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NH_(2)-MIL-53(Al)for Simultaneous Removal and Detection of Fluoride Anions

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Chinese Journal of Chemical Physics 2021年第2期34卷 227-237,I0002,I0003-I0010页

作者： dong-hua xie Xiao Ge Wen-xiu Qin Yun-xia Zhang Key Laboratory of Materials Physics Center for Environmental and Energy NanomaterialsAnhui Key Laboratory of Nanomaterials and NanotechnologyInstitute of Solid State PhysicsChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China

To address the limitations of the separate fluoride removal or detection in the existing materials,herein,amino-decorated metal organic frameworks NH_(2)-MIL-53(Al)have been succinctly fabricated by a sol-hydrothermal method for simultaneous removal and determination of *** a consequence,the proposed NH_(2)-MIL-53(Al)features high uptake capacity(202.5 mg/g)as well as fast adsorption rate,being capable of treating 5 ppm of fluoride solution to below the permitted threshold in drinking water within 15 ***,the specific binding between fluoride and NH_(2)-MIL-53(Al)results in the release of fluorescent ligand NH2-BDC,conducive to the determination of fluoride via a concentration-dependent fluorescence enhancement *** expected,the resulting NH_(2)-MIL-53(Al)sensor exhibits selective and sensitive detection(with the detection limit of 0.31μmol/L)toward fluoride accompanied with a wide response interval(0.5-100μmol/L).More importantly,the developed sensor can be utilized for fluoride detection in practical water systems with satisfying recoveries from 89.6% to 116.1%,confirming its feasibility in monitoring the practical fluoride-contaminated waters.

关键词： NH_(2)-MIL-53(Al) Fluoride Removal Detection

大断面铜包铝棒坯立式连铸成形工艺参数对连铸复合过程影响的数值模拟

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中国有色金属学报 2017年第3期27卷 514-524页

作者：刘新华付新彤付华栋谢建新北京科技大学材料先进制备技术教育部重点实验室新材料技术研究院北京100083

以100mm×100mm大断面铜包铝棒坯为对象,建立棒坯连铸复合成形的数值模型,确定模型的边界条件,并通过设计的实验验证数值模型边界条件的准确性。基于验证的边界条件,采用ProCast软件对铜包铝棒坯立式连铸复合成形过程的稳态温度场进行... 详细信息

以100mm×100mm大断面铜包铝棒坯为对象,建立棒坯连铸复合成形的数值模型,确定模型的边界条件,并通过设计的实验验证数值模型边界条件的准确性。基于验证的边界条件,采用ProCast软件对铜包铝棒坯立式连铸复合成形过程的稳态温度场进行数值模拟,得到了各工艺参数对连铸过程的影响规律,给出了工艺参数的调控策略和合理范围。结果表明,制备100mm×100mm大断面铜包铝铸坯的合理工艺参数范围为:在保持铜液温度1250℃的条件下,铝液铸造温度为760~790℃;一冷水流量为1600~2000L/h;二冷水流量为900~1100 L/h;二冷水距结晶器石墨套出口距离为20 mm;拉坯速度为80~100mm/min。

关键词：铜包铝立式连铸复合成形温度场数值模拟

AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

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Science China Life Sciences 2025年第1期 204-218页

作者： Chen Xiong Hong Ling Yingdan huang Hanzhi dong Bangxiang xie Qian Hao Xiang Zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan University Department of Oncology Shanghai Medical CollegeFudan University Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan University Department of Oncology First Affiliated Hospital of Nanchang University Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan University Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology)Institutes of Biomedical SciencesFudan University

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1 by the WEE1 inhibitors or si RNAs induced compensatory upregulation of SLC7A11, which conferred resistance to ferroptosis. Mechanistically, AZD1775 prevented the enrichment of H3K9me3, a histone marker of transcriptional repression, on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1, thereby enhancing NRF2-mediated SLC7A11 transcription. This finding was also validated using the H3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A11 expression by activating p53, thus augmenting AZD1775-induced ferroptosis. Moreover, the combination of AZD1775 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

