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Leveraging ROTI map derived from Indonesian GnSS receiver network for advancing study of Equatorial Plasma Bubble in Southeast/East Asia

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Earth and Planetary Physics 2025年第1期9卷 101-116页

作者： Prayitno Abadi Ihsan n.Muafiry Teguh.n.Pratama Angga Y.Putra Suraina Gatot h.Pramono Sidik T.Wibowo Febrylian F.Chabibi Umar A.Ahmad Wildan P.Tresna Asnawi Research Center for Climate and Atmosphere Indonesian National Research and Innovation Agency(BRIN)BandungIndonesia School of Electrical Engineering Telkom UniversityBandungIndonesia Directorate of Laboratory Management Facilities and Science and Technology Park Indonesian National Research and Innovation Agency(BRIN)PontianakIndonesia Geophysics Laboratory Master Program in PhysicsUniversitas Gadjah Mada(UGM)YogyakartaIndonesia Research Center for Space Indonesian National Research and Innovation Agency(BRIN)BandungIndonesia Indonesian Geospatial Information Agency(BIG) JakartaIndonesia Research Center for Photonics Indonesian National Research and Innovation Agency(BRIN)Tangerang SelatanIndonesia Department of Earth and Planetary Sciences Hokkaido UniversitySapporoJapan

This paper highlights the crucial role of Indonesia’s GnSS receiver network in advancing Equatorial Plasma Bubble(EPB)studies in Southeast and East Asia,as ionospheric irregularities with.n EPB can disrupt GnSS signals and degrade positioning *** by the Indonesian Geospatial Information Agency(BIG),the Indonesia Continuously Operating Reference Station(Ina-CORS)network comprises over 300 GnSS receivers spanning equatorial to southern low-latitude ***-CORS is uniquely situated to monitor EPB generation,zonal drift,and dissipation across Southeast *** provide a practical tool for EPB research,by sharing two-dimensional rate of Total Electron Content(TEC)ch.nge index(ROTI)derived from this *** generate ROTI maps with a 10-minute resolution,and samples from May 2024 are publicly available for further scientific *** preliminary findings from the ROTI maps of Ina-CORS are ***,the Ina-CORS ROTI maps reveal that the irregularities with.n a broader EPB structure persist longer,increasing the potential for these irregularities to migrate farther ***,we demonstrate that combined ROTI maps from Ina-CORS and GnSS receivers in East Asia and Australia can be used to monitor the development of ionospheric irregularities in Southeast and East *** have demonstrated the combined ROTI maps to capture the development of ionospheric irregularities in the Southeast/East Asian sector during the G5 Geomagnetic Storm on May 11,*** observed simultaneous ionospheric irregularities in Japan and Australia,respectively propagating northwestward and southwestward,before midnight,whereas Southeast Asia’s equatorial and low-latitude regions exhibited irregularities *** sharing ROTI maps from Indonesia and integrating them with regional GnSS networks,researchers can conduct compreh.nsive EPB studies,enh.ncing the understanding of EPB behavior across Southeast and East Asia and contributing significantly to ionosphe

关键词： Equatorial Plasma Bubble(EPB) GnSS receivers’network Indonesia Continuously Operating Reference Station(Ina-CORS) ionospheric map Rate of TEC ch.nge index(ROTI)map

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Dielectric-ion-conductive Znnb2O6 layer enabling rapid desolvation and diffusion for dendrite-free Zn metal batteries

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Journal of Energy Chemistry 2025年第1期100卷 693-701页

作者： haifeng Yang Jian Wang Panpan Zh.ng Xiaomin Ch.ng Qinghua Guan Jing dong Bixian Ch.n Lujie Jia Jing Zh.ng Yongzh.ng Zh.ng Yunjian Liu h.ngzh.n Lin School of Materials Science and Engineering Jiangsu University i-Lab & CAS Key Laboratory of nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences helmholtz Institute Ulm (hIU) Karlsruhe Institute of Technology (KIT) School of Materials Science and Engineering Xi'an University of Technology State Key Laboratory of Chemical Engineering East China University of Science and Technology

Rechargeable aqueous zinc-metal batteries （AZMBs） are promising candidates for large-scale energy storage systems due to their low cost and high ***,their performance and sustainability are significantly h.ndered by the sluggish desolvation kinetics at the electrode/electrolyte interface and the corresponding hydrogen evolution reaction where active water molecules tightly participate in the Zn（h2O）62+solvation ***,learnt from self-generated solid electrolyte interphase （SEI） in anodes,the dielectric but ion-conductive zinc niobate nanoparticles artificial layer is constructed on metallic Zn surface （ZnB@Zn）,acting as a rapid desolvation *** zincophilic and dielectric-conductive properties of ZnB layer accelerate interfacial desolvation/diffusion and suppress surface corrosion or dendrite formation,achieving uniform Zn plating/stripping behavior,as confirmed by electronic/optical microscopies and interface spectroscopical measurements together with theoretical ***,the as-prepared ZnB@Zn electrode exhibits excellent cycling stability of over 2000 h and robust reversibility （99.54%） even under high current density and depth of discharge ***,the assembled ZnB@Zn-based full cell displays high capacity-retention rate of 80.21%after 3000 cycles at 5 A g-1and outstanding rate performance up to 10 A *** large-areal pouch cell is stabilized for h.ndreds of cycles,highlighting the bright prospects of the dielectric but ion-conductive layer in further application of AZMBs.

