检索结果-南通市图书馆

Chinese Chemical Letters 2023年第2期34卷 412-415页

作者： Jianzhong Zhu Cheng Chen Jie dong Shasha Cheng Guodong Li Chunming Wang Defang Ouyang chung-Hang Leung Ligen Lin State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China Xiangya School of Pharmaceutical Science Central South UniversityChangsha 410083China

From ZINC database with a total of 1.8 million small molecules, four compounds are identified as prolyl hydroxylase 2 inhibitors through a virtual screening workflow that sequentially incorporates machine learning, molecular docking, and molecular dynamics. Among them, compound 103,(E)-5-(5-((2-(1Htetrazol-5-yl)hydrazineylidene)methyl)furan-2-yl)isoindoline-1,3-dione, promotes the migration and capillary tube formation capacity of human umbilical vein endothelial cells through enhancing the stability of hypoxia inducible factor-1α and increasing the level of vascular endothelial growth factor.

关键词： Machine learning Virtual screening PHD2 Angiogenesis Wound healing

A robust luminescent assay for screening alkyladenine DNA glycosylase inhibitors to overcome DNA repair and temozolomide drug resistance

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2023年第5期13卷 514-522页

作者： Ying-Qi Song Guo-dong Li Dou Niu Feng Chen Shaozhen Jing Vincent Kam Wai Wong Wanhe Wang chung-Hang Leung State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao999078China Department of Biomedical Sciences Faculty of Health SciencesUniversity of MacaoMacao999078China Institute of Medical Research Northwestern Polytechnical UniversityXi'an710072China Dr.Neher's Biophysics Laboratory for Innovative Drug Discovery State Key Laboratory of Quality Research in Chinese MedicineMacao University of Science and TechnologyMacao999078China

Temozolomide(TMZ)is an anticancer agent used to treat glioblastoma,typically following radiation therapy and/or surgical ***,despite its effectiveness,at least 50%of patients do not respond to TMZ,which is associated with repair and/or tolerance of TMZ-induced DNA *** have demonstrated that alkyladenine DNA glycosylase(AAG),an enzyme that triggers the base excision repair(BER)pathway by excising TMZ-induced N3-methyladenine(3meA)and N7-methylguanine lesions,is overexpressed in glioblastoma tissues compared to normal ***,it is essential to develop a rapid and efficient screening method for AAG inhibitors to overcome TMZ resistance in ***,we report a robust time-resolved photoluminescence platform for identifying AAG inhibitors with improved sensitivity compared to conventional steady-state spectroscopic *** a proof-of-concept,this assay was used to screen 1440 food and drug administration-approved drugs against AAG,resulting in the repurposing of sunitinib as a potential AAG *** restored glioblastoma(GBM)cancer cell sensitivity to TMZ,inhibited GBM cell proliferation and stem cell characteristics,and induced GBM cell cycle ***,this strategy offers a new method for the rapid identification of small-molecule inhibitors of BER enzyme activities that can prevent false negatives due to a fluorescent background.

关键词： Drug screening Alkyladenine DNA glycosylase N3-methyladenine Glioblastoma Temozolomide Sunitinib

A Data Transmission Method Using a Cyclic Redundancy Check and Inaudible Frequencies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Electronic Science and Technology 2016年第1期14卷 32-36页

作者： Myoungbeom chung the Division of Computer Engineering Sungkyul University

This paper describes a data transmission method using a cyclic redundancy check and inaudible *** proposed method uses inaudible high frequencies from 18 k Hz to 22 k Hz generated via the inner speaker of smart *** the proposed method,the performance is evaluated by conducting data transmission tests between a smart book and smart *** test results confirm that the proposed method can send 32 bits of data in an average of 235 ms,the transmission success rate reaches 99.47%,and the error detection rate of the cyclic redundancy check is0.53%.

