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Altered expression of MUC2 and MUC5AC in progression of colorectal carcinoma

World Journal of Gastroenterology 2010年第32期16卷 4089-4094页

作者： Xiao-dong Bu Nan Li Xiao-Qiang Tian Pei-Lin Huang Li Li jin-song Wang Xiao-jin Yu Department of Pathology School of Medicine Southeast University Nanjing 210009 Jiangsu Province China Nanjing First Hospital of Nanjing Medical University Nanjing 210006 Department of Epidemiology and Statistics School of Public Health Southeast UniversityNanjing 210009 Jiangsu ProvinceChina

AIM:To study the expression profiles of MUC2 and MUC5AC in tumorigenesis of colorectal carcinoma and in its different pathologic ***:Formalin-fixed,paraffin-embedded human colorectal tissue specimens were immunostained with antibodies against MUC2 and *** samples of normal mucosa(NM),12 samples of hyperplastic polyp(HP),15 samples of tubular adenoma with low-grade dysplasia(LGD),14 samples of tubular adenoma with high-grade dysplasia(HGD),26 samples of conventional colorectal adenocarcinoma(CCA),15 samples of mucinous carcinoma(MC),and 8 samples of signetring cell carcinoma(SRCC) were ***:MUC2 was the most widely expressed protein in each study group,although the number of MUC2positive cases was less in CCA group than in other groups(P < 0.05).The staining score for MUC2 was significantly decreased in the HP-LGD-HGD-CCA sequence(r =-0.73436,P < 0.0001).Among the neoplasms,MC and SRCC were more frequently associated with the high expression of MUC2(P < 0.05) than with that of ***5AC expression was detected in all groups but not in NM ***,the staining score for MUC5AC was higher in HP,LGD,HGD,MC and SRCC groups than in NM and CCA groups(P < 0.05).The frequency of simultaneous expression of MUC proteins was significantly higher in MC and SRCC groups than in CCA group(P < 0.05).CONCLUSION:Alterations in MUC expression occur during colorectal *** transformation process in MC and SRCC may be different from that in the traditional adenoma-carcinoma sequence.

关键词： Colorectum Tumorigenesis MUC2 MUC5AC Immunohistochemistry

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Novel Analytical Model of Mean Temperature and Experimental Research on the Rail Universal Rolling

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Chinese Journal of Mechanical Engineering 2009年第3期22卷 376-383页

作者： dong Yonggang ZHANG Wenzhi song Jianfeng College of Mechanical Engineering Yanshan University Qinhuangdao 066004 China

For building the analytical model of mean temperature in rail universal rolling, the cross-section of workpieces and the profile of horizontal roll and vertical roll are simplified rationally. The mean temperature of the web of rail, the top of rail and the base of rail are considered individually. The temperature rises for plastic deformation and friction incorresponding deformation zone, the temperature drop for contact is calculated on the base of variation principle and energy conservation law. Then the mean temperature is obtained. For verifying the theoretical model, the 18 kg/m light rail universal rolling experiments are accomplished in Yanshan University Rolling Laboratory, China and the surface temperature is measured. The surface temperature is not exact enough to express the true temperature and the mean temperature can show the status of the true temperature basically. So the mean temperature can be used to express the true temperature and this theoretical model and its results can be applied as an important reference to control the temperature of rail universal rolling and the heat treatment of the rolled rail.

关键词： mean temperature light rail universal mill rolling experiments surface temperature

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Effect of pre-recovery on microstructure and properties of rolled Al-12.18Zn-3.31Mg-1.43Cu-0.20Zr-0.04Sr aluminum alloy

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International Journal of Minerals,Metallurgy and Materials 2019年第2期26卷 241-250页

作者： Cheng-bin Cai Xiao-jing Xu jin-dong Huang Shi-hao Ju Qing Ding Cheng-song Wang Engineering Institute of Advanced Manufacturing and Modern Equipment Technology Jiangsu University

