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一种新型曳引式施工升降机的设计

机械设计与制造 2008年第8期 27-28页

作者：吴晓冬殷晨波南京工业大学机械与动力工程学院南京210009

针对目前普遍使用的齿轮齿条式施工升降机(施工电梯)的缺点,提出了一种耗能低、噪音小的曳引式施工升降机的设计方法。经过多次实际工况实验,证明该设计方法是可行的。

关键词：曳引式施工升降机曳引机设计

基于蚁群优化的分布式Qos多播路由方法研究

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计算机工程与设计 2009年第5期30卷 1107-1109页

作者：尹向东费洪晓湖南科技学院计算机与信息科学系湖南永州425006 中南大学信息科学与工程学院湖南长沙410083

提出了一种基于蚁群优化的分布式QoS多播路由算法,蚁群算法是解决多QoS约束组播路由问题的一种启发式算法,多QoS约束的组播路由技术是当前实现分布式网络多媒体的关键技术。给出了该算法实现的步骤,还结合多播路由问题的特点对算法进行... 详细信息

提出了一种基于蚁群优化的分布式QoS多播路由算法,蚁群算法是解决多QoS约束组播路由问题的一种启发式算法,多QoS约束的组播路由技术是当前实现分布式网络多媒体的关键技术。给出了该算法实现的步骤,还结合多播路由问题的特点对算法进行了改进。通过仿真实验讨论了该方法的性能,并与传统的蚁群算法对比,证实了该方法的有效性。

关键词：蚁群优化多播路由服务质量网络多媒体多QoS约束

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多舰测向交叉定位系统布局优化方法研究

计算机仿真 2015年第3期32卷 27-32页

作者：刘冬利庞海滨伊柏栋大连海事大学信息工程学院辽宁大连116026 海军大连舰艇学院信息作战系辽宁大连116018 海军大连舰艇学院研究生管理大队辽宁大连116018

在航海舰船准确定位的研究中,多舰测向交叉定位是在复杂海战场环境下较为常用的一种被动协同探测方式。参与定位的舰艇布局对测向交叉定位的探测范围和定位精度具有重要影响,应根据作战任务和作战海区地理特点对舰艇布局进行优化。舰艇... 详细信息

在航海舰船准确定位的研究中,多舰测向交叉定位是在复杂海战场环境下较为常用的一种被动协同探测方式。参与定位的舰艇布局对测向交叉定位的探测范围和定位精度具有重要影响,应根据作战任务和作战海区地理特点对舰艇布局进行优化。舰艇布局涉及了舰艇数量、舰艇间距和编队队形三个方面因素,如何进行合理配置是舰艇布局优化的难点问题。建立了多舰测向交叉定位误差的数学模型,对不同布局条件下的测向交叉定位误差分布进行了仿真。通过仿真结果的对比分析,得出不同定位需求和海区条件下舰艇数量、舰艇间距和编队队形的配置方法,从而实现舰艇定位布局的优化。

关键词：测向交叉定位布局优化仿真

Inhibitory effects of idoxifene on hepatic fibrosis in rats

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Acta Pharmacologica Sinica 2005年第5期26卷 581-586页

作者： Ya-jun ZHOU~2,dong-mei yin,Hong-shan CHEN,Jian-hua SHI,Bao-xi SHA,Xing WANGDepartment of Biochemistry & Molecular Biology Medical College,Nan Tong University,Nantong 226001,China DepartmentofBiochemistry&MolecularBiology MedicalCollegeNanTongUniversityNantong226001China

