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TIPS Is Not Associated with a Higher Risk of Developing HCC in Cirrhotic Patients:A Systematic Review and Meta-analysis

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Journal of Clinical and Translational Hepatology 2019年第3期7卷 232-237页

作者： Bin Chen Long Pang Hag-Bin Chen dong-bo wu Yong-Hong Wang En-Qiang Chen Center of Infectious Diseases West China HospitalSichuan UniversityChengduChina West China School of Medicine Sichuan UniversityChengduChina Center of Infectious Diseases West China HospitalSichuan UniversityChengdu 610041China

Background and Aims:The association between portalsystemic shunt and hepatocellular carcinoma(HCC)development in patients who have cirrhosis is still *** systematic review with meta-analysis was performed to systematically clarify the potential role of portal-systemic shunt in the development of ***:The PubMed,Embase,and Cochrane Library databases were searched for potentially eligible ***-analysis with random-effects model was performed to combine the incidence rates of HCC after portal-systemic ***,seven studies were *** the present review,we mainly focused on 859 patients(365 in the transjugular intrahepatic portal-systemic shunt(TIPS)group and 494 in the non-TIPS group)from five studies to analyze incidence rates after ***:At the end of follow-up,there were 66(18%,66/365)patients who developed HCC after TIPS intervention and 63(13%,63/494)patients who developed HCC after non-TIPS *** estimates with random-effects model did not demonstrate a significant increase of incidence of HCC after TIPS(risk ratio:1.37[confidence interval(CI):0.96 to 1.97];p=0.08)compared with non-TIPS *** analyses for those patients with transplanted liver also did not detect a significant difference between the TIPS group and non-TIPS group(risk ratio:1.10[CI:0.59 to 2.07];p=0.75).Conclusions:Current evidence suggests that portal-systemic shunt is not associated with a higher risk of HCC development in cirrhotic patients.

关键词： Transjugular intrahepatic portal-systemic shunt(TIPS) Hepatocellular carcinoma(HCC) Hepatic cirrhosis Systematic review

Development of a Multiplex PCR for Diagnosis of Staphylococcus aureus, Escherichia coli and Bacillus cereus from Cows with Endometritis

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Agricultural Sciences in China 2011年第10期10卷 1624-1629页

作者： SUN dong-bo wu Rui HE Xian-jing WANG Shuang LIN Yun-cheng HAN Xu WANG Yue-qiang GUOTing-ting wu Guo-jun YANG Ke-li College of Animal Science and Veterinary Medicine Heilongjiang Bayi Agricultural University Daqing 163319 P.R.China

Staphylococcus aureus, Escherichia coli and Bacillus cereus are the major agents of cow endometritis in dairy cows. A multiplex PCR （SEB-mPCR） was established based on the conserved genes of S. aureus, E. coli and B. cereus, and the detection limits were 103, 102 and 103 CFU mL-1, respectively. SEB-mPCR could not amplify genomic DNA of pathogenic bacteria of other common bovine diseases. A total of 309 vaginal discharge samples from cows with endometritis were tested by SEB-mPCR. Of the samples, 23.95% had the three kinds of bacteria detected, 17.15% had S. aureu and E. coli, 9.39% had E. coli and B. cereus, and 9.71% had S. aureus and B. cereus. The rates of infections with S. aureus, E. coli and B. cereus were 11.35, 16.18 and 9.06%, respectively. Therefore, SEB-mPCR has a potential as a diagnosis tool for endometritis in dairy cows.

关键词： bovine endometritis multiplex PCR S. aureus E. coli B. cereus

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Stem cell transplantation for the treatment of end-stage liver disease

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World Journal of Hepatology 2018年第12期10卷 907-910页

作者： dong-bo wu En-Qiang Chen Hong Tang Center of Infectious Diseases West China Hospital of Sichuan University

The past two decades have witnessed an explosion of research and clinical application of stem cells, transforming the field of regenerative medicine. Stem cell transplantation has already been performed to treat patients with cancer,liver diseases, and various types of chronic diseases. Indeed, stem cell-based therapies are effective in many diseases, and provide novel insights into the treatment of end-stage liver disease. Several clinical trials have indicated the efficacy profiles of stem cell transplantation in patients with end-stage liver disease, including liver cirrhosis, liver failure, and liver tumors. Animal models of acute liver failure have also provided important insights into the safety,mechanisms, and efficacy of stem cell therapies. Nevertheless, excitement due to this promising field must be tempered with careful and calculated research. In particular, studies on the quality, safety, and efficacy of stem cell transplantation are needed to ensure that qualified products are tested in well-designed clinical trials and approved by governments. Therefore, further investigations are required to effectively balance the safety with the innovation of stem cell transplantation research toward the effective treatment of end-stage liver disease.

