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Morphological analysis on adhesion and invasion involved in endometriosis with tissue culture

Chinese Medical Journal 2011年第1期124卷 148-151页

作者： SHI Jing-hua YANG Yan-jun dong zhe LANG Jing-he LENG Jin-hua Department of Obstetrics & Gynaecology Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100730 China Department of Obstetrics & Gynaecology China-Japan Friendship Hospital Belling 100029 China

Background Endometriosis （EM） is a benign gynecologic disease predominantly found in women of reproductive age. However, its pathogenesis is still poorly understood. Our experiment was designed to establish a stable and reliable cultural environment for coculture of endometrium and peritoneum, so as to observe the adhesion/invasion ability of endometrium from patients with or without EM. Methods Endometria of secretory phase and peritoneum were sampled from 6 women with endometriois during laparoscopy. Six with ovarian teratoma or simple ovarian cyst were taken as control. We cocultured endometrium and peritoneum into four groups （endometrium from EM cultured with peritoneum from EM, endometrium from control cultured with peritoneum from control, endometrium from EM cultured with peritoneum from non-EM and the endometrium from control cultured with peritoneum from EM） to observe the adhesion/invasion process in gas-liquid surface culture and in-medium culture. Specimens were collected at 1 hour, 6 hours, 12 hours, 24 hours, 2 days, 3 days, 4 days, 5 days, 6 days and 7 days for histology, immunofluorescence and immunohistochemical analysis on cytokeratin 8 （CK8） and CD10. Results The gas-liquid surface culture was superior to in-medium culture for the maintenance of tissue morphology and survival of endometrium. CK8 immunoflurescence demonstrated no remarkable difference in adhesion process between patients with and without EM. CD10 immunochemistry manifested frequent invasion of endometrial stromal cells from EM patients into peritoneum of up to 3 days culture, while the endometriotic cells from non-EM patients did not invade into peritoneum. Conclusions Gas-liquid surface culture is a suitable model for observing the early events in EM lesion formation. Endometrium from patients with EM showed increased invasion capacity during coculture, which might help to explain the etiology of endometriosis.

关键词： endometriosis endometrium peritoneum

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金银花数字化烘干系统设计与试验

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价值工程 2024年第22期43卷 106-110页

作者：周英森李保路赵东哲贾英新河北省科学院石家庄050081 京津冀国家技术创新中心河北中心石家庄050081 巨鹿应用技术研究院石家庄050081 河北省机电一体化中试基地有限公司石家庄050081 河北省国创京津冀科技发展有限公司石家庄050081

针对全国金银花主产地之一,素有“中国金银花之乡”美誉的邢台市巨鹿县金银花由散户到标准种植结构的变化,引起的金银花由分散型到集中初加工的需求,及市场对金银花品质新要求等系列问题,本系统将追溯系统融入金银花烘干系统中,整个烘... 详细信息

针对全国金银花主产地之一,素有“中国金银花之乡”美誉的邢台市巨鹿县金银花由散户到标准种植结构的变化,引起的金银花由分散型到集中初加工的需求,及市场对金银花品质新要求等系列问题,本系统将追溯系统融入金银花烘干系统中,整个烘干过程不需要人工参与,用户只需在称重前进行身份识别,整套系统即可完成称重、烘干、打包、贴签等功能,实现可追溯的数字化烘干。

关键词：金银花溯源系统数字化烘干金银花品质

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Study on the correlation and predictive value of serum pregnancyassociated plasma protein A, triglyceride and serum 25-hydroxyvitamin D levels with gestational diabetes mellitus

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World Journal of Clinical Cases 2020年第5期8卷 864-873页

作者： Zhuo Ren dong zhe Zhi Li Xin-Ping Sun Kai Yang Li Lin Department of Obstetrics and Gynecology Peking University International HospitalBeijing 102206China Department of Clinical Laboratory Peking University International HospitalBeijing 102206China

