检索结果-南通市图书馆

Alterations in lymphocyte subset patterns and co-stimulatory molecules in patients with Alzheimer disease

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2009年第12期122卷 1469-1472页

作者： XUE Shou-ru XU dong-hua YANG Xin-xin dong wan-li Department of Neurology First Affiliated Hospital of SooChow University Suzhou Jiangsu 215006 China

Alzheimer disease （AD） is characterized by the .presence of β-amyloid （Aβ） plaques in the *** evidence of inflammatory parameters, such as, complement factors, proinflammatory cytokines and lymphocytes has been found to be co-localized with Aβ plaques. The research in the past decades has demonstrated abnormalities of both the humoral and cellular immune responses, suggesting an association of immunological aberration and AD. The total percentage of lymphocytes was not found to be altered,

关键词： lymphocytes costimulatory molecule Alzheimer disease

Characteristics of traumatic brain injury models:from macroscopic blood flow changes to microscopic mitochondrial changes

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第10期18卷 2268-2277页

作者： Ding-Ding Yang Xiang-dong wan An-Di Chen Zi-Qian Yan Yi-Fan Lu Jun-Chen Liu Ya-Zhou wang Jing wang Yan Zhao Sheng-Xi Wu Guo-Hong Cai Department of Neurobiology School of Basic MedicineForth Military Medical UniversityXi’anShaanxi ProvinceChina Hebei Medical University ShijiazhuangHebei ProvinceChina College of Life Sciences&Research Center for Resource Peptide Drugs Yan’an UniversityYan’anShaanxi ProvinceChina Department of Nuclear Medicine First Affiliated Hospital of Forth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Gastroenterology First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina

Controlled cortical impingement is a widely accepted method to induce traumatic brain injury to establish a traumatic brain injury animal model.A strike depth of 1 mm at a certain speed is recommended for a moderate brain injury and a depth of>2 mm is used to induce severe brain ***,the different effects and underlying mechanisms of these two model types have not been *** study investigated the changes in cerebral blood flow,differences in the degree of cortical damage,and differences in motor function under different injury parameters of 1 and 2 mm at injury speeds of 3,4,and 5 m/*** also explored the functional changes and mitochondrial damage between the 1 and 2 mm groups in the acute(7 days)and chronic phases(30 days).The results showed that the cerebral blood flow in the injured area of the 1 mm group was significantly increased,and swelling and bulging of brain tissue,increased vascular permeability,and large-scale exudation *** the 2 mm group,the main pathological changes were decreased cerebral blood flow,brain tissue loss,and cerebral vasospasm occlusion in the injured *** motor and cognitive impairments were found on day 7 after injury in the 2 mm group;at 30 days after injury,the motor function of the 2 mm group mice recovered significantly while cognitive impairment *** sequencing showed that compared with the 1 mm group,the 2 mm group expressed more ferroptosis-related *** changes of mitochondria in the two groups on days 7 and 30 using transmission electron microscopy revealed that on day 7,the mitochondria in both groups shrank and the vacuoles became larger;on day 30,the mitochondria in the 1 mm group became larger,and the vacuoles in the 2 mm group remained *** analyzing the proportion of mitochondrial subgroups in different groups,we found that the model mice had different patterns of mitochondrial composition at different time periods,suggesting that the differenc

关键词： cerebral blood flow cognitive impairments controlled cortical impingement ferroptosis mitochondrial dysfunction motor impairments mouse model traumatic brain injury

Identification of Colletotrichum spp. isolated from strawberry in Zhejiang Province and Shanghai City,China

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第1期11卷 61-70页

作者： Liu XIE Jing-ze ZHANG Yao wan dong-wei HU Key Laboratory of Molecular Biology of Crop Pathogens and lnsects Ministry of Agriculture Institute of Bioteehnology College of Agriculture and Biotechnology Zhejiang University Hangzhou 310029 China

Strawberry anthracnose, caused by Colletotrichum spp., is a major disease of cultivated strawberry. This study identifies 31 isolates of Colletotrichum spp. which cause strawberry anthracnose in Zhejiang Province and Shanghai City, China. Eleven isolates were identified as C. acutatum, 10 as C. gloeosporioides and 10 as C. fragariae based on morphological characteristics, phylogenetic and sequence analyses. Species-specific polymerase chain reaction (PCR) and enzyme digestion further confirmed the identification of the Colletotrichum spp., demonstrating that these three species are currently the causal agents of strawberry anthracnose in the studied regions. Based on analysis of rDNA internal transcribed spacers (ITS) sequences, sequences of all C. acutatum were identical, and little genetic variability was observed between C. fragariae and C. gloeosporioides. However, the conservative nature of the MvnI specific site from isolates of C. gloeosporioides was confirmed, and this site could be used to differentiate C. gloeosporioides from C. fragariae.

