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Complete characterization of ultrafast optical fields by phase-preserving nonlinear autocorrelation

Light(Science & Applications) 2022年第10期11卷 2451-2462页

作者： Alexander Gliserin Soo Hoon Chew Seungchul kim dong Eon kim Department of Optics and Mechatronics Engineering College of Nanoscience and NanotechnologyPusan National University2 Busandaehak-ro 63beon-gilBusan 46241South Korea Department of Cogno Mechatronics Engineering College of Nanoscience and NanotechnologyPusan National University2 Busandaehak-ro 63beon-gilBusan 46241South Korea Max Planck Center for Attosecond Science Max Planck POSTECH/Korea Research Initiative77 Cheongam-roPohang 37673South Korea Department of Physics Center for Attosecond Science and TechnologyPohang University of Science and Technology77 Cheongam-roPohang 37673South Korea

Nonlinear autocorrelation was one of the earliest and simplest tools for obtaining partial temporal information about an ultrashort optical pulse by gating it with ***,since the spectral phase is lost in a conventional autocorrelation measurement,it is insufficient for a full characterization of an ultrafast electric field,requiring additional spectral information for phase ***,we show that introducing an intensity asymmetry into a conventional nonlinear interferometric autocorrelation preserves some spectral phase information within the autocorrelation signal,which enables the full reconstruction of the original electric field,including the direction of time,using only a spectrally integrating *** call this technique Phase-Enabled Nonlinear Gating with Unbalanced Intensity(PENGUIN).It can be applied to almost any existing nonlinear interferometric autocorrelator,making it capable of complete optical field characterization and thus providing an inexpensive and less complex alternative to methods relying on spectral measurements,such as frequency-resolved optical gating(FROG)or spectral phase interferometry for direct electric-field reconstruction(SPIDER).More importantly,PENGUIN allows the precise characterization of ultrafast fields in non-radiative(e.g.,plasmonic)nonlinear optical interactions where spectral information is *** demonstrate this novel technique through simulations and experimentally by measuring the electric field of~6-fs laser pulses from a Ti:sapphire *** results are validated by comparison with the well-established FROG method.

关键词： autocorrelation nonlinear characterization

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Endoscopic stenting for recurrence-related colorectal anastomotic site obstruction:Preliminary experience

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World Journal of Gastroenterology 2014年第38期20卷 13936-13941页

作者： Jung Ho kim Jong Joon Lee Jae Hee Cho Kyoung Oh kim Jun-Won Chung yoon Jae kim Kwang An Kwon dong Kyun Park Ju Hyun kim Department of Internal Medicine Gachon University Gil Medical Center

AIM: To evaluate the efficacy of stents in treating patients with anastomotic site obstructions due to cancer recurrence following colorectal surgery.

关键词： Colorectal neoplasms Endoscopy Intestinal obstruction Stents Surgical anastomosis

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Hepatitis B viral load affects prognosis of hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第34期20卷 12039-12044页

作者： Su Jong Yu yoon Jun kim Department of Internal Medicine and Liver Research Institute Seoul National University College of MedicineSeoul 110-744South Korea

Hepatocellular carcinoma(HCC)is a complex disease that is dually challenging to treat due to underlying chronic liver disease in addition to the cancer *** prognosis of patients with HCC is determined by intrahepatic tumor status and reserved hepatic *** B virus(HBV)is an established major risk factor of HCC development,and HBV viral load is being increasingly recognized as a prognostic factor in the presence of established *** HBV viral load may affect the prognosis of HBV-related HCC patients in several ***,it is associated with more frequent recurrence of HBV-related HCC after ***,it is associated with more occurrence and severity of potentially life-threatening HBV ***,it is associated with more worsened liver function,which limits the therapeutic options for HBV-related ***,directly or indirectly,can induce *** patients with a high HBV DNA level and subsequent active hepatitis,adhesion molecules expressed on the sinusoidal cells are up-regulated and may increase intrahepatic *** progression after treatment can lead to a poor prognosis by reducing number of normal functioning ***,high HBV viral load can affect the prognosis of patientswith HCC by frequent recurrence after treatment for HCC and deterioration of hepatic function associated with HCC *** meta-analysis showed that antiviral treatment reduces HCC recurrence and liver-related mortality after curative therapy of *** the strong relationship between high HBV DNA load and poor survival outcome of HCC patients due to cancer progression,it is expected that long-term antiviral therapy results in the sustained HBV suppression,control of inflammation,reduction in HCC progression,and eventually in improved overall survival.

