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Efficacy and adverse effects of oral propranolol in infantile hemangioma:a meta-analysis of comparative studies

World Journal of Pediatrics 2019年第6期15卷 546-558页

作者： Hao Yang dong-lai Hu Qiang Shu Xiao-dong Guo Department of Pediatrics Surgery Jinhua Central HospitalNo.365 Renmindong RoadWucheng DistrictJinhua 321000China Children's Hospital Zhejiang University School of MedicineNo.3333 Binsheng RoadBinjiang DistrictHangzhou 310052China

Background A number of clinical trials evaluated the efficacy and adverse effects of oral propranolol in the treatment of infantile hemangioma(IH),but the treatment has not yet been *** meta-analysis aims to reevaluate the efficacy and adverse effects of oral propranolol in comparative studies and to provide a reliable basis for clinical administration in the therapy for *** Data were obtained from PubMed,Embase,Cochrane Library,Web of Science,China National Knowledge Infra-structure and Wanfang database,from inception to December 1st,*** pooled risk ratios(RR)with 95%confidence intervals(95%CI)were calculated and used to evaluate the effect *** meta-analysis was performed using the random-effects model due to heterogeneity between the *** Cochrane Collaboration 6 aspects of bias,methodological index for non-randomized studies and the Newcastle-Ottawa Scale were used to assess the risk for *** analysis,publication bias and subgroup analysis were *** Eighteen unique studies involving 2701 unique children were included in the *** response rate was reported in 18 trials,which compared oral propranolol with other *** heterogeneity was statistically significant(P<0.00001,P=95%).The difference in the response rate was statistically significant(RR=1.40,95%CI 1.13-1.75)while compared with the ***,no significant difference in the adverse events rate(RR=0.78,95%CI 0.45-1.34)and relapse rate(RR=1.45,95%CI 0.66-3.16)were ***,the subgroup analysis indicated that the RR was 1.64(95%CI 0.24-11.36)for low-dose propranolol(1 mg/kg/day),1.42(95%CI 1.12-1.80)for medium dose(2 mg/kg/day)and 1.46(95%CI 1.17-1.82)for high dose(3 mg/kg/day),but the high dose had higher adverse events rate than medium dose,with 3.60%and 86.22%,*** effectiveness of propranolol therapy among cases of treatment duration less than 6 months(RR=1.24,95%CI 1.05-1.47)was inferior to that of t

关键词： Hemangioma Meta-analysis Propranolol

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DFT Studies on Non-IPR C_(68) and Endohedral Fullerene Sc_3N@C_(68)

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Chinese Journal of Structural Chemistry 2007年第3期26卷 321-327页

作者： WANG dong-lai SUN Xiao-Ping ZHAI Yu-Chun College of Materials and Metallurgy Northeastern University Shenyang 110004 China Department of Chemistry Anshan Teachers College Anshan 114005 China

Density functional theory （DFT） calculations on two isomers of C68 with the minimal number of fused pentagon pairs, its anions and Sc3N as well as Sc3N@C68 （6140） metallofullerene were carded out at the B3LYP/6-31G^＊ level. The optimized configurations and electrostatic potential distributions have been obtained. The calculated results show that the electrostatic potentials of C68 （6140） inside the sphere have three minima in the middle of the double bonds at fusion of two hexagonal rings. In contrast, potential minimum Vmin（r） of C68 （6275） inside the sphere occurs at the center of the sphere. Concerning the two isomers of C68, the largest regions with the most negative MEP outside the sphere are both localized in the neighborhood of pentagon-pentagon vertex fusions. They constitute the most probable active sites in chemical reactions. Our results present a reasonable explanation for the bonding between scandium atoms and fullerene cage.

关键词： C68 fullerene metallofullerene electrostatic potential bonding

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Theoretical Study of the Molecular Electrostatic Potential of C_(50)

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Chinese Journal of Structural Chemistry 2006年第6期25卷 719-723页

作者： WANG dong-lai SHEN Hong-Tao ZHAI Yu-Chun College of Materials and Metallurgy Northeastern University Shenyang 110004 China

Density functional theory （DFT） calculations on three lower energy isomers of C50 were carried out at the B3LYP/6-31G＊ level. Of the three isomers, two have D5h symmetry （a singlet state and a triplet state） and the other one has D3 symmetry. The optimized configurations and electrostatic potential distributions have been obtained. The calculated results show that potential minima Vmin（r） inside the sphere occur at the center of the sphere. The most negative value of the effective Mulliken atomic charge and the largest regions with the most negative MEP outside the sphere are localized in the neighborhood of pentagon-pentagon vertex fusions. They constitute the most probable active sites in chemical reactions. Our results offer a possible explanation for protonation and alkylation of C50 fullerene.

