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Two-week bismuth-containing quadruple therapy and concomitant therapy are effective first-line treatments for Helicobacter pylori eradication: A prospective open-label randomized trial

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World Journal of Gastroenterology 2019年第46期25卷 6790-6798页

作者： So Jeong Kim Jun-Won Chung hyun Sun Woo Su Young Kim Jung Ho Kim Yoon Jae Kim Kyoung oh Kim Kwang An Kwon dong Kyun Park College of Medicine Gachon University Graduate School of MedicineIncheon 21936South Korea Division of Gastroenterology Department of Internal MedicineGachon University Gil Medical CenterIncheon 21565South Korea Division of Gastroenterology Department of Internal MedicineYonsei University Wonju College of MedicineWonju 26426South Korea

BACKGROUND Increasing levels of antibiotic resistance have reduced the Helicobacter pylori(***)eradication rates afforded by the standard triple ***,2-wk firstline four-drug regimens must be *** To analyze the eradication rates of modified bismuth-containing quadruple therapy(mBCQT)and concomitant therapy(CT),the associated adverse events,and *** Patients infected with *** were prospectively randomized to receive mBCQT or CT for 2 *** featured a proton pump inhibitor(PPI),bismuth,metronidazole,and tetracycline,taken twice *** included a PPI,clarithromycin,metronidazole,and amoxicillin,taken twice *** 13C-urea breath test was performed no earlier than 4 wk after therapy concluded to confirm *** either the histological or rapid urease test was positive,*** infection was *** The demographic characteristics of 68 patients who received mBCQT and 68 who received CT did not differ *** intention-to-treat analysis,the eradication rate was 88.2%(60/68)in the mBCQT group and 79.4%(54/68)in the CT group(P=0.162).By per-protocol analysis,the respective eradication rates were 98.4%(60/61)and 93.1%(54/58)(P=0.199).More CT than mBCQT patients experienced adverse events[33.8%(23/68)mBCQT vs 51.5%(35/58)CT patients,respectively,P=0.037].All patients showed good compliance[85.3%(58/68)mBCQT vs 82.4%(56/68)CT patients,P=0.641].CONCLUSION The *** eradication rates of the 2-wk mBCQT and CT regimens are *** patients show good compliance,and more CT than mBCQT patients experience adverse events.

关键词： Helicobacter pylori Therapy Bismuth-containing quadruple therapy Concomitant therapy

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Role of computed tomographic colonoscopy of postoperative surveillance in patient with gastric cancer

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World Journal of Gastroenterology 2007年第11期13卷 1646-1651页

作者： Dae Won Jun oh Young Lee hyun Chul Lim Sung Joon Kwon Hang Lak Lee Byung Chul Yoon Ho Soon Choi Joon Soo Hahm Min Ho Lee dong Hoo Lee Department of Internal Medicine Hanyang University College of Medicine Seoul Korea Department of Radiology Hanyang University College of Medicine Seoul Korea Department of General Surgery Hanyang University College of Medicine Seoul Korea

AIM： TO examine the diagnostic yield of colorectal neoplasia at computed tomographic colonoscopy （CTC） as well as the feasibility of contrast enhanced CTC in patients with gastric cancer. METHODS： To examine the incidence of colon polyp we selected postoperative 188 gastric cancer patients, which we refer to as the ‘colon polyp survey group’. To examine the feasibility of CTC for early detection of colon cancer or advanced colon adenoma, we selected 47 gastric cancer patients （M：F 29：18, mean age 53.8 years）, which we call the ‘CT colonoscopy group’. All the 47 patients underwent successive CTC and colonoscopy on the same day. RESULTS： Totally 109 colon polyps were observed from 59 out of 188 gastric cancer patients, the inddence rate of colon polyps in gastric cancer patients being 31.4%. The sensitivity of CTC in detecting individuals with at least 1 lesion of any size was 57.1%, the specificity was 72.7%, the positive predictive value was 47.1%, and the negative predictive value was 71.9%. When the cutoff size was decreased to 6 mm, the sensitivity and specificity were 80.0% and 92.9%, respectively, with positive and negative predictive values of 57.1% and 97.5%, respectively. Only one patient was classified as false negative by virtual colonoscopy. CONCLUSION： The diagnostic yield of colorectal polyp was 31.4% in patients with gastric cancer, and contrast enhanced CTC is an acceptable tool for the detection of synchronous colorectal advanced adenoma and postoperative surveillance of gastric cancer patients.

