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Cancer nanomedicine in preoperative therapeutics:Nanotechnology-enabled neoadjuvant chemotherapy,radiotherapy,immunotherapy,and phototherapy

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Bioactive Materials 2023年第6期24卷 136-152页

作者： Xiaogang Qu Dong Zhou Jianpu Lu Duotian Qin Jun zhou Hai-Jun Liu Department of General Surgery Changshu Hospital Affiliated to Nanjing University of Chinese MedicineChangshu215500China Center for Nanomedicine and Department of Anesthesiology Brigham and Women’s HospitalHarvard Medical SchoolBostonMA02115USA

Surgical resection remains a mainstay in the treatment of malignant solid tumors.However,the use of neoadjuvant treatments,including chemotherapy,radiotherapy,phototherapy,and immunotherapy,either alone or in combination,as a preoperative intervention regimen,have attracted increasing attention in the last decade.Early randomized,controlled trials in some tumor settings have not shown a significant difference between the survival rates in long-term neoadjuvant therapy and adjuvant therapy.However,this has not hampered the increasing use of neoadjuvant treatments in clinical practice,due to its evident downstaging of primary tumors to delineate the surgical margin,tailoring systemic therapy response as a clinical tool to optimize subsequent therapeutic regimens,and decreasing the need for surgery,with its potential for increased morbidity.The recent expansion of nanotechnology-based nanomedicine and related medical technologies provides a new approach to address the current challenges of neoadjuvant therapy for preoperative therapeutics.This review not only summarizes how nanomedicine plays an important role in a range of neoadjuvant therapeutic modalities,but also highlights the potential use of nanomedicine as neoadjuvant therapy in preclinical and clinic settings for tumor management.

关键词： Neoadjuvant treatment Preoperative preparation Surgical resection Nanotechnology

Fabricating functionally graded Fe-Cr-Co permanent magnetic alloys via laser powder bed fusion

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Journal of Iron and Steel Research(International) 2024年第3期31卷 729-737页

作者： Ya-zhou He Ya-qing Hou Peng Shen Hao Zhang Dong Zhou Hang Su Central Iron and Steel Research Institute Co. Ltd.Beijing 100081China Material Digital R&D Center China Iron and Steel Research Institute Group Co.Ltd.Beijing 100081China

Laser powder bed fusion(LPBF)in-situ alloying technology offers the possibility to construct gradient materials with varied structures and properties.Functionally graded Fe-Cr-Co permanent magnetic alloys were fabricated by LPBF and in-situ alloying mixed powders of Fe,Cr,and Co elements.The effects of different Fe,Cr and Co contents on the microstructure,magnetic properties and hardness of Fe-Cr-Co alloys prepared by LPBF were studied.The as-built Fe-Cr-Co alloys present a single body-centered-cubic phase and have a homogeneous distribution of elements.The mechanical properties and magnetic properties of the compositionally graded sample show a gradient variation.With the increase in Cr content,the Vickers hardness of the sample increases,and the saturation magnetization of the sample decreases.The optimal magnetic properties in an isotropic state are given as coercivity HcB=21.65 kA/m,remanence Br=0.70 T and energy product(BH)_(max)=5.35 kJ/m^(3),which are comparable to or higher than the reported magnetic properties in an isotropic state prepared by traditional powder metallurgy.LPBF in-situ alloying technology has the potential to further explore Fe-Cr-Co magnetic materials,such as those consisting of multiple or more constituent elements,and to maximize the compositional flexibility of magnetic materials.

关键词： Fe-Cr-Co alloy Laser powder bed fusion In-situ alloying Functional material Magnetic property

Recent progress in solution assembly of 2D materials for wearable energy storage applications

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Journal of Energy Chemistry 2021年第11期30卷 27-42,I0002页

作者： Dong Zhou Liang Zhao Bo Li Department of Mechanical Engineering Villanova UniversityVillanovaPA 19085USA Hybrid Nano-Architectures and Advanced Manufacturing Laboratory Villanova UniversityVillanovaPA 19085USA

