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Brassica napus L. Homeodomain Leucine-Zipper Gene BnHB6 Responds to Abiotic and Biotic Stresses

Journal of Integrative Plant Biology 2005年第10期47卷 1236-1248页

作者： Shun-Wu YU Li-Da ZHANG Kai-Jing ZUO dong-qin tang Xiao-Fen SUN Ke-Xuan tang Plant Biotechnology Research Center Fudan-SJTU-Nottingham Plant Biotechnology R＆D Center School of Agriculture and Biology Shanghai Jiaotong University Shanghai 200030 China State Key Laboratory of Genetic Engineering School of Life Sciences Fudan-SJTU-Nottingham Plant Biotechnology R＆D Center Morgan-Tan International Center for Life Sciences Fudan University Shanghai 200433 China

A homeodomain leucine-zipper （HD-Zip） gene BnHB6 （GenBank accession No. AY336103） was isolated from oilseed rape （Brassica napus L.） following drought treatment through rapid amplification of cDNA ends （RACE）. The full-length cDNA of BnHB6 was 1 611 bp and contained a 936-bp open reading frame encoding 311 amino acids. Sequence analysis indicated that BnHB6 belonged to the HD-Zip I subfamily. High-stringency Southern boltting analysis showed that BnHB6 appeared in rape as a single copy but had homologous genes. Semi-quantitative reverse transcription-polymerase chain reaction （RT-PCR） analysis revealed that BnHB6 was expressed in several tissues tested under control conditions, but that expression was significantly upregulated in shoots by mannitol, NaCI, cold treatment, anaerobic culture, wounding, H2O2, abscisic acid （ABA）, and salicylic acid （SA） treatments, but not by ultraviolet treatment. Further RT- PCR analysis revealed that BnHB6 was a late-responsive gene, the expression of which was not activated by NaCI, cold treatment, H2O2, ABA, and SA at an early time point （20 min） of treatment in the shoot. However, after a certain period of treatment, the induced expression culminated and then declined until the next peak occurred. Tissue-specific analysis revealed that BnHB6 was expressed at certain levels in the roots, shoots, and flowers, and the roots were found to respond to the osmotic stimuli more rapidly than shoots to increase the expression of BnHB6. The present study implies that BnHB6 plays a positive role as a regulator of biotic and abiotic stresses on growth during seedling establishment.

关键词： Brassica napus homeodomain leucine-zipper gene water stress.

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Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi Han tang Jianian Hu Siying Kang Song qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

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Induced neural stem cells regulate microglial activation through Akt-mediated upregulation of CXCR4 and Crry in a mouse model of closed head injury

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Neural Regeneration Research 2025年第5期20卷 1416-1430页

作者： Mou Gao qin dong Dan Zou Zhijun Yang Lili Guo Ruxiang Xu Department of Neurosurgery Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of Neurosurgery Chinese PLA General HospitalBeijingChina Department of Neurology Fu Xing HospitalCapital Medical UniversityBeijingChina

Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and *** previously reported that induced neural stem cells can modulate the behavior of activated microglia via CXCL12/CXCR4 signaling,influencing their activation such that they can promote neurological ***,the mechanism of CXCR4 upregulation in induced neural stem cells remains *** this study,we found that nuclear factor-κB activation induced by closed head injury mouse serum in microglia promoted CXCL12 and tumor necrosis factor-αexpression but suppressed insulin-like growth factor-1 ***,recombinant complement receptor 2-conjugated Crry(CR2-Crry)reduced the effects of closed head injury mouse serum-induced nuclear factor-κB activation in microglia and the levels of activated microglia,CXCL12,and tumor necrosis factor-α.Additionally,we observed that,in response to stimulation(including stimulation by CXCL12 secreted by activated microglia),CXCR4 and Crry levels can be upregulated in induced neural stem cells via the interplay among CXCL12/CXCR4,Crry,and Akt signaling to modulate microglial *** agreement with these in vitro experimental results,we found that Akt activation enhanced the immunoregulatory effects of induced neural stem cell grafts on microglial activation,leading to the promotion of neurological recovery via insulin-like growth factor-1 secretion and the neuroprotective effects of induced neural stem cell grafts through CXCR4 and Crry upregulation in the injured cortices of closed head injury ***,these beneficial effects of Akt activation in induced neural stem cells were positively correlated with the therapeutic effects of induced neural stem cells on neuronal injury,cerebral edema,and neurological disorders post–closed head *** conclusion,our findings reveal that Akt activation may enhance the immunoregulatory effects of induced neura

关键词： Akt signaling cerebral edema closed head injury Crry CXCR4 induced neural stem cell microglia neuroinflammation

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Magnetron sputtered nickel oxide with suppressed interfacial defect states for efficient inverted perovskite solar cells

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Journal of Energy Chemistry 2025年第1期100卷 348-355页