关键词： Stomach cancer Colon cancer Computed tomocjraphic colonoscopy

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Endoscopic features suggesting gastric cancer in biopsy-proven gastric adenoma with high-grade neoplasia

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World Journal of Gastroenterology 2014年第34期20卷 12233-12240页

作者： Jung Ho Kim Yoon Jae Kim Jungsuk An Jong Joon Lee Jae Hee Cho Kyoung oh Kim Jun-Won Chung Kwang An Kwon dong Kyun Park Ju hyun Kim Department of Internal Medicine Gachon University Gil Medical CenterNamdong-guIncheon 405-760South Korea Department of Pathology Gachon University Gil Medical Center21 Namdong-daero 774 beon-gilNamdong-guIncheon 405-760South Korea

AIM: To elucidate the endoscopic features that predict the cancer following endoscopic submucosal dissection (ESD) in patients with high-grade neoplasia (HGN).

关键词： Stomach Neoplasms Carcinoma Adenoma Endoscopy Dissection Risk factors

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Asymmetric dynamic behaviors of magnetic domain wall in trapezoid-cross-section nanostrip

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Chinese Physics B 2020年第9期29卷 518-522页

作者： Xiao-Ping Ma Hong-Guang Piao Lei Yang dong-hyun Kim Chun-Yeol You Liqing Pan Research Institute for Magnetoelectric&Weak Magnetic-field Detection College of ScienceChina Three Gorges UniversityYichang 443002China Department of Physics Chungbuk National UniversityCheongju 28644ChungbukRepublic of Korea Department of Emerging Materials Science Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Republic of Korea

Field-driven magnetic domain wall propagation in ferromagnetic nanostrips with trapezoidal cross section has been systematically investigated by means of micromagnetic simulation. Asymmetric dynamic behaviors of domain wall, depending on the propagation direction, were observed under an external magnetic field. When the domain walls propagate in the opposite direction along the long axis of the nanostrip, the Walker breakdown fields as well as the average velocities are different. The asymmetric landscape of demagnetization energies, which arises from the trapezoidal geometry, is the main origin of the asymmetric propagation behavior. Furthermore, a trapezoid-cross-section nanostrip will become a nanotube if it is rolled artificially along its long axis, and thus a two-dimensional transverse domain wall will become a three-dimensional one. Interestingly, it is found that the asymmetric behaviors observed in two-dimensional nanostrips with trapezoidal cross section are similar with some dynamic properties occurring in three-dimensional nanotubes.

关键词： ferromagnetic nanowire magnetic domain wall geometric effect asymmetric Walker breakdown

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Effect of Post-Rolling after ECAP on Superplastic Behavior of Commercial Al-Mg Alloy

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Journal of Rare Earths 2004年第Z2期22卷 53-56页

作者： dong Hyuk Shin Byung Du Ahn hyun Soo Woo Kyeom Kim Kyung-Tae Park Department of Metallurgy and Materials Science Hanyang UniversityAnsan 425-791Korea Department of Metallurgy and Materials ScienceHanyang UniversityAnsan 425-791Korea Department of Metallurgy and Materials ScienceHanyang UniversityAnsan 425-791Korea Department of Metallurgy and Materials ScienceHanyang UniversityAnsan 425-791Korea Division of Advanced Materials Science & EngineeringHanbat National UniversityTaejon 305-719Korea

A commercial Al-Mg alloy was subjected to equal channel angular pressing of 4 passes with and without postrolling, and the effects of post-rolling on the deformation characteristics of the alloy at 723 K were examined. Post-rolling was found to influence the deformation behavior significantly. The deformation behavior of the alloy processed only by equal channel angular pressing was characterized by (a) localized deformation indicated by severe surface prominence and depression, (b) the strain rate sensitivity of 0.33, and (c) moderate high strain rate superplastic elongations. By contrast, that of the alloy processed by equal channel angular pressing and post-rolling (70 % thickness reduction) was manifested by (a) uniform deformation associated with grain boundary sliding throughout the sample, (b) a sigmoidal behavior showing the strain rate sensitivity of 0.45 at the intermediate strain rates in the logarithmic stress-strain rate curve, and (c) very large high strain rate superplastic elongations.

关键词： high superplasticity equal channel angular pressing rolling deformation mechanisms rare earths

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Intercomparison of Precipitation Simulated by Regional Climate Models over East Asia in 1997 and 1998

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Advances in Atmospheric Sciences 2007年第4期24卷 539-554页

作者： dong-Kyou LEE William J.GUTOWSKI hyun-Suk KANG Chun-Ji KIM School of Earth and Environmental Sciences Seoul National UniversitySeoulKorea Department of Geological and Atmospheric Sciences Iowa State UniversityAmesUSAJr Department of Atmospheric Sciences Yonsei UniversitySeoulKorea.School of Earth and Environmental SciencesSeoul National UniversitySeoulKorea