关键词： Cyclic redundancy check data transmission method high frequency inaudible frequencies

Representation of global precipitation anomalies using four major climate patterns

在线全文

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2015年第5期58卷 927-934页

作者： CHEN Ji chung ChiHang Department of Civil Engineering The University of Hong Kong

This study aims at finding the dominant climate patterns that influence the precipitation anomalies for different regions over the world. To this end, a multiple linear regression model is employed to represent the impact of four major climate patterns(El Ni?o-Southern Oscillation(ENSO), Indian Ocean Dipole(IOD), Arctic Oscillation(AO) and Antarctic Oscillation(AAO)) on the global precipitation anomalies. The normalized climate pattern indexes and normalized precipitation anomalies are used in the regression model. For the Northern Hemisphere, the three predictors used are the normalized NINO3.4 index(representing ENSO), normalized DMI(representing IOD) and normalized AO index; for the Southern Hemisphere, also three indexes are used as three predictors, and the normalized AO index is replaced by the normalized AAO index. The influences brought by each climate pattern can be represented by the magnitude of the corresponding regression coefficients, and the dominant climate patterns are those with the largest magnitude. The study results show that the precipitation anomalies in the northern part of South America and the northwestern part of Southeast Asia are mainly influenced by ENSO. The precipitation anomalies in East Africa and the southwestern part of Southeast Asia are mainly influenced by IOD. The precipitation anomalies in Europe and west coast of North America are mainly influenced by AO; the precipitation anomalies in the eastern part and southern part of South America, southern part of Africa, and the northeastern Australia are mainly influenced by AAO. These findings are consistent with the general understanding on the teleconnection features of the four climate patterns. Further, the regression model can be used for predicting precipitation anomalies through use of these major climate patterns.

关键词： normalized ENSO Southeast representing Australia southwestern Arctic trained instead brought

Comparison of postoperative corneal changes between dry eye and non-dry eye in a murine cataract surgery model

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2016年第2期9卷 218-224页

作者： Jin Woo Kwon Yeon Woong chung Jin A Choi Tae Yoon La dong Hyun Jee Yang Kyung Cho Department of Ophthalmology St.Vincent's HospitalCollege of Medicine The Catholic University of Korea

AIM： To compare the effects of the surgical insult of cataract surgery on corneal inflammatory infiltration, neovascularization （NV） and lymphangiogenesis （LY） between the dry eye and non-dry eye in murine cataract surgery models.METHODS： We established two groups of animals, one with normal eyes （non-dry eye） and the second with induced dry eyes. In both groups, we used surgical insults to mimic human cataract surgery, which consisted of lens extraction, corneal incision and suture. After harvesting of corneas on the 9th postoperative day and immunohistochemical staining, we compared NV, LY and CD11b＋ cell infiltration in the corneas.RESULTS： Dry eye group had significantly more inflammatory infiltration （21.75%±7.17% r/s 3.65%±1.49%; P=0.049）. The dry eye group showed significantly more NV （48.21% ±4.02% ys 26.24% ±6.01% ; P =0.016） and greater levels of LY （9.27%±0.48% ys 4.84%±1.15%; P= 0.007）. In corneas on which no surgery was performed, there was no induction of NV in both the dry and non- dry group, but dry eye group demonstrated more CD11b＋ cells infiltration than the non-dry eye group （0.360%± 0.160% vs 0.023%±0.006%; P=0.068）. Dry eye group showed more NV than non-dry eye group in both topical PBS application and subconjunctival PBS injection （P= 0.020 and 0.000, respectively）.

关键词： angiogenesis cataract surgery dry eyedisease inflammation

Clinical outcomes and safety of high-resolution manometry guided superficial partial circular muscle myotomy in per-oral endoscopic myotomy for Jackhammer esophagus: Two cases report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2019年第16期7卷 2322-2329页

作者： Youn I Choi Kyoung Oh Kim dong Kyun Park Jun-Won chung Yoon Jae Kim Kwang An Kwon Department of Gastroenterology Gil Medical Center Gachon University

BACKGROUND Jack hammer esophagus is a relatively rare disease and to date,there is no dramatic treatment ***,conventional per-oral endoscopic myotomy (POEM) have expanded their area into Jackhammer ***,several complications such as post procedure motility disorders (e.g.,passage disturbance) are issues after *** overcome these issues,we here introduced high-resolution manometry (HRM)-guided superficial partial circular muscle myotomy,which involves cutting only the superficial layer of the esophageal circular *** SUMMARY We report two cases of patients with Jackhammer esophagus who were treated with HRM-guided extremely superficial partial circular muscle myotomy during *** 1 was a 53-year-old female with medication-refractory odynophagia and case 2 was a 47-year-old man who presented with chest *** were diagnosed with Jackhammer esophagus using HRM,and the hypercontractile segments of the esophagus were ***-guided extremely superficial partial circular muscle myotomy was performed while preserving the lower esophageal ***,the circular and longitudinal muscle layers are preserved but hypercontractile movements are reduced,even after ***’ clinical symptoms dramatically improved right after POEM,and 6-mo follow-up HRM revealed completely resolved *** a 1-year follow-up period,patients were still in good health and remained symptom *** HRM-guided superficial partial circular muscle myotomy may be a promising alternative to conventional POEM for treating Jackhammer esophagus with improved efficacy.

