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Efficacy and Safety of Teriflunomide in Chinese Patients with Relapsing Forms of Multiple Sclerosis: A Subgroup Analysis of the Phase 3 TOWER Study

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Chinese Medical Journal 2018年第23期131卷 2776-2784页

作者： Wei Qiu De-Hui Huang Shi-Fang Hou Mei-Ni Zhang Tao Jin Hui-Qing dong Hua Peng Chao-dong Zhang Gang Zhao Yi-Ning Huang dong Zhou Wei-Ping Wu Bao-Jun wang Ji-Mei Li Xing-Hu Zhang Yan Cheng Hai-Feng Li Ling Li Chuan-Zhen Lu Xu Zhang Bi-Tao Bu wan-Li dong dong-Sheng Fan Xue-Qiang Hu Xian-Hao Xu Department of Neurology The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdong 510000China Department of Neurology Peking University First HospitalBeijing 100034China Department of Neurology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Neurology Baotou Central HospitalBaotouInner Mongolia 014040China Department of Neurology Beijing Friendship HospitalCapital Medical UniversityBeijing 100000China Department of Neurology Beijing Tian Tan HospitalCapital Medical UniversityBeijing 100050China Department of Neurology Tianjin Medical University General HospitalTianjin 300052China Department of Neurology The Affiliated Hospital of Qingdao UniversityQingdaoShandong 266003China Department of Neurology Hebei General HospitalShijiazhuangHebei 050051China Department of Neurology Hua Shah Hospital of the Shanghai Fudan University Medical CollegeShanghai 200040China Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325000China Department of Neurology Chinese People's Liberation Army General HospitalBeijing 100853China Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Department of Neurology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215000China Department of Neurology Beijing HospitalNational Center of GerontologyBeijing 100083China Qilu Hospital of Shandong University JinanShandong 250012China Department of Neurology Beijing HospitalBeijing 100730China Department of Neurology The First Hospital of Shanxi Medical UniversityTaiyuanShanxi 030001China Department of Neurology The First Hospital of Jilin UniversityChangchunJilin 130012China Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Neurology Shanghai Chang Zheng HospitalShanghai 200003China Department of Neurology The First Hospital of China Medical UniversityShenyang

Background:Disease-modifying therapy is the standard treatment for patients with multiple sclerosis (MS)in *** primary objective of the current analysis was to assess the efficacy and safety of two teriflunomide doses (7mg and 14mg)in the subgroup of Chinese patients with relapsing MS included in the TOWER study. Methods:TOWER was a multicenter,multinational,randomized, double-blind,parallel-group (three groups),placebo-controlled *** subgroup analysis includes 148 Chinese patients randomized to receive either teriflunomide 7mg (n =51), teriflunomide 14mg (n=43),or placebo (n=54). Results:Of the 148patients in the intent-to-treat population, adjusted annualized-relapse rates were 0.63(95% confidence interval [CI]:0.44,0.92)in the placebo group,0.48(95%CI:0.33, 0.70)in the teriflunomide 7mg group,and 0.18(95%CI:0.09,0.36)in the terifltmomide 14mg group;this corresponded to a significant relative risk reduction in the teriflunomide 14mg group versus placebo (-71.2%,P =0.0012).Terifiunomide 14mg also tended to reduce 12-week confirmed disability worsening by 68.1% compared with placebo (hazard ratio:0.319,P =0.1194).There were no differences across all treatment groups in the proportion of patients with treatment-emergent adverse events (TEAEs;72.2% in the placebo group,74.5%in the teriflunomide 7mg group,and 69.8% in the teriflunomide 14mg group);corresponding proportions for serious adverse events were 11.1%,3.9%,and 11.6%,*** most frequently reported TEAEs with teriflunomide versus placebo were neutropenia,increased alanine aminotransferase,and hair thinning. Conclusions:Teriflunomide was as effective and safe in the Chinese subpopulation as it was in the overall population of patients in the TOWER *** has the potential to meet unmet medical needs for MS patients in China.

