numerical validation studies are shown for the forced pitching response of a steel and a plastic hydrofoil. The results show that the HC algorithm is able to converge faster, and is able to avoid numerical insta- bility issues, compared to standard LC and TC algorithms, when modeling the transient FSI response of a plastic hydrofoil. Although the HC algorithm is only demonstrated for a NACA0009 hydrofoil subject to pure pitching motion, the method can be easily extended to model general 3-D FSI response and stability of complex, flexible structures in turbulent, incompressible, multiphase flows.

关键词： Fluid-structure interaction Viscous Incom- pressible Computational Added Mass Stability

Baseline HBV DNA level is the most important factor associated with virologic breakthrough in chronic hepatitis B treated with lamivudine

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2007年第30期13卷 4085-4090页

作者： Hee Bok chae Hie-Won Hann Liver Disease Prevention Center Division of Gastroenterology and Hepatology Department of Medicine Jefferson Medical College and Thomas Jefferson University Hospital Philadelphia PA 19107 United States Department of Internal Medicine College of Medicine and Medical Institute Chungbuk National University Cheongju 362-711 South Korea

AIM: To identify the factors associated with virologic breakthrough and to select a subgroup of patients who respond well to lamivudine without developing virologic breakthrough (VBT). METHODS: Of 79 patients who had received lamivudine therapy for 9-57 mo, 34 were HBeAg-positive and 45 were HBeAg-negative, 24 developed virologic breakthrough and 55 did not. Clinical and virologic factors were compared between the two groups. RESULTS: The median duration of therapy was 25 (9-57) mo. Virologic breakthrough was defined as a > 1 log HBV DNA increase following initial suppression. When several factors, including gender, duration of infection, baseline HBV DNA, and baseline ALT in HBeAg-positive chronic hepatitis patients were analyzed by logistic regression, the most important predictor of virologic breakthrough was the baseline HBV DNA (r2 = 0.12, P < 0.05). When HBeAg-postitive chronic hepatitis patients were divided into two groups by a point of 6.6 log HBV DNA, the incidence of virologic breakthough between two groups was significantly different. CONCLUSION: Lamivudine may remain an effective first line therapy for those HBeAg-positive patients with a baseline HBV DNA < 6.6 log10 copies/mL.

关键词： Hepatitis B Lamivudine Virologic breakthrough HBV DNA

Improved thermal performance of a hydronic radiant panel heating system by the optimization of tube shapes

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第6期12卷 428-437页

作者： Young T.chae Kwang Ho LEE Jae Sung PARK School of Architecture University of Illinois at Urbana-Champaign Department of Architectural Engineering Hanbat National University Department of Mechanical Engineering University of Illinois at Urbana-Champaign

The thermal performance enhancement of the hydronic radiant floor heating system by tube shape refinements is investigated in this *** analytical and detailed numerical modelings are carried out to predict the performance of the radiant *** the simple analytical model briefly investigates the possibility of the effect of the tube shape improvement with the parametric analysis,the commercial computational fluid dynamics(CFD) code(Ansys/CFX) is used to perform the detailed 3D analysis under different tube shape *** fin thickness,the number of fins,and the tube thermal conductivity turn out to have significant effects on the radiant system *** potential energy saving impacts of the tube shape refinements are also *** tube shape improvement turns out to increase the floor surface temperature and to decrease the hot water temperature drop across the system,resulting in heating energy savings.

关键词： Radiant panel system Analytical modeling Computational fluid dynamics(CFD) Tube shape Energy saving

Synthesis of a Rod-rod Diblock Copolymer, Poly (3-hexylthiophene)-block-poly(furfuryl isocyanate), through the Anionic Polymerization with an Oxyanionic Macroinitiator

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2019年第9期37卷 866-874页

作者： Chang-Geun chae Joonkeun Min In-Gyu Bak Jae-Suk Lee School of Materials Science and Engineering Gwangju Institute of Science and Technology (GIST)

A rod-rod diblock copolymer (diBCP), poly(3-hexylthiophene)-block-poly(furfuryl isocyanate)(P3HT-b-PFIC), was synthesized through the anionic polymerization with an oxyanionic macroinitiator of P3HT. The properties of the diBCP (molecular weight, dispersity, composition, thermal stability, UV-visible absorption, and thin film morphology) were determined by various analytical methods. P3HT-b-PFIC was blended with C60 in a toluene solution to prepare a thin film of binary electron donor/acceptor system. Such blending enabled partial conjugation of the two components by the Diels-Alder reaction between furan and C60 at 60℃ for 3 h;the mixture was then spin-cast as a thin film, and annealed at 250℃ for 24 h. Tapping-mode atomic force microscopy (AFM) revealed that P3HT and C60 domains had nanoscale interfaces without a large phase segregation. This result indicated that the microphase separation of C60-functionalized P3HT-b-PFIC preserved even at high temperature provided free C60 molecules with channels to diffuse on the sides of P3HT domain, thus preventing the macroscopic crystallization of free C60 through the interfacial stabilization.

