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Immobilizing Triphenylamine with Photoredox Inert Sr^(2+)Forming Sr-MOF with Controlled Electron Migration for Photocatalytic Oxidation of Thiols to Disulfides

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Chinese Journal of Chemistry 2024年第10期42卷 1093-1099页

作者： Ying-Xia Wang Fang Zheng dong-Xia Song Bao-Yue Niu Lu-Qian deng Xian-Ming Zhang Key Laboratory of Magnetic Molecules and Magnetic Information Materials(Ministry of Education) Schoolof Chemistry and Materials ScienceShanxi Normal UniversityTaiyuanShanxi 030006China Key Laboratory of Interface Science and Engineering in Advanced Material(Ministry of Education) College of ChemistryTaiyuan University of TechnologyTaiyuanShanxi 030024China

The photocatalytic oxidative coupling of thiols is one of the most popular methods to synthesize the *** and its derivatives(TPAs)are promising for the above reaction,but suffer from the easy polymerization and difficult *** overcome these obstacles while controlling the photogenerated electrons transfer directly to target substrates,herein,we constructed one TPA-based metal-organic framework(MOF),(Me_(2)NH_(2))[Sr(TCBPA)]·DMA·3H_(2)O(1),by direct self-assembly of tris(4′-carboxybiphenyl)amine(H_(3)TCBPA)and photoredox inert strontium ion(Sr^(2+)).DFT calculations revealed that the valence band maximum(VBM)and the conduction band minimum(CBM)are mainly located on TCBPA^(3-),successfully inhibiting the undesirable electron migration to metal *** results indicated that 1 displays superior performance than homogeneous H_(3)TCBPA,which may result from the abundant π…π and C—H…π interactions between the well-arranged TCBPA^(3-)and the build-in electric field between the anionic framework and the Me_(2)NH^(2+).This work highlights that immobilizing TPAs into MOFs is one promising approach to designing heterogeneous photocatalysts for the synthesis of disulfides by oxidative coupling of thiols.

关键词： Triphenylamine Metal-organic frameworks Strontium Photooxidation Thiols Disulfides

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MFS超家族转运蛋白结构基础及转运机制

科学通报 2015年第8期60卷 720-728页

作者：邓东颜宁清华大学清华-北大生命联合中心/医学院/结构生物学中心生物膜和膜工程国家重点实验室北京100084

MFS(major facilitator superfamily)转运蛋白家族是目前已知的最大的膜转运蛋白家族之一.该家族膜转运蛋白广泛存在于整个生物界,其功能也与很多生命活动现象息息相关.作为膜转运蛋白,其基本功能是协助完成物质的跨膜转运.为了更好地理... 详细信息

MFS(major facilitator superfamily)转运蛋白家族是目前已知的最大的膜转运蛋白家族之一.该家族膜转运蛋白广泛存在于整个生物界,其功能也与很多生命活动现象息息相关.作为膜转运蛋白,其基本功能是协助完成物质的跨膜转运.为了更好地理解MFS超家族蛋白如何实现物质的跨膜转运,科研人员致力于对其进行结构生物学研究.至今为止,总共有16个MFS超家族蛋白成员的结构得到解析.有限的结构信息可以提供一些线索,帮助我们理解跨膜物质转运的机制.本文除了介绍MFS超家族蛋白结构生物学和转运机制的研究进展外,还通过对已有结构和转运机制的介绍,实现对将来研究的展望.

关键词： MFS蛋白家族转运蛋白结构生物学

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代谢物组学方法及其在植物学研究中的应用

广西植物 2007年第5期27卷 765-769,691页

作者：董登峰广西大学农学院南宁530005

代谢物是生物体受遗传控制和环境影响的最终表达产物,以全体代谢物(代谢物组)为研究对象的代谢物组学是继基因组学和蛋白质组学后必然出现的又一门"组学"技术。该文综述了代谢物组的检测、数据的处理和分析等以及这些技术在植物目标分... 详细信息

代谢物是生物体受遗传控制和环境影响的最终表达产物,以全体代谢物(代谢物组)为研究对象的代谢物组学是继基因组学和蛋白质组学后必然出现的又一门"组学"技术。该文综述了代谢物组的检测、数据的处理和分析等以及这些技术在植物目标分析、基因功能、代谢途径和代谢工程、整合植物学、信号转导等研究中的应用和前景。