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Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-Min Xing Hai-dong Qian Qiao Gao Sheng-Lan Xu hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

High-speed train positioning based on a combination of Beidou navigation, inertial navigation and an electronic map

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Science China(Information Sciences) 2023年第7期66卷 237-252页

作者： Hui YANG Shuai-Qiang dong Chun-hua xie School of Electrical and Automation Engineering East China Jiaotong University Key Laboratory of Advanced Control & Optimization of Jiangxi Province East China Jiaotong University State Key Laboratory of Performance Monitoring Protecting of Rail Transit Infrastructure East China Jiaotong University

To date, the studies on the combination positioning of high-speed trains have made great progress, but the positioning accuracy of these methods is relatively low. Map-matching positioning can improve positioning accuracy, but information transmission is time-consuming. Few studies incorporate it into combination positioning. To solve the problem, this paper proposes a high-speed train positioning method based on combining a Beidou navigation system, an inertial navigation system, and an electronic map. First, the combination positioning problem is transformed into a multi-objective optimization problem, which weights the direction similarity and distance error to form a fitness function and converts the railway line and the maximum error range of each positioning system into constraints. Second, an improved differential evolution algorithm is proposed to solve this problem. By referencing the gray wolf algorithm,the differential evolution algorithm updates individuals by varying toward the direction of multiple optimal values. Then, a new combination positioning algorithm for high-speed trains is proposed. In the simulation,the increase in positioning speed and accuracy is analyzed and validated. Compared to the current algorithms, the proposed algorithm performs better. The proposed method has practical value for improving the reliability and safety of train operations.

关键词： electronic map multi-objective optimization differential evolution algorithm Beidou navigation system high-speed train positioning

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不同催根基质对郁金香生长发育的影响初探

上海农业学报 2005年第2期21卷 95-96页

作者：张永春褚云霞董燮华上海市农业科学院园艺研究所上海市彩色园林有限公司上海201711

郁金香生根阶段需要相对低温,给促成栽培带来不便。采用木屑和珍珠岩两种基质进行催根,以进口品种克斯·奈利斯和神奇圣诞为试材,比较了催根基质对根伸长、出芽率、株高、成花率、全生育期的影响。结果表明:木屑为催根基质,根伸长较快,... 详细信息

郁金香生根阶段需要相对低温,给促成栽培带来不便。采用木屑和珍珠岩两种基质进行催根,以进口品种克斯·奈利斯和神奇圣诞为试材,比较了催根基质对根伸长、出芽率、株高、成花率、全生育期的影响。结果表明:木屑为催根基质,根伸长较快,且后期不存在根老化现象,成花率也高于珍珠岩为基质的材料,且可缩短生育期。

关键词：郁金香催根基质出芽根生长发育

Dynamic recrystallization behavior and microstructure evolution of high-performance Cu-3.28Ni-0.6Si-0.22Zn-O.11Cr-0.04P during hot compression

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Rare Metals 2021年第1期40卷 156-167页

作者： Chang-Sheng Wang hua-dong Fu Jian-Xin xie Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation Institute for Advanced Materials and TechnologyBeijing 100083China

By means of isothermal compression at temperatures in the range of 650-900℃and strain rates in the range of 0.001-1 s^(-1),the dynamic recrystallization behavior and microstructural evolution of a Cu-3.28 Ni-0.6 Si-0.22 Zn-0.11 Cr-0.04 P(wt%)alloy designed by a machine learning method were investigated.A semiempirical constitutive equation,processing maps and an average activation energy were *** microstructure under different conditions and the effect of strain rate on the texture of the alloy at 800-900℃were *** results show that the suitable temperature is800-900℃;when the strain is less than 0.4,the appropriate strain rate is 0.01-0.5 s^(-1);and when the strain is greater than 0.4,the appropriate strain rate is below0.05 s^(-1).After deformation at 800℃,the main texture changed from{112}of copper to a uniform distribution with the increase in strain rate,but the sample did not have obvious texture after deformation at 850 and900℃.The above results can provide a reference for the selection of process parameters.

