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Exosomes derived from bone marrow mesenchymal stem cells inhibit neuroinflammation after traumatic brain injury

Neural Regeneration Research 2022年第12期17卷 2717-2724页

作者： Liang Wen Ya-dong Wang dong-feng shen Pei-dong Zheng Meng-Di Tu Wen-dong You Yuan-Run Zhu Hao Wang Jun-feng feng Xiao-feng Yang The First Affiliated Hospital School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Intensive Care Unit The First Hospital of JiaxingJiaxingZhejiang ProvinceChina Department of Neurosurgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Exosomes derived from bone marrow mesenchymal stem cells can inhibit neuroinflammation through regulating microglial phenotypes and promoting nerve injury ***,the underlying molecular mechanism remains *** this study,we investigated the mechanism by which exosomes derived from bone marrow mesenchymal stem cells inhibit *** in vitro co-culture experiments showed that bone marrow mesenchymal stem cells and their exosomes promoted the polarization of activated BV2 microglia to their anti-inflammatory phenotype,inhibited the expression of proinflammatory cytokines,and increased the expression of anti-inflammatory *** in vivo experiments showed that tail vein injection of exosomes reduced cell apoptosis in cortical tissue of mouse models of traumatic brain injury,inhibited neuroinflammation,and promoted the transformation of microglia to the anti-inflammatory *** screened some microRNAs related to neuroinflammation using microRNA sequencing and found that microRNA-181b seemed to be actively involved in the ***,we regulated the expression of miR181b in the brain tissue of mouse models of traumatic brain injury using lentiviral *** found that miR181b overexpression effectively reduced apoptosis and neuroinflamatory response after traumatic brain injury and promoted the transformation of microglia to the anti-inflammatory *** interleukin 10/STAT3 pathway was activated during this *** findings suggest that the inhibitory effects of exosomes derived from bone marrow mesenchymal stem cells on neuroinflamation after traumatic brain injury may be realized by the action of miR181b on the interleukin 10/STAT3 pathway.

关键词： apoptosis bone marrow mesenchymal stem cells BV2 microglia exosome interleukin 10 lentiviral transfection microRNA-181b neuroinflammation phenotype signal transducer and activator of transcription 3 traumatic brain injury

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Rational Solutions of First Order Algebraic Ordinary Differential Equations

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Journal of Systems Science & Complexity 2024年第2期37卷 567-580页

作者： feng Shuang shen Liyong School of Physical and Mathematical Sciences Nanjing Tech UniversityNanjing 211816China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China

Let f(t,y,y')=∑ _(i=0)^(n )a_(i)(t,y)y'^(i)=0 be an irreducible first order ordinary differential equation with polynomial *** in 1998 proved that there exists a constant C such that every rational solution of f(t,y,y')=0 is of degree not greater than *** show that this degree bound C depends not only on the degrees of f in t,y,y' but also on the coefficients of f viewed as the polynomial in t,y,y'.In this paper,the authors show that if f satisfies deg(f,y)0,then the degree bound C only depends on the degrees of f in t,y,y',and furthermore we present an explicit expression for C in terms of the degrees of f in t,y,y'.

关键词： Degree bound first order AODE height rational solution

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Hydrodynamic Characteristics of Undular Tidal Bores in the Qiantang River Based on Field Observations

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China Ocean Engineering 2024年第3期38卷 505-518页

作者： ZHANG Shu-yu PAN Cun-hong ZHANG shen-yang LI Ruo-hua CHENG Wenlong XIE dong-feng Zhejiang Tongji Vocational College of Science and Technology Hangzhou 311231China Zhejiang Institute of Hydraulics and Estuary Hangzhou 310020China

Understanding the undular tidal bores in the Qiantang River is essential for effective river management and *** breaking tidal bores have been studied extensively, reports on undular tidal bores in the Qiantang Riverremain limited. Furthermore, observed data on undular tidal bores fulfilling the requirements of short measurementtime intervals, and spring, medium, and neap tide coverage, and providing detailed data for the global vertical stratificationof flow velocity are quite limited. Based on field observations at Qige in the Qiantang estuary, we analyzedthe characteristics of undular tidal bores. The results showed that the flooding amplitude (a) of the first wave isalways larger than its ebbing amplitude (b). Moreover, the vertical distribution of the maximum flood velocity exhibitesthree shapes, influenced by the tidal range, while that of the maximum ebb velocity exhibites a single shape. Duringthe initial phase of the flood tide in the spring and medium tides, the upper water body experiences multiple oscillatingchanges along the flow direction, corresponding to the alternating process of the crest and trough of the tide levelupon the arrival of the tidal bore. The tidal range is a crucial parameter in tidal bore hydrodynamics. By establishingthe relationship between hydrodynamic parameters and tidal range, other hydrodynamic parameters, such as the tidalbore height, maximum flood depth–averaged velocity, maximum flood stratified velocity at the measurement points,and duration of the flood tide current, can be effectively predicted, thereby providing an important reference for rivermanagement and maintenance.

