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Evaluation of dry eye disease symptomatology and mental health status among patients with different COVID-19 statuses

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 822-830页

作者： Fang Ruan Wen-Jun Kong Qian Fan hong-Wei dong Wei Zhang Wen-Bin Wei Ying Jie Department of Ophthalmology Beijing You’an HospitalCapital Medical UniversityBeijing Infectious Eye Disease Diagnosis and Treatment CenterBeijing 100069China Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Institute of OphthalmologyBeijing Ophthalmology and Visual Sciences Key LabBeijing 100730China Tianjin Eye Hospital Tianjin Key Lab of Ophthalmology and Visual ScienceTianjin Eye InstituteNankai University Affiliated Eye HospitalNankai University Eye InstituteNankai UniversityClinical College of OphthalmologyTianjin Medical UniversityTianjin 300020China

AIM:To evaluate dry eye disease(DED)symptomatology and mental health status in different COVID-19 ***:A cross-sectional observational design was *** 123 eligible adults(46.34%of men,age range,18-59y)with COVID-19 included in the study from August to November,*** Surface Disease Index(OSDI),Five-item Dry Eye Questionnaire(DEQ-5),Hospital Anxiety and Depression Scale(HADS),and Pittsburgh Sleep Quality Index(PSQI)were used in this ***:OSDI scores were 6.82(1.25,15.91)in asymptomatic carriers,7.35(2.50,18.38)in mild cases,and 16.67(4.43,28.04)in recurrent cases,with 30.00%,35.56%,and 57.89%,respectively evaluated as having DED symptoms(χ2=7.049,P=0.029).DEQ-5 score varied from 2.00(0,6.00)in asymptomatic carriers,3.00(0,8.00)in mild cases,and 8.00(5.00,10.00)in recurrent cases,with 27.50%,33.33%,and 55.26%,respectively assessed as having DED symptoms(χ2=8.532,P=0.014).The prevalence of clinical anxiety(50.00%)and depression(47.37%)symptoms were also significantly higher in patients with recurrent infection(χ2=24.541,P<0.001;χ2=30.871,P<0.001).Recurrent infection was a risk factor for high OSDI scores[odds ratio,2.562;95%confidence interval(CI),1.631-7.979;P=0.033]and DEQ-5 scores(odds ratio,3.353;95%CI,1.038-8.834;P=0.043),whereas having a fixed occupation was a protective factor for OSDI scores(odds ratio,0.088;95%CI,0.022-0.360;P=0.001)and DEQ-5 scores(odds ratio,0.126;95%CI,0.039-0.405;P=0.001).CONCLUSION:Patients with recurrent COVID-19 have more severe symptoms of DED,anxiety,and depression.

关键词： COVID-19 dry eye disease recurrent infection mental health

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低碳建设能否助力中国城市全球价值链攀升——地位和位置的双重考察

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现代财经（天津财经大学学报） 2024年第1期44卷 55-72页

作者：董梓梅李宏天津财经大学经济学院天津300222

文章利用中国地级及以上城市面板数据,以低碳试点政策为准自然实验,运用渐进双重差分方法从全球价值链地位和全球价值链位置双重视角考察了低碳建设对全球价值链攀升的影响及作用机制。结果表明,低碳建设能够助力中国城市全球价值链攀升... 详细信息

文章利用中国地级及以上城市面板数据,以低碳试点政策为准自然实验,运用渐进双重差分方法从全球价值链地位和全球价值链位置双重视角考察了低碳建设对全球价值链攀升的影响及作用机制。结果表明,低碳建设能够助力中国城市全球价值链攀升,即城市低碳试点的设立显著促进了全球价值链地位和全球价值链位置的提升,在经过平行趋势、安慰剂等一系列稳健性检验后,该结果仍然成立;机制检验表明,低碳建设会通过推动出口贸易方式转型和促进国内中间品对进口中间品的替代来提升中国城市在全球价值链中的地位,并通过降低全球价值链下游度而非提升全球价值链上游度来提升中国城市在全球价值链中的位置;进一步研究发现,低碳建设存在全球价值链地位攀升的正向溢出效应,但并未表现出全球价值链位置攀升的溢出效应。以上结论能为我国利用低碳建设契机加速全球价值链攀升并实现区域间协同绿色高质量发展提供有益借鉴。

关键词：低碳建设全球价值链地位全球价值链位置

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Comparative transcriptomic evidence of physiological changes and potential relationships in vertebrates under different dormancy states

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Zoological Research 2024年第2期45卷 341-354页