关键词： C50 fullerene electrostatic potential protonation

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A Multiple Exponential Smoothing Scheme For Quality Control

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数理统计与管理 1993年第6期 46-54页

作者： C D lai,dong QIAN WANG Department of Statistics Massey University Department of Statistics Massey University Palmerston North New Zealand Palmerston North New Zealand

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Colon carcinoma treated with oxaliplatin and capecitabine in a 12-year-old child

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World Journal of Pediatrics 2014年第1期10卷 86-88页

作者： dong-lai Hu Xiao-dong Guo Zhi-Nan Sun Yan-Min Zhao Department of Pediatric Surgery Jinhua Hospital of Zhejiang UniversityJinhua Municipal Central HospitalJinhua 321000China

Background:XELOX(oxaliplatin 130mg/m^(2)iv,capecitabine 1000mg/m^(2)bid oral d1–14,q3w)chemotherapy has never been used in *** this report,we present a case of a 12-year-old girl with colon adenocarcinoma,treated with surgery and XELOX ***:On admission,the girl complained of abdominal pain and intestinal *** examination revealed a distended abdomen with tenderness on the left upper *** enema revealed a stenotic lesion at the distal end of the transverse colon,and abdominal computed tomography showed acute obstruction and a colonic *** was performed after the failure of conservative ***:The mass was originated from the transverse *** sections of the specimens revealed an *** colectomy was performed and regional lymph nodes were *** examination confirmed that the mass was a poorly differentiated adenocarcinoma,and XELOX chemotherapy was *** evidence of recurrent or metastatic tumor was found after 18 ***:Although complete resection is the most effective treatment,XELOX chemotherapy is beneficial to the improvement of clinical outcome of patients with colon adenocarcinoma.

关键词： chemotherapy colon adenocarcinoma XELOX regimen

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Electrostatic potential of several small molecules from density functional theory

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原子与分子物理学报 2006年第B4期23卷 29-33页

作者： WANG dong-lai ZHAI Yu-chun College of Materials and Metallurgy Northeastern University Shenyang 110006P. R. China Department of Chemistry Anshan Teachers College Anshan 114005 P. R. China

A number of density functional theory (DFT) methods were used to calculate the electrostatic potential for the series of molecules N2, F2, NH3, H2O, CHF3, CHCl3, C6H6, TiF4, CO(NH2)2 and C4H5N3O compared with QCISD (quadratic configuration interaction method including single and double substitutions) results. Comparisons were made between the DFT computed results and the QCISD ab initio ones and MP2 ab initio ones, compared with the root-mean-square deviation and electrostatic potential difference contours figures. It was found that the hybrid DFT method B3LYP, yields electrostatic potential in good agreement with the QCISD results. It is suggest this is a useful approach, especially for large molecules that are difficult to study by ab initio methods.

关键词：密度函数理论静电势能 DFT 交互作用

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Controlling Flow Instability in Straight Spur Gear Forging Using Numerical Simulation and Response Surface Method

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Acta Metallurgica Sinica(English Letters) 2018年第1期31卷 82-96页

作者： Zhao-Yang Jin Nan-Nan Li Kai Yan Jing-Xin Chen dong-lai Wei Zhen-Shan Cui School of Mechanical Engineering Yangzhou University School of Mechanical Engineering Shanghai Dianji University National Die and Mold CAD Engineering Research Center Shanghai Jiao Tong University

Workability domain without the onset of flow instability was developed by numerical simulation and response surface method （RSM） for complex-shaped straight spur gear forging. The processing map of AZ31B alloys was calculated from flow stress curves and then integrated with the finite element model to simulate the distribution of flow instability in the straight spur gear undergoing isothermal forging process. Occurrence of flow instability depends on forging temperature, punch velocity and billet reduction. Taking forging temperature and punch velocity as design variables, while billet reduction as response variable, RSM of workability domain was established. Analysis of variance indicates that forging temperature is the most significant factor determining the appearance of flow instability in the forged gear. Flow instability is easier to take place at lower temperatures of 250 and 300 ℃ in the early stage of forging but at higher temperatures of 350 and 400 ℃ in the later stage of forging, which is attributed to different deformation mechanisms and dynamic recrystallization behaviors at different temperatures or deformation levels. Meanwhile, increasing punch velocity further reduces the workability of the forged gear. Four different processing paths were chosen to carry out the gear forging trials. Visual observations and metallographic examinations demonstrate that the developed workability domain contributes to optimization of forging parameters.