BACKGROUND Gestational diabetes mellitus(GDM)is a concern due to its rapid increase in incidence in recent *** To investigate the correlation and predictive value of serum pregnancyassociated plasma protein A(PAPP-A),triglyceride(TG),and 25-hydroxyvitamin D[25-(OH)D]with GDM in early *** A total of 99 patients in early pregnancy admitted to Peking University International Hospital from November 2015 to September 2017 were included,and underwent a fasting glucose test and oral glucose tolerance test screening at 24-28 wk of *** these cases with GDM,51 were assigned to group A and the remaining 48 cases without GDM were enrolled in group *** PAPP-A,TG and 25-(OH)D in the two groups were compared and their correlation with blood sugar was *** addition,their diagnostic value in GDM was determined using receiver operating characteristic(ROC)curve *** Group A had markedly lower serum PAPP-A and 25-(OH)D levels and a significantly higher serum TG level than group B,with statistical significance(P<0.05).Furthermore,Pearson analysis identified that PAPP-A and 25-(OH)D levels were negatively correlated with fasting blood glucose(FBG)levels(r=-0.605,P<0.001),(r=-0.597,P<0.001),while TG and FBG levels were positively correlated(r=0.628,P<0.001).The sensitivity,specificity,area under the curve(AUC)and optimal cut-off value of serum PAPP-A level in the diagnosis of GDM were 72.55%,82.35%,0.861 and 16.340,respectively,while the sensitivity of TG in diagnosing GDM was 86.27%,the specificity was 66.67%,the AUC was 0.813,with an optimal cut-off value of *** corresponding sensitivity,specificity,AUC and optimal cut-off value of serum 25-(OH)D were 64.71%,70.59%,0.721 and 23.140,***,multivariate logistic regression analysis revealed that FBG,vascular endothelial growth factor,Flt-1,serum PAPP-A,TG,and 25-(OH)D were related risk factors leading to GDM in *** Serum PAPP-A,TG,and 25-(OH)D levels

关键词： Early pregnancy Serum pregnancy-associated plasma protein A level Triglyceride Serum 25-hydroxyvitamin D Gestational diabetes mellitus Oral glucose tolerance test

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环大学创新创业生态圈建设路径研究——以黑龙江科技大学为例

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未来与发展 2024年第2期48卷 75-79页

作者：赵喜江许寒梅董哲李一鸣黑龙江科技大学黑龙江哈尔滨150026

环黑龙江科技大学创新创业生态圈建设是贯彻落实“大众创业、万众创新”国家战略的需要、是引领产业振兴,落实龙江发展战略的需要、是促进城市繁荣,助力哈尔滨市创新发展的需要、是学校提升服务能力,实现高质量发展的需要,对于学校发展... 详细信息

环黑龙江科技大学创新创业生态圈建设是贯彻落实“大众创业、万众创新”国家战略的需要、是引领产业振兴,落实龙江发展战略的需要、是促进城市繁荣,助力哈尔滨市创新发展的需要、是学校提升服务能力,实现高质量发展的需要,对于学校发展具有重要的战略意义。生态圈建设坚持“校城融合”理念,秉承“一核、两带、三区”空间布局,通过优化资源集聚做强创新创意策源核、校政企合作协同创新补链延链强链、校城互动创意创新辐射兴市和拉动产业振兴繁荣经济强省等建设路径,形成区域竞争优势,营造“创新创业热土”。

关键词：环黑龙江科技大学创新创业生态圈建设路径

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慢性肾脏病患者的膳食评估

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解放军医学杂志 2024年第8期49卷 946-951页

作者：黄惠王倩骆雅咏唐正淳刘芳张睿敏董哲毅陈香美广东药科大学临床医学院广东广州510006 解放军总医院第一医学中心肾脏病医学部/肾脏疾病全国重点实验室/国家慢性肾病临床医学研究中心/肾脏疾病研究北京市重点实验室北京100853 成都中医药大学基础医学院四川成都611137

慢性肾脏病(CKD)常用的膳食评估方法包括24 h膳食回顾(24-h DR)/3 d膳食回顾(3DDR)、食物频率问卷(FFQ)、饮食记录及基于氮动态平衡估计膳食蛋白摄入量。由于亚洲人群CKD患者较多,且对其采用FFQ方法进行的相关研究很少,因此,建立适合中... 详细信息

慢性肾脏病(CKD)常用的膳食评估方法包括24 h膳食回顾(24-h DR)/3 d膳食回顾(3DDR)、食物频率问卷(FFQ)、饮食记录及基于氮动态平衡估计膳食蛋白摄入量。由于亚洲人群CKD患者较多,且对其采用FFQ方法进行的相关研究很少,因此,建立适合中国CKD人群的FFQ十分重要。本文针对CKD膳食评估方法的优缺点和研究现状,以及建立FFQ的内容和步骤进行综述,旨在为改良中国CKD患者的FFQ提供参考。