关键词：炭疽病菌草莓栽培病菌鉴定浙江省海城中国胶孢炭疽菌分离

Co/MOF-808(Zr)复合材料的制备及其对有机磷化合物的降解性能

在线全文

学校读者我要写书评

暂无评论

天津工业大学学报 2024年第1期43卷 50-55页

作者：黄艳凤焦克楠王晓荣潘杰万冬天津工业大学化学工程与技术学院天津300387

为了解决普通单金属MOFs材料几乎不能直接将双(4-硝基苯)磷酸酯(BNPP)直接降解为毒性更低的对氨基苯酚(4-AP)的问题,通过油浴法制备出MOF-808(Zr)后,采用后修饰法将草酸钴负载于MOF-808(Zr)上,制备出Co/MOF-808(Zr)复合材料,并对所制材... 详细信息

为了解决普通单金属MOFs材料几乎不能直接将双(4-硝基苯)磷酸酯(BNPP)直接降解为毒性更低的对氨基苯酚(4-AP)的问题,通过油浴法制备出MOF-808(Zr)后,采用后修饰法将草酸钴负载于MOF-808(Zr)上,制备出Co/MOF-808(Zr)复合材料,并对所制材料进行XRD和TEM表征。结果表明:MOF-808(Zr)具有高晶体结构稳定性,Co/MOF-808(Zr)的粒径在250 nm左右且分布均匀;Co/MOF-808(Zr)通过级联反应成功将有机磷神经毒剂模拟物BNPP直接降解为毒性更低的4-AP,而非一般的毒性较高的降解产物对硝基苯酚(4-NP)。其最佳级联降解反应条件为:温度45℃,Co/MOF-808(Zr)剂量为2 mg/mL,底物BNPP为0.6 mmol/L,硼氢化钠0.06 mmol/L。实践得出,Co/MOF-808(Zr)在将有机磷化合物直接降解为毒性更低的4-AP方面表现出良好的应用潜力。

关键词： Co/MOF-808(Zr) 级联反应水解BNPP 氢化4-NP 有机磷化合物降解

Kinetic insight into perovskite La_(0.8)Sr_(0.2)VO_(3) nanofibers as an efficient electrocatalytic cathode for high-rate Li-O_(2) batteries

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

InfoMat 2021年第11期3卷 1295-1310页

作者： Myeong-Chang Sung Gwang-Hee Lee dong-wan Kim School of Civil Environmental and Architectural EngineeringKorea UniversitySeoulSouth Korea

Efficient electrocatalysis at the cathode is essential for overcoming the limitations of Li-O_(2) batteries such as poor stability and low rate ***,we systematically studied the kinetic behavior of a Li-O_(2) battery comprising perovskite La_(0.8)Sr_(0.2)VO_(3) nanofibers formed by partial Sr-cation doping and V cations with multiple oxidation *** with undoped LaVO_(3) and La_(0.8)Sr_(0.2)VO_(4) nanofibers,perovskite La_(0.8)Sr_(0.2)VO_(3) nanofibers exhibited an improved capacity of 2000 mA g^(-1),and a 20-times-longer cycle life in Li-O_(2) batteries.X-ray photoelectron spectroscopy,electron paramagnetic resonance spectroscopy,and photoluminescence analyses revealed that the performance variations mainly originated from crystal defects,which modulate oxygen reduction/evolution *** in situ Raman analysis,we showed that these structural defects are closely related to the oxygen reduction/evolution behavior of La_(0.8)Sr_(0.2)VO_(3) nanofibers and result in fewer parasitic *** study offers insights into the potential rate capability of Li-O_(2) batteries and related devices.

