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Nano Research 2013年第5期6卷 348-355页

作者： Chan Woo Lee Seung-Deok Seo dong Wook Kim Sangbaek Park Kyoungsuk Jin dong-wan Kim Kug Sun Hong DepartmentofMatefials Science andEngineering Seoul National University Seou1151-744 Korea WCU Hybrid Materials Program Department of Materials Science and Engineering Seoul National University Seou1151-744 Korea Department of Material Science and Engineering Ajou University Suwon 443-749 Korea Department of Chemistry Northwestern University 245 Sheridan Road Evanston IL 60208 USA

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秦山核电操作人员取照考核情况及管理建议

中国核电 2022年第5期15卷 660-665页

作者：李冬婉中核核电运行管理有限公司浙江海盐314300

近年来,核电厂操作人员人才培养的逐步完善为各核电厂的安全稳定运行发展做出了重大贡献,但核电厂操作人员取照考核的通过率呈现出明显的波动状态,核电厂操作人员的个人素质及能力将直接影响到核电厂的运行安全。论文通过分析2015—201... 详细信息

近年来,核电厂操作人员人才培养的逐步完善为各核电厂的安全稳定运行发展做出了重大贡献,但核电厂操作人员取照考核的通过率呈现出明显的波动状态,核电厂操作人员的个人素质及能力将直接影响到核电厂的运行安全。论文通过分析2015—2019年中核运行取照考核的情况,对取照考核相关问题进行探讨,寻找影响核电厂操作人员考核成绩的因素,并最终结合2015—2019年操作人员取照考核情况以及电厂实际情况对操作员和高级操作员取照候选人及核电厂人力资源、运行、培训部门提出相应建议。

关键词：核电厂操作人员取照考核

Targeting PKM2 signaling cascade with salvianic acid A normalizes tumor blood vessels to facilitate chemotherapeutic drug delivery

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2077-2096页

作者： Cheng Qian Yueke Zhou Teng Zhang Guanglu dong Mengyao Song Yu Tang Zhonghong Wei Suyun Yu Qiuhong Shen Wenxing Chen Jaesung P.Choi Juming Yan Chongjin Zhong Li wan Jia Li Aiyun wang Yin Lu Yang Zhao Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China School of Medicine&Holistic Integrative Medicine Nanjing University of Chinese MedicineNanjing 210023China Centre for Inflammation Faculty of ScienceCentenary InstituteSchool of Life SciencesUniversity of Technology SydneySydney NSW 2050Australia Jiangsu Key Laboratory of Immunity and Metabolism Department of Pathogenic Biology and ImmunologyNational Experimental Demonstration Center for Basic Medicine EducationXuzhou Laboratory of Infection and ImmunityXuzhou Medical UniversityXuzhou 221004China Department of General Surgery Jiangsu Province Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029China Macquarie Medical School Faculty of MedicineHuman Health SciencesMacquarie UniversitySydney NSW 2109Australia

Aberrant tumor blood vessels are prone to propel the malignant progression of tumors,and targeting abnormal metabolism of tumor endothelial cells emerges as a promising option to achieve vascular normalization and antagonize tumor progression.Herein,we demonstrated that salvianic acid A(SAA)played a pivotal role in contributing to vascular normalization in the tumor-bearing mice,thereby improving delivery and effectiveness of the chemotherapeutic agent.SAA was capable of inhibiting glycolysis and strengthening endothelial junctions in the human umbilical vein endothelial cells(HUVECs)exposed to hypoxia.Mechanistically,SAA was inclined to directly bind to the glycolytic enzyme PKM2,leading to a dramatic decrease in endothelial glycolysis.More importantly,SAA improved the endothelial integrity via activating theβ-Catenin/Claudin-5 signaling axis in a PKM2-dependent manner.Our findings suggest that SAA may serve as a potent agent for inducing tumor vascular normalization.