作者： Yu-Han Niu Li-hong Guan Cheng Wang Hai-Feng Jiang Guo-Gang Li Lian-dong Yang Shun-Ping He State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhanHubei 430072China College of Life Sciences Qinghai Normal UniversityXiningQinghai 810008China Academy of Plateau Science and Sustainability Qinghai Normal UniversityXiningQinghai 810016China Key Laboratory of Biodiversity Formation Mechanism and Comprehensive Utilization of the Qinghai-Tibet Plateau in Qinghai Province Qinghai Normal UniversityXiningQinghai 810008China College of Life Sciences and Technology Xinxiang Medical UniversityXinxiangHenan 453003China College of Animal Science and Technology Northwest A&F UniversityYanglingShaanxi 712100China

Dormancy represents a fascinating adaptive strategy for organisms to survive in unforgiving *** a period of dormancy,organisms often exhibit exceptional *** period is typically divided into hibernation and aestivation based on seasonal ***,the mechanisms by which organisms adapt to their environments during dormancy,as well as the potential relationships between different states of dormancy,deserve further ***,we selected Perccottus glenii and Protopterus annectens as the primary subjects to study hibernation and aestivation,*** on histological and transcriptomic analysis of multiple organs,we discovered that dormancy involved a coordinated functional response across *** analyses revealed noteworthy disparities between the two dormant species in their responses to extreme ***,similarities in gene expression patterns pertaining to energy metabolism,neural activity,and biosynthesis were noted during hibernation,suggesting a potential correlation between hibernation and *** further explore the relationship between these two phenomena,we analyzed other dormancy-capable species using data from publicly available *** comparative analysis revealed that most orthologous genes involved in metabolism,cell proliferation,and neural function exhibited consistent expression patterns during dormancy,indicating that the observed similarity between hibernation and aestivation may be attributable to convergent *** conclusion,this study enhances our comprehension of the dormancy phenomenon and offers new insights into the molecular mechanisms underpinning vertebrate dormancy.

关键词： Hibernation Aestivation Multi-organs Convergent evolution

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Design and implementation of low-cost geomagnetic field monitoring equipment for high-density deployment

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Applied Geophysics 2024年第3期21卷 505-512,618页

作者： Sun Lu-Qiang Bai Xian-Fu Kang Jian Zeng Ning Zhu hong Zhang Ming-dong Tianjin Earthquake Agency Tianjin 300201China Yunnan Earthquake Agency Kunming 650224China

The observation of geomagnetic field variations is an important approach to studying earthquake *** 1987,the China Earthquake Administration has explored this seismomagnetic *** particular,they studied local magnetic field anomalies over the Chinese mainland for earthquake *** to the years of research on the seismomagnetic relationship,earthquake prediction experts have concluded that the compressive magnetic effect,tectonic magnetic effect,electric magnetic fluid effect,and other factors contribute to preearthquake magnetic ***,this involves a small magnitude of magnetic field *** is difficult to relate them to the abnormal changes of the extremely large magnetic field in regions with extreme earthquakes owing to the high cost of professional geomagnetic equipment,thereby limiting large-scale ***,it is difficult to obtain strong magnetic field changes before an *** Tianjin Earthquake Agency has developed low-cost geomagnetic field observation equipment through the Beijing–Tianjin–Hebei geomagnetic equipment test *** new system was used to test the availability of equipment and determine the findings based on big data..

关键词： geomagnetic field earthquake prediction low cost high density big data

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舰载雷达天线测角误差分析

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系统仿真学报 2009年第15期21卷 4607-4612页

作者：董玫张守宏吴向东赵永波西安电子科技大学雷达信号处理重点实验室西安710071

为了分析舰船姿态角对雷达测角误差的影响,根据舰船姿态角与目标空间位置的三维立体关系,建立误差模型的量化公式。利用坐标系中Z轴指向的变化分析测角误差变化的新思路,得出偏航角不影响误差的变化,俯仰角与方位角误差曲线变化的趋势相... 详细信息

为了分析舰船姿态角对雷达测角误差的影响,根据舰船姿态角与目标空间位置的三维立体关系,建立误差模型的量化公式。利用坐标系中Z轴指向的变化分析测角误差变化的新思路,得出偏航角不影响误差的变化,俯仰角与方位角误差曲线变化的趋势相反,测角误差的最大值可以预测的结论。计算机仿真结果验证了结论的正确性。

关键词：舰载雷达姿态角空间模型误差分析

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肺炎克雷伯杆菌对小鼠中性粒细胞表达IL-1β和TNF-α的影响

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第一军医大学学报 2005年第7期25卷 805-808页

作者：宋卉钱元恕董红梅汕头大学医学院药理教研室广东汕头515041 汕头大学医学院病理教研室广东汕头515041

目的观察肺炎克雷伯杆菌(Klebsiellapneumoniae,Kle.p)感染对小鼠中性粒细胞细胞因子表达的影响。方法以热灭活的Kle.p感染小鼠肺部建立急性肺炎模型,分离并纯化中性粒细胞(PMN),用RT-PCR、Westernblotting、ELISA等方法检测PMN中TNF-α... 详细信息