关键词： Hepatitis B virus DNA Hepatocellular carcinoma Progression Prognosis

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Anti-inflammatory and anti-apoptotic effects of rosuvastatin by regulation of oxidative stress in a dextran sulfate sodium-induced colitis model

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World Journal of Gastroenterology 2017年第25期23卷 4559-4568页

作者： Seung Kak Shin Jae Hee Cho Eui Joo kim Eun-Kyung kim dong Kyun Park Kwang An Kwon Jun-Won Chung Kyoung Oh kim yoon Jae kim Division of Gastroenterology and Hepatology Department of Internal Medicine Gachon University Gil Medical Center

To evaluate the anti-inflammatory and anti-apoptotic effects of rosuvastatin by regulation of oxidative stress in a dextran sulfate sodium (DSS)-induced colitis model. METHODSAn acute colitis mouse model was induced by oral administration of 5% DSS in the drinking water for 7 d. In the treated group, rosuvastatin (0.3 mg/kg per day) was administered orally before and after DSS administration for 21 d. On day 21, mice were sacrificed and the colons were removed for macroscopic examination, histology, and Western blot analysis. In the in vitro study, IEC-6 cells were stimulated with 50 ng/mL tumor necrosis factor (TNF)-α and then treated with or without rosuvastatin (2 μmol/L). The levels of reactive oxygen species (ROS), inflammatory mediators, and apoptotic markers were measured. RESULTSIn DSS-induced colitis mice, rosuvastatin treatment significantly reduced the disease activity index and histological damage score compared to untreated mice (P < 0.05). Rosuvastatin also attenuated the DSS-induced increase of 8-hydroxy-2’-deoxyguanosine and NADPH oxidase-1 expression in colon tissue. Multiplex ELISA analysis revealed that rosuvastatin treatment reduced the DSS-induced increase of serum IL-2, IL-4, IL-5, IL-6, IL-12 and IL-17, and G-CSF levels. The increased levels of cleaved caspase-3, caspase-7, and poly (ADP-ribose) polymerase in the DSS group were attenuated by rosuvastatin treatment. In vitro, rosuvastatin significantly reduced the production of ROS, inflammatory mediators and apoptotic markers in TNF-α-treated IEC-6 cells (P < 0.05). CONCLUSIONRosuvastatin had the antioxidant, anti-inflammatory and anti-apoptotic effects in DSS-induced colitis model. Therefore, it might be a candidate anti-inflammatory drug in patients with inflammatory bowel disease.

关键词： Oxidative stress Inflammatory bowel disease Rosuvastatin Apoptosis

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Recent applications of chemosensitivity tests for colorectal cancer treatment

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World Journal of Gastroenterology 2014年第44期20卷 16398-16408页

作者： Yong Sik yoon Jin Cheon kim Department of Surgery University of Ulsan College of Medicine Institute of Innovative Cancer Research and Asan Institute for Life Sciences Asan Medical Center

