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Anti-cancer effect of ethylacetate fraction from Orostachys japonicus on HT-29 human colon cancer cells by induction of apoptosis through caspase-dependent signaling pathway

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Asian Pacific Journal of Tropical Medicine 2018年第5期11卷 330-335页

作者： Deok-Seon Ryu Hyun-Ji lee Ji-Hye Kwon dong-seok lee Department of Biomedical Laboratory Science Soonchunhyang University Department of Smart Foods and Drugs Graduate School of Inje University

Objective: To investigate the anti-colon cancer effects of ethylacetate fraction from Orostachys japonicus(0. japonicus) on HT-29 cancer cells. Methods: The viability of HT-29 cells was assayed by the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2 H-tetrazolium(MTS) method. Apoptosis induction and cell cycle inhibition were confirmed by fluorescein isothiocyanate and propidium iodide staining using flow *** changes in the nucleus were observed, using a fluorescence microscope with4',6-diamidino-2-phenylindole(DAPI) nuclear staining. The expression levels of the upstream and downstream proteins involved in the anti-cancer mechanism were confirmed by Western blotting. Results: After treating HT-29 cells with different concentrations of ethylacetate fraction from O. japonicus, the viability of cells decreased in a concentration-dependent manner,while apoptosis induction and apoptotic body formation increased. Cell cycle analysis showed that the arrest occurred at the sub-G_1 and S phase. Among the upstream and downstream proteins involved in anti-cancer activity, the level of B cell lymphoma-2 decreased, and the bcl-2-associated x protein increased. The level of pro-caspase-3, pro-caspase-8, and pro-caspase-9 decreased, while the level of cleaved-caspase-3, cleaved-caspase-8, and cleaved-caspase-9 increased. Moreover, the phosphorylation, that is, activation of extracellular signal regulated kinase 1/2, Jun-N-terminal kinase, and p38 increased. Conclusions: Combining the above results, it is thought that the survival of HT-29 cells is suppressed by ethylacetate fraction from0. japonicus through mitochondrial regulation-induced caspase cascade activation, induction of apoptosis and cell cycle arrest.

关键词： Orostachys japonicus HT-29 human colon cancer cells Anti-cancer activity Apoptosis Caspase cascade

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Orostachys japonicus ethyl acetate fraction suppresses MRSA biofilm formation

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Asian Pacific Journal of Tropical Medicine 2020年第1期13卷 38-45页

作者： Jae-Hyeon Kim Su-Yeon Han Ji-Hye Kwon dong-seok lee Department of Smart Foods and Drugs Graduate School of Inje UniversityGimhae 50834Republic of Korea

Objective:To investigate the effect of Orostachys(O.)japonicus,a perennial herbaceous plant of the Family Crassulaceae,on biofilm formed by methicillin-resistant Staphylococcus aureus(MRSA).Methods:Powdered *** was extracted by 95%methanol,concentrated,and then,systematically fractionated with n-hexane,dichloromethane(DCM),ethyl acetate(EtOAc),n-butanol,and H2 O according to *** them,the flavonoid-rich EtOAc fraction demonstrated the highest antibacterial activity and was used in this *** the biofilm inhibition assay,cell-surface attachment assay,confocal laser scanning microscopy,latex agglutination assay,and real time qRT-PCR,we examined whether the EtOAc fraction inhibited the formation of MRSA ***:The EtOAc fraction exhibited distinct activity against biofilm formation and cell-surface attachment of MRSA up to 1 mg/m L through down-regulating the expression of mec A gene and the production and agglutination of penicillin-binding protein 2 a as solidly observed in biofilm inhibition assay,cell-suface attachment assay,confocal laser scanning microscopy,latex agglutination assay,and real time qRT-PCR ***:These results suggest that *** could be utilized as a potential resource for the development of new antibiofilm formation of MRSA and antibacterial agents in the future.

关键词： Orostachys japonicus MRSA Biofilm formation

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Nasal cavity fungus ball discovered accidentally:A case report

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World Journal of Clinical Cases 2025年第5期13卷 44-48页

作者： Dae-Neung lee dong Hoon lee Sang Chul Lim Department of Otolaryngology-Head and Neck Surgery Chonnam National University Medical SchoolChonnam National University Hwasun HospitalHwasun 58128South Korea Department of Otolaryngology-Head and Neck Surgery Chonnam National University Medical SchoolHwasun HospitalChonnam National University Hwasun HospitalHwasun 58128South Korea Department of Otolaryngology-Head and Neck Surgery Chonnam National University Medical SchoolKwangju 501190South Korea

BACKGROUND Fungal balls within the nasal cavity are an exceedingly rare clinical entity,typically presenting with nonspecific symptoms or being identified *** SUMMARY This report presents an incidental discovery of a fungal ball in the nasal cavity during routine imaging,with no associated clinical *** This case underscores the importance of considering the possibility of asympto-matic presentations of nasal fungal balls,which may be detected incidentally during imaging evaluations.

