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BIOCOMPATIBILITY OF A PDMS-COATED MICRO-DEVICE:BLADDER VOLUME MONITORING SENSOR

Chinese Journal of Polymer Science 2012年第2期30卷 242-249页

作者： dong Sup Lee Su Jin Kim Jun Ho sohn In Gul Kim Sae Woong Kim dong wan sohn Jong Hyun Kim Bumkyoo Choi Department of Urology St.Vincent's HospitalCollege of Medicinethe Catholic University of KoreaSuwonKorea Department of Urology Seoul St.Mary's HospitalCollege of Medicinethe Catholic University of KoreaSeoulKorea Department of Urology Yeouido St.Mary's HospitalCollege of Medicinethe Catholic University of KoreaSeoulKorea Department of Mechanical Engineering Sogang UniversitySeoulKorea

We evaluated the biocompatibility of a dimethylpolysiloxane-coated micro-device which had been designed for monitoring real-time bladder volume in previous studies. The extract assay with dimethylpolysiloxane which had been used for coating the micro-device to measure the bladder volume was performed as an in vitro cytotoxicity test. For in vivo biocompatibility testing, the inflammatory responses around the implantation site of the micro-device in subcutaneous tissue of rat were assessed by light microscope with H＆E stain and fluorescence microscope with ED1 stain and von Willebrand factor stain. The averages of cell viability in dimethylpolysiloxane group were 84.6% and 82.3% at 24 h and 72 h incubation, respectively. The qualitative evaluations with light and fluorescence microscope revealed that the inflammatory changes peaked during 2 weeks but almost disappeared at 4 weeks after implantation of devices. The quantitative evaluations for granulation layer formation and neovascularization showed that the thickness of the layer in dimethylpolysiloxane group peaked during 2 weeks but it came to be stabilized at 4 weeks as thin as at 2 weeks in control group, and the frequency of neovascularization was higher in dimethylpolysiloxane group than in control group but it was not increased with time. The dimethylpolysiloxane-coated micro-device is thought be a reliable bio-medical device.

关键词： Dimethylpolysiloxane Devices Biocompatibility testing.

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Improvement of erectile function by Korean red ginseng （Panax ginseng） in a male rat model of metabolic syndrome

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Asian Journal of Andrology 2013年第3期15卷 395-399页

作者： Sung-Dae Kim Young-Joo Kim Jung-Sik Huh Sae-Woong Kim dong-wan sohn Department of Urology School of Medicine Jeju National University Jeju 690767 Korea Department of Urology College of Medicine The Catholic University of Korea Seoul 150713 Korea

The seriousness of metabolic syndrome is not due to the disease itself but its promotion of other diseases, such as erectile dysfunction and cardiovascular and cerebrovascular diseases. We investigated the effects of Korean red ginseng （KRG, Panax ginseng） extract on erectile function in a rat model of metabolic syndrome. We divided the rats into three groups： control, metabolic syndrome＋normal saline （N/S） and metabolic syndrome ＋ KRG. To determine the occurrence of metabolic syndrome in all groups, body weight and various biochemical parameters （e.g., blood glucose, insulin, cholesterol） were measured, and the intra-abdominal glucose tolerance test was performed. To investigate penile erection, the peak intracavernosal pressure （ICP）, mean arterial pressure （MAP） and Masson＇s trichrome stain were evaluated. Erectile function was also investigated by measuring the cyclic guanosine monophosphate （cGMP） levels of the corpus cavernosum. We found that the various biochemical parameters and body weight were similar in the metabolic syndrome＋KRG group and the control group, although the values were slightly higher. The peak ICP/MAP ratio of the metabolic syndrome＋N/S group was markedly decreased compared to the other groups. The cGMP level of the corpus cavernosum in the metabolic syndrome＋N/S group was significantly lower than that of the other groups. As demonstrated in this model of metabolic syndrome with erectile dysfunction, KRG may improve erectile function.