The evaluation of therapeutic efficacy is necessary to predict the outcome of patients with metastatic colorectal cancer(CRC). In these patients, there is a critical need for predictive chemosensitivity assays and biomarkers to optimize efficacy and minimize toxicity. The introduction of targeted agents has improved the progression-free survival and overall survival of patients with metastatic disease. However, approximately 50% of patients do not show a positive response to chemotherapy and the selection of patients likely to respond to a specific regimen remains challenging. Cell culturebased chemosensitivity tests use autologous viable tumor cells to evaluate susceptibility to specific agents in vitro and predict their direct effects. Adenosine triphosphate-based assays and methyl thiazolyl-diphenyltetrazolium bromide-based assays are used widely as sensitivity tests because of their short assay period, technical simplicity, and the requirement of small amount of specimen. Among protein- and gene-based chemosensitivity assays, assessment of KRAS mutation status predicts the response to epidermal growth factor receptor-targeted therapy in CRC patients. The validation of predictive and prognostic markers enables the selection of therapeutic regimens with optimal efficacy and minimal toxicity for each patient, which has been termed personalized treatment. This review summarizes currently available predictive and prognostic chemosensitivity tests for metastatic CRC.

关键词： Colorectal adenocarcinomas Colorectal cancer Chemotherapy In vitro assays Molecular targeted therapy Individualized therapy

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Anomaly Detection Using Data Rate of Change on Medical Data

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Computers, Materials & Continua 2024年第9期80卷 3903-3916页

作者： Kwang-Cheol Rim Young-Min yoon Sung-Uk kim Jeong-In kim AI Convergence Research Institute Chosun UniversityGwangju61452Republic of Korea Interdisciplinary Program of Architectural Studies Chonnam UniversityGwangju61186Republic of Korea AINTCHAIN SOFT Co. Ltd.Mokpo-si58750Republic of Korea BK21 Human Resources Development Project Group Chosun UniversityGwangju61452Republic of Korea

The identification and mitigation of anomaly data,characterized by deviations from normal patterns or singularities,stand as critical endeavors in modern technological landscapes,spanning domains such as Non-Fungible Tokens(NFTs),cyber-security,and the burgeoning *** paper presents a novel proposal aimed at refining anomaly detection methodologies,with a particular focus on continuous data *** essence of the proposed approach lies in analyzing the rate of change within such data streams,leveraging this dynamic aspect to discern anomalies with heightened precision and *** empirical evaluation,our method demonstrates a marked improvement over existing techniques,showcasing more nuanced and sophisticated result ***,we envision a trajectory of continuous research and development,wherein iterative refinement and supplementation will tailor our approach to various anomaly detection scenarios,ensuring adaptability and robustness in real-world applications.

关键词： Anomaly data anomaly detection medical anomaly data cyber security rate of change

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Helicobacter pylori eradication with moxifloxacin-containing therapy following failed first-line therapies in South korea

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World Journal of Gastroenterology 2014年第22期20卷 6932-6938页

作者： Kyu Keun Kang dong Ho Lee dong Hyun Oh Hyuk yoon Cheol Min Shin Young Soo Park Nayoung kim Hyun Chae Jung Department of Internal Medicine Seoul National University Bundang HospitalSeongnamGyeongi-do 463-707South Korea Department of Internal Medicine Seoul National University College of MedicineSeoul 100-744South Korea

AIM: To investigate moxifloxacin-containing triple therapy as second-line treatment for Helicobacter pylori (H. pylori) infection following failed first-line treatment.

关键词： Fluoroquinolones Helicobacter pylori Disease eradication Drug resistance Second-line

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Introduction to the Special Issue on“Innovation and Application of Intelligent Processing of Data,Information and Knowledge in E-Commerce”

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Computer Modeling in Engineering & Sciences 2022年第4期131卷 19-21页

作者： Honghao Gao Jung yoon kim Yuyu Yin School of Computer Engineering and Science Shanghai UniversityShanghaiChina Department of Game Media College of Future IndustryGachon UniversitySeongnam-si13120Gyeonggi-doSouth Korea School of Computer Hangzhou Dianzi UniversityHangzhouChina

In the context of E-Commerce eco-system,there are hundreds of millions of consumers,thousands of businesses and shops,and hundreds of delivery *** E-Commerce businesses such as Alibaba Group need to support a large number of applications and business modules,and cater for hundreds of business requirements and independent changes on a daily *** intersection of these information technologies and business models provides ample research opportunities in intelligent processing of data,information and *** this special issue,we have accepted 7 papers from open calls and invitations.A summary of these papers is outlined below.