Aim:To investigate the effects of a tissue-specific selective estrogen receptormodulator,idoxifene,on hepatic fibrosis in ***:Hepatic fibrosis wasinduced by dimethylnitrosamine(DMN)in male *** DMN model of hepaticfibrosis and the hepatocytes undergoing oxidative stress were treated withidoxifene *** effect of idoxifene on hepatic fibrosis in the DMNmodel was examined by *** of idoxifene on antioxi-dant enzyme levels of copper,zinc-dependent superoxide dismutase(CuZn-SOD),and cellular glutathione peroxidase(GSHPx)were measured by *** ofidoxifene on activation,proliferation,and apoptosis of culture-activated hepaticstellate cells(HSC)were analysed by immunohistochemistry,bromodeoxyuridine(BrdU)uptake,and flow cytometry, respectively. Results:Idoxifene could mark-edly suppress DMN-induced hepatic fibrosis in male rats.A treatment of 0.4mg·kg-1·d-1of idoxifene reduced the protein levels of collagen in the DMN modelby 41.19%(P<0.05).Protein level of CuZn-SOD and activitiy of GSHPx in livertreated with DMN plus 0.4 ***-1·d-1of idoxifene were 2.65 times(P<0.05)and2.08 times greater(P<<0.05)than that of liver treated with DMN alone *** protein level of CuZn-SOD and activity of GSHPx in cultured rat hepatocytestreated with ferric nitrilotriacetate(FeNTA)plus 1×10-7mol/L of idoxifene were3.43 times(P<0.05)and 2.52 times(P<0.05)greater than that treated with *** could inhibit HSC *** with the control,theuptake of BrdU in HSC cultured with 1×10-7mol/L of idoxifene was reduced by51.87%(P<0.05),and the number of apoptotic HSCs cultured with 1×10-7mol/L ofidoxifene increased by 94.52%(P<0.05).Conclusion:Idoxifene showed inhibi-tory action on hepatic fibrosis in male rats.

关键词： fibrosis idoxifene oxidative stress hepatic stellate cell liver

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基于职业发展的新生代农民工培训体系研究

职业技术教育 2012年第7期33卷 77-80页

作者：李佩东许红华中国矿业大学管理学院江苏徐州221116

新生代农民工是我国目前农民工群体的主力军,他们具有文化水平较高、流动性较大、职业期望高等特点。但是,政府和企业及新生代农民工自身都普遍没有充分重视通过职业培训促进其职业发展,为此,应依据企业需求及新生代农民工自身需求尽快... 详细信息

新生代农民工是我国目前农民工群体的主力军,他们具有文化水平较高、流动性较大、职业期望高等特点。但是,政府和企业及新生代农民工自身都普遍没有充分重视通过职业培训促进其职业发展,为此,应依据企业需求及新生代农民工自身需求尽快为其建立完善的培训体系,以形成其完善的职业发展制度,实现其终身培训。

关键词：新生代农民工职业发展培训体系

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316L不锈钢动态再结晶行为

北京科技大学学报 2009年第12期31卷 1555-1559页

作者：项建英宋仁伯任培东北京科技大学材料科学与工程学院北京100083 酒泉钢铁股份有限公司技术中心嘉峪关735100

在Gleeble-1500热模拟试验机上,通过高温压缩实验对316L不锈钢的动态再结晶行为进行了系统研究.结果表明:316L不锈钢热变形加工硬化倾向性较大,在真应力应变曲线上没有出现明显的应力峰值σp;316L不锈钢在热变形过程中发生了动态再结晶... 详细信息

在Gleeble-1500热模拟试验机上,通过高温压缩实验对316L不锈钢的动态再结晶行为进行了系统研究.结果表明:316L不锈钢热变形加工硬化倾向性较大,在真应力应变曲线上没有出现明显的应力峰值σp;316L不锈钢在热变形过程中发生了动态再结晶,但只是在局部区域观察到了动态再结晶晶粒.对动态再结晶的实验数据进行拟合,得到316L不锈钢的热激活能和热变形方程,并给出了发生动态再结晶的临界应变和临界应力以及Zener-Hollomon参数和稳态应力的关系.

关键词：不锈钢应力应变曲线动态再结晶热变形

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端口-连接型产品配置知识的Java表达

计算机辅助设计与图形学学报 2005年第3期17卷 511-516页

作者：杨晗尹建伟董金祥罗尚虎浙江大学CAD&CG国家重点实验室杭州310027

扩展UML语言可以表达端口连接型产品的配置知识把UML表达知识转换为Java形式 ,转换后的Java知识库保持了UML表达知识的易读、易于人工修改。

关键词：产品配置扩展UML Java 知识表达

反相高效液相色谱法测定盐酸鲁拉西酮有关物质

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医药导报 2013年第2期32卷 223-225页

作者：张园园李银峰王杰晶李佩靳朝东天津中医药大学研究生院 300193 天津药物研究院分析测试中心 300193 河南大学药学院开封475001

目的建立测定盐酸鲁拉西酮有关物质的反相高效液相色谱法。方法使用YMC-Pack Pro C18柱(150 mm×6.0 mm,5μm),流动相为甲醇-5 mmol.L-1磷酸氢二铵溶液[用稀磷酸调pH至7.0](85∶15),检测波长为230 nm,流速为1.0 ***-1。结果盐酸鲁拉西... 详细信息

