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The Effect of Total Cholesterol on Myocardial Infarction in Chinese Male Hypertension Population

Biomedical and Environmental Sciences 2010年第1期23卷 37-41页

作者： JIAN-XIN LI JIE CAO XIANG-feng LU SHU-feng CHEN DA-HAI YU XIU-FANG DUAN XI-guI WU dong-feng gu Department of Evidence Based Medicine Cardiovascular lnstitute and Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beo'ing 100037 China

Objective Total cholesterol （TC） is an important risk factor for myocardial infarction （M1）, but the effect of TC on MI in Chinese male hypertension population has not been well documented. We conducted a prospective cohort study to determine the incidence and relative risk for M1 across a wide range of TC levels in Chinese male hypertension population. Methods A cohort of 5 298 male employees aged 18-74 years recruited from Capital Steel and Iron Company in Beijing of China in 1974-1980 was followed up for an average of 20.84 years. A total of 122 incident M1 cases were identified during the period of follow-up. Results The incidence of MI among participants with elevated TC and those with desirable TC in male non-hypertension population was 137.20 and 63.81 per 100 000 person-years, respectively; and the corresponding incidence in male hypertension population was 279.80 and 130.96 per 100 000 person-years, respectively. After adjustment for important covariables, 10.38%, 16.71%, and 23.80% of M1 cases were attributable to hypertension, elevated TC, and hypertension plus elevated TC, respectively. In male hypertension population, the multivariate adjusted hazard ratios of MI were 1.21, 2.39, 3.38, and 3.95 for participants with TC level of 5.17-5.68, 5.69-6.20, 6.21-6.71, and ≥6.72 mmol/L, compared with those with TC〈5.17 mmol/L. The corresponding population attributable risks were 2.92%, 9.20%, 8.87%, and 9.84%, respectively. Conclusion Elevated TC is an important independent risk factor of M1 both in male non-hypertension and hypertension populations. There is a linear association between TC level and M1 incidence in Chinese male hypertension population.

关键词： Hypertension Cholesterol Myocardial infarction Cohort studies

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China cardiovascular diseases report 2018: an updated summary

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Journal of Geriatric Cardiology 2020年第1期17卷 1-8页

作者： Li-Yuan MA Wei-Wei CHEN Run-Lin GAO Li-Sheng LIU Man-Lu ZHU Yong-Jun WANG Zhao-Su WU Hui-Jun LI dong-feng gu Yue-Jin YANG Zhe ZHENG Sheng-Shou HU National Center for Cardiovascular Diseases BeijingChina Beijing Tiantan Hospital BeijingChina Beijing Anzhen Hospital BeiingChina

1 Introduction Rapid socioeconomic progress has greatly affected the lifestyle in ***,owing to lifestyle changes,urbanization,and accelerated population aging,the risk of cardiovascular diseases(CVD)has *** incidence of CVD has been increasing continuously and this upward trend is projected to continue in the next *** growing burden of CVD has become a major public health issue.

关键词： Cardiovascular diseases Heart failure Risk factors

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上市公司资产负债率行业影响的实证研究——对已有研究结论的质疑

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财经研究 2006年第6期32卷 54-64页

作者：董逢谷袁卫秋上海财经大学统计学系上海200433

文章从行业的角度对沪深A股上市公司的资产负债率进行了较为深入的研究。与国内一些学者的研究结果不同,文章研究发现:(1)行业对资产负债率具有显著影响,但这种影响的力度相当微弱;(2)资产负债率的行业差异并不具有普遍性;(3)同一行业... 详细信息

文章从行业的角度对沪深A股上市公司的资产负债率进行了较为深入的研究。与国内一些学者的研究结果不同,文章研究发现:(1)行业对资产负债率具有显著影响,但这种影响的力度相当微弱;(2)资产负债率的行业差异并不具有普遍性;(3)同一行业内的资产负债率并不具有相似性,且行业内的差异要大于行业间的差异;(4)上市公司并不存在最优的行业资产负债率;(5)大部分行业的资产负债率与其行业特性不符。

关键词：上市公司资产负债率行业

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Association of cardiovascular diseases with milk intake among general Chinese adults

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Chinese Medical Journal 2020年第10期133卷 1144-1154页

