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Histological subtype is a significant predictor for inguinal lymph node metastasis in patients with penile squamous cell carcinoma

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Asian Journal of Andrology 2018年第3期20卷 265-269页

作者： Jin-You Wang Ming-Zhu Gao De-Xin Yu dong-dong xie Yi Wang Liang-Kuan Bi Tao Zhang De-Mao Ding Department of Urology The Second Affiliated Hospital of Anhui Medical University Hefei 230601 China Department of Oncology The Second Affiliated Hospital of Anhui Medical University Hefei 230601 China

The present study aimed to investigate the relationship between histopathological subtype and the probability of inguinal lymph node metastasis （ILNM） in patients with penile squamous cell carcinoma （PSCC）. The clinical records of 198 consecutive patients with PSCC were analyzed retrospectively. Primary lesions were reevaluated according to the 2016 World Health Organization （WHO） histopathological classification. We retrieved the clinicopathological factors from the medical records including age, clinical lymph node stage, pathological tumor stage, lymphatic invasion, and nerve invasion. Uni- and multivariate logistic regression analyses were used to explore the risk factors of ILNM. Multivariate analyses identified clinical lymph node stage （P = 0.000）, pathological tumor stage （P = 0.016）, histologic grade （P = 0.000）, and risk group of histological subtypes （P = 0.029） as independent predictors for ILNM. Compared with the low-risk group of PSCC subtypes, the intermediate- （HR： 3.66, 95% CI. 1.30-10.37, P = 0.021） and high-risk groups （HR： 28.74, 95% Ch 2.37-348.54, P = 0.008） were significantly associated with ILNM. In conclusion, the histopathological subtype of the primary lesion is a significant predictor for ILNM in patients with PSCC.

关键词： histopathological subtype inguinal lymph node metastasis penile neoplasm squamous cell carcinoma

Retroperitoneal vs transperitoneal laparoscopic lithotripsy of 20-40 mm renal stones within horseshoe kidneys

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World Journal of Clinical Cases 2020年第20期8卷 4753-4762页

作者： Xin Chen Yi Wang Liang Gao Jin Song Jin-You Wang Deng-Dian Wang Jia-Xing Ma Zhi-Qiang Zhang Liang-Kuan Bi dong-dong xie De-Xin Yu Department of Urology The Second Hospital of Anhui Medical UniversityHefei 230032Anhui ProvinceChina Center of Experimental Orthopaedics Saarland University Medical CenterHomburg 66421Germany

BACKGROUND Horseshoe kidney(HK)with renal stones is challenging for *** both retroperitoneal and transperitoneal laparoscopic approaches have been reported in some case reports,the therapeutic outcome of retroperitoneal compared with transperitoneal laparoscopic lithotripsy is *** To assess the efficacy of laparoscopic lithotripsy for renal stones in patients with *** This was a retrospective study of 12 patients with HK and a limited number(n≤3)of 20-40 mm renal stones treated with either retroperitoneal or transperitoneal laparoscopic lithotripsy(June 2012 to May 2019).The perioperative data of both groups were compared including operation time,estimated blood loss,postoperative fasting time,perioperative complications and stone-free rate(SFR).RESULTS No significant difference was observed for age,gender,preoperative symptoms,body mass index,preoperative infection,hydronephrosis degree,largest stone diameter,stone number and isthmus *** mean postoperative fasting time of the patients in the retroperitoneal group and the transperitoneal group was 1.29±0.49 and 2.40±0.89 d,respectively(P=0.019).There was no significant difference in operation time(194.29±102.48 min vs 151.40±39.54 min,P=0.399),estimated blood loss(48.57±31.85 m L vs 72.00±41.47 m L,P=0.292)and length of hospital stay(12.14±2.61 d vs 12.40±3.21 d,P=0.881)between the retroperitoneal and transperitoneal *** patients in both groups had a complete SFR and postoperative renal function was within the normal *** change in estimated glomerular filtration rate(e GFR)from the preoperative stage to postoperative day 1 in the retroperitoneal group and the transperitoneal group was-3.86±0.69 and-2.20±2.17 m L/(min·1.73 m2),respectively(P=0.176).From the preoperative stage to the 3-mo follow-up,the absolute change in e GFR values for patients in the retroperitoneal group and the transperitoneal group was-3.29±1.11 and-2.40±2.07 m L/(min·1.73 m2),respectively(P=

关键词： Horseshoe kidney Retroperitoneal Transperitoneal Laparoscopic lithotripsy Renal stones

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SiO2对MgO陶瓷烧结性能影响

人工晶体学报 2016年第9期45卷 2306-2310页

作者：冯东罗旭东张国栋谢志鹏辽宁科技大学高温材料与镁资源工程学院鞍山114051 清华大学材料科学与工程学院新型陶瓷与精细工艺国家重点实验室北京100084

以微米MgO(AR)为主要原料,纳米SiO_2(AR)为添加剂,制备镁基陶瓷材料,旨在提高MgO陶瓷烧结性能。通过XRD和SEM等检测手段对煅烧后试样的物相组成和微观结构进行表征,重点研究添加剂SiO_2对MgO陶瓷的物相组成、结构及相对密度影响。结果表... 详细信息

