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Revolutionizing breast cancer detection:Advances in fluorescent probe technology

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Nano Research 2025年第1期18卷 653-674页

作者： Qian gao Lin Tang Jun Zhan Yiyuan Xue feng Luo State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu 610041China Emergency Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Prosthodontics West China School of StomatologySichuan UniversityChengdu 610041China

With the increasing incidence of breast cancer globally,there is an urgent demand for enhanced diagnostic and therapeutic *** comprehensive review explores advancements in fluorescent probe technology for breast cancer imaging and early *** probes offer unparalleled sensitivity and specificity in detecting cancer biomarkers,enabling early diagnosis and delineation of tumor margins during *** categorize these probes into molecular,nano,ratiometric,the second near-infrared window(NIR-II),and multifunctional varieties,each with unique capabilities for targeting specific cancer *** review highlights recent innovations in probe design,emphasizing their applications in pathogenesis studies,drug development,precision medicine,and fluorescence-guided *** their promising clinical potential,challenges such as safety,biomarker targeting accuracy,system compatibility,and clinical translation *** these hurdles is crucial for the integration of fluorescent probes into standard cancer care,aiming to improve treatment outcomes and patient quality of life.

关键词： breast cancer fluorescent probes imaging early diagnosis biomarker

Synergistic promotion strategy of “dual-site” and “dual-path” to enhance the C–C coupling between CO2 and HCHO driven by photoelectrocatalysis

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Journal of Energy Chemistry 2025年第1期100卷 39-49页

作者： Hongqiang Yang Jianfeng Zheng Guoyu Wang Yifei gao Yatao Yang Jia Li Xiaojin Han Yan Cui Zhanggen Huang National Key Laboratory of High Efficiency and Low Carbon Utilization of Coal Institute of Coal Chemistry Chinese Academy of Science University of Chinese Academy of Science Shenyang University of Chemical Technology

Photoelectrocatalytic coupling CO2and volatile organic compounds （VOCs） is a promising green strategy for the synergistic conversion of the two carbon-containing resources to *** catalytic efficiency is always at the mercy of chemical inertness of CO2and the competitive hydrogen evolution of ***,a modified g-C3N4/ZnAl-LDH Z-scheme heterojunction catalyst with dual reaction site was rationally designed and precisely *** Faraday efficiency of ethanol reached 68.67%with a corresponding formation rate of 227.3μmol *** revealed by in-situ characterizations and density functional theory calculations,CO2and HCHO were absorbed at Zn site and N site,***,*CO generated from CO2and HCHO was converted to*CH3O and*CHO on the dual-active-site *** detailed reaction mechanism experiments indicated that C–C coupling only occurred between*CO and*CH3O in electrocatalysis *** from the“*CO+*CH3O”path,another“*CO+*CHO”coupling path was also detected in photoelectrocatalytic *** selectivity of ethanol was significantly enhanced due to the synthesis of dual-site catalyst and the dual-path coupling path between CO2and HCHO simultaneously driven by light and electricity.

关键词： Ethanol

Effect of Exogenous Carboxyl and Hydroxyl Groups on Pyrolysis Reaction of High Molecular Weight Poly(L-Lactide)under the Catalysis of Tin

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Chinese Journal of Polymer Science 2021年第8期39卷 966-974,I0005页

作者： Li-dong feng Xin-Chao Bian gao Li Xue-Si Chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Jilin Biomedical Polymers Engineering Laboratory Changchun 130022China

The effect of exogenous hydroxyl,carboxyl groups and/or Sn^(2+) on pyrolysis reactions of poly(L-lactide)(PLLA)was investigated by thermogravimetric analysis(TGA).The activation energy(fa)of pyrolysis reactions was estimated by the Kissinger-Akahira-Sunose *** kinetic models were also explored by the Malek method,and the random degradation behavior was determined by comparing the plots of ln{-ln[1-(1-w)05]}versus 1/7for experimental data from TGA with model *** pyrolysis reaction rate of PLLA was affected slightly by exogenous hydroxyl and carboxyl groups at lower levels of Sn with 65-70 mg·kg^(-1)but increased appreciably in the presence of extraneous Sn^(2+),-COOH/Sn^(2+),or-OH/Sn^(2+).The Ea values for the pyrolysis reactions of the PLLAs that provided lactide were different under the catalysis of Sn2+in different chemical environments because Sn^(2+) can form the new Sn-carboxylate and Sn-alkoxide with exogenous carboxyl and hydroxyl groups,which were different in steric hindrance for the formation of activated complex between Sn^(2+) and *** the catalysis of Sn^(2+),a lactide molecule can be directly eliminated selectively at a random position of PLLA molecular chains,and the molecular chain of PLLA cannot change two PLLA fragments at the elimination site of ***,it was regenerated into a new PLLA molecule with the molecular weight reduced by 144 g·mol^(-1).