关键词： tidal bores Qiantang Estuary tidal bore height tidal bore velocity propagation speed

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Highlights of mainstream solar cell efficiencies in 2023

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Frontiers in Energy 2024年第1期18卷 8-15页

作者： Wenzhong shen Yixin ZHAO feng LIU Institute of Solar Energy and Key Laboratory of Artificial Structures and Quantum Control(Ministry of Education)School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China School of Environmental Science and Engineering and Frontiers Science Center for Transformative MoleculesShanghai Jiao Tong UniversityShanghai 200240China School of Chemistry and Chemical Engineering and Frontiers Science Center for Transformative MoleculesShanghai Jiao Tong UniversityShanghai 200240China

This article continues our highlights last two years[1,2]on the highest independently confirmed mainstream(silicon,perovskite,and organic)solar cell efficiencies in *** world record power conversion efficiency(PCE)of the single-junction silicon and perovskite/silicon tandem solar cells has reached over 27%and close to 34%,respectively,in *** have also witnessed the rapid mass-production development of the silicon passivating contact and silicon back contact solar cells,as well as further progress with perovskite solar cells(PSCs).

关键词： perovskite mainstream fir

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Auto-parametric resonance of a continuous-beam-bridge model under two-point periodic excitation:an experimental investigation and stability analysis

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 445-454页

作者： Li Yuchun shen Chao Liu Wei Li dong Department of Hydraulic Engineering College of Civil EngineeringTongji UniversityShanghai 200092China

The auto-parametric resonance of a continuous-beam bridge model subjected to a two-point periodic excitation is experimentally and numerically investigated in this *** auto-parametric resonance experiment of the test model is conducted to observe and measure the auto-parametric resonance of a continuous beam under a two-point excitation on *** parametric vibration equation is established for the test model using the finite-element *** auto-parametric resonance stability of the structure is analyzed by using Newmark's method and the energy-growth exponent *** effects of the phase difference of the two-point excitation on the stability boundaries of auto-parametric resonance are studied for the test *** with the experiment,the numerical instability predictions of auto-parametric resonance are consistent with the test phenomena,and the numerical stability boundaries of auto-parametric resonance agree with the experimental *** a continuous beam bridge,when the ratio of multipoint excitation frequency(applied to the columns)to natural frequency of the continuous girder is approximately equal to 2,the continuous beam may undergo a strong auto-parametric *** with the present experiment and analysis,a hypothesis of Volgograd Bridge's serpentine vibration is discussed.

关键词： auto-parametric resonance continuous beam bridge model two-point excitation experimental investigation stability analysis vibration of Volgograd Bridge

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Diagnosis and treatment of biliary mucinous cystic neoplasms: A single-center experience