关键词：代谢物组学方法植物学应用

Developing a fluorescence substrate for HRP-based diagnostic assays with superiorities over the commercial ADHP

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Chinese Chemical Letters 2024年第6期35卷 439-444页

作者： Zhichao Zhou Fuqian Chen Xiaotong Xia dong Ye Rong Zhou Lei Li Tao deng Zhenhua Ding Fang Liu Department of Radiation Medicine Guangdong Provincial Key Laboratory of Tropical Disease ResearchSchool of Public HealthSouthern Medical UniversityGuangzhou 510515China School of Pharmaceutical Sciences Guangzhou University of Chinese MedicineGuangzhou 510006China Artemisinin Research Center Guangzhou University of Chinese MedicineGuangzhou 510006China State Key Laboratory of Respiratory Disease the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhou 510120China Guangzhou Laboratory Bio-IslandGuangzhou 510030China Nanshan Pharmaceutical Innovation Research Institute of Guangdong Province Foshan 528225China

The combination of horseradish peroxidase(HRP)and a fluorescence substrate has been attracting great interests in developing sensitive biochemical analysis and immunoassays.10-Acetyl-3,7-dihydroxyphenoxazine(ADHP or Amplex red)is the most sensitive fluorogenic substrate known for HRP in current market,however,it suffers from some drawbacks,such as non-specific reactivity to carboxylesterase and limited fluorescence *** the present study,a novel HRP substrate10-cyclopropylcarbonyl-dichloro-dihydroxyphenoxazine(AR-2),has been prepared,which exhibited improved sensitivity than ADHP in sensing ***,the fluorescence of AR-2/HRP demonstrated improved tolerance to physiological relevant p H fluctuation as compared to ADHP/*** detection of uric acid/urate oxidase reaction indicated excellent application prospect of AR-2/HRP for monitoring H_(2)O_(2)-generating biochemical *** interestingly,an enzyme-linked immunosorbent assay(ELISA)using AR-2 as the fluorescence reporter has been successfully used in detecting IgG against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)from human serum ***,AR-2 exhibits improved performances over the commercial ADHP,which will be an ideal alternative to ADHP in HRP-based fluorescence biochemical analysis and immunoassays.

关键词： Fluorescence immunoassay HRP fluorescence substrate Hydroresorufin Amplex red/ADHP SARS-CoV-2

Polyphenol-mediated interfacial deposition strategy for supported manganese oxide catalysts with excellent pollutant degradation performance

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Chinese Chemical Letters 2024年第5期35卷 493-498页

作者： dong Cheng Youyou Feng Bingxi Feng Ke Wang Guoxin Song Gen Wang Xiaoli Cheng Yonghui deng Jing Wei The Key Laboratory of Biomedical Information Engineering of Ministry of Education State Key Lab of Transducer TechnologySchool of Life Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China School of Environmental and Municipal Engineering Xi’an University of Architecture and TechnologyXi’an 710055China Department of Chemistry State Key Laboratory of Molecular Engineering of PolymersState Key Laboratory of Transducer TechnologyFudan UniversityShanghai 200433China Key Laboratory of Functional Inorganic Material Chemistry Ministry of EducationSchool of Chemistry and Materials ScienceHeilongjiang UniversityHarbin 150080China

In persulfate-based advanced oxidation process(PS-AOPs),fixing nanosized metal oxide on processable substrates is highly desirable to avoid the aggregation and loss of nanocatalysts during the practical ***,it is still challenging to develop a versatile strategy for the deposition of metal oxide nanocatalysts on various substrates with different physicochemical ***,polyphenols are utilized as a“molecular glue”and reductant to mediate the interfacial deposition of MnO_(2) nanocatalysts on different ***_(2) nanocatalysts were in-situ grown on macroscope mineral substrates(e.g.,airstone)via an interfacial redox strategy between tannic acid(TA)and oxidized KMnO4,and then employed as a fixed catalyst of peroxymonosulfate(PMS)activation for treating pharmaceutical and personal care products(PPCPs)in *** fixed MnO_(2) exhibited superior catalytic performance toward different PPCPS via a singlet oxygen(^(1)O_(2))-dominated nonradical oxidation *** in the secondary effluent of wastewater treatment plants could be effectively removed by a fixed-bed column of the fixed MnO_(2) with long term *** cycle of Mn^(4+)/Mn^(3+)and surface hydroxyl group of the fixed MnO_(2) was proved to be responsible for the activation of *** work provides a new avenue for developing fixed metal oxides for sustainable water treatment.

