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Quality and readability of online information resources on insomnia

Frontiers of Medicine 2017年第3期11卷 423-431页

作者： Yan Ma Albert C. Yang ying Duan Ming dong Albert S. Yeung Division of Interdisciplinary Medicine and Biotechnology Department of Medicine Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02215 USA Sleep Medicine Center Airforee General Hospital Beijing 100142 China IBM Software Development Lab Littleton MA 01460 USA Depression Clinical and Research Program Massachusetts General Hospital Harvard Medical School Boston MA 02114 USA

The internet is a major source for health information. An increasing number of people, including patients with insomnia, search for remedies online; however, little is known about the quality of such information. This study aimed to evaluate the quality and readability of insomnia-related online information. Google was used as the search engine, and the top websites on insomnia that met the inclusion criteria were evaluated for quality and readability. The analyzed websites belonged to nonprofit, commercial, or academic organizations and institutions such as hospitals and universities. Insomnia-related websites typically included definitions （85%）, causes and risk factors （100%）, symptoms （95%）, and treatment options （90%）. Cognitive behavioral therapy for insomnia （CBT-I） was the most commonly recommended approach for insomnia treatment, and sleep drugs are frequently mentioned. The overall quality of the websites on insomnia is moderate, but all the content exceeded the recommended reading ease levels. Concerns that must be addressed to increase the quality and trustworthiness of online health information include sharing metadata, such as authorship, time of creation and last update, and conflicts of interest; providing evidence for reliability; and increasing the readability for a layman audience.

关键词： insomnia intemet readability information quality health literacy cognitive behavioral therapy treatment

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Effects of two novel nucleoside analogues on different hepatitis B virus promoters

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World Journal of Gastroenterology 2008年第12期14卷 1836-1841页

作者： Xing-Xing He Ju-Sheng Lin ying Chang ying-Hui Zhang Yan Li Xiao-Yan Wang dong Xu Xiao-Ming Cheng Instituteof liver diseases Tongji Hospital of Tongji Medical Co11~g~Huazhong University of Science and Technology Wuhan 430030Hubei Province China

AIM： To explore the effects of the nucleoside analogues β-L-D4A and β-LPA on hepatitis B virus （HBV） promoters. METHODS： Four HBV promoters were amplified by polymerase chain reaction （PCR） and subcloned into the expression vector pEGFP-1. The four recombinants controlled by HBV promoters were confirmed by restriction analysis and sequencing. Human hepatoma HepG2 cells transfected with the recombinant plasmids were treated with various concentrations of β-L-D4A and β-LPA. Then, enhanced green fluorescent protein （EGFP）-positive cells were detected by fluorescence microscopy and using a fluorescence activated cell sorter RESULTS： Four HBV promoters were separately obtained and successfully cloned into pEGFP-1, Expression of EGFP under the control of the surface promoter （Sp） and the X promoter （Xp） was inhibited by β-L-D4A in a dosedependent manner, while expression of EGFP under the control of the core promoter （Cp） and Xp was inhibited by β-LPA in a dose-dependent manner. CONCLUSION： The two novel nucleoside analogues investigated here can inhibit the activities of HBV promoters in a dose-dependent manner. These findings may explain the mechanisms of action by which these two novel compounds inhibit HBV DNA replication.

关键词： Hepatitis B virus Nucleoside analogue Hepatitis B virus promoter Enhanced green fluorescentprotein Fluorescence activated cell sorter

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专利中药复方治疗肝纤维化的用药规律及机制研究

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科学技术与工程 2024年第8期24卷 3133-3144页

作者：韦柳婷高松林吴凡王燕凤何广英胡振斌广西中医药大学第一临床医学院南宁530000 广西中医药大学第一附属医院南宁530000

利用数据挖掘和网络药理学方法分析中药专利复方治疗肝纤维化的用药规律及机制。检索国家知识产权局中国专利公布公告网中治疗肝纤维化的中药专利复方,筛选整理后建立数据库,运用Microsoft Excel软件和中医传承计算平台(V3.0)对中药复... 详细信息

