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Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian Xin hua Jianhong dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

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Up-regulation of mitochondrial antioxidation signals in ovarian cancer cells with aggressive biologic behavior

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第5期12卷 346-356页

作者： Yue WANG Li dong Heng CUI Dan-hua shen Ying WANG Department of Obstetrics and Gynecology People's Hospital Peking University Beijing 100044 China Department of Obstetrics and Gynecology Beijing Jishuitan Hospital Peking University Beijing 100035 China Department of Pathology People's Hospital Peking University Beijing 100044 China

Objective： Recently, a high frequency of mutations in mitochondrial DNA （mtDNA） has been detected in ovarian cancer. To explore the alterations of proteins in mitochondria in ovarian cancer, a pair of human ovarian carcinoma cell lines （SKOV3/***1） with different metastatic potentials was examined. Methods： Cancer cells *** were derived from the ascitic tumor cells of nude mice bearing a tumor of ovarian cancer cells SKOV3. *** exhibited a higher degree of migration potential than its paired cell line SKOV3. The proteins in the mi- tochondria of these two cells were isolated and separated by 2-D gel electrophoresis. The differently expressed proteins were extracted and identified using matrix assisted laser desorption ionisation/time-of-flight/time-of-flight （MALDITOF/TOF）, and finally a selected protein candidate was further investigated by immunohistochemistry （IHC） method in nude mice bearing tumor tissues of these two cells. Results： A total of 35 spots with different expressions were identified between the two cells using 2D-polyacrylamide gel electrophoresis （PAGE） approach. Among them, 17 spots were detected only in either SKOV3 or *** cells. Eighteen spots expressed different levels, with as much as a three-fold difference between the two cells. Twenty spots were analyzed using MALDI-TOF/TOF, and 11 of them were identified successfully; four were known to be located in mitochondria, including superoxide dismutase 2 （SOD2）, fumarate hydratase （FH）, mitochondrial ribosomal protein L38 （MRPL38）, and mRNA turnover 4 homolog （MRTO4）. An increased staining of SOD2 was observed in *** over that of SKOV3 in IHC analysis. Conclusions： Our results indicate that the enhanced antioxidation and metabolic potentials of ovarian cancer cells might contribute to their aggressive and metastatic behaviors. The underlying mechanism warrants further study.

关键词： Ovarian carcinoma Mitochondria Invasion Proteomic Superoxide dismutase 2 (SOD2)

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鲟鱼育种及新品种选育研究进展

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中山大学学报（自然科学版）（中英文） 2025年第1期64卷 93-105页

作者：王巍宋海亮朱华董颖东天胡红霞北京市农林科学院水产科学研究所暨北京市渔业生物技术重点实验室北京100068 农业农村部“鲟鱼遗传育种”重点实验室浙江杭州311799 国家数字种业创新中心北京100097

鲟鱼是鲟形目鱼类的统称。它们不仅具有重要的进化地位,而且具有重要的经济价值。鲟鱼新品种选育研究在近几十年取得了显著进展。本文综述了鲟鱼新品种选育的主要方法,包括杂交育种、雌核发育、性逆转诱导、基因编辑、家系选育、基因组... 详细信息

鲟鱼是鲟形目鱼类的统称。它们不仅具有重要的进化地位,而且具有重要的经济价值。鲟鱼新品种选育研究在近几十年取得了显著进展。本文综述了鲟鱼新品种选育的主要方法,包括杂交育种、雌核发育、性逆转诱导、基因编辑、家系选育、基因组选择和细胞水平育种,讨论了各技术的应用现状,在育种上相关研究和取得的重要突破,并结合我们育种实践积累的经验,展望鲟鱼育种和种业的未来发展,为未来的鲟鱼育种研究提供理论基础和实践指导。

关键词：鲟鱼育种新品种

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Research on decision-making behavior of multi-agent alliance in cross-border electricity market environment: an evolutionary game

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Global Energy Interconnection 2024年第6期7卷 707-722页

作者： Zhao Luo Chenming dong Xinrui Dai hua Wang Guihong Bi Xin shen Faculty of Electric Power Engineering Kunming University of Science and TechnologyKunming650500P.R.China Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming650500P.R.China Measurement Center of Yunnan Power Grid Co. Ltd.Kunming650051P.R.China

Constructing a cross-border power energy system with multiagent power energy as an alliance is important for studying cross-border power-trading *** study considers multiple neighboring countries in the form of alliances,introduces neighboring countries’exchange rates into the cross-border multi-agent power-trading market and proposes a method to study each agent’s dynamic decision-making behavior based on evolutionary game *** this end,this study uses three national agents as examples,constructs a tripartite evolutionary game model,and analyzes the evolution process of the decision-making behavior of each agent member state under the initial willingness value,cost of payment,and additional revenue of the *** research helps realize cross-border energy operations so that the transaction agent can achieve greater trade profits and provides a theoretical basis for cooperation and stability between multiple agents.