Wearable energy storage devices are desirable to boost the rapid development of flexible and stretchable electronics. Two-dimensional (2D) materials, e.g., graphene, transition metal dichalcogenides and oxides, and MXenes, have attracted intensive attention for flexible energy storage applications because of their ultrathin 2D structures, high surface-to-volume ratio, and unique physical/chemical properties. To achieve commercialization of 2D material-based wearable energy storage devices (2DM-WESDs), scalable and cost-efficient manufacturing is a critical challenge. Among existing manufacturing technologies, solution-based assembly strategies show strong potential to achieve low-cost and scalable production. A timely review of the recent progress in solution-based assembly strategies and the resultant 2DM-WESDs will be meaningful to guide the future development of 2DM-WESDs. In this review, first, a brief introduction of exfoliation and solution preparation of 2D material species from bulk materials is discussed. Then, the solution-based assembly strategies are summarized, and the advantages and disadvantages of each method are compared. After that, two major categories of 2DM-WESDs, supercapacitor and battery, are discussed, emphasizing their state-of-the-art energy storage performances and flexibilities. Finally, insights and perspectives on current challenges and future opportunities regarding the solution assembly of 2DM-WESDs are discussed.

关键词： 2D materials Solution assembly Wearable Energy storage

On the Application of the Lattice Boltzmann Method to Predict Soil Meso Seepage Characteristics

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Fluid Dynamics & Materials Processing 2020年第5期16卷 903-917页

作者： Dong Zhou Zhuoying Tan Institute of Civil Engineering Huanghe S&T UniversityZhengzhou450063China School of Civil&Environmental Engineering University of Science and Technology BeijingBeijing100083China

In this study,a two-dimensional approach is elaborated to study with the lattice Boltzmann method(LBM)the seepage of water in the pores of a soil.Firstly,the D2Q9 model is selected to account for the discrete velocity distribution of water flow.In particular,impermeability is considered as macroscopic boundary condition for the left and right domain sides,while the upper and lower boundaries are assumed to behave as pressure boundaries controlled by different densities.The micro-boundary conditions are implemented through the standard rebound strategy and a non-equilibrium extrapolation scheme.Matlab is used for the development of the related algorithm.Finally,the influence of porosity,permeability,osmotic pressure and other factors is assessed with regard to seepage characteristics and the ensuing results are compared with Darcy’s law.The computations show that,for fixed initial conditions,the pore structure has a certain influence on the local velocity of seepage,but the overall state is stable,and the average velocity of each layer is the same.The larger the pore passage is,the faster the flow velocity is,and vice versa.For low permeability,the numerical results are consistent with the Darcy's law.The greater the pressure difference between the inlet and outlet of seepage,the greater the seepage rate.The relationship between them is linear(yet in good agreement with Darcy’s law).

关键词： Lattice Boltzmann method numerical simulation seepage field porosity Darcy’s law

Calculation and management of ketogenic diet parenteral nutrition in super-refractory status epilepticus

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Acta Epileptologica 2022年第3期5卷 136-144页

作者： Ya Zeng Jie Mu Dong Zhou Pharmacy Department West China Hospital of Sichuan University14#Third SectionRenmin Nan RoadChengdu 610041China Neurology Department West China Hospital of Sichuan University14#Third SectionRenmin Nan RoadChengdu 610041China

Super-refractory status epilepticus(SRSE)is an important neurological emergency associated with high mortality and morbidity and poses a heavy economic burden on patients.Ketogenic diet parenteral nutrition(KD-PN)is ketogenic diet therapy provided through parenteral administration and may be an adjuvant treatment for these who cannot accept enteral diet.However,the calculation and management of KD-PN presents a challenge for clinicians.This review focuses on the practical aspects of KD-PN therapy for treatment of SRSE,including the dietary composition,potential drug-diet interactions,and monitoring during KD-PN treatment.As with all SRSE treatments,KD-PN has many adverse effects,like hyperlipemia,hepatotoxicity,metabolic acidosis,insufficient ketosis or hyper-ketosis,and propofol infusion syndrome.We summarize monitoring and treatment methods in our review.This review provides some practical aspects for treatment of SRSE.