利用数据挖掘和网络药理学方法分析中药专利复方治疗肝纤维化的用药规律及机制。检索国家知识产权局中国专利公布公告网中治疗肝纤维化的中药专利复方,筛选整理后建立数据库,运用Microsoft Excel软件和中医传承计算平台(V3.0)对中药复方用药规律进行数据挖掘与分析。运用网络药理学方法探讨核心高频药对治疗肝纤维化的机制。最终筛选出专利复方147个,中药431味。高频药物包括黄芪、丹参、鳖甲和当归等,功效以补虚、活血化瘀和清热为主,核心高频药对黄芪-丹参治疗肝纤维化的主要活性成分为槲皮素、木犀草素、山奈酚和丹参酮IIA等,主要靶点为骨髓细胞瘤病毒癌基因(myelocytomatosis viral oncogene,MYC)、转录激活因子3(signal transducer and activator of transcription 3,STAT3)、丝氨酸/苏氨酸激酶1(serine/threonine kinase 1,AKT1)、雌激素受体1(estrogen receptor 1,ESR1)、FOS原癌基因(FOS proto-oncogene,FOS)、缺氧诱导因子1亚基α(hypoxia-inducible factor 1 alpha,HIF-1a)、肿瘤蛋白p53(tumor protein p53,TP53)、丝裂原活化蛋白激酶14(mitogen-activated protein kinase14,MAPK14)等,主要涉及磷脂酰肌醇3-激酶(phosphatidylinositol-3-kinase,PI3K)-蛋白激酶B(protein kinase B,Akt)、糖尿病并发症中晚期糖基化终产物及其受体(advanced glycation end products-receptor for advanced glycation end products,AGE-RAGE)、肿瘤坏死因子(tumor necrosis factor,TNF)、白细胞介素-17(interleukin-17,IL-17)、低氧诱导因子-1(hypoxia-inducible factor-1,HIF-1)、辅助性T细胞17(helper T cells 17,Th17)细胞分化信号等通路。结果表明:治疗肝纤维化的中药专利复方以补虚药、活血化瘀药和清热药为主,核心高频药对黄芪-丹参通过多成分、多靶点调控PI3K-Akt、AGE-RAGE、TNF和IL-17等通路来治疗肝纤维化。

关键词：肝纤维化中药专利复方用药规律数据挖掘作用机制网络药理学

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Giant Magnetoresistance and Madnetic Precipitates in Melt Spun Cu_(88)Co_(12) Alloy

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Chinese Physics Letters 1997年第3期14卷 198-201页

作者： WANG Wen-dong ZHU Feng-wu WENG Jun XIAO Ji-mei LAI wu-yan Department of Meterials Physics Beijing University of Science and TechnologyBeijing 100083 Institute of Physics Chinese Academy of SciencesBeijing 100080

The melt spun Cu_(88)Co_(12) has obvious giant magnetoresistance(GMR)after annealed at 450℃ for *** means of filed ion microscope with atom probe(FIM-AP),the spherical Co precipitates were clearly observed in this alloy for the first *** average diameter of the particles is about 1.7nm in the specimen annealed at 450℃ for 2h,which has the highest GMR of 30.7% at *** using both persistence size method and direct measurement method on micrographs from FIM,the size distribution of the Co particles was *** results are very useful for testing the present theory on the relationship between GMR and microstructure.

关键词： resistance alloy annealed

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神经元特异性烯醇化酶、血管紧张素Ⅱ与丙二醛在颅内感染的诊疗价值

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中国微侵袭神经外科杂志 2024年第4期28卷 215-220页

作者：吴剑红王俊戴姗珊董国丽浙江大学医学院附属第二医院临平院区神经外科浙江杭州311100

目的探讨神经元特异性烯醇化酶(neuron specific enolase,NSE)、血管紧张素Ⅱ(angiotensinⅡ,Ang-Ⅱ)与丙二醛(Malondialdehyde,MDA)检测在脑出血开颅术后颅内感染的诊疗价值。方法回顾性分析95例脑出血开颅术病例资料,根据术后1周内是... 详细信息