作者： Xin-Yan Wang Fang-Chao Liu Xue-Li Yang Jian-Xin Li Jie Gao Xiang-feng Lu Jian-feng Huang Ying Li Ji-Chun Chen Lian-Cheng Zhao Chong Shen dong-Sheng Hu Ying-Xin Zhao Ling Yu Xiao-Qing Liu Xian-Ping Wu dong-feng gu Key Laboratory of Cardiovascular Epidemiology Chinese Academy of Medical SciencesBeijing 100037China Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Department of Epidemiology and Biostatistics School of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Epidemiology and Health Statistics College of Public HealthZhengzhou UniversityZhengzhouHenan 450001China Department of Biostatistics and Epidemiology School of Public HealthShenzhen University Health Science CenterShenzhenGuangdong 518071China Shandong First Medical University JinanShandong 271000China Department of Cardiology Fujian Provincial People's HospitalFuzhouFujian 350004China Division of Epidemiology Guangdong Provincial People's Hospital and Cardiovascular InstituteGuangzhouGuangdong 510080China Sichuan Center for Disease Control and Prevention ChengduSichuan 610041China School of Medicine Southern University of Science and TechnologyShenzhenGuangdong 518055China.

Background:The association of milk intake with cardiovascular disease(CVD)and cause-specific mortality remained controversial and evidence among the Chinese population was *** aimed to study the relationship between milk intake and CVDs among general Chinese ***::A total of 104,957 participants received questionnaire *** of physical examination such as anthropometric measurements and biochemical tests during 2007 to 2008,demographic data and their information on milk intake were collected through standardized *** proportional hazard regression models were used to calculate hazard ratios(HRs)and their corresponding 95%confidence intervals(CIs)of CVD incidence,cause-specific mortality and all-cause mortality related to milk *** cubic splines(RCSs)were applied to examine dose-response ***::Among the 91,757 participants with a median follow-up period of 5.8 years,we documented 3877 CVD cases and 4091 all-cause *** with participants who never consumed milk,the multivariate-adjusted HRs(95%CIs)of CVD incidence for 1 to 150 g/day,151 to 299 g/day,and≥300 g/day were 0.94(0.86-1.03)(P>0.05),0.77(0.66-0.89)(P<0.05),and 0.59(0.40-0.89)(P<0.05),respectively;each 100 g increase of daily milk intake was associated with 11%lower risk of CVD incidence(HR,0.89;95%CI:0.85-0.94;P<0.001),and 11%lower risk of CVD mortality(HR,0.89;95%CI:0.82-0.97;P=0.008)after adjustment for age,sex,residential area,geographic region,education level,family history of CVD,smoking,alcohol drinking,physical activity level,body mass index,and healthy diet status(ideal or not).RCS analyses also showed a linear dose-response relationship with CVD(P for overall significance of the curve<0.001;P for non-linearity=0.979;P for linearity<0.001)and stroke(P for overall significance of the curve=0.010;P for non-linearity=0.998;P for linearity=0.002)incidence,and CVD mortality(P for overall significance of the curve=0.045;P for non

关键词： Milk Cardiovascular disease Incidence All-cause mortality Cause-specific mortality Prospective study Chinese population

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定性变量指数的编制及其监狱安全事故评估研究

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河北法学 2005年第5期23卷 2-6页

作者：董逢谷路万忠上海财经大学上海200433

在讨论单一现象动态总指数与多现象静态总指数分类的基础上,介绍了针对伴随安全事故发生的变量多为定性的非数值型变量的特点,怎样运用静态总指数方法编制监狱安全事故指数,并通过案例实证了运用指数评估监狱安全的实际意义,最后对研究... 详细信息

在讨论单一现象动态总指数与多现象静态总指数分类的基础上,介绍了针对伴随安全事故发生的变量多为定性的非数值型变量的特点,怎样运用静态总指数方法编制监狱安全事故指数,并通过案例实证了运用指数评估监狱安全的实际意义,最后对研究成果的理论意义作出了客观评价。

关键词：定性变量指数监狱安全安全事故评估脱逃事故监狱管理

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Exploration of Gas‑Dependent Self‑Adaptive Reconstruction Behavior of Cu_(2)O for Electrochemical CO_(2)Conversion to Multi‑Carbon Products

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Nano-Micro Letters 2025年第3期17卷 280-296页