作者： Guoqiang Ma qin Tan Zhaoning Li Jingwei Xiu Jiafeng Wang Tianle Cheng dong He Qiang Sun Xuhang Ma Francesco Lamberti Zhubing He Department of Materials Science and Engineering Institute of Innovative Materials (I2M) Shenzhen Key Laboratory of Full Spectral Solar Electricity Generation (FSSEG)Southern University of Science and Technology (SUSTech) Core Research Facilities Southern University of Science and Technology Department of Chemical Sciences Department of Industrial Engineering University of Padova

Widely used spin-coated nickle oxide （NiOx） based perovskite solar cells often suffer from severe interfacial reactions between the NiOxand adjacent perovskite layers due to surface defect states,which inherently impair device performance in a long-term view,even with surface molecule *** this study,we developed high-quality magnetron-sputtered NiOxthin films through detailed process optimization,and compared systematically sputtered and spin-coated NiOxthin film surfaces from materials to *** sputtered NiOxfilms exhibit improved crystallinity,smoother surfaces,and significantly reduced Ni3+or Ni vacancies compared to their spin-coated ***,the interface between the perovskite and sputtered NiOxfilm shows a substantially reduced density of defect *** solar cells （PSCs） fabricated with our optimally sputtered NiOxfilms achieved a high power conversion efficiency （PCE） of up to 19.93%and demonstrated enhanced stability,maintaining 86.2% efficiency during 500 h of maximum power point tracking under one standard sun ***,with the surface modification using (4-(2,7-dibromo-9,9-dimethylacridin-10（9H）-yl)butyl)p hosphonic acid （DMAcPA）,the device PCE was further promoted to 23.07%,which is the highest value reported for sputtered NiOxbased PSCs so far.

关键词： Nickle oxide Magnetron sputter Defect Stability Perovskite solar cell

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Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

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Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： Zhimin Long Chuanhua Ge Yueyang Zhao Yuanjie Liu qinghua Zeng qing tang Zhifang dong Guiqiong He Institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child Health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase

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Zoledronate-loaded aluminum salt nanovaccines amplify cellular immune response by enhancing cross-presentation

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Nano Research 2025年第1期18卷 559-571页

作者： Chunting He Penghui He Xue tang Shuting Bai Ming qin Yunting Zhang Zhaofei Guo Guangsheng Du Xun Sun Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry West China School of PharmacySichuan UniversityChengdu 610041China

Being a Th2 stimulator,classic aluminum salt-based adjuvants only stimulate weak cellular immune responses that are required for vaccination against intracellular viruses or cancerous *** a thirdgeneration bisphosphonate,zoledronate(ZOL)can enhance antigen crosspresentation by inhibiting key enzymes of the mevalonate ***,we developed the subunit antigen ovalbumin(OVA)and ZOL co-loaded aluminum hydroxide nanoparticles(APN-OVA-ZOL)and investigated their capacity for inducing cellular immune responses against the *** results showed that the developed nanovaccines could successfully encapsulate OVA and ZOL,and enabled efficient lymph node *** by the mevalonate pathway inhibition effect of ZOL,APN-OVA-ZOL significantly promoted *** a result,APN-OVA-ZOL induced robust cellular immunity,including the activation of T and B *** a EG7-OVA tumor-bearing murine model,APN-OVA-ZOL significantly inhibited the tumor growth and prolonged mice *** work provided a strong empirical foundation indicating that zoledronate-loaded aluminum salt nanovaccines had a strong potency for cancer immunotherapy.

关键词： zoledronate(ZOL) mevalonate pathway antigen cross-presentation cellular immune responses

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Two-layer formation-containment fault-tolerant control of fixed-wing UAV swarm for dynamic target tracking

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Journal of Systems Engineering and Electronics 2023年第6期34卷 1375-1396页

作者： qin Boyu ZHANG dong tang Shuo XU Yang School of Astronautics Northwestern Polytechnical UniversityXi’an 710072China Shaanxi Aerospace Flight Vehicle Design Key Laboratory Xi’an 710072China School of Civil Aviation Northwestern Polytechnical UniversityXi’an 710072China

This paper tackles the formation-containment control problem of fixed-wing unmanned aerial vehicle(UAV)swarm with model uncertainties for dynamic target tracking in three-dimensional space in the faulty case of UAVs’actuator and *** fixed-wing UAV swarm under consideration is organized as a“multi-leader-multi-follower”structure,in which only several leaders can obtain the dynamic target information while others only receive the neighbors’information through the communication *** simultaneously realize the formation,containment,and dynamic target tracking,a two-layer control framework is adopted to decouple the problem into two subproblems:reference trajectory generation and trajectory *** the upper layer,a distributed finite-time estimator(DFTE)is proposed to generate each UAV’s reference trajectory in accordance with the control ***,a distributed composite robust fault-tolerant trajectory tracking controller is developed in the lower layer,where a novel adaptive extended super-twisting(AESTW)algorithm with a finite-time extended state observer(FTESO)is involved in solving the robust trajectory tracking control problem under model uncertainties,actuator,and sensor *** proposed controller simultaneously guarantees rapidness and enhances the system’s robustness with fewer chattering ***,corresponding simulations are carried out to demonstrate the effectiveness and competitiveness of the proposed two-layer fault-tolerant cooperative control scheme.

