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Isolation and characterization of a Neisseria sp. from the captive wild goose (Anser anser)

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Integrative Zoology 2016年第2期11卷 128-133页

作者： Chengmin WANG Jing LUO Haijing WANG Said AMER Hua DING ying dong Hongxuan HE National Research Center For Wildlife Born Diseases Key Laboratory of Animal Ecology and Conservation BiologyInstitute of ZoologyChinese Academy of SciencesBeijingChina Department of Zoology Faculty of ScienceKafr El Sheikh UniversityKafr El SheikhEgypt Department of Infectious Diseases Hangzhou Center for Disease Control and PreventionHangzhouChina Department of Medical Oncology the Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouChina

The present study investigated 15 dead cases of captive wild goslings(Anser anser),which were bred in a small poultry farm in Shandong Province,*** examined cases presented diverse clinical signs accompanied with neurological manifestations and fatal *** culture identified the gram-negative Neisseria *** the brain homogenate of most examined cases(10/15,66.7%).The isolated bacteria were identified based on morphologic characteristics,biochemical tests and 16S rDNA *** proved that 1 identical bacterial strain(BNO09-3)was isolated from the positive *** phylogeny based on the 16S rDNA gene sequences indicated that this isolate has a close relationship with various strains of genus Neisseria *** from liver and feces of *** is the first report of Neisseria *** fatality in captive wild geese in China.

关键词： 16S rDNA Anser anser China Neisseria sp.

Expression and location of α-fetoprotein during rat colon development

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World Journal of Gastroenterology 2009年第14期15卷 1738-1743页

作者： Xiao-Yan Liu Dan dong Peng Sun Jun Du Luo Gu ying-Bin Ge Department of Physiology Nanjing Medical University Nanjing 210029 Jiangsu Province China

AIM： To investigate the expression of α-fetoprotein （AFP）, a cancer-associated fetal glycoprotein, and its involvement during rat colon development. METHODS： Colons from Sprague-Dawley rat fetuses, young and adult （8 wk old） animals were used in this study. Expression levels of AFP in colons of different development stage were detected by reversetranscriptase PCR （RT-PCR） and Western blotting. To identify the cell location of AFP in the developing rat colons, double-immunofluorescent staining was performed using antibodies to specific cell markers and AFP, respectively. RESULTS： The highest levels of AFP mRNA were detected in colons of rats at embryonic day 18.5 （e18.5）. Compared to e18.5 d, the AFP expression was significantly decreased during rat development （85% for e20.5, P 〈 0.05, 58% for postnatal day 0.5 （P〈0.5）, P 〈 0.05, 37% for P7, P 〈 0.05, 24% for P14, P 〈 0.05, and 11% for P21, P 〈 0.05） and undetected in adult rats. Only the 72-kDa isoform of AFP was detected by Western blotting, the expression pattern was similar to AFP mRNA and conformed to the results of mRNA expression. The AFP positive staining was identical to different distribution patterns in fetuses, young and adult animals and positive staining for both AFP and vimentin was overlapped in mesenchymal cells at each stage tested. CONCLUSION： This study has for the first time demonstrated that AFP is localized in the mesenchyme of rat colon from the embryo to the weaning stage by immunofluorescence and presents 72-kDa isoform in the developing rat colons by Western blotting. The dynamic expression of AFP in the various developmental stages of the colon indicates that AFP might be involved in many aspects of colon development.