The independently designed and manufactured ultra-high-strength aluminum alloy Al-12.18 Zn-3.31 Mg-1.43 Cu-0.20 Zr-0.04 Sr was investigated via scanning electron microscopy observations, X-ray diffraction analysis, hardness tests, electrical conductivity tests, tensile tests, intergranular corrosion tests, and exfoliation corrosion tests. The effect of pre-recovery on the microstructure and mechanical properties of this aluminum alloy was also studied. The results show that the pre-recovery heat treatment releases deformation energy, inhibits recrystallization, and decreases the dislocation density. Although the pre-recovery heat treatment has little effect on the hardness, electrical conductivity, and elongation of this aluminum alloy, it can dramatically improve the alloy's tensile strength(the maximum tensile strength increased from 785.0 MPa to 809.2 MPa). Moreover, the tensile properties of this aluminum alloy have a certain degree of isotropy, and the pre-recovery heat treatment does not affect this property. In addition, the rolled aluminum alloy exhibits good corrosion resistance, but the effect of the pre-recovery heat treatment on the alloy's resistance to intergranular and exfoliation corrosion is negligible.

关键词： ultra-high strength aluminum alloy pre-recovery microstructure mechanical property corrosion resistance

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Gaussian particle filter based pose and motion estimation

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第10期8卷 1604-1613页

作者： WU Xue-dong song Zhi-huan State Key Lab. of Industrial Control Technology Institute of Industrial Process Control Zhejiang University Hangzhou 310027 China Department of Electronic Information and Electrical Engineering Fujian University of Technology Fuzhou 350014 China

Determination of relative three-dimensional （3D） position, orientation, and relative motion between two reference frames is an important problem in robotic guidance, manipulation, and assembly as well as in other fields such as photogrammetry. A solution to pose and motion estimation problem that uses two-dimensional （2D） intensity images from a single camera is desirable for real-time applications. The difficulty in performing this measurement is that the process of projecting 3D object features to 2D images is a nonlinear transformation. In this paper, the 3D transformation is modeled as a nonlinear stochastic system with the state estimation providing six degrees-of-freedom motion and position values, using line features in image plane as measuring inputs and dual quaternion to represent both rotation and translation in a unified notation. A filtering method called the Gaussian particle filter （GPF） based on the panicle filtering concept is presented for 3D pose and motion estimation of a moving target from monocular image sequences. The method has been implemented with simulated data, and simulation results are provided along with comparisons to the extended Kalman filter （EKF） and the unscented Kalman filter （UKF） to show the relative advantages of the GPF. Simulation results showed that GPF is a superior alternative to EKF and UKF.

关键词： Gaussian particle filter (GPF) Pose and motion estimation Line features Monocular vision Extended Kalman filter(EKF) Unscented Kalman filter (UKF) Dual quatemion

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Effects of oceanic ice cover and density stratification on the propagation of hydroacoustic waves

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Journal of Hydrodynamics 2022年第6期34卷 1151-1155页

作者： Ya-dong Liu dong-qiang Lu Ming-song Zou Shanghai Institute of Applied Mathematics and Mechanics School of Mechanics and Engineering ScienceShanghai UniversityShanghai200072China China Ship Scientific Research Center Wuxi214082China Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai200072China

The propagation characteristic of hydroacoustic waves is studied for an ideal compressible two-layer fluid with different densities covered by an elastic ice *** conditions are simplified by adopting linear assumption and then the dispersion relation is *** analysis and visualization of the dispersion relation present the introduction of compressibility leads to the appearance of hydroacoustic wave modes while the density stratification leads to the appearance of interfacial wave *** ice thickness and the density ratio of the two fluid layers increase the wave number and group speed of hydroacoustic waves at the same frequency while the phase speed decreases.

