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Improvement of erectile function by Korean red ginseng （Panax ginseng） in a male rat model of metabolic syndrome

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Asian Journal of Andrology 2013年第3期15卷 395-399页

作者： Sung-Dae Kim Young-Joo Kim Jung-Sik Huh Sae-Woong Kim dong-wan Sohn Department of Urology School of Medicine Jeju National University Jeju 690767 Korea Department of Urology College of Medicine The Catholic University of Korea Seoul 150713 Korea

The seriousness of metabolic syndrome is not due to the disease itself but its promotion of other diseases, such as erectile dysfunction and cardiovascular and cerebrovascular diseases. We investigated the effects of Korean red ginseng （KRG, Panax ginseng） extract on erectile function in a rat model of metabolic syndrome. We divided the rats into three groups： control, metabolic syndrome＋normal saline （N/S） and metabolic syndrome ＋ KRG. To determine the occurrence of metabolic syndrome in all groups, body weight and various biochemical parameters （e.g., blood glucose, insulin, cholesterol） were measured, and the intra-abdominal glucose tolerance test was performed. To investigate penile erection, the peak intracavernosal pressure （ICP）, mean arterial pressure （MAP） and Masson＇s trichrome stain were evaluated. Erectile function was also investigated by measuring the cyclic guanosine monophosphate （cGMP） levels of the corpus cavernosum. We found that the various biochemical parameters and body weight were similar in the metabolic syndrome＋KRG group and the control group, although the values were slightly higher. The peak ICP/MAP ratio of the metabolic syndrome＋N/S group was markedly decreased compared to the other groups. The cGMP level of the corpus cavernosum in the metabolic syndrome＋N/S group was significantly lower than that of the other groups. As demonstrated in this model of metabolic syndrome with erectile dysfunction, KRG may improve erectile function.

关键词： erectile dysfunction ginseng metabolic syndrome penis

Gluon-pair-creation production model of strong interaction vertices

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Chinese Physics C 2020年第9期44卷 53-61页

作者：万秉东乔从丰 School of Physics University of Chinese Academy of ScienceYuquan Road 19ABeijing 10049China CAS Center for Excellence in Particle Physics Beijing 10049China

By studying theηc exclusive decay to double glueballs,we introduce a model to phenomenologically mimic the gluon-pair-vacuum interaction vertices,namely the 0^++*** on this model,we study glueball production in pseudoscalar quarkonium decays,explicitlyηc→f0(1500)η(1405),ηb→f0(1500)η(1405),andηb→f0(1710)η(1405)*** them f0(1500)and f0(1710)are well-known scalars possessing large glue components,whileη(1405)is a potential candidate for a pseudoscalar *** preliminary calculation results indicate that these processes are marginally accessible in the presently running experiments BES III,BELLE II,and LHCb.

关键词： glueball production nonperturbative methods quarkonium decays

Salidroside Ameliorates Lung Injury Induced by PM_(2.5) by Regulating SIRT1-PGC-1αin Mice

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Biomedical and Environmental Sciences 2024年第4期37卷 367-376页

作者： LI Xiao Hong LIU Yu Mei SHAN Hui TAN Jin Feng ZHOU Jian SONG Yuan Jin LI Si Qi LIU Chen XU dong Qun YU Li LI wan Wei School of Public Health Shandong Second Medical UniversityWeifang 261053ShandongChina Key Laboratory of Health Inspection and Quarantine Weifang 261053ShandongChina Weifang Environmental Monitoring Station Weifang 261042ShandongChina Department of Orthopedics The 80th Army Hospital of PLAWeifang 261000ShandongChina Environment and Health Related Product Safety Institute of Chinese Center for Disease Control and Prevention Beijing 100021China School of Basic Medicine Shandong Second Medical UniversityWeifang 261053ShandongChina