关键词： hundreds intersection invitation

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Peroral endoscopic myotomy for treatment of Guillain-Barre syndrome-associated achalasia: A rare case

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World Journal of Gastroenterology 2017年第5期23卷 926-930页

作者： Seung Kak Shin Kyoung Oh kim Eui Joo kim Su Young kim Jung Ho kim yoon Jae kim Jun-Won Chung Kwang An Kwon dong Kyun Park Department of Internal Medicine Gachon University Gil Medical CenterIncheon 21565South Korea

Guillain-Barre syndrome (GBS)-associated achalasia is a very rare disease of uncertain cause. We report the case of a patient diagnosed with GBS-associated type I achalasia who was successfully treated with peroral endoscopic myotomy (POEM). A 30-year-old man who was diagnosed with GBS 3 mo before was referred to our department with dysphagia and meal-related regurgitation. The results of esophagography, endoscopy, and high-resolution manometry (HRM) revealed type I achalasia. POEM that utilized a submucosal tunneling technique was performed to treat the GBS-associated type I achalasia. After POEM, smooth passage of a contrast agent into the stomach was shown in follow-up esophagography, and follow-up HRM revealed a decrease in the mean integrated relaxation pressure 22.9 mmHg to 9.6 mmHg. The patient remained without dysphagia for 7 mo, even though the patient’s neurological problems were not fully resolved. POEM may be a safe and effective treatment for GBS-associated type I achalasia.

关键词： Peroral endoscopic myotomy Achalasia Guillain-Barre syndrome

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Clinical outcome after pulmonary metastasectomy from primary hepatocellular carcinoma:Analysis of prognostic factors

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World Journal of Gastroenterology 2008年第37期14卷 5717-5722页

作者： Jong-Bum Kwon Khun Park Young-Du kim Jong-Hee Seo Seok-Whan Moon Deog-Gon Cho Yong-Whan kim dong-Goo kim Seung-Kew yoon Hyeon-Woo Lim Department of Thoracic and Cardiovascular Surgery the Catholic University of KoreaSeoul 137-701 Korea Department of Surgery the Catholic University of KoreaSeoul 137-701 Korea Department of Internal Medicine the Catholic University of KoreaSeoul 137-701 Korea Department of Preventive Medicine the Catholic University of KoreaSeoul 137-701 Korea

AIM： To review the surgical outcomes in terms of the surgical indications and relevant prognostic factors. METHODS： Sixteen patients underwent therapeutic lung surgery between March 1999 and May 2006. The observation period was terminated on May 31, 2007. The surgical outcomes and the clinicopathological factors were compared. RESULTS： There was no mortality or major morbidity encountered in this study. The mean follow-up period after metastasectomy was 26.7 ＋ 28.2 （range： 1-99 mo）, and the median survival time was 20 mo. The 1- and 5-year survival rates were 56% and 26%, respectively. At the end of the follow-up, 1 patient died from hepatic failure without recurrence, 6 died from hepatic failure with a recurrent hepatocellular carcinoma （HCC）, and 4 died from recurrent HCC with cachexia. Among several clinical factors, Kaplan Meier analysis revealed as a treatment for the that liver transplantation primary lesion, grade of cell differentiation, and negative evidence HBV infection were independent predictive factors. On Cox＇s proportional hazard model, there were no significant factors affecting survival after pulmonary metastasectomy in patients with HCC. CONCLUSION： A metastasectomy should be performed before other treatments in selected patients, Although not significant, patients with liver transplantation of a primary HCC survived longer, Liver transplantation might be the most beneficial modality that can offer patients better survival, A multi- institutional and collaborative study would be needed for identifying clinical prognostic factors predicting survival in patients with HCC and lung metastasis.

关键词： Hepatocellular carcinoma Pulmonary metastasis Metastasectomy Liver transplantation Thoracoscopy

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