关键词： Rod-rod diblock copolymer Poly(3-hexylthiophene)-block-poly(furfuryl isocyanate) C60 Diels-Alder reaction Nanoscale interfaces

Combustion Characteristics of Solid Refuse Fuels from Different Waste Sources

在线全文

学校读者我要写书评

暂无评论

Journal of Renewable Materials 2020年第7期8卷 789-799页

作者： Jong Seong chae Seok Wan Kim Tae In Ohm Department of Civil and Environmental Engineering Hanbat National UniversityDaejeon34158Korea Department of Fire and Environmental Safety Daegu Haany UniversityDaegu38610Korea

In the production(as co-fuel or alone)of solid refuse fuel(SRF),knowledge about the characteristics of the raw materials is required for an ecofriendly and effective combustion *** are commonly produced by drying combustible waste and removing incombustible matter,resulting in a higher combustibility as compared to the original ***,the characteristics of SRFs may highly vary depending on where and from which materials they were ***,we investigated the characteristics of various SRFs using thermogravimetric analysis(TGA).As a TGA sample is commonly small,on the scale of milligrams,and,unlike homogeneous fuels,SRFs are heterogeneous,individual SRF samples analysed with this method may not represent the bulk material,and sample properties may vary significantly between ***,we further performed combustion experiments using a small-scale combustor and sample sizes from 1 to 10 *** optimise SRF combustor design and determine the SRF characteristics,proximate,elemental,heating value,TG,and differential thermogravimetric analyses were conducted,and weight losses and gas concentrations at different temperatures were measured upon *** lower heating values of the three analysed SRFs were 20,976,16,873,and 19,762 kJ/kg,and their Cl contents were 0.89,0.95,and 1.27 wt.%(legal criterion[Cl]<2.0 wt.%).TGA and small combustor experiments showed that complete weight loss was achieved below 500°***,CO was detected until 620°C.

关键词： Solid refuse fuel small-scale combustor thermogravimetric analysis waste gas concentration

A novel electrospinning method for self-assembled tree-like fibrous scaffolds:Microenvironment-associated regulation of MSC behavior and bone regeneration

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2022年第20期115卷 52-70页

作者： Jeong In Kim Ju Yeon Kim Sung-Ho Kook Jeong-chae Lee Cluster for Craniofacial Development and Regeneration Research Institute of Oral Biosciences and School of DentistryJeonbuk National UniversityJeonju 54896Republic of Korea Department of Bionanosystem Engineering Jeonbuk National UniversityJeonju 54896Republic of Korea Department of Bioactive Material Sciences Research Center of Bioactive MaterialsJeonbuk National UniversityJeonju 54896Republic of Korea

Numerous studies highlight advantages of electrospun scaffolds in bone tissue engineering,in which cellular behavior is tightly affected by fiber topographical cues of ***,the classic electrospinning setup limits a desired presentation of biomimetic fibrous microenvironments that sense mechanosignaling and regulate stem cell *** aims of this study were to fabricate advanced asspun scaffolds presenting tree-like microfiber/nanonet networks and to evaluate their regulatory potentials on behavior of human mesenchymal stem cells(h MSCs)and bone *** we developed a novel electrospinning setup that allowed the presentation of patterned Trunk microfibers(TMF)and/or branched nanonet fibers(BNn Fs)in biomimetic fibrous *** the cellular mechanisms,anisotropichierarchical topography of TMF controlled behavior of h MSCs through focal adhesion formation and Yesassociated protein(YAP)induction,whereas BNn F disturbed such mechanosensing responses in the *** fiber microenvironment-related expression and nuclear localization of YAP *** correlated with the potentials of as-spun scaffolds to enhance osteogenic differentiation of the h MSCs and alveolar bone defect healing in an animal ***,this study provides an advanced approach of the modified electrospinning setup for presentation of biomimetic fibrillar microenvironments in as-spun scaffolds along with their application in stem cell behavior regulation and regenerative tissue engineering.

关键词： Electrospinning Advanced biomimetic scaffolds Stem cell behavior Mechanosensing Bone tissue engineering

Sliding Wear Behavior of Plasma Sprayed Zirconia Coating on Cast Aluminum against Silicon Carbide Ceramic

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2005年第5期21卷 666-670页

作者： Thuong-Hien LE Young-Hun chae Seock-Sam KIM School of Mechanical Engineering Graduate School Kyungpook National University Daegu 702-701 KoreaEngineering Tribology Research Institute Kyungpook National University Daegu 702-701 KoreaSchool of Mechanical Engineering Kyungpook National University Daegu 702-701 Korea

The sliding wear behaviors of ZrO2-22 wt pct MgO （MZ） and ZrO2-8 wt pct Y2O3（YZ） coatings deposited on a cast aluminum alloy with bond layer （NiCrCoAlY） by plasma spray were investigated under dry test conditions at room temperature. Under all load conditions, the wear mechanisms of the MZ and YZ coatings were almost the same. The material transfer and pullout were involved in the wear process of the studied coatings under the test conditions. The wear rate of the MZ coating was less than that of the YZ coating. While increasing the normal load, the wear rates of the MZ and YZ coatings increased. SEM was used to examine the worn surfaces and to elucidate likely wear mechanisms. Energy dispersive X-ray spectroscopy （EDX） analysis of the worn surfaces indicated that material transfer occurred in the direction from the SiC ball to the disk. Fracture toughness had a significant influence on the wear performance of the coatings. It was suggested that the material transfer played an important role in the wear behavior.

关键词： Plasma spray Zirconia coating Wear mechanism Fracture toughness