Objective This study aimed to clarify the intervention effect of salidroside(SAL)on lung injury caused by PM_(2.5) in mice and illuminate the function of SIRT1-PGC-1ɑ*** Specific pathogen-free(SPF)grade male C57BL/6 mice were randomly assigned to the following groups:control group,SAL group,PM_(2.5) group,SAL+PM_(2.5) *** the first day,SAL was given by gavage,and on the second day,PM_(2.5) suspension was given by intratracheal *** whole experiment consist of a total of 10 cycles,lasting 20 *** the end of treatment,blood samples and lung tissues were collected and *** of pathological changes in lung tissue using inverted microscopy and transmission electron *** expression of inflammatory,antioxidants,apoptosis,and SIRT1-PGC-1ɑproteins were detected by Western *** Exposure to PM_(2.5) leads to obvious morphological and pathologica changes in the lung of ***_(2.5) caused a decline in levels of antioxidant-related enzymes and protein expressions of HO-1,Nrf2,SOD2,SIRT1 and PGC-1ɑ,and an increase in the protein expressions of IL-6,IL-1β,Bax,caspase-9 and cleaved ***,SAL reversed the aforementioned changes caused by PM_(2.5) by activating the SIRT1-PGC-1α *** SAL can activate SIRT1-PGC-1ɑ to ameliorate PM2.5-induced lung injury.

关键词： PM_(2.5) Salidroside Oxidative stress Inflammation Apoptosis SIRT1-PGC-1α

β-Receptor blocker enhances the anabolic effect of PTH after osteoporotic fracture

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Bone Research 2024年第2期12卷 302-313页

作者： Jie Huang Tong Wu Yi-Rong Jiang Xuan-Qi Zheng Huan wang Hao Liu Hong wang Hui-Jie Leng dong-Wei Fan wan-Qiong Yuan Chun-Li Song Department of Orthopedics Peking University Third Hospital100191 BeijingChina Beijing Key Laboratory of Spinal Disease 100191 BeijingChina Engineering Research Center of Bone and Joint Precision Medicine 100191 BeijingChina

The autonomic nervous system plays a crucial role in regulating bone metabolism,with sympathetic activation stimulating bone resorption and inhibiting bone *** found that fractures lead to increased sympathetic tone,enhanced osteoclast resorption,decreased osteoblast formation,and thus hastened systemic bone loss in ovariectomized(OVX)***,the combined administration of parathyroid hormone(PTH)and theβ-receptor blocker propranolol dramatically promoted systemic bone formation and osteoporotic fracture healing in OVX *** effect of this treatment is superior to that of treatment with PTH or propranolol *** vitro,the sympathetic neurotransmitter norepinephrine(NE)suppressed PTH-induced osteoblast differentiation and mineralization,which was rescued by ***,NE decreased the PTH-induced expression of Runx2 but enhanced the expression of Rankl and the effect of PTH-stimulated osteoblasts on osteoclastic differentiation,whereas these effects were reversed by ***,PTH increased the expression of the circadian clock gene Bmal1,which was inhibited by NE-βAR ***1 knockdown blocked the rescue effect of propranolol on the NE-induced decrease in PTHstimulated osteoblast *** together,these results suggest that propranolol enhances the anabolic effect of PTH in preventing systemic bone loss following osteoporotic fracture by blocking the negative effects of sympathetic signaling on PTH anabolism.

关键词： blocker metabolism inhibited

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基于反向传播神经网络的拉曼光谱去噪方法

光谱学与光谱分析 2022年第5期42卷 1553-1560页

作者：王忠万冬冬单闯李月娥周庆国兰州大学信息科学与工程学院甘肃兰州730000

拉曼光谱技术作为一种典型的光学检测方法,因其独特的非侵入性、快速、原位和极高的特异性,在生物分析、疾病诊断及分子识别等众多领域得到广泛应用。拉曼光谱的指纹特性使其成为生物医学分析领域的重要工具,但拉曼散射信号微弱,数据处... 详细信息