关键词： Ocean ice sheet density stratified fluid hydroacoustic propagation

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Molecular dynamics simulation of alkaline electrolyte diffusion in anion exchange membrane

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Science China(Technological Sciences) 2020年第11期63卷 2241-2255页

作者： song BingYe LI dong HE YaLing HUANG dong TONG ZiXiang Key Laboratory of Thermo-Fluid Science and Engineering of MOE School of Energy&Power EngineeringXi’an Jiaotong UniversityXi’an 710049China

During the operation of alkaline direct liquid fuel cells,the alkaline electrolyte is usually needed in the anode electrode to accelerate the electrochemical reaction kinetics of the liquid ***,the crossover of the alkaline solution in the anode through the anion exchange membrane to the cathode can increase the transfer resistance of the oxygen in the *** order to reduce the crossover of the alkaline solution,the diffusion process of the alkaline solution in the anion exchange membrane needs to be fully *** this work,interface models of anion exchange membrane-alkaline electrolytes are established based on the cell structure of the quaternary ammonium polysulfone(QAPS)membrane to simulate the dynamic process of the alkaline solution in the *** effect of the type and the concentration of the alkaline solution on the transportation of the metal ions and OH^-in the membrane are *** results show that the agglomeration of Na+is formed more easily than K^+in the interface *** of the strong interaction of Na^+on OH^-,OH^-ions appear to be concentrated,resulting in that the diffusion coefficients of the metal ion and OH^-in the in Na^+solution are lower than those in the K^+*** addition,with the raised concentration of electrolyte solution,the aggregation degrees of the metal ions and OH^-can be increased,which means an enlarged mass transfer resistance of the ***,by adding a polytetrafluoroethylene(PTFE)layer on the QAPS membrane,the distribution of metal ions tends to be concentrated,and the number of hydrophilic channels in the QAPS membrane is reduced,which significantly increases the alkali resistance of the anion exchange membrane.

关键词： direct liquid fuel cells anion exchange membrane alkali crossover QAPS membrane

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Engineering DNA Materials for Sustainable Data Storage Using a DNA Movable-Type System

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Engineering 2023年第10期29卷 130-136页

作者： Zi-Yi Gong Li-Fu song Guang-Sheng Pei Yu-Fei dong Bing-Zhi Li Ying-jin Yuan Frontiers Science Center for Synthetic Biology&Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China School of Biomedical Informatics The University of Texas Health Science Center at Houston(UTHealth)HoustonTX 77030USA

DNA molecules are green materials with great potential for high-density and long-term data ***,the current data-writing process of DNA data storage via DNA synthesis suffers from high costs and the production of hazards,limiting its practical ***,we developed a DNA movable-type storage system that can utilize DNA fragments pre-produced by cell factories for data *** this system,these pre-generated DNA fragments,referred to herein as“DNA movable types,”are used as basic writing units in a repetitive *** process of data writing is achieved by the rapid assembly of these DNA movable types,thereby avoiding the costly and environmentally hazardous process of de novo DNA *** this system,we successfully encoded 24 bytes of digital information in DNA and read it back accurately by means of high-throughput sequencing and decoding,thereby demonstrating the feasibility of this *** its repetitive usage and biological assembly of DNA movable-type fragments,this system exhibits excellent potential for writing cost reduction,opening up a novel route toward an economical and sustainable digital data-storage technology.

关键词： Synthetic biology DNA data storage DNA movable types Economical DNA data storage

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Small intestinal lipomas:Diagnostic value of multi-slice CT enterography

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World Journal of Gastroenterology 2010年第21期16卷 2677-2681页

作者： Fang, song-Hua dong, Dan-Jun Chen, Fang-Hong jin, Mei Zhong, Bai-Shu Zhejiang Univ Sir Run Run Shaw Inst Clin Med Sir Run Run Shaw Hosp Dept Radiol Hangzhou 310016 Zhejiang Peoples R China Zhejiang Prov Peoples Hosp Dept Radiol Hangzhou 310017 Zhejiang Peoples R China Zhejiang Univ Sir Run Run Shaw Inst Clin Med Sir Run Run Shaw Hosp Dept Pathol Hangzhou 310016 Zhejiang Peoples R China Zhejiang Univ Affiliated Hosp 1 Sch Med Dept Radiol Hangzhou 310013 Zhejiang Peoples R China

