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Clinical significance of isolated biliary candidiasis in patients with unresectable cholangiocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2016年第5期15卷 533-539页

作者： In-Ho Kim Jae-Ki Choi dong-gun lee In Seok lee Tae Ho Hong Young Kyoung You Ho Jong Chun Myung Ah lee Departments of Internal Medicine Division of Medical 0ncologySeoul St. Mary’s Hospital The Catholic University of Korea Seoul Korea Departments of Internal Medicine Division of Infectious Diseases Bucheon St. Mary’s Hospital The Catholic University of Korea Seoul Korea Division of Infectious Diseases Seoul St. Mary’s Hospital The Catholic University of Korea Seoul Korea Division of Gastroenterology Seoul St. Mary’s Hospital The Catholic University of Korea Seoul Korea Department of Surgery Seoul St. Mary’s Hospital The Catholic University of Korea Seoul Korea Department of Radiology Seoul St. Mary’s Hospital The Catholic University of Korea Seoul Korea Department of Hepato-Biliary-Pancreatic Cancer Center Seoul St. Mary’s Hospital The Catholic University of Korea Seoul Korea

BACKGROUND: The frequency of isolated biliary candidiasis is increasing in cancer patients. The clinical signiifcance of isolated biliary candidiasis remains unclear. We analyzed the risk factors of biliary candidiasis and outcomes of the patients with unresectable cholangiocarcinoma after percutaneous transhepatic biliary drainage (PTBD). METHODS: Among 430 patients who underwent PTBD between January 2012 and March 2015, 121 patients had unresectable cholangiocarcinoma. Bile and blood samples were collected for consecutive fungal culture. RESULTS: The study cohort included 49 women and 72 men with a median age of 71 years. Multivariate analysis showed that cancer progression (P=0.013), concurrent presence of another microorganism (P=0.010), and previous long-term (>7 days) antibiotic use (P=0.011) were potential risk factors of biliary candidiasis. Chemotherapy was not associated with overall biliary candidiasis (P=0.196), but was signiifcantly related to repeated biliary candidiasis (P=0.011). Patients with isolated biliary candidiasis showed remarkably reduced survival compared with those without (median overall sur-vival (OS): 32 vs 62 days,P=0.011)Subgroup analysis was also performed. Patients with repeated candidiasis had markedly decreased survival compared with those with transient candi-diasis (median OS: 30 vs 49 days,P=0.046). Biliary candidiasis was identiifed as a poor prognostic factor by univariate and multivariate analyses (P=0.033). Four cases of repeated can-didiasis (4/19, 21%) showedCandida species in consecutive blood culture until the end of the study, but others showed no candidemia. CONCLUSIONS: Isolated biliary candidiasis may be associ-ated with poor prognosis in patients with unresectable chol-angiocarcinoma. Especially, repeated biliary candidiasis may have the possibility of progression to candidemia. We suggest that biliary dilatation treatment or antifungal agents might be helpful for patients with biliary candidiasis.

关键词： biliary candidiasis biliary obstruction cholangiocarcinoma percutaneous transhepatic biliary drainage

Hematologic diseases: High risk of Clostridium difficile associated diarrhea

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World Journal of Gastroenterology 2014年第21期20卷 6602-6607页

作者： Tae-Geun Gweon Myung-Gyu Choi Myong Ki Baeg Chul-Hyun Lim Jae Myung Park In Seok lee Sang Woo Kim dong-gun lee Yeon Joon Park Jong Wook lee Division of Gastroenterology Department of Internal MedicineSeoul St Mary’s hospitalThe Catholic University of KoreaCollege of MedicineSeoul 137-701South Korea Division of Infectious Diseases Department of Internal MedicineSeoul St Mary’s hospitalThe Catholic University of KoreaCollege of MedicineSeoul 137-701South Korea Department of Laboratory Medicine Seoul St Mary’s hospitalThe Catholic University of KoreaCollege of MedicineSeoul 137-701South Korea Division of Hematologic Diseases Department of Internal MedicineSeoul St Mary’s hospitalThe Catholic University of KoreaCollege of MedicineSeoul 137-701South Korea

AIM: To investigate the incidence and clinical outcome of Clostridium difficile (C. difficile) associated diarrhea (CDAD) in patients with hematologic disease.

关键词： Clostridium difficile associated diarrhea Incidence Clinical outcome Patients with hematologic disease Intravenous immunoglobulin

Aligned Ion Conduction Pathway of Polyrotaxane‑Based Electrolyte with Dispersed Hydrophobic Chains for Solid‑State Lithium–Oxygen Batteries

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Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram Kim Myeong‑Chang Sung Gwang‑Hee lee Byoungjoon Hwang Sojung Seo Ji‑Hun Seo dong‑Wan Kim Department of Materials Science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea School of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials Science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves ***-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： Solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity Hydrophobic chain

Glycyrrhizin attenuates HMGB1-induced hepatocyte apoptosis by inhibiting the p38-dependent mitochondrial pathway

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World Journal of Gastroenterology 2012年第7期18卷 679-684页

作者： Geum-Youn Gwak Tae gun Moon dong Ho lee Byung Chul Yoo Department of Medicine Samsung Medical CenterSugnkyunkwan University School of Medicine50 Irwon-DongGangnam-Gu135-710 SeoulSouth Korea

AIM： To examine how High-mobility group box I （HMGB1） regulates hepatocyte apoptosis and, furthermore, to determine whether glycyrrhizin （GL）, a known HMGB1 inhibitor, prevents HMGBl-induced hepatocyte apoptosis.