关键词： erectile dysfunction ginseng metabolic syndrome penis

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Anti-inflammatory and Antimicrobial Effects of Anthocyanin Extracted from Black Soybean on Chronic Bacterial Prostatitis Rat Model

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Chinese Journal of Integrative Medicine 2018年第8期24卷 621-626页

作者： Byung Il Yoon Woong Jin Bae Yong Sun Choi Su Jin Kim U Syn Ha Sung-Hoo Hong dong wan sohn Sae Woong Kim Department of Urology International St Mary's HospitalThe Catholic Kwandong University of Korea Department of Urology College of MedicineThe Catholic University of Korea

Objective： To investigated the anti-inflammatory and antimicrobial effects of anthocyanins extracted from black soybean on the chronic bacterial prostatitis（CBP） rat ***： The SpragueDawley rats were divided into 4 groups,including control,ciprofloxacin,anthocyanins and anthocyanins with ciprofloxacin groups（n=8 in each group）.Then,drip infusion of bacterial suspension（Escherichia coli Z17O2：K1：H^-） into Sprague-Dawley rats was conducted to induce *** 4 weeks,results of prostate tissue,urine culture,and histological analysis on the prostate were analyzed for each ***： The use of ciprofloxacin,anthocyanins,and anthocyanins with ciprofloxacin showed statistically significant decreases in bacterial growth and improvements in the reduction of prostatic inflammation compared with the control group（P〈0.05）.The anthocyanins with ciprofloxacin group showed a statistically significant decrease in bacterial growth and improvement in prostatic inflammation compared with the ciprofloxacin group（P〈0.05）.Conclusions： These results suggest that anthocyanins may have anti-inflammatory and antimicrobial effects,as well as a synergistic effect with ***,we suggest that the combination of anthocyanins and ciprofloxacin may be effective in treating CBP to obtain a higher rate of treatment success.

关键词： prostatitis anti-bacterial agents anthocyanins

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Aligned Ion Conduction Pathway of Polyrotaxane‑Based Electrolyte with Dispersed Hydrophobic Chains for Solid‑State Lithium–Oxygen Batteries

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Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram Kim Myeong‑Chang Sung Gwang‑Hee Lee Byoungjoon Hwang Sojung Seo Ji‑Hun Seo dong‑wan Kim Department of Materials Science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea School of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials Science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves ***-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： Solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity Hydrophobic chain

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Synthesis and Rheological Investigation of Model Symmetric 3-Arm Star Polyethylene

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Chinese Journal of Polymer Science 2014年第1期32卷 51-63页

作者： Feng Liu dong wan 唐涛 State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of Sciences Graduate School of the Chinese Academy of Sciences

A variety of linear and 3-arm star polyethylene （PE） model polymers covering a wide range of molecular weight are synthesized by the living polymerization of butadiene and the subsequent hydrogenation. Several rheological parameters of these model linear and 3-arm star PE samples are analyzed for detecting the long chain branching （LCB） structure. It is found that the analyses based on zero shear viscosity, vGP plot and flow activation energy are very sensitive to the 3-arm star PEs. The information on the presence of LCB can be obtained with these methods even for low molecular weight samples, which can not be determined by GPC-MALLS. However the information about the LCB structure can not be obtained by the rheological methods alone.

关键词： Long chain branching Rheology Star polymers Polyethylene Thermorheology.