关键词： Chinese Patients Efficacy Phase 3 Relapsing Multiple Sclerosis Safety Teriflunomide TOWER

Optimally arranged TiO_(2)@MoS_(2) heterostructures with effectively induced built-in electric field for high-performance lithium-sulfur batteries

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能源化学:英文版 2023年第8期83卷 496-508,I0012页

作者： Jeongyoub Lee Changhoon Choi Jung Been Park Seungho Yu Jinho Ha Hyungsoo Lee Gyumin Jang Young Sun Park Juwon Yun Hayoung Im Subin Moon Soobin Lee Jung-Il Choi dong-wan Kim Jooho Moon Department of Materials Science and Engineering Yonsei UniversitySeoul 03722Republic of Korea School of Civil Environmental and Architectural EngineeringKorea UniversitySeoul 02841Republic of Korea Energy Storage Research Center Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea School of Mathematics and Computing(Computational Science and Engineering) Yonsei UniversitySeoul 03722Republic of Korea

To overcome the serious technological issues affecting lithium-sulfur(Li-S) batteries,such as sluggish sulfur redox kinetics and the detrimental shuttle effect,heterostructure engineering has been investigated as a strategy to effectively capture soluble lithium polysulfide intermediates and promote their conversion reaction by integrating highly polar metal oxides with catalytically active metals ***,to fully exploit the outstanding properties of heterostructure-based composites,their detailed structure and interfacial contacts should be designed ***,optimally arranged TiO_(2)and MoS_(2)-based heterostructures(TiO_(2)@MoS_(2)) are fabricated on carbon cloth as a multifunctional interlayer to efficiently trap polysulfide intermediates and accelerate their redox *** to the synergistic effects between TiO_(2)and MoS_(2)and the uniform heterointerface distribution that induces the ideally oriented built-in electric field,Li-S batteries with TiO_(2)@MoS_(2)interlayers exhibit high rate capability(601 mA h g^(-1)at 5 C),good cycling stability(capacity-fade rate of 0.067% per cycle over 500 cycles at2 C),and satisfactory areal capacity(5.2 mA h cm^(-2)) under an increased sulfur loading of 5.2 mg cm^(-2).Moreover,by comparing with a MoS_(2)@TiO_(2)interlayer composed of reversely arranged heterostructures,the effect of the built-in electric field’s direction on the electrocatalytic reactions of polysulfide intermediates is thoroughly investigated for the first *** superior electrocatalytic activities of the rationally arranged TiO_(2)@MoS_(2)interlayer demonstrate the importance of optimizing the built-in electric field of heterostructures for producing high-performance Li-S batteries.

关键词： Lithium-sulfur batteries Shuttle effect TiO_(2)-MoS_(2)heterostructure engineering Built-in electric field Multifunctional interlayers

Usage of Displaced Current in Langmuir Probe Measurement

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Chinese Physics Letters 2012年第7期29卷 179-183页

作者： MING Zhang-Jian LI Hong CHEN Zhi-Peng LUO Chen XIE Jin-Lin LAN Tao LIU A-Di LIU wan-dong CAS Key Laboratory of Basic Plasma Physics Department of Modern PhysicsUniversity of Science and Technology of ChinaHefei 230026

We investigate the possibility of the usage of displaced current in Langmuir probe measurement theoretically and *** displaced current flows through the self-generated or artificial capacitance of the reference electrode under an alternative sweep *** can increase the total current afforded by the reference electrode,and eliminate the interference deriving from the finite plasma sheath resistance of the reference *** results in both theory and experiment lead to the conclusion that the usage of displaced current is valid and more efficient with a floating probe *** method is applied in some harsh plasma environments when the grounded chamber wall can easily be contaminated by the dielectric.