关键词： Stem cell transplantation End-stage liver disease Clinical treatment Efficacy Safety

Pronounced impact of size and shape effects on creep rupture life of a K439B superalloy combustion chamber casting simulator

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China Foundry 2025年

作者： Wen-tong Liu Yi-dong wu Lei Gao Jing-yang Chen Cheng-bo Xiao Xi-dong Hui State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing Science and Technology on Advanced High Temperature Structural Materials Laboratory Beijing Institute of Aeronautical Materials

The size and shape effect(SSE) of components has become a critical issue for mechanical properties, application reliability, and processing. In this study, the creep rupture life(CRL) of components with different wall thicknesses and positions in a combustion chamber casing simulator made of K439B superalloy was investigated. The intrinsic mechanisms of the SSE were explored from the dendrite structure, volume fraction and size of the γ' phase, and element segregation, etc. It is shown that this casting exhibits a strong SSE of creep rupture life, characterized by a significant difference in the CRL values up to 60% with the variation of wall thickness and position in the casing. In terms of casting technology, the influence of SSE on CRL is actually determined by the cooling rate. The SSE on the creep rupture life originates from the dendrite structure(such as the secondary dendrite arm spacing), volume fraction size of the γ' phase in the dendrite trunk, and elements segregation rate. This work may have implications for the design and application of engineering components with large sizes and complex structures.

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Sky location of massive black hole binaries in the foreground of Galactic white dwarf binaries

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 97-108页

作者： Pan Guo Hong-bo Jin Cong-Feng Qiao Yue-Liang wu The International Centre for Theoretical Physics Asia-Pacific University of Chinese Academy of Sciences The School of Physical Sciences University of Chinese Academy of Sciences Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University National Astronomical Observatories Chinese Academy of Sciences Institute of Theoretical Physics Chinese Academy of Sciences

For space-based gravitational wave （GW） detection,the main noise source for massive black hole binaries （MBHBs） is attributed to approximately 10～7double white dwarf binaries in the *** a GW source,the amplitude of the detector response,recorded by a space-based gravitational wave detector,exhibits a modulation effect with a year period when observing the source from various orbital *** the adverse conditions mentioned above,where there is a strong foreground noise and annual modulation in the signals,we employed the wavelet transform and the strong-amplitude relevant orbital position search methods,which allows the weak MBHB sources to achieve higher locating *** detail,for two MBHB sources of lower intensity,the precision of luminosity distance,represented by the ratio ?DL/DLat the 95%confidence level,is enhanced by factors of ～*** angular resolutions,denoted by??s,are enhanced by a factor of ～*** improvements increase the number of detectable GW sources,facilitate multi-messenger follow-up observations and provide constraints on the cosmological constant.

关键词： space-based gravitational wave detection gravitational waves massive black hole binaries

A Hybrid Approach for Pavement Crack Detection Using Mask R-CNN and Vision Transformer Model

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Computers, Materials & Continua 2025年第1期82卷 561-577页

作者： Shorouq Alshawabkeh Li wu Daojun dong Yao Cheng Liping Li Faculty of Engineering China University of GeosciencesWuhan430074China

Detecting pavement cracks is critical for road safety and infrastructure *** methods,relying on manual inspection and basic image processing,are time-consuming and prone to *** deep-learning(DL)methods automate crack detection,but many still struggle with variable crack patterns and environmental *** study aims to address these limitations by introducing the Masker Transformer,a novel hybrid deep learning model that integrates the precise localization capabilities of Mask Region-based Convolutional Neural Network(Mask R-CNN)with the global contextual awareness of Vision Transformer(ViT).The research focuses on leveraging the strengths of both architectures to enhance segmentation accuracy and adaptability across different pavement *** evaluated the performance of theMaskerTransformer against other state-of-theartmodels such asU-Net,TransformerU-Net(TransUNet),U-NetTransformer(UNETr),SwinU-NetTransformer(Swin-UNETr),You Only Look Once version 8(YoloV8),and Mask R-CNN using two benchmark datasets:Crack500 and *** findings reveal that the MaskerTransformer significantly outperforms the existing models,achieving the highest Dice SimilarityCoefficient(DSC),precision,recall,and F1-Score across both ***,the model attained a DSC of 80.04%on Crack500 and 91.37%on DeepCrack,demonstrating superior segmentation accuracy and *** high precision and recall rates further substantiate its effectiveness in real-world applications,suggesting that the Masker Transformer can serve as a robust tool for automated pavement crack detection,potentially replacing more traditional methods.