目的建立测定盐酸鲁拉西酮有关物质的反相高效液相色谱法。方法使用YMC-Pack Pro C18柱(150 mm×6.0 mm,5μm),流动相为甲醇-5 mmol.L-1磷酸氢二铵溶液[用稀磷酸调pH至7.0](85∶15),检测波长为230 nm,流速为1.0 ***-1。结果盐酸鲁拉西酮与中间体和降解产物在上述色谱条件下能有效分离,且在2.772～1 108.800μ***-1范围内线性关系良好(r=0.999 9)。结论该方法测定结果准确,操作简单,灵敏度高,专属性强,可用于盐酸鲁拉西酮的有关物质检查。

关键词：鲁拉西酮,盐酸色谱法,高效液相

Single-cell exome sequencing reveals polyclonal seeding and TRPS1 mutations in colon cancer metastasis

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Signal Transduction and Targeted Therapy 2024年第10期9卷 4637-4652页

作者： Jianqiang Cai Weilong Zhang Yalan Lu Wenjie Liu Haitao Zhou Mei Liu Xinyu Bi Jianmei Liu Jinghua Chen Yanjiang yin Yiqiao Deng Zhiwen Luo Yi Yang Qichen Chen Xiao Chen Zheng Xu Yueyang Zhang Chaoling Wu Qizhao Long Chunyuan Huang Changjian Yan Yan Liu Lei Guo Weihua Li pei Yuan Yucheng Jiao Wei Song Xiaobing Wang Zhen Huang Jianming ying Hong Zhao Department of Hepatobiliary Surgery State Key Laboratory of Molecular OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Key Laboratory of Gene Editing Screening and R&D of Digestive System Tumor Drugs Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Hematology Lymphoma Research CenterPeking University Third HospitalBeijingChina Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of HealthBeijing Key Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical CollegeBeijingChina Department of Biochemistry and Molecular Biology State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijingChina Department of Colorectal Surgery State Key Laboratory of Molecular OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Pathology State Key Laboratory of Molecular OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Liver metastasis remains the primary cause of mortality in patients with colon cancer. Identifying specific driver gene mutations that contribute to metastasis may offer viable therapeutic targets. To explore clonal evolution and genetic heterogeneity within the metastasis, we conducted single-cell exome sequencing on 150 single cells isolated from the primary tumor, liver metastasis, and lymphatic metastasis from a stage IV colon cancer patient. The genetic landscape of the tumor samples revealed that both lymphatic and liver metastases originated from the same region of the primary tumor. Notably, the liver metastasis was derived directly from the primary tumor, bypassing the lymph nodes. Comparative analysis of the sequencing data for individual cell pairs within different tumors demonstrated that the genetic heterogeneity of both liver and lymphatic metastases was also greater than that of the primary tumor. This finding indicates that liver and lymphatic metastases arose from clusters of circulating tumor cell (CTC) of a polyclonal origin, rather than from a single cell from the primary tumor. Single-cell transcriptome analysis suggested that higher EMT score and CNV scores were associated with more polyclonal metastasis. Additionally, a mutation in the TRPS1 (Transcriptional repressor GATA binding 1) gene, TRPS1 R544Q, was enriched in the single cells from the liver metastasis. The mutation significantly increased CRC invasion and migration both in vitro and in vivo through the TRPS1R544Q/ZEB1 axis. Further TRPS1 mutations were detected in additional colon cancer cases, correlating with advanced-stage disease and inferior prognosis. These results reveal polyclonal seeding and TRPS1 mutation as potential mechanisms driving the development of liver metastases in colon cancer.

关键词： metastasis colon cancer