关键词： Poly(L-lactide) Pyrolysis mechanism Carboxyl group Hydroxyl group Tin

An Unprecedented Efficiency with Approaching 21%Enabled by Additive‑Assisted Layer‑by‑Layer Processing in Organic Solar Cells

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Nano-Micro Letters 2025年第2期17卷 372-375页

作者： Shuai Xu Youdi Zhang Yanna Sun Pei Cheng Zhaoyang Yao Ning Li Long Ye Lijian Zuo Ke gao Key Laboratory of Advanced Green Functional Materials College of ChemistryChangchun Normal UniversityChangchun 130032People’s Republic of China Shandong Provincial Key Laboratory for Science of Material Creation and Energy Conversion School of Chemistry and Chemical EngineeringShandong UniversityQingdao 266237People’s Republic of China College of Polymer Science and Engineering Sichuan UniversityChengdu 610065People’s Republic of China State Key Laboratory and Institute of Elemento‑Organic Chemistry Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer MaterialsRenewable Energy Conversion and Storage Center(RECAST)College of ChemistryNankai UniversityTianjin 300071People’s Republic of China Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640People’s Republic of China Tianjin Key Laboratory of Molecular Optoelectronic Sciences School of Materials Science and EngineeringTianjin UniversityTianjin 300350People’s Republic of China State Key Laboratory of Silicon Materials MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China

Recently published in Joule,feng Liu and colleagues from Shanghai Jiaotong University reported a record-breaking 20.8%power conversion efficiency in organic solar cells(OSCs)with an interpenetrating fibril network active layer morphology,featuring a bulk p-in structure and proper vertical segregation achieved through additive-assisted layer-by-layer *** optimized hierarchical gradient fibrillar morphology and optical management synergistically facilitates exciton diffusion,reduces recombination losses,and enhances light capture *** approach not only offers a solution to achieving high-efficiency devices but also demonstrates the potential for commercial applications of OSCs.

关键词： Organic solar cells Additive-assisted layer-by-layer processing Three-dimensional fibril morphology Bulk p-i-n structure Optical management

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烟草粉体添加对造纸法再造烟叶品质的影响

纸和造纸 2022年第5期41卷 19-22页

作者：张梦源殷沛沛熊珍董高峰刘晶云南中烟工业有限责任公司技术中心云南昆明650106 中烟施伟策(云南)再造烟叶有限公司云南玉溪653100

为考察烟草粉体添加对造纸法再造烟叶品质的影响。按照常规造纸法工艺流程制备造纸法再造烟叶,并在涂布过程中加入烟草粉体,采用单因素实验方法研究不同烟草粒径和添加比例与造纸法再造烟叶热水可溶物、化学指标、产品造碎率和感官质量... 详细信息

为考察烟草粉体添加对造纸法再造烟叶品质的影响。按照常规造纸法工艺流程制备造纸法再造烟叶,并在涂布过程中加入烟草粉体,采用单因素实验方法研究不同烟草粒径和添加比例与造纸法再造烟叶热水可溶物、化学指标、产品造碎率和感官质量指标之间的关系。结果表明:(1)在同等目数的条件下,随着烟草粉体使用比例的提升,综合造碎率逐渐升高;烟草粉体添加量每增加5%,总糖增幅平均值为3.27%,还原糖增幅为2.23%;烟气的浓度提升,香气量提升,烟气的强度提升,木质气息逐渐改善,烟草自然本香逐渐增加;再造烟叶产品的热水可溶物值逐渐升高;(2)在添加量一定的条件下,高目数样品的造碎率平均低于低目数样品的造碎率;随着目数的增加,烟气的透发性、细腻柔和度、明亮清晰度和透发性逐渐提升,自然烟草香气特征逐渐提升;产品的热水可溶物值没有明显的影响。说明烟草粉体按一定比例添加对再造烟叶成品具有一定的影响作用,主要是影响成品的热水可溶物、化学指标和感官质量指标,而烟草粉体粒径对造碎率和感官质量指标有所改善,其他指标变化不明显。

关键词：烟草粉体再造烟叶热水可溶物造碎率感官质量指标

Progress in crystallization of major histocompatibility complex class I in vertebrates

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Chinese Science Bulletin 2014年第12期59卷 1308-1316页

作者： Lei feng Mingwei Sun Songpeng dong feng-Shan gao Molecular Immunology Laboratory College of Life Science and Technology Dalian University Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences School of Life Sciences University of Science and Technology of China

The major histocompatibility complex(MHC)of proteins that exists in all vertebrates is encoded by a cluster of genes associated with the immune response and related *** is divided into MHC I,II,and III;MHC I is involved in antigenic presentation,binding T cell receptors,and leading ultimately to specific cellular immune *** complicated functions of MHC I are determined by the nature of the *** crystal structure of MHC I has been solved for many animals,revealing the relationship between spatial structure and *** I consists of an a heavy chain and a b2m light chain,both ligated non-covalently to a complex when a peptide is bound to the antigenic-binding *** a heavy chain is divided into an extracellular domain,a transmembrane domain,and an intracellular *** extracellular domain consists of sub-regions a1,a2,and *** a1 and a2 together form the antigenic-binding groove and bind antigenic peptides with 8–10 amino acid *** I can form a stable spatial structure;however,it should be noted that there are differences in the structure of MHC I among animal species,including anchored amino acids in binding peptides,binding sites,molecular distance,crystallization conditions,***,progress in determination of the crystal structure of human,mouse,chicken,non-human primate,and swine MHC I is described in detail.