目的观察肺炎克雷伯杆菌(Klebsiellapneumoniae,Kle.p)感染对小鼠中性粒细胞细胞因子表达的影响。方法以热灭活的Kle.p感染小鼠肺部建立急性肺炎模型,分离并纯化中性粒细胞(PMN),用RT-PCR、Westernblotting、ELISA等方法检测PMN中TNF-α和IL-1β的表达改变。结果Kle.p感染促进了早期小鼠中性粒细胞肿瘤坏死因子-α(TNF-α)和白介素-1β(IL-1β)的mRNA表达及分泌,TNF-αmRNA表达在感染6h最高,12h后降低;IL-1β的mRNA表达在感染12h最强;24h后两者表达均减弱,但仍显著强于对照组。Westernblotting结果显示,感染6h后TNF-α、IL-1β的蛋白表达量最高,24h后表达明显减少。ELISA结果显示,TNF-α分泌量在感染后6h最高,24h后明显降低,但仍较对照组高;IL-1β分泌量峰值在感染12h后出现。结论TNF-α可能主要参与小鼠感染热灭活Kle.p早期的PMN免疫防御功能;而IL-1β则主要参与感染中后期的PMN免疫防御功能。

关键词：肺炎克雷伯杆菌中性粒细胞细胞因子

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Influence of reduced-port laparoscopic surgery on perioperative indicators, postoperative recovery, and serum inflammation in patients with colorectal carcinoma

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1734-1741页

作者： hong-Biao Wu dong-Fang Liu Ye-Lei Liu Xiao-Feng Wang Yue-Peng Cao Department of Colorectal Surgery The First Affiliated Hospital of Ningbo UniversityNingbo 315000Zhejiang ProvinceChina

BACKGROUND Conventional five-port laparoscopic surgery,the current standard treatment for colorectal carcinoma(CRC),has many *** To assess the influence of reduced-port laparoscopic surgery(RPLS)on perioperative indicators,postoperative recovery,and serum inflammation indexes in patients with *** The study included 115 patients with CRC admitted between December 2019 and May 2023,52 of whom underwent conventional five-port laparoscopic surgery(control group)and 63 of whom underwent RPLS(research group).Comparative analyses were performed on the following dimensions:Perioperative indicators[operation time(OT),incision length,intraoperative blood loss(IBL),and rate of conversion to laparotomy],postoperative recovery(first postoperative exhaust,bowel movement and oral food intake,and bowel sound recovery time),serum inflammation indexes[high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),and interleukin-6(IL-6)],postoperative complications(anastomotic leakage,incisional infection,bleeding,ileus),and therapeutic *** The two groups had comparable OTs and IBL ***,the research group had a smaller incision length;lower rates of conversion to laparotomy and postoperative total complication;and shorter time of first postoperative exhaust,bowel movement,oral food intake,and bowel sound recovery;all of which were ***,hs-CRP,IL-6,and TNF-αlevels in the research group were significantly lower than the baseline and those of the control group,and the total effective rate was *** RPLS exhibited significant therapeutic efficacy in CRC,resulting in a shorter incision length and a lower conversion rate to laparotomy,while also promoting postoperative recovery,effectively inhibiting the inflammatory response,and reducing the risk of postoperative complications.

关键词： Reduced-port laparoscopic surgery Colorectal carcinoma Perioperative indicators Postoperative recovery Serum inflammation indexes

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Esophageal cancer screening,early detection and treatment:Current insights and future directions

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1180-1191页

作者： hong-Tao Qu Qing Li Liang Hao Yan-Jing Ni Wen-Yu Luan Zhe Yang Xiao-dong Chen Tong-Tong Zhang Yan-dong Miao Fang Zhang Department of Emergency Yantai Mountain HospitalYantai 264000Shandong ProvinceChina Cancer Center Yantai Affiliated Hospital of Binzhou Medical UniversityThe 2nd Medical College of Binzhou Medical UniversityYantai 264100Shandong ProvinceChina

Esophageal cancer ranks among the most prevalent malignant tumors globally,primarily due to its highly aggressive nature and poor survival *** to the 2020 global cancer statistics,there were approximately 604000 new cases of esophageal cancer,resulting in 544000 *** 5-year survival rate hovers around a mere 15%-25%.Notably,distinct variations exist in the risk factors associated with the two primary histological types,influencing their worldwide incidence and *** cell carcinoma displays a high incidence in specific regions,such as certain areas in China,where it meets the cost-effect-iveness criteria for widespread endoscopy-based early diagnosis within the local ***,adenocarcinoma(EAC)represents the most common histological subtype of esophageal cancer in Europe and the United *** role of early diagnosis in cases of EAC originating from Barrett's esophagus(BE)remains a subject of *** effectiveness of early detection for EAC,particularly those arising from BE,continues to be a debated *** variations in how early-stage esophageal carcinoma is treated in different regions are largely due to the differing rates of early-stage cancer *** areas with higher incidences,such as China and Japan,early diagnosis is more common,which has led to the advancement of endoscopic methods as definitive *** techniques have demonstrated remarkable efficacy with minimal complications while preserving esophageal *** screening,prompt diagnosis,and timely treatment are key strategies that can significantly lower both the occurrence and death rates associated with esophageal cancer.