关键词： Salvianic acid A Tumor vascular normalization PKM2 β-Catenin Claudin-5 Endothelial glycolysis Tight junctions Doxorubicin

Investigation on the surface active sites variation of mineral dusts

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Journal of Central South University 2001年第3期13卷 169-174页

作者： dong Fa-qin, wan Pu, FENG Qi-ming, SONG Gong-bao, PENG Tong-jiang (Institute of Mineral Materials and Applications, Southwest University of Science and Technology, Mianyang 621002, China) Institute of Mineral Materials and Applications Southwest University of Science and Technology Mianyang China

The paper analyzed the groups naked and the transformed of fibro us brucite, wollastonite, chrysotile asbestos, sepiolite, palygorskite, clinopti lolite, crocidolite and diatomaceous earth mineral dusts by using IR under acid and alkali etched, strong mechanical and polarized molecular interaction. The re sults show that the active site focuses on ends in stick dusts and on defects or hole edges in pipe dusts. The inside active sites of dusts play the main role i n small molecular substance. The shape of dusts affects their distributions and densities of active sites. The strong mechanical and weak chemical force make th e active site feature of minerals change, the powder process brings about more n aked surface groups and more combined types. The dust activity relates to the ty pe, contribution, and naked level of surface groups. The studied dust surface gr oups are mainly as follows: OH -, Mg(OH) -, Si-O-Si, Ca-O-Si, -Mg-O H 2, -Al(Si)-OH,-Mg(Ca)-OH 2,Ca-O, -Si...OH, Mg(Fe)-OH. Due to the diffe rence of surface composition and structure, the minerals have a large disparity on activity and character of surface groups. The one side surface group of chrys otile layer is the same as fibrous brucite and stripped layer with more naked gr oup. The fibrous sepiolite and palygorskite surface OH - similar to crocidolit e is naked with their surface structural defects and cleavage. The more deve lopm ent of mineral defects, the higher of OH -(H 2O +)content, the main H 2O + of clinoptilolite is partly transformed into H +, NH + 4 or OH -. The acid etched process may change OH - concentration, distribution and increase the de fects and porosity of mineral fiber surface. The alkali etched has no effect on Si-O, Si-OH etc. and destroyed Al-O,Al-OH - acid site of sepiolite, palygo rskite and clinoptilolite. Some surface groups of remnant differ from original d usts. The surface process of small polarized molecular or middle moleular′s bra nch may produce ionation and new coordinate bond, and change the active properti es and

关键词： mineral dusts surface group active site

Biocompatible custom ceria nanoparticles against reactive oxygen species resolve acute inflammatory reaction after intracerebral hemorrhage

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Nano Research 2017年第8期10卷 2743-2760页

作者： dong-wan Kang Chi Kyung Kim Han-Gil Jeong Min Soh Taeho Kim In-Young Choi SeuI-Ki Ki Do Yeon Kim Wookjin Yang Taeghwan Hyeon Seung-Hoon Lee Laboratory of Innovative Nanobiotechnology Biomedical Research Institute Seoul National University Hospital Seoul 03080 Republic of Korea Department of Neurology Seoul National University Hospital Seou103080 Republic of Korea Department of Neurology Korea University Guro Hospital and Korea University College of Medicine Seou108308 Republic of Korea Center for Nanoparticle Research Institute for Basic Science (IBS) Seoul 151-742 Republic of Korea School of Chemical and Biological Engineering and Institute of Chemical Processes Seoul National University Seoul 151-742 Republic of Korea

Intracerebral hemorrhage （ICH） is a devastating subtype of stroke with a high mortality rate, for which there currently is no effective treatment. A perihematomal edema caused by an intense inflammatory reaction is more deleterious than the hematoma itself and can result in neurological deterioration and death. Ceria nanoparticles （CeNPs） are potent free radical scavengers with potential for biomedical applications. As oxidative stress plays a major role in post-ICH inflammation, we hypothesized that CeNPs might protect against ICH. To test this hypothesis, core CeNPs were synthesized using a modified reverse micelle method and covered with phospholipid-polyethylene glycol （PEG） to achieve biocompatibility. We investigated whether our custom-made biocompatible CeNPs have protective effects against ICH. The CeNPs reduced oxidative stress, hemin-induced cytotoxicity, and inflammation in vitro. In a rodent ICH model, intravenously administered CeNPs were mainly distributed in the hemorrhagic hemisphere, suggesting that they could diffuse through the damaged blood-brain barrier. Moreover, CeNPs attenuated microglia/macrophage recruitment around the hemorrhagic lesion and inflammatory protein expression. Finally, CeNP treatment reduced the brain edema by 68.4% as compared to the control. These results reveal the great potential of CeNPs as a novel therapeutic agent for patients with ICH.