Regional climate simulations in Asia from May 1997 to August 1998 were performed using the Seoul National University regional climate model （SNURCM） and Iowa State University regional climate model （***5/LSM）, which were developed by coupling the NCAR/Land Surface Model （LSM） and the Mesoscale Model （MM5）. However, for physical processes of precipitation, the SNURCM used the Grell scheme for the convective parameterization scheme （CPS） and the simple ice scheme for the explicit moisture scheme （EMS）, while the ***5/LSM used the Betts-Miller scheme for CPS and the mixed phase scheme for EMS.The simulated precipitation patterns and amounts over East Asia for the extreme climatic summer in 1997 （relative drought conditions） and 1998 （relative flood conditions） were especially focused upon. The ***5/LSM simulated more precipitation than was observed in 1997 due to more moisture and cloud water in the lower levels, despite weak upward motion. In the SNURCM, strong upward motion resulted in more precipitation than that was observed in 1998, with more moisture and cloud water in the middle levels. In the ***5/LSM, weak upward motion, unchanged moisture in the lower troposphere, and the decrease in latent heat flux at the surface increased convective precipitation only by 3% for the 1998 summer event. In the SNURCM, strong upward motion, the increase in moisture in the lower troposphere, and the increase in latent heat flux at the surface increased convective precipitation by 48% for the summer of 1998. The main differences between both simulations were moisture availability and horizontal momentum transport in the lower troposphere, which were also strongly influenced by large-scale forcing.

关键词： regional climate simulation summer precipitation variability extreme climatic event physical process

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BIOCOMPATIBILITY OF A PDMS-COATED MICRO-DEVICE:BLADDER VOLUME MONITORING SENSOR

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Chinese Journal of Polymer Science 2012年第2期30卷 242-249页

作者： dong Sup Lee Su Jin Kim Jun Ho Sohn In Gul Kim Sae Woong Kim dong Wan Sohn Jong hyun Kim Bumkyoo Choi Department of Urology St.Vincent's HospitalCollege of Medicinethe Catholic University of KoreaSuwonKorea Department of Urology Seoul St.Mary's HospitalCollege of Medicinethe Catholic University of KoreaSeoulKorea Department of Urology Yeouido St.Mary's HospitalCollege of Medicinethe Catholic University of KoreaSeoulKorea Department of Mechanical Engineering Sogang UniversitySeoulKorea

We evaluated the biocompatibility of a dimethylpolysiloxane-coated micro-device which had been designed for monitoring real-time bladder volume in previous studies. The extract assay with dimethylpolysiloxane which had been used for coating the micro-device to measure the bladder volume was performed as an in vitro cytotoxicity test. For in vivo biocompatibility testing, the inflammatory responses around the implantation site of the micro-device in subcutaneous tissue of rat were assessed by light microscope with H＆E stain and fluorescence microscope with ED1 stain and von Willebrand factor stain. The averages of cell viability in dimethylpolysiloxane group were 84.6% and 82.3% at 24 h and 72 h incubation, respectively. The qualitative evaluations with light and fluorescence microscope revealed that the inflammatory changes peaked during 2 weeks but almost disappeared at 4 weeks after implantation of devices. The quantitative evaluations for granulation layer formation and neovascularization showed that the thickness of the layer in dimethylpolysiloxane group peaked during 2 weeks but it came to be stabilized at 4 weeks as thin as at 2 weeks in control group, and the frequency of neovascularization was higher in dimethylpolysiloxane group than in control group but it was not increased with time. The dimethylpolysiloxane-coated micro-device is thought be a reliable bio-medical device.

关键词： Dimethylpolysiloxane Devices Biocompatibility testing.

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Interdecadal Variability of East Asian Summer Monsoon Precipitation over 220 Years (1777-1997)

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Advances in Atmospheric Sciences 2010年第2期27卷 253-264页

作者： Chun-Ji KIM 钱维宏 hyun-Suk KANG dong-Kyou LEE Atmospheric Sciences Program School of Earth and Environmental Sciences Seoul National University National Institute of Meteorological Research Korea Meteorological Administration Department of Geophysics Peking University

In this study, long-term （1777–1997） precipitation data for Seoul, Korea, wetness indices from eastern China, and modern observations are used to identify the interdecadal variability in East Asian summer monsoon precipitation over the last 220 years. In the East Asian monsoon region, two long-term timescales of dry–wet transitions for the interdecadal variability and quasi-40-and quasi-60-year timescales are dominant in the 220-year precipitation data of Seoul, as well as in the wetness indices over China. The wet and dry spells between Seoul （southern China） and northern China are out-of-phase （out-of-phase） at the quasi-60-year timescale, and in-phase （out-of-phase by approximately 90 ？ before 1900 and in-phase after 1900） at the quasi-40-year timescale. In particular, during the last century, the dominant long-term timescales over East Asia tend to decrease from the quasi-60-year to the quasi-40-year with increasing time. The dominant quasi-40-year and quasi-60-year timescales of the Seoul precipitation in Korea are strongly correlated with these timescales of the northern Pacific Ocean.