关键词： High-mobility group box 1 Hepatocyte Apoptosis Glycyrrhizin p38 Mitochondria

Impacts of optimization strategies on performance,power/energy consumption of a GPU based parallel reduction

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Journal of Central South University 2017年第11期24卷 2624-2637页

作者： Phuong Thi Yen lee Deok-Young lee Jeong-gun Smart Computing Lab. Department of Computer EngineeringHallym UniversityChuncheon 24252Korea College of General Education Hallym UniversityChuncheon 24252Korea

In the era of modern high performance computing, GPUs have been considered an excellent accelerator for general purpose data-intensive parallel applications. To achieve application speedup from GPUs, many of performance-oriented optimization techniques have been proposed. However, in order to satisfy the recent trend of power and energy consumptions, power/energy-aware optimization of GPUs needs to be investigated with detailed analysis in addition to the performance-oriented optimization. In this work, in order to explore the impact of various optimization strategies on GPU performance, power and energy consumptions, we evaluate performance and power/energy consumption of a well-known application running on different commercial GPU devices with the different optimization strategies. In particular, in order to see the more generalized performance and power consumption patterns of GPU based accelerations, our evaluations are performed with three different Nvdia GPU generations(Fermi, Kepler and Maxwell architectures), various core clock frequencies and memory clock frequencies. We analyze how a GPU kernel execution is affected by optimization and what GPU architectural factors have much impact on its performance and power/energy consumption. This paper also categorizes which optimization technique primarily improves which metric(i.e., performance, power or energy efficiency). Furthermore, voltage frequency scaling(VFS) is also applied to examine the effect of changing a clock frequency on these metrics. In general, our work shows that effective GPU optimization strategies can improve the application performance significantly without increasing power and energy consumption.

关键词： parallel reduction GPU code optimization power energy voltage frequency scaling

Prediction of Melt Pool Dimension and Residual Stress Evolution with Thermodynamically-Consistent Phase Field and Consolidation Models during Re-Melting Process of SLM

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Computers, Materials & Continua 2021年第1期66卷 87-112页

作者： Kang-Hyun lee gun Jin Yun Department of Aerospace Engineering Seoul National UniversitySeoul08826South Korea Institute of Advanced Aerospace Technology Seoul National UniversitySeoul08826South Korea

Re-melting process has been utilized to mitigate the residual stress level in the selective laser melting(SLM)process in recent ***,the complex consolidation mechanism of powder and the different material behavior after the first laser melting hinder the direct implementation of the re-melting *** this work,the effects of re-melting on the temperature and residual stress evolution in the SLM process are investigated using a thermo-mechanically coupled finite element *** degree of consolidation is incorporated in the energy balance equation based on the thermodynamically-consistent phase-field *** drastic change of material properties due to the variation of temperature and material state is also *** the proposed simulation framework,the single-track scanning is simulated first to predict the melt pool dimension and validate the proposed model with the existing experimental *** obtained thermal histories reveal that the highest cooling rate is observed at the end of the local solidification time which acts as an important indicator for the alleviation of temperature ***,the scanning of a whole single layer that consists of multiple tracks is simulated to observe the stress evolution with several re-melting *** the full melting of powder material in the first scanning process,the increase of residual stress level is observed with one remelting ***,the predicted stress level with the re-melting process shows the variation trend attributable to the accumulated heat in the *** numerical issues and the detailed implementation process are also introduced in this paper.

关键词： Selective laser melting thermo-mechanical analysis Ti-6Al-4V additive manufacturing re-melting residual stress

PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 1993-1994页

作者： Anup Bhusal Won-Ha lee Kyoungho Suk Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU Biomedical Convergence Program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea School of Life Sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea Brain Science and Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.

关键词： inflammation considerably

Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun Jeong lee Su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

The Characteristics of CLHS Driving for High Luminance Efficiency in AC PDP

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Plasma Science and Technology 2016年第11期18卷 1116-1122页

作者： gun-Su KIM Chi-Hyung AHN Seok-Hyun lee Department of Electrical and Electronic Engineering Youngsan UniversityYangsanGyeongnam 50510Korea Korea Railroad Research Institute Uiwang Gyeonggi 16105Korea School of Electrical Engineering Inha UniversityIncheon 22212Korea

This paper proposes a CLHS （Capacitor Less Half Sustain） driving method that is applied to a long gap panel to reduce the power consumption. In order to reduce the power consumption in moving images, the luminous efficiency should be improved at the low discharge load （〈25%）. The weight of reactive power consumption tends to increase as the low discharge load decreases. Thus, it is very important to improve the luminous efficiency at low discharge load. It is well known that a long gap panel improves the luminance and the luminous efficiency but it is very difficult to drive the panel due to high driving voltage. It is confirmed that the main factors which cause a long gap panel to increase the minimum driving voltages are not only a long discharge gap but also self-erasing discharge. Self-erasing discharge is generated between the address and sustain electrodes in a sustain period. The CLHS driving method can reduce the reactive power consumption in a sustain period because energy recovery capacitors were removed in the sustain circuit. The CLHS driving method can reduce the minimum driving voltage of the long gap panel because the self-erasing discharge was prevented. When the CLHS driving method was applied to the panel with an ITO gap of 100 μm, Vs and VA minimum voltages are reduced by about 9 V and 12 V compared with those of the normal driving method. The luminance and the luminous efficiency also increased by about 24.3% and 33.3% at the discharge load of 4% compared with those at the normal condition.

关键词： PDP plasma long gap CLHS