关键词： ceria nanoparticles intracerebral hemorrhage free radical injury anti-inflammation neuroprotective agents biomedical application

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城镇污水处理厂生化池与补水口泡沫特征比较

中国环境科学 2023年第11期43卷 5737-5745页

作者：王方舒郭佳李佶成杨传玺马英姿董晓婉陈栋青岛理工大学环境与市政工程学院山东青岛266525 青岛李村河水务有限公司山东青岛266001 珲春市住房和城乡建设局吉林珲春133300

选取青岛市某污水处理厂好氧池(H)、MBR池(M)以及生态补水排水口处(B)三个点位的泡沫混合液,从水质指标、有机组分、微生物群落结构三方面综合分析上述点位的泡沫特征差异,结果表明:在水质指标上,与H、M相比,B点位泡沫混合液的TOC、TN... 详细信息

选取青岛市某污水处理厂好氧池(H)、MBR池(M)以及生态补水排水口处(B)三个点位的泡沫混合液,从水质指标、有机组分、微生物群落结构三方面综合分析上述点位的泡沫特征差异,结果表明:在水质指标上,与H、M相比,B点位泡沫混合液的TOC、TN、蛋白质、UV254、溶解氧浓度显著升高,而表面张力和粘度有所降低.在有机组分上,与H、M相比,B点位泡沫混合液的烷烃类、脂肪酸类物质丰度显著增高,BFK丰度显著降低;三个点位主要有机组分均是蛋白质,且匹配度较高的物质均是Mucin和Nisin,B点位富里酸类腐殖质占比有所升高,蛋白质有所下降.推测,H、M两个点位中,BFK是主要起泡剂,疏水性蛋白质、富里酸类腐殖质是主要稳泡剂;B点位,LCFAs是主要的起泡剂,烷烃类、疏水性蛋白质、富里酸类腐殖质是主要稳泡剂.在微生物群落结构上,与H、M相比,B点位微生物群落结构发生显著变化,在门水平上,B点位Proteobacteria占比高达97.27%,而H、M点位则以Actinobacteriota为主,占比分别为58.5%、47.9%;在属水平上,B点位丰度较高的主要有g_unclassified_Acidovorax、s_uncultured_g_Undibacterium、Pseudomonas,而H、M点位则主要有Skermania、Candidatus Microthrix.

关键词：污水处理生化池补水口泡沫特征

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高适应性下肢外骨骼机器人的结构设计与分析

机械设计 2023年第1期40卷 77-87页

作者：丛佩超龙耀祖万东宝广西科技大学机械与汽车工程学院广西柳州545616

针对当前下肢外骨骼机器人适用范围有限及舒适性较差等问题,文中设计了一款具有高适应性的下肢外骨骼机器人,实现了腿部长度的连续调节;基于不同支撑周期内的系统受力状态,并综合考虑地面反力和人体驱动力影响,利用D-H参数法、拉格朗日... 详细信息

针对当前下肢外骨骼机器人适用范围有限及舒适性较差等问题,文中设计了一款具有高适应性的下肢外骨骼机器人,实现了腿部长度的连续调节;基于不同支撑周期内的系统受力状态,并综合考虑地面反力和人体驱动力影响,利用D-H参数法、拉格朗日方程建立了下肢外骨骼机器人的运动学与动力学模型;运用三角函数样条插值法对步态采集仪收集的人体步态数据进行优化,得到了髋、膝、踝各关节间的运动关系;对文中设计的下肢外骨骼机器人进行了动力学仿真,得到了其相应的关节角度变化、足底受力及系统运动状态,上述仿真结果验证了文中设计方案的有效性,并为后续驱动电机选型及控制系统设计提供实验依据。

关键词：下肢外骨骼机器人高适应性步态规划 ADAMS 动力学仿真

PHASE BOUNDARY OF α_2 PRECIPITATION IN Ti-Al-La TERNARY SYSTEM

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Acta Metallurgica Sinica(English Letters) 1989年第1期2卷 69-72页

作者： YA NG Rui LI dong wan Xiaojing Institute of Metal Research,Academia Sinica,Shenyang,China

The phase boundary,of α_2 precipitation at 600℃ in Ti-AI-La ternary system has been de- termined by TEM examination,which shows three kinds of phase regions,namely the single α phase region,the transitional phase region where there is superlattice reflection but no α_2 precipitation,and the α+α_2 region.A point of maximum aluminium content was found to exist on the α/(α+α_2)boundary and the track of the boundary was explained in terms of the internal oxidation of lanthanum and the electron concentration rule for α_2 formation.