关键词： Zn metal battery Dielectric artificial layer Rapid ion diffusion Zincophilic diffusion Active water inhibition

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AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

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Science Ch.na Life Sciences 2025年第1期 204-218页

作者： Ch.n Xiong h.ng Ling Yingdan huang h.nzhi dong Bangxiang Xie Qian hao Xiang Zhou Fudan University Sh.nghai Cancer Center and Institutes of Biomedical Sciences Fudan University Department of Oncology Shanghai Medical CollegeFudan University Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan University Department of Oncology First Affiliated Hospital of Nanchang University Beijing Institute of hepatology Beijing Youan HospitalCapital Medical University Beijing Engineering Research Center for Precision Medicine and Transformation of hepatitis and Liver Cancer Key Laboratory of Breast Cancer in Sh.nghai Fudan University Shanghai Cancer CenterFudan University Sh.nghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology)Institutes of Biomedical SciencesFudan University

Tumor suppressor p53-mediated cell cycle arrest and DnA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enh.nced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1 by the WEE1 inhibitors or si RnAs induced compensatory upregulation of SLC7A11, which conferred resistance to ferroptosis. Mech.nistically, AZD1775 prevented the enrichment of h3K9me3, a histone marker of transcriptional repression, on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1, thereby enh.ncing nRF2-mediated SLC7A11 transcription. This finding was also validated using the h3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A11 expression by activating p53, thus augmenting AZD1775-induced ferroptosis. Moreover, the combination of AZD1775 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and nRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enh.ncing ferroptosis in cancers with wild-type p53.

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Alkaline leach.ng mech.nism of MSWI bottom ash: the pivotal role of Si(Al) chemical bonding environments

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Science Ch.na Technological Sciences 2025年

作者： ningning ShAO Zekun JIAO Weipeng FEnG Yu JIn Fanlong KOnG Zhijun dong Zuotai Zh.nG Institute of Technology for Marine Civil Engineering Shenzhen Institute of Information Technology (SZIIT) Guizhou nASh Ecological Technology Co. LTD School of Environmental Science and Engineering Key Laboratory of Municipal Solid Waste Recycling Technology and Management of Shenzhen City Southern University of Science and Technology (SUSTech)

Municipal solid waste incineration bottom ash(MSWIBA) is a complex assemblage of aluminosilicate materials encompassing diverse solid wastes. Thus, its complexity poses great challenges to their resource utilization. For the sake of the alkali activation use of MSWIBA, this work focused on the characterizations and alkaline leach.ng experiments of various classified MSWIBA after sorting. Among the different categories of MSWIBA, waste glass(BA-G) and other unidentified slags(BA-O) were identified as potential precursors for alkali activation use. The alkaline leach.ng experiments proved that alkaline concentration, reaction temperature, reaction time, and raw material classification influenced the leach.ng process and results. Among these, the Si/Al chemical bonding environments from the material type played a pivotal role. Wh.n the materials had Qn(n>2) as the primary bonding structure, steric h.ndrance by the chain frameworks affected the alkali dissolution process, resulting in gradual disintegration from the outer layers inward. For the materials dominated by Q1frameworks, Oh-could penetrate the frameworks, leading to their rapid depolymerization and outward dissolution. Overall, the Si/Al bonding environment played a crucial role in alkaline dissolution, providing theoretical guidance for classifying the alkali-activation utilization of MSWIBA and other aluminosilicate solid wastes.