作者： Chaoran Zhang Yichuan gu Qu Jiang Ziyang Sheng Ruohan feng Sihong Wang Haoyue Zhang Qianqing Xu Zijian Yuan Fang Song State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Structural reconstruction of electrocatalysts plays a pivotal role in catalytic performances for CO_(2)reduction reaction(CO_(2)RR),whereas the behavior is by far superficially ***,we report that CO_(2)accessibility results in a universal self-adaptive structural reconstruction from Cu_(2)O to Cu@CuxO composites,ending with feeding gas-dependent microstructures and catalytic *** CO_(2)-rich atmosphere favors reconstruction for CO_(2)RR,whereas the CO_(2)-deficient one prefers that for hydrogen evolution *** the assistance of spectroscopic analysis and theoretical calculations,we uncover a CO_(2)-induced passivation behavior by identifying a reductionresistant but catalytic active Cu(I)-rich amorphous layer stabilized by*CO ***,we find extra CO production is indispensable for the robust production of *** inverse correlation between durability and FECO/FEC2H4 is disclosed,suggesting that the selfstabilization process involving the absorption of*CO intermediates on Cu(I)sites is essential for durable *** by this insight,we design hollow Cu_(2)O nanospheres for durable and selective CO_(2)RR electrolysis in producing *** work recognizes the previously overlooked passivation reconstruction and self-stabilizing behavior and highlights the critical role of the local atmosphere in modulating reconstruction and catalytic processes.

关键词： CO_(2)reduction reaction Electrocatalysts Cu_(2)O Reconstruction Self-adaptive electrocatalysis

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Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi Song Ruixin Li Xiaolei Chu Qi Li Ruihua Li Qingwen Li Kai-Yu Tong Xiaosong gu dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

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Constructing quasi-2D perovskite to collect hot carriers to reduce open-circuit voltage loss for efficient inverted perovskite solar cells

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Science China Chemistry 2025年

作者： Lei gu Xing Li Chao Wu Yang feng Chunming Yang Lin Song Frontiers Science Center for Flexible Electronics Institute of Flexible Electronics Northwestern Polytechnical University Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences

Inverted perovskite solar cells （PSCs） have received great attention owing to the high certificated power conversion efficiency（PCE） reaching 26.7%. However, interfacial charge recombination is far superior to perovskite bulk charge recombination due to the use of fullerenes and their derivatives in inverted perovskite solar cells, which induces devastating open circuit voltage（VOC） losses. For this reason the present work attempts to use 4-chloropiperidine hydrochloride for the upper surface modification of perovskite to construct a quasi-two-dimensional （2D） structure with suitable 2D layer widths （n=2, 3 dominant）,which has a smaller electron carrier transport barrier without sacrificing short-circuit current （JSC） in the device. This strategy effectively passivates the interfacial defect states while promoting energy level alignment to achieve carrier dissociation and equilibrium transport at the interface, which in turn resulted in improved fill factor （FF）. In addition, additional energy levels are provided by 2D perovskites to collect hot carriers, resulting in improved device open circuit voltage （VOC）. As a result, the device PCE increases from 22.37%to 24.11%after the 4CPD treatment. In addition, the 4CPD-treated PSCs maintain 90%of the initial PCE after storage in an N2atmosphere at 50°C for 1,080 h, whereas the control devices show a 15%PCE loss under the same aging conditions. This work provides new opportunities to suppress interfacial charge recombination in inverted devices.

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China cardiovascular diseases report 2015： a summary

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Journal of Geriatric Cardiology 2017年第1期14卷 1-10页

作者： Wei-Wei CHEN Run-Lin GAO Li-Sheng LIU Man-Lu ZHU Wen WANG Yong-Jun WANG Zhao-Su WU Hui-Jun LI dong-feng gu Yue-Jin YANG Zhe ZHENG Li-Xin JIANG Sheng-Shou HU National Center for Cardiovascular Diseases Beijing China Beijing Tiantan Hospital Beijing China Beijing Anzhen Hospital Beijing China

1 Introduction Major and profound changes have taken place in China over the past 30 years. An epidemic of cardiovascular diseases （CVD） in China is emerging as a result of lifestyle changes, urbanization, and the accelerated process of aging. The incidence of CVD is continuously increasing and will remain an upward trend in the next decade. Since 2005,

关键词： Atrial fibrillation Cardiovascular diseases Hypertension Risk factors Statistics Stroke

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Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai Xu Zhen gu Hua Yan Dingding Shen Xiaosong gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

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