关键词： ternary system Ti-Al-La phase boundary α_2 precipitation internal oxidation electron concentration

Anti-quorum sensing and anti-biofilm formation activities of plant extracts from South Korea

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Asian Pacific Journal of Tropical Biomedicine 2018年第8期8卷 411-417页

作者： Okhee Choi dong-wan Kang Su Kyung Cho Yeyeong Lee Byeongsam Kang Juyoung Bae Seunghoe Kim Jeong Hoon Lee Seung Eun Lee Jinwoo Kim Institute of Agriculture & Life Science Gyeongsang National University Gyeonsangnam-do Agriculture Extension Services Department of Plant Medicine Gyeongsang National University Division of Applied Life Science Gyeongsang National University National Institute of Horticultural and Herbal Science Rural Development Administration

Objective: To investigate anti-quorum sensing(anti-QS) and anti-biofilm formation(antiBF) activities of the ethanol extracts of 388 plants. Methods: The anti-QS activity of the plant extracts was evaluated by disc-diffusion assays using the bio-reporter strain, Chromobacterium violaceum CV017. Pseudomonas aeruginosa PAO1, Yersinia enterocolitica ATCC 9610, and Agrobacterium tumefaciens C58, which possess QS systems, were used to evaluate the antiBF activity of the plant extracts. Results: Among 388 plant extracts, the Cornus controversa(C. controversa) and Cynanchum wilfordii extracts exhibited the strongest anti-QS activity. The C. controversa extract exhibited anti-BF activity against Pseudomonas aeruginosa, Yersinia enterocolitica and Agrobacterium tumefaciens, whereas the Cynanchum wilfordii extract exhibited no anti-BF activity against Pseudomonas aeruginosa. In addition, the C. controversa extract suppressed soft rot of cabbage. Conclusions: The C. controversa extract inhibits bacterial QS and BF, and is capable of controlling soft rot. Therefore, this extract has potential for the prevention and treatment of bacterial infections and for the development of alternatives to antibiotics.

关键词： Plant extracts Quorum sensing Biofilm formation Cornus controversa

Time-resolved Spectral Properties of Fermi-GBM Bright Long Gamma-Ray Bursts

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Research in Astronomy and Astrophysics 2024年第2期24卷 58-73页

作者： wan-Kai wang Wei Xie Zhi-Fu Gao Shuo Xiao Ai-Jun dong Bin Zhang Qi-Jun Zhi Department of Astronomy School of Physics and Electronic ScienceGuizhou Normal UniversityGuiyang 550001China Guizhou Provincial Key Laboratory of Radio Astronomy Data Processing Guizhou Normal UniversityGuiyang 550001China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China

The prompt emission mechanism of gamma-ray bursts(GRBs)is still unclear,and the time-resolved spectral analysis of GRBs is a powerful tool for studying their underlying physical processes.We performed a detailed time-resolved spectral analysis of 78 bright long GRB samples detected by Fermi/Gamma-ray Burst Monitor.A total of 1490 spectra were obtained and their properties were studied using a typical Band-shape model.First,the parameter distributions of the time-resolved spectrum are given as follows:the low-energy spectral indexα~-0.72,high-energy spectral indexβ~2.42,the peak energy E_(p)~221.69 keV,and the energy flux F~7.49×10^(-6)erg cm^(-2)s^(-1).More than 80%of the bursts exhibit the hardest low-energy spectral indexα_(max),exceeding the synchrotron limit(-2/3).Second,the evolution patterns of a and E_(p)were statistically analyzed.The results show that for multi-pulse GRBs the intensity-tracking pattern is more common than the hard-to-soft pattern in the evolution of both E_(p)andα.The hard-to-soft pattern is generally shown in single-pulse GRBs or in the initial pulse of multi-pulse GRBs.Finally,we found a significant positive correlation between F and E_(p),with half of the samples exhibiting a positive correlation between F andα.We discussed the spectral evolution of different radiation models.The diversity of spectral evolution patterns indicates that there may be more than one radiation mechanism occurring in the GRB radiation process,including photo spheric radiation and synchrotron radiation.However,it may also involve only one radiation mechanism,but more complicated physical details need to be considered.

关键词： (stars:)gamma-ray burst general-methods statistical-methods data analysis