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Provenance of upper Permian-lowermost Triassic sandstones, Wutonggou low-order cycle, Bogda Mountains, NW China:implications on the unroofing history of the Eastern North Tianshan Suture

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Journal of Palaeogeography 2020年第3期9卷 314-334页

作者： dong-Yu Zheng wan Yang Geology and Geophysics Program Missouri University of Science and TechnologyRollaMO 65409USA

This study investigates the provenance of sedimentary rocks in Bogda Mountains, NW China, and reconstructs the lithology and unroofing history of the Eastern North Tianshan Suture. Petrographic point counting data of sandstones and compositions of conglomerates of upper Permian-lowermost Triassic Wutonggou low-order cycle from Zhaobishan, North Tarlong, Taodonggou, and Dalongkou sections in the southern and northern foothills of Bogda Mountains were used to interpret the temporal and spatial variations of lithology of the Eastern North Tianshan Suture, which is the sediment source area. Three compositional trends were identified. A trend of upwardincreasing quartz content and granitic pebbles in Zhaobishan section suggests a change from the undissected volcanic arc, accretionary wedge and trench setting to predominantly transitional volcanic arc and subordinate accretionary wedge and trench, in the eastern part of the Eastern North Tianshan Suture. In North Tarlong and Taodonggou sections, however, the lithic content decreases and the contents of quartz and granitic pebbles increase up sections. These trends indicate that the western part of the Eastern North Tianshan Suture changed from an undissected volcanic arc to the transitional volcanic arc, accretionary wedge and trench. No clear trend in the lithic-rich sandstones of the Dalongkou section indicates that sediments were derived from the undissected volcanic arc in the Eastern North Tianshan Suture and local rift shoulders. Compositional variations of studied rocks suggest that the Eastern North Tianshan Suture was an amalgamated complex with great spatial and temporal heterogeneities in lithology and experienced persistent unroofing during late Permian-earliest Triassic. This study reconstructs a key element of the Chinese Tianshan Suture and serves as an example to understand the unroofing processes of ancient sutures.

关键词： Provenance Wutonggou low-order cycle Bogda Mountains Unroofing Eastern North Tianshan Suture NW China

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Method for assessing the similarity and distance between curves/trials and its applications in gait analysis

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仪器仪表学报 2008年第10期29卷 2017-2023页

作者： wang Weijie Ming dong wan Baikun Institute of Motion Analysis and Research Department of Orthopedic and Trauma Surgery Ninewells Medical School the University of Dundee Dundee DD1 9SY United Kingdom Department of Biomedical Engineering College of Precision Instruments and Optoelectronics Engineering Tianfin University Tianjin 300072 China The Collage of Physical Education and Sport Science Suzhou University Suzhou 215006 China

In clinical assessment or sports exercise,it is common that a subject is required to repeat a specific per- formance so that a stable movement pattern is obtained and *** practice,however,the trials done by a sub- ject vary more or less,depending on the psychological or physical *** of the trials can be used as rep- resentatives of the stable movement pattern,and some ***,there is a demand for a new method to identify which trials/curves are *** traditional methods used to assess curve similarity are not perfectly suitable for the case where there are only a few of trials *** study proposes a similarity-distance coefficient to assess the similarity of curves/trials.A group of designed curves are used to validate the *** results show that given joint kinematic data during gait as examples,the proposed coefficient can be used to quantitatively evaluate the similarity of trials,and thus find which trials would be representative (s) for the gait *** proposed method could be applied in various situations where repeat movements have to be measured and analysed.

关键词：曲线相似性模拟技术测量方法

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EFFECT OF A MOVING BOUNDARY ON THE FLUID TRANSIENT FLOW IN LOW PERMEABILITY RESERVOIRS

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Journal of Hydrodynamics 2012年第3期24卷 391-398页

作者： LUO wan-Jing wanG Xiao-dong School of Energy Resources China University of Geosciences Beijing 100083 China

In a low permeability reservoir, the existence of a moving boundary is considered in the study of the transient porous flow with threshold pressure gradient. The transmission of the moving boundary directly indicates the size of the drainage area as well as the apparent influences on the pressure behavior. The nonlinear transient flow mathematical model in which the threshold pressure gradient and the moving boundary are incorporated is solved by advanced mathematical methods. This paper presents some new analytical solutions describing the pressure distribution at a constant rate and the production decline in a constant pressure production with the boundary propagation. It is shown that the greater the threshold pressure gradient, the slower the transmission of the moving boundary, the larger the pressure loss will be, and there is no radial flow in the middle and later phases of the wellface pressure for a well at a constant rate. We have the the maximum moving boundary at a specific drawdown pressure for a low permeability reservoir The greater the threshold pressure gradient, the smaller the maximum moving boundary distance, the quicker the production decline for a well in a constant pressure production will be. The type curve charts for the modern well test analysis and the rate transient analysis with a moving boundary are obtained and the field test and the production data are interpreted as examples to illustrate how to use our new results.

