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High Strength Electrospun Single Copolyacrylonitrile(coPAN)Nanofibers with Improved Molecular Orientation by Drawing

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Chinese Journal of Polymer Science 2021年第2期39卷 174-180,I0006页

作者： Tang-Cheng Xu dong-hua han Yong-Mei Zhu Gai-Gai Duan Kun-Ming Liu Hao-Qing Hou Department of Chemistry and Chemical Engineering Jiangxi Normal UniversityNanchang 330022China Co-Innovation Center of Efficient Processing and Utilization of Forest Resources College of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037China School of Metallurgical and Chemical Engineering Jiangxi University of Science and TechnologyGanzhou 341000China

High-performance carbon nanofibers are highly dependent on the performance of their precursors,especially polyacrylonitrile(PAN).In this work,the copolymer of PAN(coPAN)was synthesized for electrospinning.A self-assembling set-up was used for the stretching of single coPAN *** and Raman spectroscopies were used to characterize the chemical structure of coPAN *** electron microscopy(SEM)and atomic force microscopy(AFM)were used to monitor the morphology of single coPAN nanofibers under different drawing ***-tensile test was used to determine the mechanical properties of single coPAN *** results indicated that the drawing led to an increase in degree of molecular orientation along the fiber axis from 0.656 to 0.808,tensile strength from 304 MPa to 595 MPa,and modulus from 3.1 GPa to 12.4 *** research would provide fundamental information of high-performance electrospun coPAN nanofibers and offer opportunities for the preparation of high-performance carbon nanofibers.

关键词： Single nanofiber Electrospinning Polyacrylonitrile Molecular orientation Mechanical property

Microstructural evolution during the progressive transformation-induced plasticity effect in a Fe-0.1C-5Mnmedium manganese steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 369-379页

作者： Mei Zhang Wenhao Li Yangfei Chen Yang Jiang Xiaofei Guo han dong School of Materials Science and Engineering Shanghai UniversityShanghai 200444China State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200444China

The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile ***-situ observations under scanning electron microscopy,transmission electron microscopy,and X-ray diffraction analysis were conducted to characterize the progressive transformation-induced plasticity process and associated fracture initiation *** findings were discussed with the local strain measurements via digital image *** results indicated that Lüders band formation in the steel was limited to 1.5%strain,which was mainly due to the early-stage martensitic phase transformation of a very small amount of the less stable large-sized retained austenite(RA),which led to localized stress concentrations and strain hardening and further retardation of *** small-sized RA exhibited high stability and progressively transformed into martensite and contributed to a stably extended Portevin-Le Chatelier *** volume fraction of RA gradually decreased from 26.8%to 8.2%prior to *** the late deformation stage,fracture initiation primarily occurred at the austenite/martensite and ferrite/martensite interfaces and the ferrite phase.

关键词： medium-Mn steel retained austenite progressive transformation-induced plasticity effect local strain fracture initiation

Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-Min Xing Hai-dong Qian Qiao Gao Sheng-Lan Xu hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

完全腔镜甲状腺切除术的临床疗效及并发症分析

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中国现代普通外科进展 2020年第5期23卷 399-401页

作者：董汉华郑州大学附属郑州中心医院甲状腺外科河南郑州450000

探讨完全腔镜甲状腺切除术(TET)治疗甲状腺乳头状癌(PTC)的手术方法及效果。选取拟实施甲状腺手术治疗的PTC患者200例作为研究对象,采用随机数字表法分为腔镜组(TET手术)、传统组(传统手术治疗)两组,每组各100例;对比两组手术时间、术... 详细信息

探讨完全腔镜甲状腺切除术(TET)治疗甲状腺乳头状癌(PTC)的手术方法及效果。选取拟实施甲状腺手术治疗的PTC患者200例作为研究对象,采用随机数字表法分为腔镜组(TET手术)、传统组(传统手术治疗)两组,每组各100例;对比两组手术时间、术中出血量、清除淋巴结数目、术后引流量、手术切口大小、术后不同时间点的疼痛程度(VAS)评分、手术并发症的发生情况。腔镜组手术时间长于传统组(P0.05);腔镜组与传统组在术后2、6、12和24 h的4个时间点进行VAS评分对比,差异有统计学意义(P<0.05);腔镜组手术并发症率4.00%,低于传统组的13.00%,差异有统计学意义(P<0.05)。TET治疗PTC与传统手术一样效果可靠,且具有手术创伤小、切口小、术后疼痛程度低、并发症少的优势。

关键词：完全腔镜甲状腺切除术甲状腺乳头状癌疼痛评分

Facile synthesis of the dodecahydridododecaborate (B12H122-) from borane Lewis base adducts

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Science China Chemistry 2025年

作者： Yi Jing Xin-Ran Liu Xing-hua Wang Hui han Sha-Sha Liang Xi-Meng Chen dong-Hui Wei Lai-Sheng Wang Xue-Nian Chen College of Chemistry Zhengzhou University School of Chemistry and Chemical Engineering Henan Key Laboratory of Boron Chemistry and Advanced MaterialsHenan Normal University Department of Chemistry Brown University

Polyhedral boranes are a class of well-known boron molecular clusters widely used in energy,chemistry,medicine,and materials science because of their unique physical and chemical *** efforts have been made in the past decades to find more effective synthetic methods for this important class of boron ***,existing synthetic methods suffer from low efficiency and low ***,we report a facile one-pot synthesis of[（CH3）3S]2B12H12with moderate yields at mild *** mechanisms for the multi-step chemoselective synthesis of B12H122-without other by-products are elucidated based on theoretical results and our previous *** Lewis base used in B–H bond condensation reaction,which acts as a hydrogen or to balance the newly generated polyhedral borane charges,is proposed and studied in *** current study has led to a more effective and selective synthetic method for B12H122-and has also implicated the syntheses of other new polyhedral boranes.