目的探讨神经元特异性烯醇化酶(neuron specific enolase,NSE)、血管紧张素Ⅱ(angiotensinⅡ,Ang-Ⅱ)与丙二醛(Malondialdehyde,MDA)检测在脑出血开颅术后颅内感染的诊疗价值。方法回顾性分析95例脑出血开颅术病例资料,根据术后1周内是否出现颅内感染分为感染组(n=35)与未感染组(n=60),比较两组基线资料,生化指标:白细胞计数(white blood cell count,WBC)、C反应蛋白(C-reactive protein,CRP)、降钙素原(procalcitonin,PCT)、白蛋白(albumin,ALB),实验室指标(NSE、Ang-Ⅱ、MDA)。采用Logistic多因素回归,分析影响脑出血开颅术后颅内感染的危险因素。采用受试者工作特征曲线(receiver operating characteristic,ROC),分析NSE、Ang-Ⅱ、MDA诊断脑出血开颅术后颅内感染的效能。感染组病人均接受鞘内注射药物治疗,治疗3 d后依据临床体征分为感染控制组(n=25)与感染未控制组(n=10),分别于治疗后3d、7d、14d检测病人NSE,Ang-Ⅱ,MDA水平。结果与未感染组比较,感染组合并糖尿病率、术后凝血功能障碍发生率及PCT、ALB、NSE、Ang-Ⅱ、MDA水平均较高(P<0.05)。Logistic多因素回归分析结果显示:合并糖尿病(OR=1.812,95%CI:1.505~2.515)、术后凝血功能障碍(OR=1.856,95%CI:1.512~2.526)、PCT水平高(OR=1.850,95%CI:1.519~2.494)、NSE水平高(OR=1.824,95%CI:1.537~2.638)、Ang-Ⅱ水平高(OR=1.885,95%CI:1.584~2.649)、MDA水平高(OR=1.964,95%CI:1.558~2.715)是影响脑出血开颅术后颅内感染的独立危险因素。NSE、Ang-Ⅱ、MDA三者联合诊断脑出血开颅术后颅内感染的AUC为0.912(95%CI:0.740~0.948)。治疗后14d,NSE、Ang-Ⅱ、MDA动态变化显示,感染控制组治疗后3d、7d、14d NSE、Ang-Ⅱ、MDA水平均低于感染未控制组(P<0.05)。结论NSE、Ang-Ⅱ、MDA三者联合检测,可提高对脑出血开颅术后感染的诊断价值与疗效评估价值。

关键词：颅内感染神经元特异性烯醇化酶血管紧张素Ⅱ 丙二醛

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Ultrasound-triggered microbubble destruction enhances the radiosensitivity of glioblastoma by inhibiting PGRMC1-mediated autophagy in vitro and in vivo

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Military Medical Research 2022年第3期9卷 331-350页

作者： ying He Xun-Hu dong Qiong Zhu Ya-Li Xu Ming-Liang Chen Zheng Liu Department of Ultrasound Xinqiao HospitalThird Military Medical University(Army Medical University)Chongqing400037China Department of Chemical Defense Medicine School of Military Preventive MedicineThird Military Medical University(Army Medical University)Chongqing400038China Institute of Toxicology School of Military Preventive MedicineThird Military Medical University(Army Medical University)Chongqing400038China Institute of Pathology and Southwest Cancer Centre Southwest HospitalThird Military Medical University(Army Medical University)Chongqing400038China