拉曼光谱技术作为一种典型的光学检测方法,因其独特的非侵入性、快速、原位和极高的特异性,在生物分析、疾病诊断及分子识别等众多领域得到广泛应用。拉曼光谱的指纹特性使其成为生物医学分析领域的重要工具,但拉曼散射信号微弱,数据处理分析大量依赖分析人员、自动化处理能力低等因素都会极大影响该技术在实际中的应用。实验设备、环境产生的噪声、待测生物样本的自发荧光等各种干扰因素使得高质量拉曼光谱数据的获得变得较为困难,各种随机噪声会干扰拉曼光谱图中指纹谱峰信息的识别,增大拉曼特征提取的难度,因此,噪声抑制在拉曼光谱预处理中显得十分重要。采用反向传播算法,从数据本身的特征出发,基于理想光谱片段和含噪光谱片段的线性差异,分别构建噪声判定神经网络和光谱去噪神经网络模型。以随机生成的一系列洛伦兹峰数学模型叠加生成拉曼光谱,对生成的拉曼光谱分别加入不同强度的噪声,以此为实验数据,对比新方法和经典滑动窗口均值法、Savitzky-Golay滤波法、傅里叶变换法、小波阈值变换方法去噪的结果。对均方根误差和信号噪声比两个指标进行分析,结果显示,在低噪声干扰下所有去噪方法都能较好地完成任务,但滑动窗口均值方法在光谱的边缘去噪效果会出现下降。随着噪声信号的增大,滑动窗口均值方法、S-G滤波方法、傅里叶变换方法去噪性能都出现明显下降。而基于反向传播神经网络的去噪方法要优于傅里叶变换法、滑动窗口均值法、S-G滤波器法,同时该方法在避免复杂参数寻优设置的同时,获得了和最优阈值小波变换方法近乎一致的去噪效果,大大简化了参数设置,更适合拉曼光谱去噪的自动化实现。

关键词：拉曼光谱神经网络光谱去噪

Synthesis of Magnetically Modified Fe-Al Pillared Bentonite and Heterogeneous Fenton-like Degradation of Orange II

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Journal of Wuhan University of Technology(Materials Science) 2015年第2期30卷 302-306页

作者：陈坤 wanG Guanghua 李文兵 wan dong HU Qin LU Lulu WEI Xiaobi CHENG Zhengzai College of Chemical Engineering and Technology Wuhan University of Science and Technology

Magnetically modified Fe-Al pillared bentonite（Fe3O4/ Fe-Al-Bent） was prepared via chemical co-precipitation method and characterized by powder X-ray diffraction（XRD）, Brunauer-EmmettTeller（BET）, Fourier transform infrared spectroscopy（FTIR） and scanning electron microscopy（SEM）. A series of experiments were carried out to investigate the degradation of Orange II by the obtained heterogeneous catalysts in the presence of H2O2. The experimental result indicated that the synthetic materials had a high catalytic activity and good reusability.

关键词： Fe3O4 nanoparticles pillared bentonite heterogeneous Fenton-like Orange II

CRISPR/Cas9-mediated mutagenesis of VvMLO3 results in enhanced resistance to powdery mildew in grapevine(Vitis vinifera)

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Horticulture Research 2020年第1期7卷 1200-1213页

作者： dong-Yan wan Ye Guo Yuan Cheng Yang Hu Shunyuan Xiao Yuejin wang Ying-Qiang Wen State Key Laboratory of Crop Stress Biology for Arid Areas College of HorticultureNorthwest A&F UniversityYangling 712100 ShaanxiChina Key Laboratory of Horticultural Plant Biology and Germplasm Innovation in Northwest China Ministry of AgricultureYangling 712100 ShaanxiChina Institute for Bioscience and Biotechnology Research&Department of Plant Sciences and Landscape Architecture University of Maryland College ParkRockvilleMD 20850USA

Grapevine(Vitis vinifera),one of the most economically important fruit crops in the world,suffers significant yield losses from powdery mildew,a major fungal disease caused by Erysiphe *** addition to suppressing host immunity,phytopathogens modulate host proteins termed susceptibility(S)factors to promote their proliferation in *** this study,CRISPR/Cas9(clustered regularly interspaced short palindromic repeats/CRISPR-associated 9)technology was used to enable the targeted mutagenesis of MLO(mildew resistance Locus O)family genes that are thought to serve as S factors for powdery mildew *** deletions or insertions were induced in one or both alleles of two grapevine MLO genes,VvMLO3 and VvMLO4,in the transgenic plantlets of the powdery mildew-susceptible cultivar Thompson *** editing efficiency achieved with different CRISPR/Cas9 constructs varied from 0 to 38.5%.Among the 20 VvMLO3/4-edited lines obtained,one was homozygous for a single mutation,three harbored biallelic mutations,seven were heterozygous for the mutations,and nine were chimeric,as indicated by the presence of more than two mutated alleles in each *** of the 20 VvMLO3/4-edited grapevine lines showed normal growth,while the remaining lines exhibited senescence-like chlorosis and ***,four VvMLO3-edited lines showed enhanced resistance to powdery mildew,which was associated with host cell death,cell wall apposition(CWA)and H2O2 *** together,our results demonstrate that CRISPR/Cas9 genome-editing technology can be successfully used to induce targeted mutations in genes of interest to improve traits of economic importance,such as disease resistance in grapevines.