关键词： Fungi Mycoses Fungus ball Nasal cavity Nasal surgical procedures Case report

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Aligned Ion Conduction Pathway of Polyrotaxane‑Based Electrolyte with Dispersed Hydrophobic Chains for Solid‑State Lithium–Oxygen Batteries

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Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram Kim Myeong‑Chang Sung Gwang‑Hee lee Byoungjoon Hwang Sojung Seo Ji‑Hun Seo dong‑Wan Kim Department of Materials Science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea School of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials Science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves ***-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： Solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity Hydrophobic chain

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The association between C-reactive protein to albumin ratio and 6-month neurological outcome in patients with in-hospital cardiac arrest

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World Journal of Emergency Medicine 2024年第3期15卷 223-228页

作者： Ji Ho lee dong Hun lee Byung Kook lee seok Jin Ryu Department of Emergency Medicine Chonnam National University HospitalGwangju 61469Republic of Korea Department of Emergency Medicine Chonnam National University Medical SchoolGwangju 61469Republic of Korea

The global incidence rates of in-hospital cardiac arrest(IHCA)range from1.2 to 9.0 per1,000 hospitalized patients,as per the National Cardiac Arrest Database.[1] While IHCAs tend to exhibit superior 30-day survival rates relative to out-of-hospital cardiac arrests (OHCA) due to situational advantages,such as immediate access to medical personnel and treatments.

关键词： patients cardiac IHC

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Novel acoustic features for speech emotion recognition

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Science China(Technological Sciences) 2009年第7期52卷 1838-1848页

作者： ROH Yong-Wan KIM dong-Ju lee Woo-seok HONG Kwang-seok School of Information and Communication Engineering Sungkyunkwan University300Chunchun-dongJangan-guSuwonKyungki-do440-746Korea Development Division / DSP Development Team Tamul Multimedia10th Fl.Anyang Trade Center1107Bisan-DongDongAn-GuAnyang-City431-050Korea

This paper focuses on acoustic features that effectively improve the recognition of emotion in human *** novel features in this paper are based on spectral-based entropy parameters such as fast Fourier transform(FFT) spectral entropy,delta FFT spectral entropy,Mel-frequency filter bank(MFB) spectral entropy,and Delta MFB spectral ***-based entropy features are *** reflect frequency characteristic and changing characteristic in frequency of *** implement an emotion rejection module using the probability distribution of recognized-scores and *** reduces the false recognition rate to improve overall ***-scores and rejected-scores refer to probabilities of recognized and rejected emotion recognition results,*** scores are first obtained from a pattern recognition *** pattern recognition phase uses the Gaussian mixture model(GMM).We classify the four emotional states as anger,sadness,happiness and *** proposed method is evaluated using 45 sentences in each emotion for 30 subjects,15 males and 15 *** results show that the proposed method is superior to the existing emotion recognition methods based on GMM using energy,Zero Crossing Rate(ZCR),linear prediction coefficient(LPC),and pitch *** demonstrate the effectiveness of the proposed *** of the proposed features,combined MFB and delta MFB spectral entropy improves performance approximately 10% compared to the existing feature parameters for speech emotion recognition *** demonstrate a 4% performance improvement in the applied emotion rejection with low confidence score.

关键词： speech emotion recognition MFB spectral entropy entropy emotion recognition rejection

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A Wireless Sensor Network Platform for Elderly Persons at Home

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稀有金属材料与工程 2006年第A03期35卷 95-99页

作者： Young-dong lee Dae-seok lee Wan-Young Chung Risto Myllylae Dept of Computer Network Eng Graduate School of SoftwareDongseo UniversityBusan 617-716Korea Division of Computer & Information Eng Dongseo UniversityBusan 617-716Korea Dept of Electrical and Information Engineering University of OuluLinnanmaa 90570 OuluFinland

A small size ubiquitous healthcare system for the home care of elderly persons was designed and *** system comprised a wireless sensor network node,base station and server computer for the continuous monitoring of ECG *** data,an important vital sign that is commonly used in clinical and trauma care,were displayed on a graphical user interface (GUI) by transferring the data to a PDA or a terminal *** data transfer was accomplished through a base-station connected to a server computer using TCP/***-time ECG data of elderly persons or patients,as well as historical data,can also be retrieved and played back to assist the *** ubiquitous healthcare system presented in this study can effectively reduce social medical expenses,which will increase greatly in the aging society.