关键词： threshold pressure gradient moving boundary well test analysis low permeability reservoir rate transient analysis

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Analysis and Prevention for Oscillation Failure of Capacitive Micro-accelerometers

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Chinese Journal of Mechanical Engineering 2010年第3期23卷 336-345页

作者： wan Caixin dong Jingxin HAN Fengtian State Key Laboratory of Precision Measurement Technology and Instruments Tsinghua University Beijing 100084 China

As actuator of the force-rebalanced servo loop, the electrostatic force generator of the micro-accelerometer shows high nonlinearity while the interpole of the micro-electro-mechanical system（MEMS） sensor is far away from its balance position. The control system cannot rebalance itself with the limited bandwidth after an external long overload, because the characteristics of the force generator differ from normal case. Although for similar problems, solutions with cascading lead-lag blocks, with the anti-windup（AW） technology, or with the sliding-mode control, are widely reported, the problems such as performance loss or difficulty to synthesize a digital controller still remain. Based on existing researches, remedies are developed by analyzing the characteristic of the system not only near the balance position, but also corresponding to the whole moveable range of the interpole, and a new controller is proposed. The solution is compared with the common solutions of cascading lead-lag blocks method, AW methods, and sliding mode methods. Comparison results show that the proposed solution avoid performance loss, compared to cascading lead-lag blocks solution; the proposed solution is easily synthesized and implemented in the analog servo loop of the micro-accelerometer, compared to digital AW methods; at the same time, the proposed solution avoids suffering the chattering effect problem but just utilize it, compared to the sliding-mode control solution. Nevertheless, comparison results show the solution is lack of commonality, since the solution is only more suitable to micro electrostatic force-rebalance system. The SIMULINK models with and without the proposed solution, taking typical micro-accelerometer parameters, have been set up for simulation; corresponding experiments utilizing electrometric method are also conducted after the successful simulations. Simulation and experiment results verify that the micro-accelerometer will reliably return to normal operati

关键词： variable structure systems micro-electro-mechanical system acceleration measurement oscillation failure

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Template synthesis of imine-based covalent organic framework core-shell structure and hollow sphere:a case of COFTTA-DHTA

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Science China Chemistry 2017年第8期60卷 1098-1102页

作者： Sun,Bing wang,dong wan,Lijun Key Laboratory of Molecular Nanostructure and Nanotechnology Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China

Controllably synthesizing well-dispersed covalent organic frameworks （COFs） with uniform both morphology and size is still a challenge. Herein, we report the template-directed synthesis of ***-based core-shell hybrids under solvothermal conditions by using amino-functionalized SiO2 microspheres as templates coupled with stepwise addition of initial monomer molecules. The modified amino groups on the surfaces of SiO2 templates play an important role in the formation of well-defined NH2-f-SiO2@COFTTA-DHXA core-shell hybrids. COFTTA-DHTA hollow spheres can be obtained by etching SiO2 cores of NH2-f-SiO2@COFTTA-DHTA. Both the NH2-f-SiO2@COFTTA-I）HTA and COFxTA-DHVA hollow spheres possess the well-defined morphology, high crystallinity and porosity, excellent dispersion property and high chemical stability. The template synthesis method demonstrated in this work provides a general method for the shape-controlled synthesis of COF-based materials, which is important for the further applications in the fields such as energy storage, drug delivery and catalysis.

关键词： covalent organic framework template synthesis organic porous material core-shell structure hollow sphere

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