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Preparation and evaluation of a water-in-oil nanoemulsion drug delivery system loaded with salidroside

Chinese Journal of Natural Medicines 2021年第3期19卷 231-240页

作者： liANG Chun-Xia qi dong-li ZHANG li-Na LU Peng liU Zhi-dong State Key Laboratory of Component-based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique Ministry of EducationTianjin University of Traditional Chinese MedicineTianjin 301617China

Salidroside(SAL)is a phenolic substance with high solubility and low permeability,which make it easy to cause the efflux effect of P-glycoprotein and degradation of intestinal flora,resulting in lower *** aim of this study was to develop and optimize a water-in-oil nanoemulsion of SAL(w/o SAL-N)to explore its suitability in oral drug delivery *** this work,SAL-N was successfully prepared by water titration method at K_(m)=1 to construct the pseudo-ternary phase *** characterization including the average viscosity,pH,refractive index,particle size,PDI,TEM,DSC,the content of SAL,and stability study were *** was evaluated for drug release in vitro and pharmacokinetic studies in *** optimized nanoemulsion formulation consisted of Labrafil M 1944 CS(63%),Span-80/Tween-80/EtOH(27%)and 200 mg·mL^(-1) SAL solution(SAL-SOL)(10%).Low viscosity and suitable pH were expected for the *** spherical morphology and nanoscale size of SAL-N enhanced the stability of the nanoemulsion *** vitro drug release showed that SAL-N had a better controlled release property than SAL-SOL at earlier time *** pharmacokinetic studies exhibited that SAL-N had significantly higher in t_(1/2)(2.11-fold),AUC_(0-48 h)(1.75-fold)and MRT0-48 h(2.63-fold)than SAL-SOL(Plivered via the oral *** can be seen w/o nanoemulsion is a strategy for the drug with polyphenols to delay the release,enhance oral absorption and reduce metabolic rate.

关键词： Salidroside Water-in-oil nanoemulsion Polyphenol Drug release Pharmacokinetics Bioavailability

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Stress Study on CrN Thin Films with Different Thicknesses on Stainless Steel

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Acta Metallurgica Sinica(English Letters) 2018年第3期31卷 329-336页

作者： Di Fan Hao Lei Chao-qian Guo dong-li qi Jun Gong Chao Sun Institute of Metal Research Chinese Academy of SciencesShenyang 110016China University of Chinese Academy of Sciences Beijing 100049China School of Science Shenyang Ligong UniversityShenyang 110159China

The reliability of a substrate curvature-based stress measurement method for CrN thin films on substrate with fluctuant surface was *** stress error led by the ignorance of substrate thermal deformation was *** showed that this error could be as large as several hundred MPa under general deposition *** in the CrN thin films with different thicknesses ranging from 110 to 330 nm on stainless steel was studied by this method,in comparison with conventional results on silicon *** thin films＇ morphology and structure were investigated and related to the film stress.A significant result of the comparison is that stress evolution in the thin films on steel obviously differs from that on silicon wafer,not only because the two substrates have different coefficients of thermal expansion,which provokes thermal stress,but also the considerable discrepancy in the thin films＇ grain coarsening rate and structure that induce different intrinsic stresses.

关键词： Stress CrN film Magnetron sputtering Stoney equation Steel substrate

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Reversal of Apoptotic Resistance by Lycium barbarum Glycopeptide 3 in Aged T Cells

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Biomedical and Environmental Sciences 2008年第3期21卷 212-217页

作者： LONG-GUO YUAN HONG-BIN DENG li-HuI CHEN DIAN-dong li AND qi-YANG HE Institute of Medicinal BiotechnoIogy Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100050 China

Objective To study whether Lycium barbarurn glycopeplide 3 （LBGP3） affects T cell apoptosis in aged mice. Methods LBGP3 was purified with DEAE cellulose and Sephadex columns. Apoptotic ＂sub-G1 peak＂ was detected by flow cytometry and DNA ladder was resolved by agarose gel electrophoresis. Levels of IFN-7 and IL-10 were measured with specific kits and mRNA expression was detected by RT-PCR. Apoptosis-related proteins of FliP, FasL, and Bcl-2 were determined by Western blotting. Results LBGP3 was purified from Fructus Lycii water extracts and identified as a 41 kD glycopeptide. Treatment with 200 p.g/mL LBGP3 increased the apoptotic rate of T cells from aged mice and showed a similar DNA ladder pattern to that in young T cells. The reversal of apoptotic resistance was involved in down-regulating the expression of Bcl-2 and FliP, and up-regulating the expression of FasL. Conclusion Lycium barbarum glycopeptide 3 reverses apoptotic resistance of aged T cells by modulating the expression of apoptosis-related molecules.