关键词： Alpha-fetoprotein Development Mesenchyme Colon Rat

成人非梗阻性巨十二指肠症1例病例报告和文献复习

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中国医药导报 2024年第15期21卷 183-185页

作者：尹文董雨徐辉吴从业袁捷南京医科大学附属南京医院南京市第一医院消化科江苏南京210006 南京医科大学附属南京医院南京市第一医院影像科江苏南京210006

巨十二指肠是一种以十二指肠显著扩张为特征的疾病,临床较为少见。其病因可分为梗阻性和非梗阻性。本文报道了1例在南京市第一医院河西院区首次确诊的巨十二指肠症患者。入院后完善胃肠镜,CT小肠造影,肠系膜上动脉CT血管造影检查,排除... 详细信息

巨十二指肠是一种以十二指肠显著扩张为特征的疾病,临床较为少见。其病因可分为梗阻性和非梗阻性。本文报道了1例在南京市第一医院河西院区首次确诊的巨十二指肠症患者。入院后完善胃肠镜,CT小肠造影,肠系膜上动脉CT血管造影检查,排除其他梗阻因素后诊断为先天性非梗阻性巨十二指肠症。先天性巨十二指肠大多在婴幼儿时期确诊,且需要手术治疗。成人先天性巨十二指肠极为罕见,需与其他梗阻性病因鉴别。本病例提供了该病的胃肠镜图像及影像学检查资料,为本病的确诊提供思路。

关键词：内镜检查非梗阻性巨十二指肠症病例报告

肝癌首次化疗患者生活质量与负性情绪的关系及影响因素

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中国健康心理学杂志 2024年第8期32卷 1186-1190页

作者：董玲玲古小改郝娜张丽岳颖郑州大学第二附属医院消化内科三病区 450003 郑州大学第二附属医院消化内科二病区郑州大学第二附属医院护理部郑州市第七人民医院检验科

目的:分析肝癌首次化疗患者生活质量的影响因素。方法:选择2021年6月-2023年6月收治的60例肝癌患者,收集患者年龄、性别等一般资料,并采用肝癌患者生活质量量表(QOL-LC)、汉密顿焦虑量表(HAMA)、汉密顿抑郁量表(HAMD)、社会支持评定量表... 详细信息

目的:分析肝癌首次化疗患者生活质量的影响因素。方法:选择2021年6月-2023年6月收治的60例肝癌患者,收集患者年龄、性别等一般资料,并采用肝癌患者生活质量量表(QOL-LC)、汉密顿焦虑量表(HAMA)、汉密顿抑郁量表(HAMD)、社会支持评定量表(SSRS)、家庭关怀度量表(APGAR)评估患者生活质量、负性情绪、社会支持水平及家庭关怀度,采用单因素分析及多因素Logistic回归分析肝癌患者生活质量的影响因素,采用pearson相关性分析肝癌患者生活质量与负性情绪、社会支持水平及家庭关怀度的关系。结果:60例患者QOL-LC得分范围为107~196分,平均158.93±15.89分。单因素分析显示,独居、卡氏功能评分、HAMA评分、HAMD评分、社会支持度及家庭关怀度均是肝癌患者生活质量的影响因素(t=2.032,2.876,61.499,63.672,79.097,82.342;P<0.05)。多因素Logistic回归分析显示,焦虑、抑郁、低水平社会支持是肝癌患者生活质量的独立危险因素(OR=3.888,3.418,0.291;95%置信区间为1.423~10.628,1.509~7.739,0.141~0.599)。pearson相关性分析显示,肝癌患者QOL-LC评分与HAMA评分、HAMD评分均呈负相关关系(r=-0.428,-0.475;P<0.001),与SSRS评分、APGAR评分呈正相关关系(r=0.524,0.537;P<0.001)。结论:心理状况、社会支持度均是肝癌首次化疗患者生活质量的独立影响因素。

关键词：肝癌化疗生活质量负性情绪社会支持家庭关怀度

Glass formation in Fe-Cr-Zr-B-Mo alloys by tuning Nb addition

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China Foundry 2021年第5期18卷 450-456页

作者： Cong-ran Fu Wei Zhang Qing-chun Xiang ying-dong Qu ying-lei Ren Bo Yu Ke-qiang Qiu School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China Shenyang Research Institute of Foundry Co.Ltd. Shenyang 110022China