关键词：慢性肾脏病膳食评估 24 h膳食回顾食物频率问卷

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Integration of Artificial Intelligence, Blockchain, and Wearable Technology for Chronic Disease Management: A New Paradigm in Smart Healthcare

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Current Medical Science 2021年第6期41卷 1123-1133页

作者： Yi XIE Lin LU Fei GAO Shuang-jiang HE Hui-juan ZHAO Ying FANG Jia-ming YANG Ying AN zhe-wei YE zhe dong Department of Orthopedic Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Laboratory of Intelligent Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China School of Electronic Information and Communications Huazhong University of Science and TechnologyWuhan 430074China Wuhan Fourth Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430032China School of Cyber Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China

Chronic diseases are a growing concern worldwide,with nearly 25% of adults suffering from one or more chronic health conditions,thus placing a heavy burden on individuals,families,and healthcare *** the advent of the“Smart Healthcare”era,a series of cutting-edge technologies has brought new experiences to the management of chronic *** them,smart wearable technology not only helps people pursue a healthier lifestyle but also provides a continuous flow of healthcare data for disease diagnosis and treatment by actively recording physiological parameters and tracking the metabolic ***,how to organize and analyze the data to achieve the ultimate goal of improving chronic disease management,in terms of quality of life,patient outcomes,and privacy protection,is an urgent issue that needs to be *** intelligence(AI)can provide intelligent suggestions by analyzing a patient’s physiological data from wearable devices for the diagnosis and treatment of *** addition,blockchain can improve healthcare services by authorizing decentralized data sharing,protecting the privacy of users,providing data empowerment,and ensuring the reliability of data *** AI,blockchain,and wearable technology could optimize the existing chronic disease management models,with a shift from a hospital-centered model to a patient-centered *** this paper,we conceptually demonstrate a patient-centric technical framework based on AI,blockchain,and wearable technology and further explore the application of these integrated technologies in chronic disease ***,the shortcomings of this new paradigm and future research directions are also discussed.

关键词： artificial intelligence blockchain wearable technology/devices chronic diseases smart healthcare health monitoring personalization healthcare management patient-centric

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Application of Disability-Adjusted Life Years to Evaluate the Burden and Trend of Tuberculosis — China, 1990–2019

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China CDC weekly 2022年第11期4卷 220-225页

作者： zhe dong Qiqi Wang Shicheng Yu Jianjun Liu Hui Zhang Fei Huang Hongyan Yao Chinese Center for Disease Control and Prevention BeijingChina

Summary What is already known about this topic?China is a country with a high burden of tuberculosis(TB).However,the evaluation of TB burden is usually based on traditional epidemiological indicators,and disability-adjusted life year(DALY)is rarely *** is added by this report?In China,the number of DALYs caused by TB in 2019 was estimated to be 1.36 million,and the agestandardized rate(ASR)was 86.46/100,*** DALYs of TB decreased significantly from 1990 to 2019,with the largest decline from 2001 to *** burden is higher among men than women,and the highest among the *** are the implications for public health practice?Application of DALYs can reflect the damage in health to China’s residents caused by *** the future,we should strengthen research,monitor years lived with disability(YLDs),and reduce the burden of the elderly and ***-effective analysis based on DALYs should be conducted to provide a scientific basis for decision-making.

关键词： Application burden elderly

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生物降解塑料的分类和应用研究进展

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塑料科技 2024年第1期52卷 117-123页

作者：刘金凤者东梅杨勇胡孝义胡嘉伟丁树岩李永泉中石化(北京)化工研究院有限公司北京100013

为缓解不可降解塑料废弃物带来的白色污染问题,发展生物降解塑料以部分替代不可降解塑料是研究热点。文章概述了生物降解塑料,介绍了石化基生物降解塑料和生物基生物降解塑料的特点和研究进展,并对其在医疗卫生、包装和地膜中的应用进... 详细信息