关键词： Multi-agent alliance Cross-border transactions Electricity market Evolutionary game Decision-making

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Ruthenium catalyzed amination cyclization of 1,2,4-butanetriol with primary amines:A borrowing hydrogen strategy for 3-pyrrolidinol synthesis

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Chinese Chemical Letters 2020年第1期31卷 103-106页

作者： Qing-Song Xu Chen Li Yong Xu Defeng Xu Mei-hua shen hua-dong Xu School of Pharmaceutical Engineering & Life Science Changzhou University

A ruthenium based catalytic system([Ru(p-cymene)Cl2]2/XantPhos with substoichiometric Cs2CO3)has been established to effectively achieve the first direct amination cyclization of 1,2,4-butanetriol with primary aromati... 详细信息

关键词： Amination cyclization N-Alkylation 1,2,4-Butanetriol 3-Pyrrolidinol Borrowing hydrogen Hydrogen autotransfer [Ru(p-cymene)Cl2]2

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Nano-sized Fe_2O_3/Fe_3O_4 facilitate anaerobic transformation of hexavalent chromium in soil–water systems

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Journal of Environmental Sciences 2017年第7期29卷 329-337页

作者： Yaxian Zhang hua Li Libo Gong Guowen dong Liang shen Yuanpeng Wang Qingbiao Li Department of Chemical and Biochemical Engineering College of Chemistry and Chemical EngineeringXiamen University College of Chemistry and Life Science Quanzhou Normal University

The purpose of this study is to investigate the effects of nano-sized or submicro Fe_2O_3/Fe_3O_4 on the bioreduction of hexavalent chromium（Cr（VI）） and to evaluate the effects of nano-sized Fe_2O_3/Fe_3O_4 on the microbial communities from the anaerobic flooding *** results indicated that the net decreases upon Cr（VI） concentration from biotic soil samples amended with nano-sized Fe_2O_3（317.1 ± 2.1 mg/L） and Fe_3O_4（324.0 ± 22.2 mg/L） within21 days,which were approximately 2-fold of Cr（VI） concentration released from blank control assays（117.1 ± 5.6 mg/L）.Furthermore,the results of denaturing gradient gel electrophoresis（DGGE） and high-throughput sequencing indicated a greater variety of microbes within the microbial community in amendments with nano-sized Fe_2O_3/Fe_3O_4 than the control ***,Proteobacteria occupied a predominant status on the phylum level within the indigenous microbial communities from chromium-contaminated ***,some partial decrease of soluble Cr（VI） in abiotic nano-sized Fe_2O_3/Fe_3O_4 amendments was responsible for the adsorption of nano-sized Fe_2O_3/Fe_3O_4 to soluble Cr（VI）.Hence,the presence of nano-sized Fe_2O_3/Fe_3O_4 could largely facilitate the mobilization and biotransformation of Cr（VI） from flooding soils by adsorption and bio-mediated processes.

关键词： Chromium Iron oxide Nanoparticle Reduction High-throughput sequencing Cr(Ⅵ) reducing bacteria

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Treatment of primary tracheal schwannoma with endoscopic resection:A case report

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World Journal of Clinical Cases 2022年第28期10卷 10279-10285页

作者： Yong-Shuai shen Xiang-dong Tian Yi Pan hua Li Department of Endoscopy Tianjin Cancer Hospital Airport HospitalTianjin 300000China Department of Endoscopy Tianjin Medical University Cancer Institute and HospitalTianjin 300060China Department of Pathology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin’s Clinical Research Center for CancerTianjin 300060China Department of Endoscopy Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin’s Clinical Research Center for CancerTianjin 300060China