Fe-based bulk metallic glasses(BMGs)with high boron content have potential application as a coating material used in the framework for storing spent nuclear fuels to support their safe long-term *** high glass forming ability(GFA)and large supercooled liquid region are therefore required for such Fe-based BMGs in either the glassy powder fabrication or the subsequent coating *** order to meet these requirements,the influence of Nb content on the GFA of Fe_(57)Cr_(10)Zr_(8)B_(18)Mo_(7-x)Nb_(x)(x=1-5,at.%)alloys was investigated,as Nb has positive roles in GFA and thermal stability of *** results indicate that a fully amorphous phase in the as-cast samples with 3 mm in diameter is obtained for both the Fe_(57)Cr_(10)Zr_(8)B_(18)Mo_(5)Nb_(2) and Fe_(57)Cr_(10)Zr_(8)B_(18)Mo_(4)Nb_(3) *** corresponding supercooled liquid regions of the two BMGs are 78 K and 71 K,*** mechanism for improving their GFA was analyzed based on the principle of metal solidification,the parameters for glass formation and thermal properties of the *** compression strength and Vicker’s hardness of the two BMGs are 1,950 MPa and 1,310 HV,2,062 MPa and 1,180 HV,*** developed BMGs with high B content,good GFA,and very high hardness can be used as coating materials to the framework for spent nuclear fuels.

关键词： amorphous microstructure Nb glass-forming ability coating material

Applications of an AMSR-E RFI Detection and Correction Algorithm in 1-DVAR over Land

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Journal of Meteorological Research 2014年第4期28卷 645-655页

作者：吴莹翁富忠 Key Laboratory for Aerosol-Cloud-Precipitation of China Meteorological Administration Nanjing University of Information Science & Technology School of Atmospheric Physics Nanjing University of Information Science & Technology NOAA/NESDIS/Center for Satellite Application and Research College ParkMD 20742 USA

Land retrievals using passive microwave radiometers are sensitive to small fluctuations in land brightness temperatures. As such, the radio-frequency interference （RFI） signals emanating from man-made microwave radiation transmitters can result in large errors in land retrievals. RFI in C-and X-band channels can con-taminate remotely sensed measurements, as experienced with the Advanced Microwave Scanning Radiometer （AMSR-E） and the WindSat sensor. In this work, applications of an RFI detection and correction algorithm in retrieving a comprehensive suite of geophysical parameters from AMSR-E measurements using the one-dimensional variational retrieval （1-DVAR） method are described. The results indicate that the values of retrieved parameters, such as land skin temperature （LST）, over these areas contaminated by RFI are much higher than those from the global data assimilation system （GDAS） products. The results also indicate that the differences between new retrievals and GDAS products are decreased evidently through taking into account the RFI correction algorithm. In addition, the convergence metric （χ2） of 1-DVAR is found to be a new method for identifying regions where land retrievals are affected by RFI. For example, in those regions with much stronger RFI, such as Europe and Japan, χ2 of 1-DVAR is so large that convergence cannot be reached and retrieval results may not be reliable or cannot be obtained. Furthermore,χ2 also decreases with the RFI-corrected algorithm for those regions with moderate or weak RFI. The results of RFI detected byχ2 are almost consistent with those identified by the spectral difference method.

关键词： microwave remote sensing radio-frequency interference (RFI) AMSR-E 1-DVAR

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以能力为导向的兼职潜水员人才培养模式研究

实验室科学 2024年第2期27卷 183-186页

作者：刘辉李志辉吴向君官东海军工程大学动力工程学院湖北武汉430033

兼职潜水员作为舰艇部队重要作战力量,构建系统科学的兼职潜水员人才培养模式是增强部队战斗力的重要举措。论文以兼职潜水员岗位履行能力的创新潜水专业人才培养为主线,以实战化潜水作业核心能力培养为导向,构建了以能力为导向的人才... 详细信息

兼职潜水员作为舰艇部队重要作战力量,构建系统科学的兼职潜水员人才培养模式是增强部队战斗力的重要举措。论文以兼职潜水员岗位履行能力的创新潜水专业人才培养为主线,以实战化潜水作业核心能力培养为导向,构建了以能力为导向的人才培养方案,规划了科学合理的人才培养成长路径,建立了标准的分级分类训练和考核认证体系,为健全水面舰艇兼职潜水员人才培养模式改革提供有益探索。