关键词： wireless sensor network ubiquitous healthcare ECG TinyOS platform

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Fake News Detection on Social Media: A Temporal-Based Approach

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Computers, Materials & Continua 2021年第12期69卷 3563-3579页

作者： Yonghun Jang Chang-Hyeon Park dong-Gun lee Yeong-seok Seo Department of Computer Engineering Yeungnam UniversityGyeongsan38541Korea

Following the development of communication techniques and smart devices,the era of Artificial Intelligence(AI)and big data has *** increased connectivity,referred to as hyper-connectivity,has led to the development of smart *** in these smart cities can access numerous online contents and are always *** developments,however,also lead to a lack of standardization and consistency in the propagation of information throughout communities due to the consumption of information through social media *** cannot often be verified,which can confuse the *** increasing influence of social media has thus led to the emergence and increasing prevalence of fake *** this study,we propose a methodology to classify and identify fake news emanating from social *** collected content from Twitter to detect fake news and statistically verified that the temporal propagation pattern of quote retweets is effective for the classification of fake *** verify this,we trained the temporal propagation pattern to a two-phases deep learning model based on convolutional neural networks and long short-term *** fake news classifier demonstrates the ability for its early ***,it was verified that the temporal propagation pattern was the most influential feature compared to other feature groups discussed in this paper.

关键词： Artificial intelligence deep learning fake news rumor smart city data analysis

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POLYMERIZATION OF ISOBUTYL VINYL ETHER CATALYSED BY DINUCLEAR HALF-TITANOCENES

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Chinese Journal of Polymer Science 2008年第5期26卷 611-620页

作者： Nguyen Thi Le Thanh seok Kyun Noh Won seok Lyoo dong-Ho lee School of Display and Chemical Engineering Yeungnam University214-1 DaedongGyeongsanGyeongbuk 712-749Korea School of Textiles Yeungnam University214-1 DaedongGyeongsanGyeongbuk 712-749Korea Department of Polymer Science Engineering CollegeKyungpook National UniversityDaegu 702-701Korea

Polymerization of isobutyl vinyl ether(IBVE)has been studied with mononuclear half-titanocene,CpTiCl_3[1]and dinuclear half-titanocenes,[(C_5H_4)_2(CH_2)_n][(TiCl_3)_2][2(n=3),3(n=6)],and[(C_5H_4)_2(CH_2)_n[(TiCl_2OR_2](R=2,6- diisopropylphenoxyl)[4(n=3),5(n=6)],in the presence of methyl aluminoxanes(MAO)as cocatalyst in methylene *** influences of the length of polymethylene brigde and the substitution of aryloxy group at the metal center have been investigated at three polymerization temperature(...

关键词： Dinuclear half-titanocene Poly(isobutyl vinyl ether) Vinyl ether polymerization by metallocene Stereoregularity control by metallocene.

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Silver-palladium alloy deposited by DC magnetron sputtering method as lubricant for high temperature application

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中国有色金属学会会刊：英文版 2009年第4期19卷 1001-1004页

作者： Jung-Dae KWON Sung-Hun lee Koo-Hyun lee Jong-Joo RHA Kee-seok NAM Sang-Hoon CHOI dong-Min lee dong-Il KIM Materials Processing Division Korea Institute of Materials Science Technology Research & Development Institute Korea Plant Service and Engineering

The silver-palladium(Ag-Pd) alloy coating as a solid lubricant was investigated for its application to the high temperature stud bolts used in nuclear power plants.A hex bolt sample was prepared in the following steps:1) bolt surface treatment using alumina grit blasting for cleaning and increasing the surface area;2) nickel(Ni) film coating as a glue layer on the surface of the bolt;and 3) Ag-Pd alloy coating on the Ni *** films were deposited by using a direct current(DC) magnetron sputtering *** thickness and composition of the Ag-Pd alloy film have effect on the friction coefficient,which was determined using axial force measurement.A 500 nm-thick Ag-Pd(80-20,molar ratio) alloy film has the lowest friction coefficient of 0.109.A cyclic test was conducted to evaluate the durability of bolts coated with either the Ag-Pd(80-20) alloy film or N-5000 *** a cycle,the bolts were inserted into a block using a torque wrench,which was followed by heating and *** only one cycle,it was not possible to remove the bolts coated with the N-5000 oil from the ***,the bolts coated with the Ag-Pd(80-20) alloy could be easily removed up until 15 cycles.

关键词：银钯合金直流电高温润滑剂沉积磁控溅射法固体润滑涂层高温螺栓

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