关键词： resistance Vitis insertion

Spore production in the solid-state fermentation of stevia residue by Trichoderma guizhouense and its effects on corn growth

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Journal of Integrative Agriculture 2021年第5期20卷 1147-1156页

作者： LIU Hong-jun DUAN wan-dong LIU Chao MENG Ling-xue LI Hong-xu LI Rong SHEN Qi-rong Jiangsu Provincial Key Lab of Solid Organic Waste Utilization/Key Laboratory of Plant Immunity Jiangsu Collaborative Innovation Center of Solid Organic Wastes/Educational Ministry Engineering Center of Resource-saving fertilizers/Nanjing Agricultural UniversityNanjing 210095P.R.China Institute of Botany Jiangsu Province and Chinese Academy of SciencesNanjing 210014P.R.China

Trichoderma is an important and widely used plant growth-promoting fungus(PGPF).In this study,stevia residue amended with amino acids hydrolyzed from animal carcasses was used for the production of Trichoderma guizhouense NJAU 4742 by solid-state fermentation,and then its potential to promote corn plant growth was evaluated in combination with chemical fertilizer(CF)or organic fertilizer(OF).The highest spore number of 7×10^(9) CFU g^(–1) fresh weight was obtained under the following optimal parameters:material ratio of 50%(stevia residue:rice bran=1:1),pH value of 3.0(amended with 6.67%amino acids),initial moisture content of 60%,inoculum size of 10%,material thickness of 3 cm and an incubation time of 4 *** aboveground corn plant biomass obtained with *** applied alone and with CF treatments were slightly higher than those of no fertilizer control and CF treatments,***,*** applied with OF significantly(P<0.05)increased aboveground biomass compared to OF and yielded the highest aboveground biomass among all the ***,*** applications primarily influenced the fungal bulk soil community composition,among which three OTUs(OTU_(2) and OTU_(9) classified as Chaetomium,and OTU_(4)classified as Trichoderma)were stimulated in both bulk and rhizosphere ***,a specific OTU_(3)(Phymatotrichopsis)was only stimulated by *** applied with OF,possibly leading to high soil *** results show that it is feasible to employ stevia residue in the eco-friendly fermentation of ***,which is strongly suggested for enhancing OF applications.

关键词： Trichoderma solid-state fermentation stevia residue plant growth-promoting fungi soil fungal community

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布尔台煤矿综放工作面矿压显现规律研究

煤炭工程 2022年第12期54卷 78-83页

作者：郝万东中国煤炭科工集团太原研究院有限公司山西太原030006

针对神东矿区特大型矿井放顶煤开采矿压监测研究不足的问题,以布尔台煤矿放顶煤工作面为背景,对该条件下的矿压显现规律进行了现场实测研究。巷道变形监测显示,辅运巷顶板位移累计下沉量为100~130mm,正帮帮鼓量150mm,副帮帮鼓量累计100m... 详细信息

针对神东矿区特大型矿井放顶煤开采矿压监测研究不足的问题,以布尔台煤矿放顶煤工作面为背景,对该条件下的矿压显现规律进行了现场实测研究。巷道变形监测显示,辅运巷顶板位移累计下沉量为100~130mm,正帮帮鼓量150mm,副帮帮鼓量累计100m,顶板离层最大为5mm,巷道变形程度可控;围岩应力结果显示,超前支承压力影响范围大于75m,须严格执行超前锚杆索支护;工作面液压支架受力监测结果显示,初次来压步距为71.3m,来压持续长度为16.9m,周期来压平均步距为14.8m,来压距离约为9m;微震监测结果显示,微震事件多聚集在机头和机尾附近,微震大能量事件聚集在侧向采空区煤柱附近,工作面推进速度越快,微震总能量越大,保持工作面匀速开采有利于工作面矿压治理。该研究结果可为高产高效放顶煤开采矿井矿压防治提供借鉴参考。

关键词：神东矿区综放工作面矿压显现微震