关键词： Esophageal cancer Screening Early detection Treatment Endoscopic mucosal resection Endoscopic submucosal dissection

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Qualitative exploration of home life experiences and care needs among elderly patients with temporary intestinal stomas

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World Journal of Gastroenterology 2024年第22期30卷 2893-2901页

作者： Si-Meng Wang Jian-Ling Jiang Rui Li Juan-Juan Wang Chun-hong Gu Jia Zeng Xiao-Hui Wei mei Chen Wuxi Medical College of Jiangnan University Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina Department of Gastrointestinal Surgery Tongren Hospital Shanghai Jiao Tong University School of MedicineShanghai 200335China Department of Nursing Tong Ren Hospital Shanghai Jiao Tong University School of MedicineShanghai 200335China

BACKGROUND This study employed a phenomenological research approach within qualitative research to explore the challenges encountered by elderly individuals with temporary colostomies in managing their daily lives and care *** the anus surgery combined with temporary colostomy has emerged as a prevalent treatment modality for low rectal ***,the ileostomy is susceptible to peri-stoma skin complications,as well as fluid,electrolyte,and nutritional imbalances,posing challenges to effective *** successful selfmanagement of patients is intricately linked to their adjustment to temporary colostomy;nonetheless,there remains a dearth of research examining the factors influencing self-care among temporary colostomy patients and the obstacles they *** To investigate the lived experiences,perceptions,and care requirements of temporary colostomy patients within their home environment,with the ultimate goal of formulating a standardized management *** Over the period of June to August 2023,a purposive sampling technique was utilized to select 12 patients with temporary intestinal stomas from a tertiary hospital in Shanghai,*** a phenomenological research approach,a semi-structured interview guide was developed,and qualitative interviews were conducted using in-depth interview *** acquired data underwent coding,analysis,organization,and summarization following Colaizzi’s seven-step *** The findings of this study revealed that the experiences and needs of patients with temporary intestinal stomas can be delineated into four principal themes:Firstly,Temporary colostomy patients bear various burdens and concerns about the uncertainty of disease progression;secondly,patients exhibit limited self-care capabilities and face information deficits,resulting in heightened reliance on healthcare professionals;thirdly,patients demonstrate the potential for internal motivation through proactive self-adj

关键词： Elderly Temporary intestinal stomas Life experiences Intestinal ostomy complications Qualitative study

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OsWRKY78 regulates panicle exsertion via gibberellin signaling pathway in rice

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Journal of Integrative Plant Biology 2024年第4期66卷 771-786页

作者： Enyang mei Mingliang He Min Xu Jiaqi Tang Jiali Liu Yingxiang Liu Zhipeng hong Xiufeng Li Zhenyu Wang Qingjie Guan Xiaojie Tian Qingyun Bu State Key Laboratory of Black Soils Conservation and Utilization Key Laboratory of Soybean Molecular Design BreedingNortheast Institute of Geography and AgroecologyChinese Academy of SciencesHarbin 150081China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Saline-alkali Vegetation Ecology Restoration Northeast Forestry UniversityMinistry of EducationHarbin 150040China College of Life Science Northeast Forestry UniversityHarbin 150040China

Panicle exsertion is one of the crucial agronomic traits in rice(Oryza sativa).Shortening of panicle exsertion often leads to panicle enclosure and severely reduces seed ***(GA)plays important roles in regulating panicle ***,the underlying mechanism and the relative regulatory network remain ***,we characterized the oswrky78 mutant showing severe panicle enclosure,and found that the defect of oswrky78 is caused by decreased bioactive GA *** analysis demonstrates that OsWRKY78 can directly activate GA biosynthesis and indirectly suppress GA ***,we found OsWRKY78 can interact with and be phosphorylated by mitogen-activated protein kinase(MAPK)kinase OsMAPK6,and this phosphorylation can enhance OsWRKY78 stability and is necessary for its biological *** together,these results not only reveal the critical function of OsWRKY78,but also reveal its mechanism via mediating crosstalk between MAPK and the GA signaling pathway in regulating panicle exsertion.

关键词： gibberellin MAPK cascades OsWRKY78 panicle exsertion rice

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