关键词： electrocatalysts La_(0.8)Sr_(0.2)VO_(3) Li-O_(2)battery nanofiber perovskite structure

Therapeutic effect of human amniotic epithelial cell transplantation into the lateral ventricle of hemiparkinsonian rats

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2009年第20期122卷 2449-2454页

作者： YANG Xin-xin XUE Shou-ru dong wan-li Kong Yan Department of Neurology First Affiliated Hospital of SooChow University Suzhou Jiangsu 215006 China

Background Human amniotic epithelial cells （HAECs） are able to secrete biologically active neurotrophins such as brain-derived neurotrophic factor and neurotrophin-3, both of which exhibit trophic activities on dopamine neurons. Previous study showed that when human amniotic epithelial cells were transplanted into the striatum of 6-hydroxydopamine （6-OHDA）-induced Parkinson disease rats, the cells could survive and exert functional effects. The purpose of this study was to investigate the survival and the differentiation of human amniotic epithelial cells after being transplanted into the lateral ventricle of Parkinson＇s disease （PD） rats, and to investigate the effects of grafts on healing PD in models. Methods The Parkinson＇s model was made with stereotactic microinjection of 6-hydroxydopamine （6-OHDA） into the striatum of a rat. The PD models were divided into two groups： the HAECs group and the normal saline （NS） group. Some untreated rats were taken as the control. The rotational asymmetry induced by apomorphine of the HAECs group and the NS group were measured post cell transplantation. The expression of nestin and vimentin in grafts were determined by immunohistology. Ten weeks after transplantation the density of tyrosine hydroxylase positive cells in the substantia nigra of the HAECs group, NS group and the untreated group was determined. The differentiation of grafts was determined by TH immunohistology. High performance liquid chromatography （HPLC） was used to determine monoamine neurotransmitter levels in the striatum. Results The rotational asymmetry induced by apomorphine of the HAECs group was ameliorated significantly compared to the NS group two weeks after transplantation （P 〈0.01）. The grafts expressed nestin and vimentin five weeks after transplantation. TH immunohistochemistry indicated that the TH positive cells in the substantia nigra of the HAECs group increased significantly compared to the NS group （P 〈0.01）. Tyrosine hydroxylase （TH） posit

关键词： Parkinson's disease human amniotic epithelial cell transplantation brain derived neurotrophic factor

SsdchA is a novel secretory cellobiohydrolase driving pathogenicity in Sclerotinia sclerotiorum

在线全文

学校读者我要写书评

暂无评论

The Crop Journal 2024年第2期12卷 493-502页

作者： Yangui Chen Yijuan Ding Siqi Zhao Nan Yang Zhaohui Wu Ping Zhang Hongmei Liao Mengquan dong Yang Yu Huafang wan Wei Qian Integrative Science Center of Germplasm Creation in Western China(Chongqing)Science City College of Agronomy and BiotechnologySouthwest UniversityChongqing 400715China Academy of Agricultural Sciences Southwest UniversityChongqing 400715China Engineering Research Center of South Upland Agriculture Ministry of EducationChongqing 400715China College of Plant Protection Southwest UniversityChongqing 400715China

The necrotrophic fungus, Sclerotinia sclerotiorum, employs an array of cell wall-degrading enzymes(CWDEs), including cellulase, to dismantle host cell walls. However, the molecular mechanisms through which S. sclerotiorum degrades cellulose remain elusive. Here, we unveil a novel secretory cellobiohydrolase, SsdchA, characterized by a signal peptide and a Glyco_hydro_7(GH7) domain. SsdchA exhibits a robust expression of during early infection stages. Interestingly, colony morphology and growth rates remain unaffected across the wild-type, SsdchA deletion strains and SsdchA overexpression strains on potato dextrose agar(PDA) medium. Nevertheless, the pathogenicity and cellobiohydrolase activity decreased in the SsdchA deletion strains, but enhanced in the SsdchA overexpression strains. Moreover,the heterologous expression of SsdchA in Arabidopsis thaliana leads to reduced cellulose content and heightened susceptibility to S. sclerotiorum. Collectively, our data underscore the pivotal role of the novel cellobiohydrolase SsdchA in the pathogenicity of S. sclerotiorum.