关键词： interdecadal variability East Asian summer monsoon precipitation timescales dry–wet transition

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NLP-Based Subject with Emotions Joint Analytics for Epidemic Articles

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Computers, Materials & Continua 2022年第11期73卷 2985-3001页

作者： Woo hyun Park Isma Farah Siddiqui dong Ryeol Shin Nawab Muhammad Faseeh Qureshi Department of Electrical and Computer Engineering Sungkyunkwan UniversitySuwon16419Korea Department of Software Engineering Mehran University of Engineering&TechnologyJamshoroPakistan Department of Computer Education Sungkyunkwan UniversitySeoul03063Korea

have been focused on addressing the Covid-19 pandemic;for example,governments have implemented countermeasures,such as quarantining,pushing vaccine shots to minimize local spread,investigating and analyzing the virus’characteristics,and conducting epidemiological investigations through patient management and ***,researchers worldwide require funding to achieve these ***,there is a need for documentation to investigate and trace disease ***,it is time consuming and resource intensive to work with documents comprising many types of unstructured ***,in this study,natural language processing technology is used to automatically classify these *** used statistical methods include data cleansing,query modification,sentiment analysis,and ***,owing to limitations with respect to the data,it is necessary to understand how to perform data analysis suitable for medical *** solve this problem,this study proposes a robust in-depth mixed with subject and emotion model comprising three *** first is a subject and non-linear emotional module,which extracts topics from the data and supplements them with emotional *** second is a subject with singular value decomposition in the emotion model,which is a dimensional decomposition module that uses subject analysis and an emotion *** third involves embedding with singular value decomposition using an emotion module,which is a dimensional decomposition method that uses emotion *** accuracy and other model measurements,such as the F1,area under the curve,and recall are evaluated based on an article on Middle East respiratory syndrome.A high F1 score of approximately 91%is *** proposed joint analysis method is expected to provide a better synergistic effect in the dataset.

关键词： Computational linguistic AI epidemic healthcare classification

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Phytogenic feed additives alleviate pathogenic Escherichia coli-induced intestinal damage through improving barrier integrity and inhibiting inflammation in weaned pigs

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Journal of Animal Science and Biotechnology 2023年第1期14卷 295-306页

作者： Se Yeon Chang Min Ho Song Ji Hwan Lee Han Jin oh Yong Ju Kim Jae Woo An Young Bin Go dong Cheol Song hyun AhCho Seung Yeol Cho dong Jun Kim Mi Suk Kim Hyeun Bum Kim Jin Ho Cho Department of Animal Science Chungbuk National UniversityCheongju 28644South Korea. Division of Animal and Dairy Science Chungnam National UniversityDaejeon 34134South Korea. Eugene-Bio Suwon 16675South Korea. Department of Animal Resources Science Dankook UniversityCheonan 31116South Korea.

Background:This study was conducted to investigate the effects of each phytogenic feed additive(PFA;PFA1,bitter citrus extract;PFA2,a microencapsulated blend of thymol and carvacrol;PFA3,a mixture of bitter citrus extract,thymol,and carvacrol;PFA4,a premixture of grape seed,grape marc extract,green tea,and hops;PFA5,fenugreek seed powder)on the growth performance,nutrient digestibility,intestinal morphology,and immune response in weaned pigs infected with Escherichia coli(***).Results:A total of 634-week-old weaned pigs were placed in individual metabolic cages and assigned to seven treatment *** seven treatments were as follows:1)NC;basal diet without *** challenge,2)PC;basal diet with *** challenge,3)T1;PC+0.04%PFA1,4)T2;PC+0.01%PFA2,5)T3;PC+0.10%PFA3,6)T4;PC+0.04%PFA4,7)T5;PC+0.10%*** experiments lasted in 21 d,including 7 d before and 14 d after the first *** *** the *** challenge treatments,all pigs were orally inoculated by dividing a total of 10 mL of *** F18 for 3 consecutive *** PFA-added groups significantly increased(P<0.05)average daily gain and feed efficiency and decreased(P<0.05)the fecal score at d 0 to 14 post-inoculation(PI).Tumor necrosis factorαwas significantly lower(P<0.05)in the PFA-added groups except for T1 in d 14 PI compared to the PC *** T3 had a higher(P<0.05)immunoglobulin G and immunoglobulin A concentration compared to the PC treatment at d 7 ***,T3 showed significantly higher(P<0.05)villus height:crypt depth and claudin 1 expression in ileal mucosa,and significantly downregulated(P<0.05)the expression of calprotectin compared to the PC ***:Supplementation of PFA in weaned pigs challenged with *** alleviated the negative effects of *** and improved growth *** them,the mixed additive of bitter citrus extract,thymol,and carvacrol showed the most effective results,improving immune response,intestinal morphology,and expression of tight junction

关键词： Barrier integrity Escherichia coli Immunity Phytogenic feed additive Post-weaning diarrhea Weaned pigs

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