关键词： Jackhammer esophagus Hypercontractile Partial circular muscle myotomy Case report

Effect of Qingxue Dan on obesity and metabolic biomarker: a double-blind randomized-controlled pilot study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2016年第3期36卷 291-298页

作者： Wonseok chung Jimi Ryu Seokhee chung Sungsoo Kim Department of Korean Rehabilitation Medicine College of Korean Medicine Kyung-hee University

OBJECTIVE: To investigate the clinical effect of Qingxue Dan(QXD) on obesity and metabolic biomarker related to ***: A randomized, double blinded, placebo-controlled trial with a paralleled study design was conducted. Twenty-six obese volunteers aged between 30 and 60 with obesity and more than 2 metabolic risk factors were recruited at the department of oriental rehabilitation medicine, Kyunghee university oriental medical hospital, Seoul, Korea. Subjects were randomly assigned to an intervention(QXD) group or a placebo group, and treated with 900 mg/d of QXD or placebo medicine for 8 weeks. Primary endpoint was the change of body mass index(BMI) at 8 week from baseline. Secondary outcomes included the change of body composition, abdominal fat mass measured with Dual energy X-ray absorptiometry(DXA), blood pressure,lipid profiles and the homeostasis model assessment for insulin resistance(HOMA-IR).RESULTS: BMI was decreased in the QXD group sig-nificantly. Total body fat, abdominal fat mass measured with DXA Region of Interest and waist circumference(WC) showed a trend toward decreasing in the QXD group, but fat free mass was decreased in all groups. Triglyceride(TG) was decreased in QXD group significantly, but WC, total cholesterol and high-density lipoprotein cholesterol were increased in both group. BP didn't change during the study period. HOMA-IR is decreased in both groups without group ***: 8-weeks of oral administrations of QXD(900 mg/d) reduces BMI, with a tendency of lose of total body fat mass, especially abdominal fat. It also significantly reduced serum TG *** results suggest QXD could be used to treat obesity and metabolic risk factors. Further study is needed to confirm our pilot findings.

关键词： Qingxue Dan Obesity Hypertension Hyperlipidemias Insulin resistance Randomized controlled trail

The genetics of race differentiation——should it be studied?

在线全文

学校读者我要写书评

暂无评论

National Science Review 2023年第4期10卷 6-7页

作者： chung-I Wu NSR School of Life Sciences Sun Yat-sen University

In this issue, NSR publishes an article entitled ‘Expression profiles of east-west highly differentiated genes in Uyghur genomes’ by Ning et al.(2023) [1]. Briefly, it is about the regulation of gene expression in Uyghur genomes, which are admixed between Asian and European genomes. In evolutionary terms, this is a case of post-isolation secondary contact over a time span of thousands of years. In most other cases, such as African Americans, the admixture has a time span of <300 years. Furthermore,

关键词：

Forms and Aesthetics of Bridges

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Engineering 2018年第2期4卷 103-112页

作者： Man-chung Tang Chinese Academy of Engineering Beijing 100088 China US National Academy of Engineering Washington DC 20001 USA T.Y. Lin International Group San Francisco CA 94104 USA

The objective of a bridge design is to produce a safe bridge that is elegant and satisfies all functionality requirements, at a cost that is acceptable to the owner. A successful bridge design must be natural, simple, original, and harmonious with its surroundings. Aesthetics is not an additional consideration in the design of a bridge, but is rather an integral part of bridge design. Both the structural configuration and the aesthetics of a bridge must be considered together during the conceptual design stage. To achieve such a task, the bridge design engineer must have a good understanding of structural theory and bridge aesthetics.

关键词： Form Aesthetics Bridge Concept Design Environment

ADDITIVE PERTURBATIONS OF LOCAL C-SEMIGROUPS

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematica Scientia 2015年第6期35卷 1566-1576页

作者： chung-Cheng KUO Department of Mathematics Fu Jen University

In this paper, we apply the contraction mapping theorem to establish some bounded and unbounded additive perturbation theorems concerning local C-semigroups. Some growth conditions of perturbations of local C-semigrou... 详细信息

关键词： local C-semigroup generator abstract Cauchy problem perturbation