关键词： Lycium barbarum glycopeptide 3 Aged T cells Cytokines Apoptosis Senescence

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An unprecedented synthesis of axially chiral biaryls by rearrangement and aromatization of carbocations with central-to-axial conversion of chirality

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Science China Chemistry 2024年第9期67卷 2998-3003页

作者： qi liu Xue-dong li liang Cheng li liu Beijing National Laboratory for Molecular Sciences(BNLMS) CAS Key Laboratory of Molecular Recognition and FunctionCAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The central-to-axial chirality conversion represents a fascinating class of chemical processes consisting of the destruction of stereogenic centers and the simultaneous installation of axial chiral elements,which provides efficient methods for the preparation of axially chiral ***,developing catalytic asymmetric approaches for constructing these central chirality precursors and the efficient central-to-axial chirality conversion remains a challenge due to the requirement of aromatization or elimination *** this work,we have developed an unprecedented enantioselective intramolecular FriedelCrafts alkylation with unactivated-ketone carbonyls from which a chiral tertiary alcohol was generated with high efficiency and excellent *** addition,the central-to-axial chirality conversion strategy has been successfully applied to the synthesis of enantioenriched biaryls via a less-explored carbocation-initiated rearrangement and aromatization under the promotion of Lewis *** methodology provided a straightforward and sustainable access to a broad range of biaryl-2-carboxylic acid and in excellent yields(up to 92%)and excellent central-to-axial chirality conversion(up to 99%conversion percentage).This work could be a great model for developing new methods for synthesizing axially chiral biaryls and a general protocol for the rearrangement and aromatization of carbocations for further functionalization.

关键词： br?nsted acid catalysis desymmetrization phosphoric acid axially chiral biaryls central-to-axial conversion

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Viability for a class of semilinear differential equations of retarded type

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Applied Mathematics(A Journal of Chinese Universities) 2009年第1期24卷 36-44页

作者： dong qi-xiang li Gang School of Math. Sci., Yangzhou Univ., Yangzhou 225002, China School of Math. Sci. Yangzhou Univ. Yangzhou China

Let X be a Banach space, A ： D（A） X → X the generator of a compact C0- semigroup S（t）： X → X, t ≥ 0, D a locally closed subset in X, and f ：（a, b） × X →X a function of Caratheodory type. The main result of this paper is that a necessary and sufficient condition in order to make D a viable domain of the semilinear differential equation of retarded type u＇（t） = Au（t）＋ f（t, u（t - q））, t ∈ [to, to ＋ T], with initial condition uto = φ ∈C（[-q, 0]; X）, is the tangency condition lim infh10 h^-1d（S（h）v（O）＋hf（t, v（-q））; D） = 0 for almost every t ∈ （a, b） and every v ∈ C（[-q, 0]; X） with v（0）, v（-q）∈ D.

关键词： viability differential equation retarded type tangency condition

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Hydrogen-rich surface of MoC catalysts for efficient CO_(2) hydrogenation induced by a coupled hydrogen donator

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Nano Research 2024年第8期17卷 7762-7767页

作者： dong Xu Si-Yuan Xia qi-Yuan li Jie-Sheng Chen Xin-Hao li School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesShanghai Jiao Tong UniversityShanghai 200240China

Direct CO_(2) hydrogenation offers an important strategy for promoting the global carbon balance,but high thermodynamic and kinetic stability of CO_(2) has restricted its applicability to only a handful of industrial ***,we introduce a proof-of-concept application of the electron-rich Pt surface to promote hydrogen donation for electron-rich MoC particles acting as hydrogen acceptors,thereby constructing hydrogen-rich surface of MoC active ***,the formed hydrogen-rich and electronrich surface could greatly decrease reaction activation energy to boost the efficient CO_(2) hydrogenation into formic acid over the MoC *** optimized MoC@NC/Pt-0.1(NC:nitrogen-doped carbon)catalyst exhibits a high turnover frequency(TOF)value of 1.2 h^(−1) at a lower temperature of 60℃and a TOF of 24.2 h^(−1) under standard reaction conditions widely used in the literature,exceeding 7 times of MoC@NC catalyst and surpassing the benchmark classical non-noble metal active center-based heterogeneous catalyst.