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 495-501页

作者： Jun-Jun Jia Ya-Fen Cheng Mei-Bao feng Li Liu Ming-Qi Shuai Xiao-dong shen Xiao-feng Tang Shu-Sen Zheng Division of Hepatobiliary and Pancreatic Surgery Department of Surgerythe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of International Healthcare Center the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Pathology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Library the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Background: Biliary mucinous cystic neoplasms(BMCNs) are rare hepatobiliary cystic tumors, which can be divided into noninvasive and invasive types. This study aimed to investigate the diagnosis, treatment, and prognosis of BMCNs in a large single center. Methods: We analyzed 49 patients with BMCNs confirmed by postoperative pathology at the First Afflliated Hospital, Zhejiang University School of Medicine between January 2007 and December 2021. Results: Among the 49 patients, 37 were female(75.5%), and the average age was 57.04 years. Common symptoms included abdominal discomfort, jaundice and fever, while 22 patients(44.9%) had no symptoms. Serum carbohydrate antigen(CA) 19-9 and CA125 concentrations were elevated in 34.8% and 19.6% of patients, respectively. Forty-eight patients had tumors in the intrahepatic bile ducts and only one had a tumor in the extrahepatic bile duct. Forty-eight patients with noninvasive intrahepatic BMCNs were further analyzed in terms of pathological features: 34(70.8%) had low-grade intraepithelial neoplasms(LGINs), and 14(29.2%) had high-grade intraepithelial neoplasms(HGINs). The potential immunohistochemical markers of BMCNs were cytokeratin(CK) 19, CK7, estrogen receptor and progesterone receptor. Follow-up data for 37 patients with intrahepatic BMCNs were obtained. The median overall survival(OS) of BMCNs was not reached. The longest survival time was 137 *** 5-and 10-year OS rates were 100% and 85.4%, respectively. The 5-and 10-year recurrence-free survival(RFS) rates were 93.9% and 80.2%, respectively. Conclusions: BMCNs are rare cystic neoplasms that commonly occur in middle-aged females. BMCNs can only be diagnosed and classified by postoperative pathology, as there are no specific clinical presentations, serological indicators or imaging modalities for preoperative diagnosis. Complete surgical resection is necessary for BMCNs, and the postoperative prognosis is favorable.

关键词： Biliary mucinous cystic neoplasms Low-grade intraepithelial neoplasms High-grade intraepithelial neoplasms Overall survival Recurrence-free survival

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Numerical investigation on the flow and thermal behaviors of the volumetric solar receivers with different morphologies

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Science China(Technological Sciences) 2024年第9期67卷 2749-2757页

作者： DU shen LI dong LI MengJie HE YaLing National Innovation Platform(Center)for Industry-Education Integration of Energy Storage Technology Key Laboratory of Thermo-Fluid Science and Engineering of Ministry of EducationXi’an Jiaotong UniversityXi’an 710049China

Morphologies of the porous materials influence the processes of solar radiation transport, flow, and thermal behaviors within volumetric solar receivers. A comprehensive comparative study is conducted by applying pore scale numerical simulations on volumetric solar receivers featuring various morphologies, including Kelvin, Weaire-Phelan, and foam configurations. The idealized unit cell and X-ray computed tomography scan approaches are employed to reconstruct pore scale porous *** Carlo ray tracing and pore scale numerical simulations are implemented to elucidate the radiative, flow, and thermal behaviors of distinct receivers exposed to varying thermal boundary conditions and real irradiation situations. The findings demonstrate that the foam structure exhibits greater solar radiation absorptivity, while Kelvin and Weaire-Phelan structures enhance the penetration depth under non-perpendicular solar irradiation. In comparison with Kelvin and Weaire-Phelan configurations, the foam structure presents efficient convective heat transfer, with the Weaire-Phelan structure showing pronounced thermal non-equilibrium phenomena. The variance in convective heat transfer coefficient between Kelvin and Weaire-Phelan configurations is approximately 8.4%. The foam structure exhibits higher thermal efficiency and flow resistance under nonperpendicular irradiation compared to Kelvin and Weaire-Phelan structures, attributed to its smaller pore size and intricate flow channels. An increase of 1.3% in thermal efficiency is observed with a substantial rise in pressure drop of 32.2%.

关键词： volumetric solar receiver porous morphology pore scale method solar radiation absorption thermal performance flow resistance

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Which Neighborhoods Have Easier Access to Online Home Delivery Services?A Spatiotemporal Accessibility Analysis in Nanjing,China

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Chinese Geographical Science 2024年第4期34卷 722-738页

作者： KONG Yu ZHEN feng ZHANG Shanqi shen Lizhen School of Architecture and Urban Planning Nanjing UniversityNanjing 210093China Provincial Engineering Research Center of Smart City Planning and Digital Governance Nanjing 210093China

The rise in online home delivery services(OHDS)has had a significant impact on how urban services are supplied and used in recent *** on the spatial accessibility of OHDS are emerging,but few is known about the temporal dimension of OHDS accessibility as well as the geographic and socioeconomic differences in the spatiotemporal accessibility of *** study measures the spatiotemporal accessibility of four types of OHDS,namely leisure,fresh and convenient,medical,and catering *** geographic and socioeconomic disparities in the spatiotemporal accessibility of these four types of OHDS are then identified using spatial statistical methods and the Kruskal-Wallis test(K-W test).The case study in Nanjing,China,suggests that:1)spatiotemporal accessibility better reflects the temporal variation of OHDS accessibility and avoids overestimation of OHDS accessibility when only considering its spatial dimension.2)The spatiotemporal accessibility of OHDS varies geographically and *** located in the main city or neighborhoods with higher housing prices,higher population density,and higher point of interest(POI)mix have better OHDS spatiotemporal *** study contributes to the understanding of OHDS accessibility from a spatiotemporal perspective,and the empirical insights can assist policymakers in creating intervention plans that take into account variations in OHDS spatiotemporal accessibility.