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Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway

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Neural Regeneration Research 2025年第11期20卷 3245-3258页

作者： Jiayi Wang Mengke Zhao dong Fu Meina Wang Chao han Zhongyue Lv Liang Wang Jing Liu Stem Cell Clinical Research Center The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina Dalian Innovation Institute of Stem Cell and Precision Medicine DalianLiaoning ProvinceChina Institute(College)of Integrative Medicine Dalian Medical UniversityDalianLiaoning ProvinceChina

Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem cell therapy and advancing the frontiers of stem cell-derived *** lays a foundation for the development of potentially potent new treatment modalities for ischemic ***,the precise mechanisms underlying the efficacy and safety of human neural stem cell-derived extracellular vesicles remain unclear,presenting challenges for clinical *** promote the translation of therapy based on human neural stem cell-derived extracellular vesicles from the bench to the bedside,we conducted a comprehensive preclinical study to evaluate the efficacy and safety of human neural stem cell-derived extracellular vesicles in the treatment of ischemic *** found that administration of human neural stem cell-derived extracellular vesicles to an ischemic stroke rat model reduced the volume of cerebral infarction and promoted functional recovery by alleviating neuronal *** human neural stem cell-derived extracellular vesicles reduced neuronal apoptosis by enhancing phosphorylation of phosphoinositide 3-kinase,mammalian target of rapamycin,and protein kinase B,and these effects were reversed by treatment with a phosphoinositide 3-kinase *** findings suggest that human neural stem cell-derived extracellular vesicles play a neuroprotective role in ischemic stroke through activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling ***,we showed that human neural stem cell-derived extracellular vesicles have a good in vivo safety ***,human neural stem cell-derived extracellular vesicles are a promising potential agent for the treatment of ischemic stroke.

关键词： behavior exosome extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKT)

Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-dong J.han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

支气管哮喘合并肺结核患者脑源性神经营养因子和神经激肽A表达对预后的影响分析

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中华医院感染学杂志 2017年第4期27卷 785-787,791页

作者：刘畅周向东李华韩忠王杰海南医学院附属医院呼吸内科海南海口570102

目的探究支气管哮喘合并肺结核患者脑源性神经营养因子(BDNF)和神经激肽A(NKA)表达对预后的影响,以便于更好地监测患者病情进展,改善患者预后,提高患者生活质量。方法随机选取2014年1月-2015年12月医院收治55例支气管哮喘合并肺结核患... 详细信息

目的探究支气管哮喘合并肺结核患者脑源性神经营养因子(BDNF)和神经激肽A(NKA)表达对预后的影响,以便于更好地监测患者病情进展,改善患者预后,提高患者生活质量。方法随机选取2014年1月-2015年12月医院收治55例支气管哮喘合并肺结核患者为观察组对象,另选取30名在医院体检的健康成人为对照组,观察并记录两组受试者治疗前后BDNF、NKA、第一秒用力呼吸量(FEV1)和呼气峰值(PEF)变化情况,分析比较。结果哮喘急性期患者BDNF水平显著高于哮喘缓解期患者和对照组,治疗后,缓解期和急性期支气管哮喘患者BDNF均下降,与治疗前比较差异有统计学意义(P<0.05);支气管哮喘缓解期患者NKA显著高于对照组,而哮喘急性期患者显著高于缓解期患者,两组比较差异有统计学意义(P<0.05),治疗后,均有明显降低,较治疗前差异有统计学意义(P<0.05);治疗后,两组患者FEV1和PEF等肺功能指标明显改善,较治疗前差异有统计学意义(P<0.05)。结论支气管哮喘患者体内NKA和BDNF含量较正常人显著升高,有利于疾病早期诊断和监测,便于控制病情发展,预后较好。

关键词：支气管哮喘肺结核脑源性神经营养因子神经激肽A 预后

基于多AGENT联合意图的反潜编队仿真模型研究

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系统仿真学报 2009年第20期21卷 6356-6359页

作者：郑文恩陆铭华董汉权海军潜艇学院潜艇作战软件研究中心青岛266071

分析了反潜编队的协同作战过程,提出了编队多Agent的形式化描述方法,给出了单个兵力Agent的行为模型,包括组成结构和控制策略。提出了多Agent联合意图的六元组模型,并应用于舰艇和直升机协同反潜过程进行了形式化描述。采用黑板模型,实... 详细信息

分析了反潜编队的协同作战过程,提出了编队多Agent的形式化描述方法,给出了单个兵力Agent的行为模型,包括组成结构和控制策略。提出了多Agent联合意图的六元组模型,并应用于舰艇和直升机协同反潜过程进行了形式化描述。采用黑板模型,实现多Agent兵力的战场态势和作战状态共享;基于有穷状态自动机,给出了多Agent兵力协同作战过程描述模型。最后,指出多Agent联合意图理论在计算机兵力生成方面,尤其是兵力协同作战研究方面,具有理论和方法可行性和可实现性。

关键词： Agent 联合意图协同反潜编队仿真黑板模型