关键词： electron-rich Pt nanoparticles hydrogen donation hydrogen-rich MoC nanoparticles CO_(2) hydrogenation formic acid

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Role of Prosurvival Molecules in the Action of lidamycin toward Human Tumor Cells

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Biomedical and Environmental Sciences 2009年第3期22卷 244-252页

作者： A-JING YANG WEI-WEI SHI YONG li ZHEN WANG RONG-GUANG SHAO DIAN-dong li qi-YANG HE Institute of Medicinal Biotechnology Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100050 China

Objective lidamycin, an enediyne antibiotic, leads to apoptosis and mitotic cell death of human tumor cells at high and low concentrations. The reason why tumor cells have distinct responses to lidamycin remains elusive. This study was to elucidate if cellular prosurvival molecules are involved in these responses. Methods Cleavage of chromatin and DNA was observed by chromatin condensation and agarose gel electrophoresis. Accumulation of rhodamine 123 in lidamycin-treated cells was assayed by flow cytometry. Cell multinucleation was detected by staining with Hoechst 33342. Western blot and senescence-associated β-galactosidase （SA-β-gal） staining were used to analyze protein expression and senescence-like phenotype, respectively. Results SIRT1 deacetylase remained unchanged in 0.5 nmol/L lidamycin whereas cleavage occurred when apoptosis was induced by lidamycin. Increased FOXO3a, SOD-1 and SOD-2 expression and transient phosphorylation of ERK were detected after exposure of human hepatoma BEL-7402 cells to 0.5 nmol/L lidamycin. High expressions of SIRT1 and Akt were found in colon carcinoma HCT116 p53 knock-out cells exposed to lidamycin. Degradation of PARP and p53 by lidamycin as a substitute for SIRT1 and Akt was confirmed with caspase inhibitor Q-VD-OPh and proteasome inhibitor MG132. Resistance to lidamycin-induced DNA cleavage was observed in breast cancer doxorubicin-resistant MCF-7 cells. This was not induced by P-glycoprotein as no accumulation of rhodamine 123 was detected in the resistant cells following exposure to lidamycin. In contrast to sensitive MCF-7 cells, a lower multinucleation rate for the resistant cells was measured following exposure to equal concentrations of lidamycin. Conclusions Cellular prosurvival molecules, such as SIRTI, Akt, SOD-1, SOD-2 and other unknown factors can influence the action of lidamycin on human tumor cells.

关键词： lidamycin Prosurvival molecules SIRTI deacetylase Apoptosis Mitotic cell death Multidrug resistance

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Unraveling role of double-exchange interaction in electrochemical water oxidation by external magnetic field

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Rare Metals 2024年第1期43卷 289-297页

作者： Jun li Jun-Ming li Hong Hong dong-Xue liu qing-qi Cao Dun-Hui Wang National Laboratory of Solid State Microstructures and Jiangsu Provincial Key Laboratory for Nanotechnology Nanjing UniversityNanjing 210093China School of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China

Double-exchange(DE) interaction plays an important role in electrocatalytic oxygen evolution reaction(OER).However,precise achievement of DE interaction often requires foreign dopants or vacancy engineering,leading to destabilization of the catalysts and deterioration of *** contrast,the utilization of environmentally friendly,contactless,and continuously adjustable magnetic fields to study the OER process is profitable to avoid aforementioned interference factors and further elucidate the direct relationship_(0.5)between DE interaction and OER ***,by using cobalt hydroxide carbonate(Co(OH)(CO_(3))·xH_(2)O,CoHC) nanostructures as a proof-of-concept study,external magnetic fields are carefully implemented to verify the role of DE interaction during water oxidation *** studies reveal that external magnetic fields effectively enhance the reaction rate of the catalyst,the overpotential decreases from 386 to 355 mV(100 mA·cm^(-2)),while Tafel slopes drastically decline from 93 to 67 mV·dec^(-1)(1.0 T).Moreover,magnetic field increment exhibits robust *** in situ Raman and impedance measurements under external field,it can be found that magnetic field promotes the electron migration between Co^(2+) and Co^(3+) in the CoHC catalysts with the assistance of DE interactions,thus boosting the OER efficiency.