关键词： Redox strategy Manganese oxides Fixed catalyst Peroxymonosulfate PPCPs

Maternal weight and its association with risk of overweight in offspring:a trajectory analysis from a birth cohort in China

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World Journal of Pediatrics 2024年第5期20卷 496-505页

作者： Rui deng Wei-Qin Li Xing-Xiu Li Liu-Mei Wei Jie Hu Jun-Hong Leng Bin dong Institute of Child and Adolescent Health School of Public HealthPeking University Health Science CenterNo.38 Xueyuan RdHaidian DistrictBeijing100191China Tianjin Women and Children’s Health Center No.96 Guizhou RdHeping DistrictTianjin300070China Menzies Health Institute Queensland Griffith UniversityNathanQLD4111Australia

Background Most studies on the association of maternal pregnancy weight with offspring weight trajectory have a short follow-up *** study aimed to explore the associations of maternal prepregnancy body mass index(BMI)and gestational weight gain(GWG)with childhood weight trajectories in a 7-year birth *** A total of 946 mother–child pairs(467 boys and 479 girls)from a longitudinal birth cohort in Tianjin City,China,were included in this study,ranging from pregnancy to offspring at 7 *** outcome variable was defined as overweight or not overweight in offspring at the last round.A group-based trajectory model was applied to identify childhood BMI trajectory *** Five discrete BMI trajectory groups were identified and characterized as constant underweight(25.2%),constant normal weight(42.8%),and high or increasing trajectory[at risk of overweight(16.9%),progressive overweight(11.0%)and progressive obesity(4.1%)].Maternal prepregnancy overweight was associated with 1.72(95%CI 1.14–2.60,P=0.01)to 4.02(95%CI 1.94–8.36,P<0.001)times the risk of all high or increasing trajectory groups,and excessive GWG was related to groups at risk of overweight[relative risk ratio(RRR)2.09,95%CI 1.27–3.46,P=0.004]and progressive obesity(RRR 3.33,95%CI 1.13–9.79,P=0.029).Children in all high or increasing trajectory groups were associated with greater overweight risk at the last round[risk ratios(RRs)ranged from 3.54(95%CI 2.53–4.95,P<0.001)to 6.18(95%CI 4.05–9.42,P<0.001)].Conclusion Maternal prepregnancy overweight and excessive gestational weight gain were associated with increasing or high-level childhood body mass index trajectories as well as a greater risk of overweight at 7 years.

关键词： Body-weight trajectory Child Gestational weight gain Overweight Pregnancy

Molecular Cloning of MSRG-11 Gene Related to Apoptosis of Mouse Spermatogenic Cells

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Acta Biochimica et Biophysica Sinica 2005年第3期37卷 159-166页

作者： Yun deng dong-Song NIE Jian WANG Xiao-Jun TAN Zhao-Yan NIE Hong-Mei YANG Liang-Sha HU Guang-Xiu LU Human Reproductive and Stem Cell Engineering Institute,Central South University,Changsha 410078,China Human Reproductive and Stem Cell Engineering Institute Central South UniversityChangsha 410078 China

Beginning with a new contig of the expressed sequence tags(Mm.63892)obtained bycomparing testis libraries with other tissue and cell line libraries using the digital differential display program,we cloned a new gene which is related to the apoptosis of mouse spermatogenic cells using the Genscanprogram and polymerase chain reaction(PCR)*** sequence data have been submitted to theGenBank database under accession number *** full cDNA length is 1074 bp,and the gene with7 exons and 6 introns is located in mouse chromosome 1 *** protein is recognized as a new member ofcahnodulin(CaM)binding protein family because the sequence contains three short calmodulin-binding motifscontaining conserved Ile and Gln residues(IQ motif)and is considered to play a critical role in interactions ofIQ motif-containing proteins with CaM *** putative protein encoded by this gene has 192 aminoacid residues with a theoretical molecular mass of 23.7 kDa and a calculated isoelectric point of *** shares no significant homology with any known protein in ***-PCR and Northern blotanalyses revealed that 1.3 kb MSRG-11 transcript was strongly expressed in adult mouse testis but weaklyexpressed in the spleen and *** MSRG-11 gene was expressed at various levels,faintly at twoweeks postpartum and strongly from three weeks postpartum in adult *** green fluorescence pro-duced by pEGFP-C2/MSRG-11 was detected in the cytoplasm of COS7 cells 24 h ***3.1(-)/MSRG-11 plasmid was constructed and introduced into COS7 cells using Lipofectamine 2000transfection reagent(Invitrogen,Carlsbad,USA).MSRG-11 can accelerate COS7 cell apoptosis,whichsuggests that this gene may play an important role in the development of mouse testes and is a candidate geneof testis-specific *** on these observations,it was considered that we cloned a new gene whichprobably accelerates spermatogenetic cell apoptosis in mouse.