关键词： Epilepsy Super-refractory status epilepticus Ketogenic diet parenteral nutrition

Filamin A Gene Associated Periventricular Nodular eterotopia and Epilepsy in a Cohort of Chinese Patients

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Chinese Medical Journal 2017年第20期130卷 2506-2507页

作者： Wen-Yu Liu Dong Zhou Department of Neurology West China Hospital Sichuan University Chengdu Sichuan 610041 China

Periventricular nodular heterotopia （PNH） is a cortical malformation commonly found in epilepsy patients caused by the failure of neurons to migrate.Patients with PNH present with various clinical manifestations and genetic mutations. Despite their remarkable structural malformations, PNH patients generally have no neurological deficits or cognitive disabilities. However, particularly in patients with abnormal cortical development, the systematic abnormalities can also be severely delayed.

关键词： Filamin A： Periventricular Nodular Heterotopia Phenotype Social Support

Update on the role of noncoding RNAs in vitiligo

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Chinese Medical Journal 2022年第7期135卷 793-795页

作者： Ting zhou dong Li Yunhua Deng Department of Dermatology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubel 430030China

Vitiligo is a prevailing disfiguring skin disorder characterized by the selective absence of functional melanocytes,affecting 0.5%to 1%of the global population.^([1])Several hypotheses have been proposed for its pathogenesis,including autoimmunity,oxidative stress,genetic and environmental factors,and metabolic abnormalities.^([2])No individual factor can completely explain the complex progression of this disease.Most of the human genome encodes RNAs that are not translated into proteins,termed noncoding RNAs(ncRNAs).

关键词： Vit noncoding pathogenesis

Internal Polarization Field Induced Hydroxyl Spillover Effect for Industrial Water Splitting Electrolyzers

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Nano-Micro Letters 2024年第2期16卷 438-449页

作者： Jingyi Xie Fuli Wang Yanan zhou Yiwen dong Yongming Chai Bin dong State Key Laboratory of Heavy Oil Processing College of Chemistry and Chemical EngineeringChina University of Petroleum(East China)Qingdao 266580People’s Republic of China

The formation of multiple oxygen intermediates supporting efficient oxygen evolution reaction(OER)are affinitive with hydroxyl adsorption.However,ability of the catalyst to capture hydroxyl and maintain the continuous supply at active sits remains a tremendous challenge.Herein,an affordable Ni2P/FeP2 heterostructure is presented to form the internal polarization field(IPF),arising hydroxyl spillover(HOSo)during OER.Facilitated by IPF,the oriented HOSo from FeP2 to Ni2P can activate the Ni site with a new hydroxyl transmission channel and build the optimized reaction path of oxygen intermediates for lower adsorption energy,boosting the OER activity(242 mV vs.RHE at 100 mA cm-2)for least 100 h.More interestingly,for the anion exchange membrane water electrolyzer(AEMWE)with low concentration electrolyte,the advantage of HOSo effect is significantly amplified,delivering 1 A cm^(-2)at a low cell voltage of 1.88 V with excellent stability for over 50 h.

关键词： Hydroxyl spillover effect Internal polarization field Heterostructure Oxygen reduction reaction Anion exchange membrane water electrolysis

Design strategies for rechargeable aqueous metal-ion batteries

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Science China Chemistry 2024年第1期67卷 165-190页

作者： Yang Li Xin Zhao Yifu Gao Yichen Ding Zhichun Si Liubing dong Dong Zhou Feiyu Kang Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China College of Chemistry and Materials Science Jinan UniversityGuangzhou 511443China

Rechargeable aqueous metal-ion batteries(AMBs)have attracted extensive scientific and commercial interest due to their potential for cost-effective,highly safe,and scalable stationary energy storage.However,their limited output voltage,inadequate energy density,and poor reversibility of ambiguous electrode reactions in aqueous electrolytes strongly limit their practical viability.This review aims to elucidate the challenges of existing AMBs from the material design to whole device applications.We summarize the emerging electrochemistry,fundamental properties,and key issues in interfacial behaviors of various classes of prevailing AMBs,including aqueous alkali metal-ion batteries and multivalent-ion batteries,and present an appraisal of recent advances for addressing the performance deficiency.Specifically,the progress of zinc-ion batteries is highlighted to provide a ubiquitous guideline for their commercialization in the grid-scale energy storage.Finally,we figure out the dominating general challenges for achieving high-performance AMBs,laying out a perspective for future breakthroughs.

关键词： aqueous metal-ion batteries aqueous alkali metal-ion batteries zinc-ion batteries interfacial behavior stationary energy storage