为缓解不可降解塑料废弃物带来的白色污染问题,发展生物降解塑料以部分替代不可降解塑料是研究热点。文章概述了生物降解塑料,介绍了石化基生物降解塑料和生物基生物降解塑料的特点和研究进展,并对其在医疗卫生、包装和地膜中的应用进展进行综述。文章指出:目前生物降解塑料的发展受成本、使用性能(如阻隔性能、力学性能、耐热性能等)限制较大,通过优化加工工艺、选择合适的助剂可提高生物降解塑料的综合性能。未来的研究应该在保证生物降解材料性能的同时降低其生产成本。

关键词：石化基生物降解塑料生物基生物降解塑料包装领域农用地膜

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高效液相色谱-串联四极杆质谱法测定荔枝中降糖氨酸A和亚甲基环丙基甘氨酸

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化学分析计量 2024年第6期33卷 15-20页

作者：董喆胡越孙姗姗曹进李梦怡高飞中国食品药品检定研究院北京100050 北京市职业病防治研究院北京100093

建立高效液相色谱-串联四极杆质谱定量分析荔枝中降糖氨酸A和亚甲基环丙基甘氨酸两种降糖氨酸的测定方法。荔枝样品以90%乙醇为提取溶剂进行超声提取,离心取上清,氮吹后用水复溶。经丹磺酰氯衍生化后,采用Waters HSS T3色谱柱(100 mm×2... 详细信息

建立高效液相色谱-串联四极杆质谱定量分析荔枝中降糖氨酸A和亚甲基环丙基甘氨酸两种降糖氨酸的测定方法。荔枝样品以90%乙醇为提取溶剂进行超声提取,离心取上清,氮吹后用水复溶。经丹磺酰氯衍生化后,采用Waters HSS T3色谱柱(100 mm×2.1 mm,1.8μm)进行分离,柱温为35℃,水(含0.1%甲酸)和乙腈为流动相,梯度洗脱,流量为0.3 mL/min。质谱采用电喷雾电离源,正离子扫描,多反应监测模式进行检测。两种降糖氨酸的质量浓度在0.01~0.50μg/mL范围内与其色谱峰面积线性良好,相关系数均大于0.999,降糖氨酸A的检出限为0.05 mg/kg,亚甲基环丙基甘氨酸的检出限为0.08 mg/kg,加标回收率为81.4%~98.7%,相对标准偏差为3.2%~5.9%(n=6)。该方法操作简单,分析时间短,灵敏度高,准确可靠,为荔枝中降糖氨酸A和亚甲基环丙基甘氨酸两种降糖氨酸的测定提供了有效的技术手段。

关键词：高效液相色谱-串联四极杆质谱法荔枝降糖氨酸A 亚甲基环丙基甘氨酸

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High-voltage LiCoO_(2) cathodes for high-energy-density lithiumion battery

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Rare Metals 2022年第12期41卷 3946-3956页

作者： Jing-Chao Zhang zhe-dong Liu Cui-Hua Zeng Jia-Wei Luo Yi-Da Deng Xiao-Ya Cui Ya-Nan Chen School of Materials Science and Engineering Tianjin UniversityTianjin 300072China Beijing Frontier Research Center for Biological Structures Tsinghua UniversityBeijing 100084China Ministry of Education Key Laboratory of Protein Sciences Beijing Advanced Innovation Center for Structural BiologySchool of Life SciencesTsinghua UniversityBeijing 100084China

As the earliest commercial cathode material for lithium-ion batteries,lithium cobalt oxide(LiCoO_(2)) shows various advantages,including high theoretical capacity,excellent rate capability,compressed electrode density,*** now,it still plays an important role in the lithium-ion battery *** to these advantages,further increasing the charging cutoff voltage of LiCoO_(2)to guarantee higher energy density is an irresistible development trend of LiCoO_(2)cathode materials in the ***,using high charging cutoff voltage may induce a lot of negative effects,especially the rapid decay of cycle *** are mainly caused by rapid destruction of crystal structure and aggravation of interface side reaction at high voltage during the ***,how to maintain a stable crystal structure of LiCoO_(2)to ensure the excellent long cycle performance at high voltage is a hot research issue in the further application of LiCoO_(2).In this review,we summarized the failure causes and extensive solutions of LiCoO_(2)at high voltage and promoted some new modification ***,the development trend of solving the failure problem of high-voltage LiCoO_(2)in the future such as defect engineering and high-temperature shock technique is also discussed.

关键词： Lithium-ion battery Lithium cobalt oxide(LiCoO_(2))cathode High voltage Cycle performance Crystal structure

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