AIM:To analyze the clinical and imaging features of the small intestinal lipomas and to evaluate the diagnostic value of multi-slice computed tomography(CT) ***:Fourteen cases(one had two intestinal lesions) of surgically confirmed lipomas of the small intestine were retrospectively *** location,size,clinical and radiological aspects were ***:Twelve patients presented with abdominal pain,of whom three complained of paroxysmal *** or bloody stools was mentioned in five *** lesion was detected incidentally during routine physical *** lesion was found unexpectedly during the preoperational evaluation for *** of the abdomen revealed palpable masses in four *** CT scan showed round or oval well-defined hypo-intense intraluminal masses with the attenuation ranging from-130 HU to-60 *** contrast enhancement CT scan,no striking enhancement was ***:The small intestinal lipomas are rare and difficult to diagnose merely based on clinical manifestations,while the characteristic features at small intestinal CT enterography can help establish reliable prospective diagnoses.

关键词： Lipoma Small bowel Computed tomography X-ray Enterography

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Inhibitory Effect of MiR-449b on Cancer Cell Growth and Invasion through LGR4 in Non-Small-Cell Lung Carcinoma

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Current Medical Science 2018年第4期38卷 582-589页

作者： dong YANG jin-song LI Qian-yu XU Tian XIA Jia-hong XIA Department of Thoracic Surger Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China Department of Cariovascular Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China

Non-small-cell lung carcinoma （NSCLC） is one of the most frequently diagnosed malignancies worldwide. Previous studies have shown that microRNA-449b （miR-449b） functions as a tumor suppressor in many cancers. However, the role of miR- 449b in NSCLC is still unknown. In the present study, miR-449b was significantly down- regulated in NSCLC samples and cell lines. Bioinformatics analysis revealed that 3＇-UTR region of leucine rich repeat containing G protein-coupled receptor 4 （LGR4） mRNA had putative complementary sequences to miR-449b, which was further confirmed by the luciferase assay. Western blotting showed that restoration of miR-449b in NSCLC cells decreased the expression of LGR4. Interestingly, over-expression of miR-449b inhibited growth and invasion of NSCLC cells in vitro. Furthermore, ectopic expression of LGR4 reversed miR-449b-suppressed proliferation and invasion of NSCLC cells. Therefore, the data of the present study demonstrate that miR-449b inhibits tumor cell growth and invasion by targeting LGR4 in NSCLC.

关键词： non-small-cell lung carcinoma microRNA-449b leucine rich repeat containing G protein-coupled receptor 4 growth invasion

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Crystal Structure, DFT and Electrochemical Property of a Novel C3-symmetrical 1,3,5-Tri（9-ethyl-6-nitrocarbazol-3-yl） Benzene

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Chinese Journal of Structural Chemistry 2019年第9期38卷 1455-1462页

作者： dong jin-Long WEN Bin WANG song song Zhen REN Jian-Guo ZHAO San-Hu Department of Chemistry Taiyuan Normal UniversityJinzhong030619China School of Chemistry and Chemical Engineering Shanxi UniversityTaiyuan030006China Department of Chemistry Xinzhou Teachers UniversityXinzhou034000China

A novel C3-symmetrical molecule, 1,3,5-tri(9-ethyl-6-nitrocarbazol-3-yl) benzene(IV), was synthesized and characterized by 1 H NMR, 13 C NMR and UV-vis spectroscopy, elemental analyses and X-ray single crystal diffraction analysis. For this complex: C48 H36 N6 O6, Mr = 792.83, triclinic system, space group P1, a = 11.568(6), b = 13.158(7), c = 17.856(10) ?, α = 95.419(9), β = 107.345(8), γ = 114.682(8)o, V = 2281(2) ?3, Z = 2, Dc = 1.154 g/cm3, λ = 0.71073 ?, F(000) = 828, S = 1.083, R = 0.0836 and wR = 0.1926 for 3304 observed reflections with I > 2ζ(I). The compound possesses good thermal stability with the decomposition temperature(Td) of 265 ℃. The absorption and emission spectra show that the compound can emit blue light in CHCl3, and the quantum yield of compound IV in EtOH was 0.66. Furthermore, the electrochemical properties of compound IV were also studied by cyclic voltammetry(CV) method, and the results correspond to the data of theoretical calculation by the Gaussian 09 software.

关键词： C3-symmetrical molecule crystal structure DFT TG analysis electrochemical property

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