关键词： Magnetic field Double-exchange(DE)interaction Electrocatalysis Oxygen evolution reaction(OER) Cobalt hydroxide carbonate

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Realizing the excellent oxidation resistance of an environmental barrier coating through aluminum surface modification

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Journal of Advanced Ceramics 2024年第7期13卷 976-986页

作者： lin dong Wen-qi Yang lin Chen Guan-Jun Yang Chang-Jiu li State Key Laboratory for Mechanical Behavior of Materials School of Materials Science and EngineeringXi’an Jiaotong UniversityXi’an 710049China Xi’an Aerospace Engine Company limited in China Aerospace Science and Technology Corporation Xi’an 710065China

The lifetime of Si-based environmental barrier coatings(EBCs)is constrained by thermally grown SiO_(2)oxidelayer(SiO_(2)-TGO),which can cause premature cracking and *** address this issue,a new approach for surfacemodification using aluminum is *** oxidation performance was examined in a 50 vol%H_(2)O-50 vol%O_(2)environment at 1350℃for up to 300 *** results indicate that a dense ytterbium aluminum garnet(YbAG)layer wasformed after modification,decreasing the porosity by 80%.Due to the elimination of fast diffusion channels and the lowoxygen permeability of YbAG,aluminum modification significantly reduced the growth rate of SiO_(2)-TGO by nearly twoorders of ***,its thickness decreased by more than 70%after 300 h of exposure.A diffusioncontrolled oxidation mechanism indicates that the modified dense surface is equivalent to an initial SiO_(2)layer with a specificthickness,causing a shift in the oxidation time and increasing the oxidation *** research provides valuableinsights for designing Si-based EBC with improved lifetimes.

关键词： environmental barrier coating(EBC) oxidation modification diffusion cracking

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Host-induced silencing of MpPar6 confers Myzus persicae resistance in transgenic rape plants

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Journal of Integrative Agriculture 2024年第1期23卷 187-194页

作者： qi Zhang Wenqin Zhan Chao li ling Chang Yi dong Jiang Zhang State Key Laboratory of Biocatalysis and Enzyme Engineering School of Life SciencesHubei UniversityWuhan 430062China Oil Crops Research Institute Chinese Academy of Agricultural SciencesWuhan 430062China Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural SciencesShenzhen 518000China

Plant-mediated RNA interference(RNAi)has emerged as a promising technology for insect *** green peach aphid,Myzus persicae,feeds on over 400 species of host *** napus(rape)is the second most important oilseed crop *** persicae is highly reproductive and causes severe damage to the rape plants due to its quite flexible life *** this study,we tested the RNAi effects of transgenic rape plants on *** in vitro feeding *** with artificial diets containing double-stranded RNAs(dsRNAs)targeting seven aphid genes,we identified a new gene encoding the partitioning-defective protein 6(Par6)as the most potent RNAi ***-and stage-expression analysis of Par6 suggested this gene is highly expressed in the embryo and adult stage of *** next generated transgenic rape plants expressing ds Par6 by Agrobacteriummediated transformation and obtained nine independent transgenic *** to wild-type control plants,transgenic rape lines expressing ds Par6 showed strong resistance to *** assays revealed that feeding transgenic rape plants to *** significantly decreased MpPar6 expression and survival rate and impaired ***,we showed that the resistance levels to *** are positively correlated with ds Par6 expression levels in transgenic rape *** study demonstrates that transgenic rape plants expressing ds Par6 are efficiently protected from *** with the genes involved in embryo development could be the effective RNAi targets for controlling aphids and potentially other insect pests.

关键词： oilseed rape pest control aphid double-stranded RNA RNA interference

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