关键词： Processing map Finite element method Response surface method Straight spur gear Magnesium alloy

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Low-noise and low-power pixel sensor chip for gas pixel detectors

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Nuclear Science and Techniques 2024年第3期35卷 142-152页

作者： Zhuo Zhou Shi-Qiang Zhou dong Wang Xiang-Ming Sun Chao-Song Gao Peng-Zhen Zhu Wei-Ping Ren Jun Liu Mu-Xian Li Chen Lian Chun-lai dong PLAC Key Laboratory of Quark and Lepton Physics(MOE)Central China Normal UniversityWuhan 430079China

Topmetal-M2 is a large-area pixel sensor chip fabricated using the GSMC 130 nm CMOS process in *** pixel array of Topmetal-M2 consists of pixels of 400 rows×512 columns with a pixel pitch of 45μm×45μ*** array is divided into 16 subarrays,with pixels of 400 rows×32 columns per *** pixel incorporates two charge sensors:a diode sensor and a Topmetal *** in-pixel circuit primarily consists of a charge-sensitive amplifier for energy measurements,a discriminator with a peak-holding circuit,and a time-to-amplitude converter for time-of-arrival *** pixel of Topmetal-M2 has a charge input range of~0-3 k e-,a voltage output range of~0-180 mV,and a charge-voltage conversion gain of~59.56μV∕e-.The average equivalent noise charge of Topmetal-M2,which includes the readout electronic system noise,is~43.45 e-.In the scanning mode,the time resolution of Topmetal-M2 is 1 LSB=1.25μs,and the precision is^()7.41μ*** an operating voltage of 1.5 V,Topmetal-M2 has a power consumption of~49 mW∕cm~*** this article,we provide a comprehensive overview of the chip architecture,pixel working principles,and functional behavior of ***,we present the results of preliminary tests conducted on Topmetal-M2,namely,alpha-particle and soft X-ray tests.

关键词： Charge collection Gas detectors Semiconductor detectors X-ray detectors

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Hallopeau type of pemphigus vegetans confined to the right foot： case report

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Chinese Medical Journal 2009年第5期122卷 588-590页

作者： MA dong-lai FANG Kai Department of Dermatology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

In pemphigus vegetans, intertriginous areas are more commonly involved, and verrucous vegetations develop easily in these areas. In this article, we report a case of Hallopeau type of pemphigus vegetans confined to th... 详细信息

关键词： pemphigus vegetans foot involvement

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Triple administration of osimertinib followed by chemotherapy for advanced lung adenocarcinoma: A case report

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World Journal of Clinical Cases 2021年第11期9卷 2627-2633页

作者： Xu-Yan Hu Yu-Cheng Fei Wen-Chao Zhou Jin-Miao Zhu dong-lai Lv Department of Clinical Medicine Bengbu Medical CollegeBengbu 233030Anhui ProvinceChina Department of Clinical Oncology 901 Hospital of Joint Logistics Support Force of People Liberation ArmyHefei 230031Anhui ProvinceChina Intelligent Pathology Institute The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230036Anhui ProvinceChina Department of Pharmaceutical Engineering Hefei Normal UniversityHefei 230601Anhui ProvinceChina

BACKGROUND Osimertinib is the recommended first-line treatment for adult patients with epidermal growth factor receptor(EGFR)mutation positive advanced or metastatic non-small cell lung cancer(NSCLC).However,primary or acquired resistance to EGFR-tyrosine kinase inhibitors(EGFR-TKIs)seems inevitable,and when drug-resistance occurs during treatment with osimertinib,the standard of care is to discontinue the *** SUMMARY A 57-year-old female patient with lung adenocarcinoma presented with an irritating cough accompanied by chest distress of one month *** enhanced head magnetic resonance imaging scan showed brain *** EGFR mutation(exon 21 L858R)was detected in pleural *** patient was treated with oral osimertinib(80 mg once daily)from January 2018 but developed progressive disease on December *** was then successfully treated with rechallenge and tri-challenge with osimertinib(80 mg once daily)by resensitization chemotherapy twice after the occurrence of drug-resistance to osimertinib,and to date has survived for 31 *** This case may provide some selective therapeutic options for NSCLC patients with acquired drug-resistance who were previously controlled on osimertinib treatment.

关键词： Osimertinib Retreatment Epidermal growth factor receptor Tyrosine kinase inhibitor Non-small cell lung cancer Case report

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