关键词： online home delivery services(OHDS) spatiotemporal accessibility neighborhoods accessibility differences Nanjing City China

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Power equipment vibration visualization using intelligent sensing method based on event-sensing principle

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Global Energy Interconnection 2024年第2期7卷 228-240页

作者： Mingzhe Zhao Xiaojun shen Lei Su Zihang dong Tongji University No.1239 Siping RoadYangpu DistrictShanghai 200092P.R.China State Grid Shanghai Municipal Electric Power Company Electric Power Science Research Institute Shanghai 200437P.R.China Department of Electrical and Electronic Engineering Imperial College LondonLondonSW72AZU.K.

Vibration measurements can be used to evaluate the operation status of power equipment and are widely applied in equipment quality inspection and fault ***-sensing technology can sense the change in surface light intensity caused by object vibration and provide a visual description of vibration *** on the analysis of the principle underlying the transformation of vibration behavior into event flow data by an event sensor,this paper proposes an algorithm to reconstruct event flow data into a relationship correlating vibration displacement and time to extract the amplitude-frequency characteristics of the vibration signal.A vibration measurement test platform is constructed,and feasibility and effectiveness tests are performed for the vibration motor and other power *** results show that event-sensing technology can effectively perceive the surface vibration behavior of power and provide a wide dynamic ***,the vibration measurement and visualization algorithm for power equipment constructed using this technology offers high measurement accuracy and *** results of this study provide a new noncontact and visual method for locating vibrations and performing amplitude-frequency analysis on power equipment.

关键词： Power equipment Event sensing Non contact measurement Graphic display Feasibility

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Anomaly-Resistant Decentralized State Estimation Under Minimum Error Entropy With Fiducial Points for Wide-Area Power Systems

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 74-87页

作者： Bogang Qu Zidong Wang Bo shen Hongli dong Hongjian Liu the College of Automation Engineering Shanghai University of Electric PowerShanghai 200090China IEEE the Department of Computer Science Brunel University LondonUxbridgeMiddiesex UB83PHUK the College of Information Science and Technology Donghua UniversityShanghai 200051 the Engineering Research Center of Digitalized Textile and Fashion Technology Ministry of EducationShanghai 201620China the Artificial Intelligence Energy Research Institute Northeast Petroleum UniversityDaqing 163318 the Heilongjiang Provincial Key Laboratory of Networking and Intelligent Control Northeast PetroleumDaqing 163318 the Sanya Offshore Oil&Gas Research Institute Northeast Petroleum UniversitySanya 572024China the Key Laboratory of Advanced Perception and Intelligent Control of High-End Equipment Ministry of EducationAnhui Polytechnic UniversityWuhu 2410000 the School of Mathematics and Physics Anhui Polytechnic UniversityWuhu 241000China

This paper investigates the anomaly-resistant decentralized state estimation(SE) problem for a class of wide-area power systems which are divided into several non-overlapping areas connected through transmission lines. Two classes of measurements(i.e., local measurements and edge measurements) are obtained, respectively, from the individual area and the transmission lines. A decentralized state estimator, whose performance is resistant against measurement with anomalies, is designed based on the minimum error entropy with fiducial points(MEEF) criterion. Specifically, 1) An augmented model, which incorporates the local prediction and local measurement, is developed by resorting to the unscented transformation approach and the statistical linearization approach;2) Using the augmented model, an MEEF-based cost function is designed that reflects the local prediction errors of the state and the measurement;and 3) The local estimate is first obtained by minimizing the MEEF-based cost function through a fixed-point iteration and then updated by using the edge measuring information. Finally, simulation experiments with three scenarios are carried out on the IEEE 14-bus system to illustrate the validity of the proposed anomaly-resistant decentralized SE scheme.

关键词： Decentralized state estimation(SE) measurements with anomalies minimum error entropy unscented Kalman filter wide-area power systems

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