BACKGROUND Schwannoma is a benign tumor originating from the peripheral nerve *** clinical symptoms of tracheal schwannoma depend on the location of the tumor,and the most common clinical symptoms are cough and *** most effective treatment for benign tumors is complete resection of the primary lesion at an early *** experience has demonstrated that primary tracheal schwannoma can be safely excised with a high-frequency electric knife in a minimally invasive *** SUMMARY We report a 61-year-old asymptomatic woman who underwent chest computed tomography(CT),which accidentally found an intraluminal tracheal mass without enlarged lymph ***,the patient underwent bronchoscopy,which found that the tracheal mass originated from the left wall of the upper trachea,was less than 1.5 cm in size,immovable,smooth and 4 cm away from the vocal cord,resulting in partial upper respiratory tract *** was performed using an endoscopic resection for en bloc removal of the tracheal *** diagnosis was primary tracheal schwannoma.A follow-up was performed after endoscopic surgery,and bronchoscopy and thoracic CT were used to monitor whether there was a *** present,there is no evidence of recurrence,and the patient had a good quality of *** resection may be effective and safe in the treatment of primary tracheal *** Primary tracheal schwannoma is a very rare benign *** this case,we cured it by complete endoscopic resection.

关键词： Schwannoma Tracheal tumor Endoscopic therapy High-frequency electric knife En bloc Case report

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A new modified remote user authentication scheme using smart cards

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Applied Mathematics(A Journal of Chinese Universities) 2008年第3期23卷 371-376页

作者： shen Zhong-hua School of Sci. Hangzhou Normal Univ. Hangzhou 310036 China

In 2000, a remote user authentication scheme using smart cards was proposed and the masquerade attacks were proved successful on this scheme. Recently, Kumar has suggested the idea of check digits to overcome the above attacks with a new scheme that removes these threats well. In this paper it is pointed out that the weakness still exists in Kumar＇s scheme, and the intruder can login to the remote system through having some information. A new scheme which can overcome these attacks and appears more secure and efficient than Kumar＇s is presented.

关键词： remote user authentication smart card cryptography

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Laboratory simulation of soil respiration response to environmental conditions in intertidal zones of Jiangsu Province,China

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Water Science and Engineering 2022年第2期15卷 134-140页

作者： Peng Wang Xia shen Zu-lin hua Xiao-dong Liu Yi-xin Ma Key Laboratory of Integrated Regulation and Resource Development on Shallow Lake of Ministry of Education Hohai UniversityNanjing 210098China Yangtze Institute for Conservation and Development Hohai UniversityNanjing 210098China Key Laboratory of Ocean Space Resource Management Technology of Ministry of Natural Resources Hangzhou 310012China State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Nanjing Hydraulic Research InstituteNanjing 210029China

As major contributor to the blue carbon sink,intertidal zones play a crucial role in the global carbon *** recent years,more attention has been given to the carbon cycle in intertidal ***,due to highly variable and uncertain environmental conditions,it is difficult to clarify the quantitative relationship between soil respiration and environmental factors through in-situ *** this study,the response of soil respiration characteristics to variations in the temperature and water table was investigated using a monitoring apparatus of CO_(2)flux at the soil-air interface in the intertidal *** results showed that soil respiration flux was significantly correlated with temperature,and the correlation best fitted the DoseResp ***,the respiration flux was enhanced with the descent of water table,a relationship could be described by a quadratic *** effect of the water table on soil respiration became more pronounced with the rise of *** results provide significant clarification of the impact of human activities on the carbon cycle in bare intertidal zones and as well as support for numerical simulations of the carbon cycle in bare intertidal zones.

关键词： Intertidal zone Carbon flux Soil respiration Human activities Water table

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Stochastic Iterative Learning Control With Faded Signals

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IEEE/CAA Journal of Automatica Sinica 2019年第5期6卷 1196-1208页

作者： Ganggui Qu dong shen the College of Information Science and Technology Beijing University of Chemical TechnologyBeijing 100029China

Stochastic iterative learning control(ILC) is designed for solving the tracking problem of stochastic linear systems through fading channels. Consequently, the signals used in learning control algorithms are faded in the sense that a random variable is multiplied by the original signal. To achieve the tracking objective, a two-dimensional Kalman filtering method is used in this study to derive a learning gain matrix varying along both time and iteration axes. The learning gain matrix minimizes the trace of input error covariance. The asymptotic convergence of the generated input sequence to the desired input value is strictly proved in the mean-square sense. Both output and input fading are accounted for separately in turn, followed by a general formulation that both input and output fading *** examples are provided to verify the effectiveness of the proposed schemes.

关键词： Fading channels iterative learning control (ILC) Kalman filtering, mean-square convergence stochastic systems

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