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CnKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zh.ng Ruizhi Li Yin Wang Peifeng Li hai Zhu dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enh.ncer of kinase suppressor of Ras 2(CnKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CnKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mech.nism involved has not yet been fully *** has demonstrated that CnKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CnKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CnKSR2 interactors were significantly enriched in the proteome of the *** also showed that CnKSR2 interacted with the microtubule protein DYnC1h1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CnKSR2 expression in mouse neuroblastoma cells(neuro 2A),we observed significant ch.nges in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CnKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CnKSR2 and the centrosome,and offer new insights into the underlying mech.nisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CnKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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Surface modification of ultra-high molecular weight polyethylene for joint prosthesis and sports applications

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中国有色金属学会会刊：英文版 2004年第z1期14卷 36-40页

作者： h.dong Department of Metallurgy and Materials The University of Birmingham Birmingham B15 2TT UK

The recent progresses in the surfaee modification of ultra high molecular weight polyethylene (UhMWPE) using such advanced surface modification technologies as conventional ion implantation (CⅡ), new plasma immersion ion implantation (PⅢ) and novel active screen plasma (ASP), were all reported. Significantly improved wear resistance was achieved, which has great potential for extending the life-span of joint replacement prostheses and enh.ncing the performance of such sports equipment as skis and snowboards.

关键词： UhMWPE ion implantation PI3 active-screen plasma

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Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

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Science Ch.na Chemistry 2025年第01期 201-208页

作者： hui-Feng Wang Wen-Jie Shi Yu-Xin Yang Bao-Xia dong Tong-Bu Lu Di-Ch.ng Zh.ng School of Chemistry and Chemical Engineering Yangzhou University Institute for new Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enh.nced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher th.n that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co ni-In and ni Zn-In also show different fold increase th.n those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strength.ned DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

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Accurate fundamental invariant-neural network representation of ab initio potential energy surfaces

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national Science Review 2023年第12期10卷 26-39页

作者： Bina Fu dong h.Zh.ng State Key Laboratory of Molecular Reaction Dynamics and Center for Theoretical and Computational Chemistry Dalian Institute of Chemical Physics Chinese Academy of Sciences hefei national Laboratory University of Ch.nese Academy of Sciences

highly accurate potential energy surfaces are critically important for chemical reaction dynamics. The large number of degrees of freedom and the intricate symmetry adaption pose a big challenge to accurately representing potential energy surfaces(PESs) for polyatomic reactions. Recently, our group has made substantial progress in this direction by developing the fundamental invariant-neural network(FI-nn)approach. here, we review these advances, demonstrating that the FI-nn approach can represent highly accurate, global, full-dimensional PESs for reactive systems with even more th.n 10 atoms. These multi-ch.nnel reactions typically involve many intermediates, transition states, and products. The complexity and ruggedness of this potential energy landscape present even greater challenges for full-dimensional PES representation. These PESs exhibit a high level of complexity, molecular size, and accuracy of fit. Dynamics simulations based on these PESs have unveiled intriguing and novel reaction mech.nisms, providing deep insights into the intricate dynamics involved in combustion, atmospheric, and organic chemistry.

关键词： FI-nn full-dimensional PESs multi-ch.nnel reaction reaction mech.nism

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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose M.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon Luis h.Pagan Rivera Jorge D.Miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA national Institutes of health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mech.nisms are not well understood,but the data suggests that plasticity with.n the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mech.nism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mech.nical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

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DESIGn　AnD　PREPARATIOn　OF　SILICOn　nITRIDE　COMPOSITE　WITh　hIGh　FRACTURE　TOUGhnESS　AnD　nACRE　STRUCTURE

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Acta Metallurgica Sinica(English Letters) 1996年第6期9卷 479-484页

作者： Y huang h.n hao Y.L. Ch.n and B.L.Zhou (1)Department of Materials Science and Engineering, Tsinghua University,Beijing 100084, Ch.na 2)Institute of Metal Research, Ch.nese Academy of Sciences,Sh.nyang 110015, Ch.na ) Tsinghua Univ Beijing China

A new way of designing and preparing silicon nitride ceramic composite with high fracture toughness and nacre structure has been proposed. To mimic the laminated structure of nacre, Si_3n_4 matrix ceramic layer can be obtained through compacting rolling method. To mimic the secondary tough.ning of nacre structure, SiC whisker is added into Si_3n_4 and acts as the secondary tough.ning phase. Boron nitride (Bn)is selected to mimic the organic layer in nacre so as to form the weak interfaces between Si_3n_4 layers. Alumina is added into Bn to adjust the bonding strength of the *** Si_3n_4 sheets are stacked into the die after coating with Bn. After the removal of the organic matter in them, the green body is hot pressed at 1820℃for 1.5 hours under n_2 atmosphere. The fracture toughness of the so-made Si_3n_4 composite at room temperature is 20.36MPa m￣(1/2), the three-point bending strength at room temperature is 651.47MPa. The crack spreads and deflects along the interface between Bn and Si_3n_4 layer and extends through the Bn layer into Si_3n_4 layer. The improvement of the fracture toughness may be due to the staircase-shape-like crack which provides the long crack path, the fracture and deformation of Si_3n_4 layer, and the pullout of SiC whiskers from the Si_3n_4 layer.

关键词： secondary tough.ning,compact rolling silicon nitride nacre Structure

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