Background:Ultrasound-triggered microbubble destruction(UTMD) is a widely used noninvasive technology in both military and civilian medicine,which could enhance radiosensitivity of various ***,little information is available regarding the effects of UTMD on radiotherapy for glioblastoma or the underlying *** study aimed to delineate the effect of UTMD on the radiosensitivity of glioblastoma and the potential involvement of ***:GL261,U251 cells and orthotopic glioblastoma-bearing mice were treated with ionizing radiation(IR) or IR plus *** was observed by confocal microscopy and transmission electron *** blotting and immunofluorescence analysis were used to detect progesterone receptor membrane component 1(PGRMC1),light chain 3 beta 2(LC3B2) and sequestosome 1(SQSTM1/p62) *** vectors or siRNAs transfection,and fluorescent probes staining were used to explore the underlying ***:UTMD enhanced the radiosensitivity of glioblastoma in vitro and in vivo(P0.05).Furthermore,UTMD inhibited PGRMC1expression and binding with LC3B2 in IR-exposed glioblastoma cells(P<0.01).PGRMC1 inhibitor AG-205 or PGRMC1siRNA pretreatment enhanced UTMD-induced LC3B2 and p62 accumulation in IR-exposed glioblastoma cells,thereby promoting UTMD-mediated radiosensitization(P<0.05).Moreover,PGRMC1 overexpression abolished UTMD-caused blockade of autophagic degradation,subsequently inhibiting UTMD-induced radiosensitization of glioblastoma ***,compared with IR plus UTMD group

关键词： Ultrasound-triggered microbubble destruction Radiosensitization Progesterone receptor membrane component 1 Autophagy Glioblastoma

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Discrete Boltzmann model for implosion- and explosion- related compressible flow with spherical symmetry

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Frontiers of physics 2018年第5期13卷 31-44页

作者： Ai-Guo Xu Guang-Cai Zhang Yu-dong Zhang Pei Wang Yang-Jun ying National Key Laboratory of Computational Physics Institute of Applied Physics and Computational Mathematics P.O. Box 8009-26 Beijing 100088 China Center for Applied Physics and Technology MOE Key Center for High Energy Density Physics Simulations College of Engineering Peking University Beijing 100871 China Key Laboratory of Transient Physics Nanjing University of Science and Technology Nanjing 210094 China

To kinetically model implosion- and explosion-related phenomena, we present a theoretical framework for constructing a discrete Boltzmann model （DBM） with spherical symmetry in spherical coordinates. To achieve this goal, a key technique is to use local Cartesian coordinates to describe the particle velocity in the kinetic model. Therefore, geometric effects, such as divergence and convergence, are described as a ＂force term＂. To better access the nonequilibrium behavior, even though the corre- sponding hydrodynamic model is one-dimensional, the DBM uses a discrete velocity model （DVM） with three dimensions. A new scheme is introduced so that the DBM can use the same DVM regard- less of whether or not there are extra degrees of freedom. As an example, a DVM with 26 velocities is formulated to construct the DBM at the Navier-Stokes level. Via the DBM, one can study simulta- neously the hydrodynamic and thermodynamic nonequilibrium behaviors in implosion and explosion processes that are not very close to the spherical center. The extension of the current model to a multiple-relaxation-time version is straightforward.

关键词： discrete Boltzmann model compressible flows spherical symmetry geometric effects thermodynamic nonequilibrium

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Roux-en-Y胃旁路联合胃癌根治术治疗重度肥胖合并胃癌的病例报告

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中华胃肠外科杂志 2024年第09期27卷 978-979页

作者：李璟东张俊昌吴嘉敏董志勇蔡念王存川暨南大学附属第一医院胃肠外科一区肥胖代谢外科(减重中心) 广州澳门仁伯爵综合医院普通外科中国澳门

患者男性, 39岁, 于2022年6月26日为暨南大学附属第一医院肥胖代谢外科收治。身高172.5 cm, 体质量141.8 kg, 体质指数(body mass index, BMI):47.7 kg/m2, 腰围:147 cm, 体脂率:46.4%。入院血压155/93 mmHg(1 mmHg=0.133 kPa)。血红蛋...