关键词： MSRG-11 gene testis-specific expression spermatogenetic cell apoptosis IQ motif

师范类高校实践育人共同体构建路径探析一以长沙师范学院艺术设计类专业学生为例

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特立研究 2024年第1期 75-79页

作者：邓东京廖瑶慧长沙师范学院宣传统战部湖南长沙410100 长沙师范学院继续教育学院湖南长沙410100

实践育人是高校人才培养的重要组成部分,是实践与育人的有机整合,是推动和形成全员育人、全过程育人、全方位育人的主要途径。长沙师范学院艺术设计类专业围绕“思想引领、文化滋养、艺术熏陶”,以“践行社会主义核心价值观,传承和弘扬... 详细信息

实践育人是高校人才培养的重要组成部分,是实践与育人的有机整合,是推动和形成全员育人、全过程育人、全方位育人的主要途径。长沙师范学院艺术设计类专业围绕“思想引领、文化滋养、艺术熏陶”,以“践行社会主义核心价值观,传承和弘扬特立精神,滋养大学生成长成才”为主线,将青年担当、专业学习和创新创业实践有机融合,初步探索出“一二二三四五”的实践育人路径,有利于促进学生综合实践能力的提升和学生的全面成长成才。

关键词：师范类高校艺术设计类专业实践育人育人路径

Stability mechanism and control of the pumpable supports in longwall recovery room

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International Journal of Mining Science and Technology 2024年第7期34卷 957-974页

作者： dong Zhang Jianbiao Bai Zhijun Tian Zizheng Zhang Yonghong Guo Rui Wang Ying Xu Hao Fu Shuai Yan Min deng Shuaigang Liu State Key Laboratory of Coal Resources and Safe Mining China University of Mining and TechnologyXuzhou 221116China Key Laboratory of Xinjiang Coal Resources Green Mining Xinjiang Key Laboratory of Coal-bearing Resources Exploration and ExploitationXinjiang Engineering Research Center of Green Intelligent Coal MiningXinjiang Institute of EngineeringUrumqi 830023China Work Safety Key Laboratory on Prevention and Control of Gas and Roof Disasters for Southern Goal Mines Hunan Provincial Key Laboratory of Safe Mining Techniques of Coal MinesHunan University of Science and TechnologyXiangtan 411201China School of Mines China University of Mining and TechnologyXuzhou 221116China

The load-bearing performance(LBP)of pumpable supports(PPS)is crucial for the stability of longwall pre-driven recovery room(PRR)surrounding ***,the unbalanced bearing coefficient(UBC)of the PPS(undertaking unequal load along the mining direction)has not been investigated.A mechanical model of the PRR was established,considering the main roof cantilever beam structure,to derive an assessment formula for the load,the failure criteria,and the UBC of the ***,the generation mechanisms,and influencing factors of the UBC were *** sensitivity analysis shows that the main roof hanging length(l_(2))and the spacing between the PPS(r)significantly impact the UBC.A novel design of the PPS and the coupling control technology were proposed and applied to reduce the UBC of the PPS in the adjacent longwall *** results showed no failure of the PPS at the test site,with the UBC(ζ)reduced to 1.1 consistent with the design value(1.15)basically,fully utilizing the collaborative LBP of the ***,the maximum roof-to-floor convergence of the PRR was 234 mm,effectively controlling the stability of the surrounding rock of the PRR and ensuring the mining equipment recovery.

关键词： Pre-driven recovery room Pumpable supports Unbalanced bearing coefficient Hydraulic fracture Stability analysis Surrounding rock control