关键词： High-performance copper alloy Hot compression Dynamic recrystallization Processing map Texture evolution

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植物激素对棉花蕾铃脱落的调控研究进展

作物学报 2025年第1期51卷 1-29页

作者：谢章书谢学方屠小菊刘爱玉董合忠周仲华湖南农业大学农学院/作物生理与分子生物学教育部重点实验室湖南长沙410128 中国热带农业科学院橡胶研究所海南海口571101 山东省农业科学院经济作物研究所山东济南250000

棉花蕾铃脱落是一个普遍存在的现象,有对逆境环境胁迫的主动适应性脱落,也有因品种遗传特性、环境条件、栽培措施以及生物和非生物胁迫被动的受损脱落。蕾铃脱落直接影响着棉花的产量,国内外现有公开报道多集中于20世纪50、60年代关于... 详细信息

棉花蕾铃脱落是一个普遍存在的现象,有对逆境环境胁迫的主动适应性脱落,也有因品种遗传特性、环境条件、栽培措施以及生物和非生物胁迫被动的受损脱落。蕾铃脱落直接影响着棉花的产量,国内外现有公开报道多集中于20世纪50、60年代关于乙烯和脱落酸对棉花蕾铃脱落影响的初步发现。结合其他植物的研究结果来看,蕾铃脱落似乎与生长素、赤霉素和细胞分裂素等促生长类激素的下降以及乙烯和脱落酸等抑制生长类激素的升高密切相关,激素在植物体内不仅介导新陈代谢过程,还协调着与信号通路相关的调控因子,在脱落过程中起着关键作用。本文从植物激素调控入手,综述了近年来包括脱落区形成和作用的分子调控机制以及各激素在棉花蕾铃脱落以及其他植物(生殖)器官脱落过程中的响应和调控机制等。发现目前以棉花蕾铃脱落为对象的研究非常匮乏,且多集中于少数激素对棉花生殖生长影响的有限研究,缺乏对导致蕾铃脱落的深层次机制的探究和解析。因此,未来研究方向应着重于探究棉花蕾铃脱落的遗传基础、发掘新的抗脱落基因资源和培育抗脱落棉花品种,同时加强在以棉花为模型植物下,蕾铃脱落与植物激素调节的关系研究,为提高棉花产量提供理论依据和技术支持。

关键词：棉花植物激素蕾铃脱落研究现状研究方向

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中药灌洗治疗化脓性骨关节感染

实用中西医结合临床 2009年第6期9卷 6-7页

作者：陈卫东何建华谢水华陈雨姣熊跃江西省南昌市中西医结合医院南昌330003

目的:探讨治疗化脓性骨关节感染的新方法。方法:对16例不同类型的骨关节感染病人在进行相应外科处理后,按照辨证论治原则,使用相应中药灌洗液进行局部灌洗。结果:16例病人中,效果优良者(痊愈和显效)12例,效果欠佳者(有效和无效)4例(1例... 详细信息

目的:探讨治疗化脓性骨关节感染的新方法。方法:对16例不同类型的骨关节感染病人在进行相应外科处理后,按照辨证论治原则,使用相应中药灌洗液进行局部灌洗。结果:16例病人中,效果优良者(痊愈和显效)12例,效果欠佳者(有效和无效)4例(1例在拆除内固定物后有效)。结论:使用中药灌洗液进行局部灌洗,局部药物浓度高,可充分发挥中药有效药理成分的作用,从而达到清热利湿解毒及清除坏死组织的功效,具有减少耐药菌株产生、对骨关节组织无损害、可反复进行等优点。

关键词：中药灌洗骨关节感染