关键词： Probe electrode eliminate

Characteristics of traumatic brain injury models:from macroscopic blood flow changes to microscopic mitochondrial changes

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Neural Regeneration Research 2023年第10期18卷 2268-2277页

作者： Ding-Ding Yang Xiang-dong wan An-Di Chen Zi-Qian Yan Yi-Fan Lu Jun-Chen Liu Ya-Zhou wang Jing wang Yan Zhao Sheng-Xi Wu Guo-Hong Cai Department of Neurobiology School of Basic MedicineForth Military Medical UniversityXi’anShaanxi ProvinceChina Hebei Medical University ShijiazhuangHebei ProvinceChina College of Life Sciences&Research Center for Resource Peptide Drugs Yan’an UniversityYan’anShaanxi ProvinceChina Department of Nuclear Medicine First Affiliated Hospital of Forth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Gastroenterology First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina

Controlled cortical impingement is a widely accepted method to induce traumatic brain injury to establish a traumatic brain injury animal model.A strike depth of 1 mm at a certain speed is recommended for a moderate brain injury and a depth of>2 mm is used to induce severe brain ***,the different effects and underlying mechanisms of these two model types have not been *** study investigated the changes in cerebral blood flow,differences in the degree of cortical damage,and differences in motor function under different injury parameters of 1 and 2 mm at injury speeds of 3,4,and 5 m/*** also explored the functional changes and mitochondrial damage between the 1 and 2 mm groups in the acute(7 days)and chronic phases(30 days).The results showed that the cerebral blood flow in the injured area of the 1 mm group was significantly increased,and swelling and bulging of brain tissue,increased vascular permeability,and large-scale exudation *** the 2 mm group,the main pathological changes were decreased cerebral blood flow,brain tissue loss,and cerebral vasospasm occlusion in the injured *** motor and cognitive impairments were found on day 7 after injury in the 2 mm group;at 30 days after injury,the motor function of the 2 mm group mice recovered significantly while cognitive impairment *** sequencing showed that compared with the 1 mm group,the 2 mm group expressed more ferroptosis-related *** changes of mitochondria in the two groups on days 7 and 30 using transmission electron microscopy revealed that on day 7,the mitochondria in both groups shrank and the vacuoles became larger;on day 30,the mitochondria in the 1 mm group became larger,and the vacuoles in the 2 mm group remained *** analyzing the proportion of mitochondrial subgroups in different groups,we found that the model mice had different patterns of mitochondrial composition at different time periods,suggesting that the differenc

关键词： cerebral blood flow cognitive impairments controlled cortical impingement ferroptosis mitochondrial dysfunction motor impairments mouse model traumatic brain injury

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基于等级保护的网络容灾系统模型

计算机科学 2005年第3期32卷 47-49页

作者：蔡皖东西北工业大学计算机学院西安710072

等级保护是信息安全技术的重要原则之一,作为信息安全重要组成部分的网络容灾系统同样要遵循这一原则。本文详细论述了容灾系统等级划分、4种不同等级的网络容灾系统模型以及灾难管理等内容。

关键词：等级保护网络容灾系统信息安全技术灾难管理

Association of Polygenic Risk Score with Age at Onset and Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease in a Chinese Cohort

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Neuroscience Bulletin 2020年第7期36卷 696-704页

作者： Wei-Wei Li Zhen wang dong-Yu Fan Ying-Ying Shen dong-wan Chen Hui-Yun Li Ling Li Heng Yang Yu-Hui Liu Xian-Le Bu wang-Sheng Jin Fan Zeng Zhi-Qiang Xu Jin-Tai Yu Li-Yong Chen Yan-Jiang wang Department of Neurology and Centre for Clinical Neuroscience Duping HospitalThird Military Medical UniversityChongqing 400042China Department of Anaesthesiology Daping HospitalThird Military Medical UniversityChongqing 400042China Chongqing Key Laboratory of Aging and Diseases Chongqing 400042China Centre for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031China Department of Neurology Huashan HospitalFudan UniversityShanghai 200040China

To evaluate whether the polygenic profile modifies the development of sporadic Alzheimer’s disease(sAD)and pathological biomarkers in cerebrospinal fluid(CSF),462 sAD patients and 463 age-matched cognitively normal(CN)controls were genotyped for 35 singlenucleotide polymorphisms(SNPs)that are significantly associated with ***,the alleles found to be associated with sAD were used to build polygenic risk score(PRS)models to represent the genetic *** operating characteristic(ROC)analyses and the Cox proportional hazards model were used to evaluate the predictive value of PRS for the sAD risk and age at *** measured the CSF levels of Aβ42,Aβ42/Aβ40,total tau(T-tau),and phosphorylated tau(P-tau)in a subgroup(60 sAD and 200 CN participants),and analyzed their relationships with the *** found that 14 SNPs,including SNPs in the APOE,BIN1,CD33,EPHA1,SORL1,and TOMM40 genes,were associated with sAD risk in our *** PRS models built with these SNPs showed potential for discriminating sAD patients from CN controls,and were able to predict the incidence rate of sAD and age at ***,the PRSs were correlated with the CSF levels of Aβ42,Aβ42/Aβ40,T-tau,and *** study suggests that PRS models hold promise for assessing the genetic risk and development of *** genetic risk profiles vary among populations,large-scale genome-wide sequencing studies are urgently needed to identify the genetic risk loci of sAD in Chinese populations to build accurate PRS models for clinical practice.