以微米MgO(AR)为主要原料,纳米SiO_2(AR)为添加剂,制备镁基陶瓷材料,旨在提高MgO陶瓷烧结性能。通过XRD和SEM等检测手段对煅烧后试样的物相组成和微观结构进行表征,重点研究添加剂SiO_2对MgO陶瓷的物相组成、结构及相对密度影响。结果表明:添加SiO_2对MgO陶瓷基体起到促烧作用。随着SiO_2加入量的增加,烧后试样的相对密度和烧后线变化率呈先增大后减小趋势。加入4mol%的SiO_2,经1550℃煅烧后试样相对密度达到96.5%;引入的SiO_2与基体中的MgO生成M_2SO_4新相,同时钉扎在方镁石晶界及晶界气孔处,通过抑制方镁石相的晶界移动,进而阻碍方镁石晶粒的长大,促进了基体致密化程度。

关键词： MgO 烧结性 SiO2添加剂

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硅通孔内铜电沉积填充机理研究进展(英文)

电化学 2022年第7期28卷 7-22页

作者：孙云娜吴永进谢东东蔡涵王艳丁桂甫上海交通大学微米纳米加工技术国家级重点实验室中国上海200240 上海交通大学电子信息与电气工程学院中国上海200240

上海交通大学多元兼容集成制造技术团队针对TSV互连的深孔填充电镀难题,借助有限元软件和任意拉格朗日-欧拉算法,完成了方程组的数值解算,实现了TSV填充模式的数值仿真。利用有限元和任意拉格朗日-欧拉算法分析了盲孔的填充机制,通孔的... 详细信息

上海交通大学多元兼容集成制造技术团队针对TSV互连的深孔填充电镀难题,借助有限元软件和任意拉格朗日-欧拉算法,完成了方程组的数值解算,实现了TSV填充模式的数值仿真。利用有限元和任意拉格朗日-欧拉算法分析了盲孔的填充机制,通孔的蝴蝶形式的电镀填充过程,以及不同深宽比孔的同时填充模式,并利用仿真数据进行了样品的研制及参数优化。分析了电镀的电流密度和热处理温度对电镀填充TSV-Cu的力学属性的影响。通过原位压缩试验研究了电流密度对TSV-Cu的力学性能和显微组织的影响。利用单轴薄膜拉伸试验分析了热处理工艺对TSV-Cu材料属性的影响。结果表明,随着热处理温度的升高,TSV-Cu的断裂强度和屈服强度明显下降,杨氏模量呈波纹状变化但变化趋势缓慢。基于上述研究结果,研究了热失配应力所导致的互连结构热变形机制,通过自主搭建的原位测试系统,实时观测TSV-Cu随温度变化而产生的变形大小,以研究影响TSV-Cu互连热应力应变的规律。结果表明,TSV-Cu的热变形过程分为弹性变形阶段、类塑性强化阶段以及塑性变形阶段。

关键词：硅通孔数值模拟铜电沉积机理任意拉格朗日-欧拉 2.5D转接板

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Multi-layer multi-pass friction rolling additive manufacturing of Al alloy:Toward complex large-scale high-performance components

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 425-438页

作者： Haibin Liu Run Hou Chenghao Wu Ruishan xie Shujun Chen College of Mechanical&Energy Engineering Beijing University of TechnologyBeijing 100124China Chongqing Research Institute of Beijing University of Technology Chongqing 401121China

At present,the emerging solid-phase friction-based additive manufacturing technology,including friction rolling additive man-ufacturing(FRAM),can only manufacture simple single-pass *** this study,multi-layer multi-pass FRAM-deposited alumin-um alloy samples were successfully prepared using a non-shoulder tool *** material flow behavior and microstructure of the over-lapped zone between adjacent layers and passes during multi-layer multi-pass FRAM deposition were studied using the hybrid 6061 and 5052 aluminum *** results showed that a mechanical interlocking structure was formed between the adjacent layers and the adja-cent passes in the overlapped center *** friction and rolling of the tool head led to different degrees of lateral flow and plastic deformation of the materials in the overlapped zone,which made the recrystallization degree in the left and right edge zones of the over-lapped zone the highest,followed by the overlapped center zone and the non-overlapped *** tensile strength of the overlapped zone exceeded 90%of that of the single-pass deposition *** is proved that although there are uneven grooves on the surface of the over-lapping area during multi-layer and multi-pass deposition,they can be filled by the flow of materials during the deposition of the next lay-er,thus ensuring the dense microstructure and excellent mechanical properties of the overlapping *** multi-layer multi-pass FRAM deposition overcomes the limitation of deposition width and lays the foundation for the future deposition of large-scale high-performance components.