关键词： fixed-wing unmanned aerial vehicle(UAV)swarm two-layer control formation-containment dynamic target tracking

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Bmpkci is highly expressed in resistant silkworm strain:implication of its role in resistance to BmDNV-Z

Bmpkci is highly expressed in resistant silkworm strain:impl...

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华东六省一市生物化学与分子生物学学会2006年学术交流会

作者： Ke-Ping Chen,Hui-qing Chen, Xu-dong tang, qin Yao,Lin-Ling Wang,Xu Hang (Institute of Life Sciences,Jiangsu University , 301# Xuefu Road,Zhenjiang 212013, P. R. China Institute of Life Sciences,Zhejiang University,Hangzhou,P. R. China)

Using fluorescent differential display technique,a special band named Bm541 was identified by screening for gene expressed differentially among the resistant silkworm strain Qiufeng, the susceptible strain Huaba35 and the near isogenic line BC6, which carries the resistant gene to BmDNV. After 5’RACE technique with specially designed primers, a 1148 bp cDNA clone containing a 387 bp open reading frame (ORF) was obtained. This gene has been registered in GenBank under the accession number *** amino acid sequence (BmPKCI) showed 73.1% identity to the PKCI of Drosophila pseudoobscura. In the deduced sequence of BmPKCI, the HIT motif, which is essential for PKCI function, and theα- helix region, which is conserved among the PKCI family, were present. The data from QRT-PCR suggested that the expression levels of BmPKCI in BC6 and Qiufeng both treated with BmDNV-Z were present at significantly higher than that of Huaba35,4.29- and 2. 59 fold respectively, which maybe indicated that BmPKCI played a role in resistance to BmDNV-Z.

关键词： PKCI Bombyx mori resistant BmDNV-Z FDD qRT-PCR

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Effects of aging treatment and heat input on the microstructures and mechanical properties of TIG-welded 6061-T6 alloy joints

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International Journal of Minerals,Metallurgy and Materials 2013年第3期20卷 259-265页

作者： dong Peng Jun Shen qin tang Cui-ping Wu Yan-bing Zhou College of Material Science & Engineering Chongqing University Fabrication Workshop Dongfang Turbine Co. Ltd.

Aging treatment and various heat input conditions and mechanical properties of TIG welded 606I-T6 alloy joints were adopted to investigate the microstructural evolution by microstructural observations, microhardness tests, and tensile tests. With an increase in heat input, the width of the heat-affected zone （HAZ） increases and grains in the fusion zone （FZ） coarsen. Moreover, the hardness of the HAZ decreases, whereas that of the FZ decreases initially and then increases with an increase in heat input. Low heat input results in the low ultimate tensile strength of the welded joints due to the presence of partial penetrations and pores in the welded joints. After a simple artificial aging treatment at 175℃ for 8 h, the microstructure of the welded joints changes slightly. The mechanical properties of the welded joints enhance significantly after the aging process as few precipitates distribute in the welded seam.

关键词： aluminum alloys tungsten inert gas welding heat input aging mechanical properties microstructure

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High Slope Stability of Diversion Power System Intake of Jinchuan Hydropower Station

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Journal of Mountain Science 2013年第6期10卷 1109-1117页

作者： tang Liang-qin tang Kui NIE De-xin WANG Jun-jie LIU dong-yan Key Laboratory of Hydraulic and Waterway Engineering of the Ministry of Education Chongqing Jiaotong University State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan University School of Mathematics and Statistic Chongqing University of Technology College of Environment and Civil Engineering Chengdu University of Technology College of Civil Engineering Chongqing University

The excavated height of the left bank slope of the diversion power system intake in Jinchuan hydropower station is about 16o m. The stability and safety of the slope during construction and its operation/utilization become one of the most important geological engineering problems. At the same time, it is also crucial to select a safe and economic excavation gradient for the construction. We studied the problem of how to select a safe and economic slope ratio by analyzing the geological condition of the high slope, including the lithology, slope structure, structural surface and their combinations, rock weathering and unloading, hydrology, and the natural gradient. The study results showed that the use of an excavation gradient larger than the gradient observed during site investigation and the gradient recommended in standards and field practice manuals is feasible. Then, we used the finite element method and rigid limit equilibrium method to evaluate the stability of the excavation slope under natural, rainstorm and earthquake conditions. The calculated results showed that the excavated slope only has limited failure, but its stability is greatly satisfactory. The research findings can be useful in excavation and slope stabilization projects.

关键词： Jinchuan Hydropower Station Highslope Excavation slope ratio Stability

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