关键词： Pavement crack segmentation transportation deep learning vision transformer Mask R-CNN image segmentation

GFRF R-CNN:Object Detection Algorithm for Transmission Lines

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Computers, Materials & Continua 2025年第1期82卷 1439-1458页

作者： Xunguang Yan Wenrui Wang Fanglin Lu Hongyong Fan bo wu Jianfeng Yu Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai201210China University of Chinese Academy of Sciences Beijing100049China Jingwei Textile Machinery Co. Ltd.Beijing100176China

To maintain the reliability of power systems,routine inspections using drones equipped with advanced object detection algorithms are essential for preempting power-related *** increasing resolution of drone-captured images has posed a challenge for traditional target detection methods,especially in identifying small objects in high-resolution *** study presents an enhanced object detection algorithm based on the Faster Regionbased Convolutional Neural Network(Faster R-CNN)framework,specifically tailored for detecting small-scale electrical components like insulators,shock hammers,and screws in transmission *** algorithm features an improved backbone network for Faster R-CNN,which significantly boosts the feature extraction network’s ability to detect fine *** Region Proposal Network is optimized using a method of guided feature refinement(GFR),which achieves a balance between accuracy and *** incorporation of Generalized Intersection over Union(GIOU)and Region of Interest(ROI)Align further refines themodel’s *** results demonstrate a notable improvement in mean Average Precision,reaching 89.3%,an 11.1%increase compared to the standard Faster *** highlights the effectiveness of the proposed algorithm in identifying electrical components in high-resolution aerial images.

关键词： Faster R-CNN transmission line object detection GIOU GFR

Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan Chen Xiu-Qing Qiao Guo Hui bojing Sun dongfang Hou Meidi Wang Xueqian wu Tao wu dong-Sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Cadmium sulfide

Deep learning identification of novel autophagic protein-protein interactions and experimental validation of Beclin 2-Ubiquilin 1 axis in triple-negative breast cancer

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Oncology Research 2025年第1期33卷 67-81页

作者： XIANG LI WENKE JIN LIFENG wu HUAN WANG XIN XIE WEI HUANG bo LIU State Key Laboratory of Southwestern Chinese Medicine Resources School of Pharmacy and College of Medical TechnologyChengdu University of Traditional Chinese MedicineChengdu611137China Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu610041China

Background:Triple-negative breast cancer(TNBC),characterized by its lack of traditional hormone receptors and HER2,presents a significant challenge in oncology due to its poor response to conventional *** is an important process for maintaining cellular homeostasis,and there are currently autophagy biomarkers that play an effective role in the clinical treatment of *** contrast to targeting protein activity,intervention with proteinprotein interaction(PPI)can avoid unrelated crosstalk and regulate the autophagy process with minimal interference ***:Here,we employed Naive Bayes,Decision Tree,and k-Nearest Neighbors to elucidate the complex PPI network associated with autophagy in TNBC,aiming to uncover novel therapeutic ***,the candidate proteins interacting with Beclin 2 were initially screened in MDA-MB-231 cells using Beclin 2 as bait protein by immunoprecipitation-mass spectrometry assay,and the interaction relationship was verified by molecular docking and CO-IP experiments after *** formation,cellular immunofluorescence,cell scratch and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)tests were used to predict the clinical therapeutic effects of manipulating candidate ***:By developing three PPI classification models and analyzing over 13,000 datasets,we identified 3733 previously unknown autophagy-related *** network analysis revealed the central role of Beclin 2 in autophagy regulation,uncovering its interactions with 39 newly identified ***,the CO-IP studies identified the substantial interaction between Beclin 2 and Ubiquilin 1,which was anticipated by our model and discovered in immunoprecipitation-mass spectrometry assay ***,in vitro investigations showed that overexpressing Beclin 2 increased Ubiquilin 1,promoted autophagy-dependent cell death,and inhibited proliferation and metastasis in MDA-MB-231 ***:This study not

关键词： Triple-negative breast cancer(TNBC) Autophagy Protein-protein interactions(PPI) Artificial intelligence(AI) Beclin 2 Ubiquilin 1