关键词： aluminum alloy additive manufacturing solid-state friction stir welding multi-layer multi-pass

Superhydrophobic and corrosion-resistant siloxane-modified MgAl-LDHs coatings on magnesium alloy prepared under mild conditions

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 450-463页

作者： Wenxi Zhang Zhangzelong Zhuo Dan Xu Liang Wu Zhihui xie Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province College of Chemistry and Chemical EngineeringChina West Normal UniversityNanchong 637002China College of Materials Science and Engineering/National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China

We have developed a superhydrophobic and corrosion-resistant LDH-W/PFDTMS composite coating on the surface of Mg *** composite comprised a tungstate-intercalated(LDH-W)underlayer that was grown at low temperature(relative to hydrothermal reaction conditions)under atmospheric pressure and an outer polysiloxane layer created from a solution containing perfluorodecyltrimethoxysilane(PFDTMS)using a simple immersion *** successful intercalation of tungstate into the LDH phase and the following formation of the polysiloxane layer were confirmed through X-ray diffraction(XRD),Fourier transform infrared(FTIR)spectroscopy,and X-ray photoelectron spectroscopy(XPS).The corrosion resistance of the LDH-W film,both before and after the PFDTMS modification,was evaluated using electrochemical impedance spectroscopy(EIS),Tafel curves,and immersion *** results showed that Mg coated with LDH-W/PFDTMS exhibited significantly enhanced corrosion protection compared to the unmodified LDHW film,with no apparent signs of corrosion after exposure to 3.5wt%NaCl solution for 15 ***,the LDH-W/PFDTMS coating demonstrated superior superhydrophobicity and self-cleaning properties against water and several common beverages,as confirmed by static contact angle and water-repellency *** results offer valuable insights into preparing superhydrophobic and corrosion-resistant LDH-based composite coatings on Mg alloy surfaces under relatively mild reaction conditions.

关键词： Mg alloy corrosion coating layered double hydroxide

AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

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Science China Life Sciences 2025年第1期 204-218页

作者： Chen Xiong Hong Ling Yingdan Huang Hanzhi dong Bangxiang xie Qian Hao Xiang Zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan University Department of Oncology Shanghai Medical CollegeFudan University Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan University Department of Oncology First Affiliated Hospital of Nanchang University Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan University Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology)Institutes of Biomedical SciencesFudan University

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1 by the WEE1 inhibitors or si RNAs induced compensatory upregulation of SLC7A11, which conferred resistance to ferroptosis. Mechanistically, AZD1775 prevented the enrichment of H3K9me3, a histone marker of transcriptional repression, on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1, thereby enhancing NRF2-mediated SLC7A11 transcription. This finding was also validated using the H3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A11 expression by activating p53, thus augmenting AZD1775-induced ferroptosis. Moreover, the combination of AZD1775 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

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Attenuation of peak ground accelerations from the great Wenchuan earthquake

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Earthquake Engineering and Engineering Vibration 2009年第2期8卷 179-188页

作者： Wang dong xie Lili Institute of Engineering Mechanics China Earthquake Administration Harbin 150080 China School of Civil Engineering and Architecture Harbin Institute of Technology Harbin 150090 China

Over 800 accelerograms recorded by 272 ground-level stations during the Wenchuan earthquake are used to analyze the influence of rupture distance, local site conditions and azimuth on peak ground accelerations （PGAs）. To achieve a better understanding of the characteristics of ground motions, the spatial distributions of the EW, NS and UD components of PGAs are obtained. Comparisons between the EW and NS components, the fault-normal and fault-parallel components, and the vertical and horizontal components of PGAs are performed, and the regression formula of the vertical-to-horizontal ratio of PGAs is developed. The attenuation relationship of peak horizontal accelerations （PHAs） is compared with several contemporary attenuation relationships. In addition, an analysis of residuals is conducted to identify the potential effects of rupture distance, azimuth and site conditions on the observed values of PHAs. The analysis focuses on medium-hard soil site conditions, as they provided most of the data used in this study.

关键词： Wenchuan earthquake peak ground acceleration (PGA) attenuation rupture distance azimuth

Unraveling the significance of cobalt on transformation kinetics,crystallography and impact toughness in high-strength steels

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 380-390页

作者： Yishuang Yu Jingxiao Zhao Xuelin Wang Hui Guo Zhenjia xie Chengjia Shang Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China

This work reveals the significant effects of cobalt(Co)on the microstructure and impact toughness of as-quenched highstrength steels by experimental characterizations and thermo-kinetic *** results show that the Co-bearing steel exhibits finer blocks and a lower ductile-brittle transition temperature than the steel without ***,the Co-bearing steel reveals higher transformation rates at the intermediate stage with bainite volume fraction ranging from around 0.1 to *** improved impact toughness of the Co-bearing steel results from the higher dense block boundaries dominated by the V1/V2 variant ***,the addition of Co induces a larger transformation driving force and a lower bainite start temperature(BS),thereby contributing to the refinement of blocks and the increase of the V1/V2 variant *** findings would be instructive for the composition,microstructure design,and property optimization of high-strength steels.

关键词： high-strength steel cobalt transformation kinetics crystallography impact toughness