关键词： Cellobiohydrolase Cellulose Pathogenicity Sclerotinia sclerotiorum Secretory protein SsdchA

Molecular insights into clinical trials for immune checkpoint inhibitors in colorectal cancer:Unravelling challenges and future directions

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第13期30卷 1815-1835页

作者： Samantha Sharma Naresh Singh Anita Ahmed Turk Isabella wan Akshay Guttikonda Julia Lily dong Xinna Zhang Mateusz Opyrchal Department of Medical and Molecular Genetics Indiana University School of MedicineIndianapolisIN 46202United States Division of Hematology/Oncology Department of MedicineIndiana University School of MedicineIndianapolisIN 46202United States Melvin and Bren Simon Comprehensive Cancer Center Indiana University School of MedicineIndianapolisIN 46202United States

Colorectal cancer(CRC)is a complex disease with diverse etiologies and clinical *** considerable progress in development of CRC therapeutics,challenges remain regarding the diagnosis and management of advanced stage metastatic CRC(mCRC).In particular,the five-year survival rate is very low since mCRC is currently rarely *** the past decade,cancer treatment has significantly improved with the introduction of cancer immunotherapies,specifically immune checkpoint *** aimed at blocking immune checkpoints such as PD-1,PD-L1,and CTLA-4 target inhibitory pathways of the immune system,and thereby enhance anti-tumor *** therapies thus have shown promising results in many clinical trials alone or in *** efficacy and safety of immunotherapy,either alone or in combination with CRC,have been investigated in several clinical *** trials,including KEYNOTE-164 and CheckMate 142,have led to Food and Drug Administration approval of the PD-1 inhibitors pembrolizumab and nivolumab,respectively,for the treatment of patients with unresectable or metastatic microsatellite instability-high or deficient mismatch repair ***,these drugs benefit only a small percentage of patients,with the benefits of immunotherapy remaining elusive for the vast majority of CRC *** this end,primary and secondary resistance to immunotherapy remains a significant issue,and further research is necessary to optimize the use of immunotherapy in CRC and identify biomarkers to predict the *** review provides a comprehensive overview of the clinical trials involving immune checkpoint inhibitors in *** underlying rationale,challenges faced,and potential future steps to improve the prognosis and enhance the likelihood of successful trials in this field are discussed.

关键词： Colorectal cancer Immune checkpoint inhibitors Clinical trials Immunotherapy Microsatellite instability Microsatellite stability DNA mismatch repair

Stable operation of highly loaded pure Si-Fe anode under ambient pressure via carboxy silane-directed robust solid electrolyte interphase

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第7期94卷 568-576页

作者： Guntae Lim dong Guk Kang Hyeon Gyu Lee Yen Hai Thi Tran Kihun An Junghyun Choi Kwang Chul Roh Do Youb Kim Seung-wan Song Department of Chemical Engineering&Applied Chemistry Chungnam National University Daejeon 34134Republic of Korea Energy Storage Materials Center Korea Institute of Ceramic Engineering&TechnologyJinju 52851Republic of Korea Advanced Energy Materials Research Center Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea

Incorporation of higher content Si anode material beyond 5 wt% to Li-ion batteries(LIBs)is challenging,owing to large volume change,swelling,and solid electrolyte interphase(SEI)instability ***,a strategy of diacetoxydimethylsilane(DAMS)additive-directed SEI stabilization is proposed for a stable operation of Si-0.33FeSi_(2)(named as Si-Fe)anode without graphite,which provides siloxane inorganics and organics enrichment that compensate insufficient passivation of fluoroethylene carbonate(FEC)additive and reduce a dependence on *** stable cycling performance of highly loaded(3.5 mA h cm^(-2))pure Si-Fe anode is achieved with 2 wt%DAMS combined with 9 wt%FEC additives under ambient pressure,yielding high capacity 1270 mA h g^(-1)at 0.5 C and significantly improved capacity retention of 81% after 100 cycles,whereas short circuit and rapid capacity fade occur with FEC only ***-directed robust SEI layer dramatically suppresses swelling and particles crossover through separator,and therefore prevents short circuit,demonstrating a possible operation of pure Si or Sidominant anodes in the next-generation high-energy-density and safe LIBs.

关键词： High-energy Li-ion battery Pure Si-Fe anode without graphite Silane additive SEI layer Suppressed swelling