关键词：主要组织相容性复合体脊椎动物结晶条件主要组织相容性复合物胞外结构域氨基酸残基空间结构细胞免疫应答

Targeting capabilities of engineered extracellular vesicles for the treatment of neurological diseases

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Neural Regeneration Research 2025年第11期20卷 3076-3094页

作者： Xinyu Yang Xiangyu gao Xiaofan Jiang Kangyi Yue Peng Luo Department of Neurosurgery Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina

Recent advances in research on extracellular vesicles have significantly enhanced their potential as therapeutic agents for neurological *** to their therapeutic properties and ability to cross the blood–brain barrier,extracellular vesicles are recognized as promising drug delivery vehicles for various neurological conditions,including ischemic stroke,traumatic brain injury,neurodegenerative diseases,glioma,and ***,the clinical application of natural extracellular vesicles is hindered by their limited targeting ability and short clearance from the *** address these limitations,multiple engineering strategies have been developed to enhance the targeting capabilities of extracellular vesicles,thereby enabling the delivery of therapeutic contents to specific tissues or ***,this review aims to highlight the latest advancements in natural and targeting-engineered extracellular vesicles,exploring their applications in treating traumatic brain injury,ischemic stroke,Parkinson's disease,Alzheimer's disease,amyotrophic lateral sclerosis,glioma,and ***,we summarized recent clinical trials involving extracellular vesicles and discussed the challenges and future prospects of using targeting-engineered extracellular vesicles for drug delivery in treating neurological *** review offers new insights for developing highly targeted therapies in this field.

关键词： Alzheimer's disease amyotrophic lateral sclerosis engineered extracellular vesicles glioma ischemic stroke neurological diseases Parkinson's disease psychosis targeted drug delivery traumatic brain injury

一种新的分组码译码方法在移动衰落信道中的性能研究及应用

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山东大学学报（理学版） 2002年第1期37卷 54-57,64页

作者：袁东风高春艳张立军山东大学信息科学与工程学院山东济南250100 清华大学电子工程系北京100084

广义阵列码 (Generalizedarraycode)简化了分组码的网格构造 ,本文将一种基于此结构的分组码的最大似然译码在Rayleigh衰落信道中进行了尝试 .研究了不同判决方式 (软判决和硬判决 )下 ,分组码采用这种最大似然译码的性能 .将此译码技... 详细信息

广义阵列码 (Generalizedarraycode)简化了分组码的网格构造 ,本文将一种基于此结构的分组码的最大似然译码在Rayleigh衰落信道中进行了尝试 .研究了不同判决方式 (软判决和硬判决 )下 ,分组码采用这种最大似然译码的性能 .将此译码技术应用于Rayleigh衰落信道图像传输系统中进行差错控制。

关键词：译码方法移动衰落信道分组码网格译码 Rayleigh衰落信道图像传输差错控制

Life-Cycle Bearing Capacity for Pre-Stressed T-beams Based on Full-Scale Destructive Test

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Structural Durability & Health Monitoring 2025年第1期19卷 145-166页

作者： Yushan Ye Tao gao Liankun Wang Junjie Ma Yingchun Cai Heng Liu Xiaoge Liu China Construction Seventh Engineering Division Corp. Ltd.Zhengzhou450004China School of Water Conservancy and Transportation Zhengzhou UniversityZhengzhou450001China

To investigate the evolution of load-bearing characteristics of pre-stressed beams throughout their service life and to provide a basis for accurately assessing the actual working state of damaged pre-stressed concrete T-beams,destructive tests were conducted on full-scale pre-stressed concrete *** on the measurement and ana-lysis of beam deﬂection,strain,and crack development under various loading levels during the research tests,combined with the veriﬁcation coefﬁcient indicators speciﬁed in the codes,the veriﬁcation coefﬁcients of bridges at different stages of damage can be *** results indicate that the T-beams experience complete,incom-plete linear,and non-linear stages during the destructive test *** the complete linear elastic stage,both the deﬂection and bottom strain veriﬁcation coefﬁcients comply with the speciﬁcations,indicating a good structural load-bearing capacity no longer adheres to the code’s *** the non-linear stage,both coefﬁcients exhi-bit a sharp increase,resulting in a further decrease in the structure’s load-bearing *** to the pro-visions of the current code,the beam can be in the incomplete linear stage when both values fall within the code’s speciﬁed *** strain veriﬁcation coefﬁcient sourced from the compression zone at the bottom of theﬂange is not recommended for assessing the bridge’s load-bearing capacity.

关键词： Pre-stressed T-beams whole process destructive test bearing capacity veriﬁcation coefﬁcient