患者男性, 39岁, 于2022年6月26日为暨南大学附属第一医院肥胖代谢外科收治。身高172.5 cm, 体质量141.8 kg, 体质指数(body mass index, BMI):47.7 kg/m2, 腰围:147 cm, 体脂率:46.4%。入院血压155/93 mmHg(1 mmHg=0.133 kPa)。血红蛋白:141.30 g/L, 血小板计数234×109/L, 红细胞计数:5.42×1012/L, 肌酐:51.20 μmol/L, 葡萄糖:6.93 mmol/L, 空腹血糖:6.90 mmol/L, 糖化血红蛋白7.5%, 总胆固醇:7.68 mmol/L, 甘油三酯:1.63 mmol/L, 高密度蛋白C:1.20 mmol/L。其余均未见明显异常。术前胃镜报告结果显示:(1)慢性浅表性胃炎并糜烂;(2)十二指肠球部炎性反应。彩超显示肝脏增大, 脂肪肝, 胆脾未见异常。综合考虑诊断为:2型糖尿病, 代谢综合征, 肥胖症, 脂肪肝。

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Windborne migration routes of newly-emerged fall armyworm from Qinling Mountains-Huaihe River region,China

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Journal of Integrative Agriculture 2021年第3期20卷 694-706页

作者： wu Qiu-lin SHEN Xiu-jing HE Li-mei JIANG Yu-ying LIU Jie HU Gao wu Kong-ming State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193P.R.China College of Plant Protection Fujian Agriculture and Forestry UniversityFuzhou 350002P.R.China National Agro-Tech Extension and Service Center Beijing 100125P.R.China Department of Entomology Nanjing Agricultural UniversityNanjing 210095P.R.China

The fall armyworm(FAW,Lepidoptera:Noctuidae),Spodoptera frugiperda(***),invaded China in mid-December 2018;since then,it has become a great threat to Chinese agricultural *** Mountains-Huaihe River region(QM-HRR)is the transitional zone between northern and southern China,an important region for both corn and wheat *** on the actual occurrence of QM-HRR invaded by FAW in 2019,daily mean surface air temperature and nocturnal wind conditions at 925 hPa were examined,and migratory routes of FAW moths originated in QM-HRR were modeled by a forward-trajectory-analysis *** results indicated that migratory activities of FAW adults emerged in QM-HRR were initiated from late *** moths from western QM-HRR,where has complex topographic terrain,mainly flied to Ningxia and Inner Mongolia before mid ***,FAW moths from the eastern QM-HRR primarily engaged in high-altitude northward transport assisted by the prevailing southerly winds before mid August,and the North China Plain was identified as the main destination of ***,the migration trajectories of FAW moths had a possibility to reach the Northeast China *** mid August,FAW moths in eastern QM-HRR largely migrated southward and returned to the Yangtze River *** study provides detailed information on the occurrence and migration routes of FAW moths from QM-HRR and will be helpful for early warning and development of integrated pest management strategies for the control of this exotic insect pest.

关键词： Spodoptera frugiperda invasive pest Qinling Mountains-Huaihe River region atmospheric circulation windborne migration trajectory

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右美托咪定对老年腹腔镜胆囊摘除术患者麻醉镇静镇痛效果和认知功能的影响

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四川生理科学杂志 2024年第1期46卷 191-193页

作者：童晓梅董显林吴兵玉山县黄家驷医院·玉山县人民医院麻醉科江西上饶334700 玉山县中医院麻醉科江西上饶334700

目的:观察右美托咪定对老年腹腔镜胆囊摘除术患者麻醉镇静镇痛效果和认知功能的影响。方法:选取2020年10月至2023年8月期间于本院接受腹腔镜胆囊摘除术的60例老年胆囊结石患者为研究对象,使用随机数字表法随机分为对照组与观察组,各30... 详细信息

目的:观察右美托咪定对老年腹腔镜胆囊摘除术患者麻醉镇静镇痛效果和认知功能的影响。方法:选取2020年10月至2023年8月期间于本院接受腹腔镜胆囊摘除术的60例老年胆囊结石患者为研究对象,使用随机数字表法随机分为对照组与观察组,各30例。对照组使用静吸复合麻醉,观察组在对照组基础上增加右美托咪定。对比两组镇静效果、镇痛效果及术后认知功能。结果:观察组镇静效果、镇痛效果及患者术后认知功能均明显优于对照组(P<0.05)。结论:老年腹腔镜胆囊摘除术患者使用右美托咪定镇静效果确切,镇痛效果明显,并对患者术后认知功能的影响更小。

关键词：右美托咪定腹腔镜胆囊摘除术镇静效果认知功能

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