关键词：能力水面舰艇潜水员人才模式

Switching from efavirenz to elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide reduces central nervous system symptoms in people living with HIV

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Chinese Medical Journal 2021年第23期134卷 2850-2856页

作者： Huan Xia Xiao-Jie Huang Yue Hu Li-ying Gao Yue wu Hao wu Zhong-Fang Yan Ping Ma Department of Infectious Diseases Tianjin Second People’s HospitalTianjin 300192China Center for Infectious Diseases Beijing Youan HospitalCapital Medical UniversityBeijing 100069China.

Background:Central nervous system(CNS)symptoms after efavirenz(EFV)treatment in people living with human immunodeficiency virus(HIV)could persist and impact their quality of *** assessed the impact of EFV-based regimen replacement with elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide(E/C/F/TAF),which is considered an alternative option for subjects who do not tolerate *** specifically,we assessed the safety and the efficacy of E/C/F/TAF and its effects on the participants’neuropsychiatric toxicity symptoms in a real-life ***:A prospective cohort study was conducted among virologic suppressed HIV-positive participants receiving EFV-based regimens with ongoing CNS toxicity≥grade *** participants were switched to single-pill combination regimens E/C/F/TAF and followed up for 48 *** neuropsychiatric toxicity symptoms were measured using a CNS side effects questionnaire,as well as the Hospital Anxiety and Depression Scale and the Pittsburgh Sleep Quality *** primary outcome measure was the proportion of participants experiencing grade 2 or higher CNS toxicity after EFV switch off at weeks 12,24,and *** endpoints included virologic and immunological responses and the effect on fasting lipids at week 48 after ***:One hundred ninety-six participants(96.9%men,median age:37.5 years,median:3.7 years on prior EFV-containing regimens)were included in the *** improvements in anxiety and sleep disturbance symptoms were observed at 12,24,and 48 weeks after switching to E/C/F/TAF(P<0.05).No significant change in depression symptom scores was *** 48 weeks after switch,HIV viral load<50 copies/mL was maintained in all of the participants,median fasting lipid levels were moderately increased(total cholesterol[TC]:8.2 mg/dL,low-density lipoprotein cholesterol[LDL-C]:8.5 mg/dL,high-density lipoprotein cholesterol[HDL-C]:2.9 mg/dL,and triglyceride(TG):1.6 mg/dL,and the TC:HDL-C ratio remained ***

关键词： HIV Efavirenz Elvitegravir Tenofovir alafenamide Central nervous system

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一种缸盖热芯盒砂芯变形问题分析及改进

铸造设备与工艺 2024年第2期 46-48,52页

作者：王洁英吕清轲吴玉成汪继革张聚辉鲁栋潍柴重机股份有限公司山东潍坊261108

以一种大型单体气缸盖铸造过程中热芯盒砂芯变形问题为例,总结了热芯盒砂芯在大型单体气缸盖生产中的应用。分析热芯盒砂芯变形原因,解决了一类热芯盒砂芯浇注过程中变形导致铸件报废的问题。为有效解决热芯盒砂芯浇注过程中变形问题,... 详细信息

以一种大型单体气缸盖铸造过程中热芯盒砂芯变形问题为例,总结了热芯盒砂芯在大型单体气缸盖生产中的应用。分析热芯盒砂芯变形原因,解决了一类热芯盒砂芯浇注过程中变形导致铸件报废的问题。为有效解决热芯盒砂芯浇注过程中变形问题,除了严格控制热芯盒制芯工艺参数外,还要控制热芯盒砂芯固化层厚度一致性保证砂芯强度,采取芯撑固定工艺,为砂芯提供支撑力抵抗铁水浮力。

关键词：热芯盒砂芯变形芯撑