关键词： Alzheimer's disease Single nucleotide polymorphism Polygenic risk score Cerebrospinal fluid Biomarker Amyloid-beta Tau

Studies on the Protonation and Complexations of Dioxotetraamine Macrocycles

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Chinese Chemical Letters 1996年第9期7卷 864-867页

作者： wan dong CHEN Xiang Chen YIN Shou Rong ZHUa Hua Kuan LIN Appolin Bave KONDIANO Mei Rong LIN and Yun Ti CHEN (Department of Chemistry.Nankai University,Tianjin 300071)(Department of Chemistry,Jining Teacher’s College,Jining 272125)(Institute of Modern Op Department of Chemistry Jining Teacher's College Jining 272125 Department of Chemistry Nankai University Tianjin 300071 Institute of Modern Optics Nankai University Tianjin 300071

14-Membered macrocyclic dioxotetraamines deprotonate stepwisely upon coordination to cupric ions. Singly- and doubly-deprotonated complexes are the main species, While for 13-membered analogs, non- and doubly-deproton... 详细信息

关键词： Studies on the Protonation and Complexations of Dioxotetraamine Macrocycles

Diagnostic performance of the current risk-stratified approach with computed tomography for suspected choledocholithiasis and its options when negative finding

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Hepatobiliary & Pancreatic Diseases International 2019年第4期18卷 366-372页

作者： Hyun Woo Lee Tae Jun Song Do Hyun Park Sang Soo Lee dong-wan Seo Sung Koo Lee Myung-Hwan Kim Jae Hyuck Jun Ji Eun Moon Yeon Han Song Digestive Disease Center and Research Institute Department of Internal MedicineSoonchunhyang University School of MedicineBucheonKorea Division of Gastroenterology Department of Internal MedicineUniversity of Ulsan College of MedicineAsan Medical CenterSeoulKorea Division of Gastroenterology Department of Internal MedicineUniversity of Eulji College of MedicineEulji Medical CenterDaejeonKorea Department of Biostatistics Clinical trial centerSoonchunhyang University Bucheon HospitalBucheonKorea

Background:Several studies evaluated the current guideline of the American Society for Gastrointestinal Endoscopy(ASGE)and reported only suboptimal *** study evaluated the diagnostic performance of the ASGE guideline based on computed tomography(CT)and role of endoscopic ultrasonography(EUS)and magnetic resonance cholangiopancreatography(MRCP)in patients with suspected choledocholithiasis but negative CT ***:Patients with suspected choledocholithiasis undergoing ERCP between January 2016 and January 2017 were retrospectively *** patients underwent CT to detect *** or MRCP was performed when the CT scan showed negative *** were classified into the high and intermediate-risk groups,based on predictors from the ASGE ***:Of 583 patients with suspected choledocholithiasis,340(58.3%)had stones on ERCP(65.9%in the high-risk group and 40.6%in the intermediate-risk group).The accuracy of ASGE guideline for CT was 63.98%(79.12%sensitivity,42.80%specificity)and 36.02%(20.88%sensitivity,57.20%specificity)in the high-risk and intermediate-risk groups,*** 103 patients in the high-risk group underwent both CT and US,the accuracy of CT was higher than that of US for detecting choledocholithiasis(78.64%vs.53.40%),with a significant difference in area under the curve(AUC)(0.78 vs.0.59,P<0.001).Of 339 with negative CT finding,the accuracy of EUS was higher than that of MRCP(90.91%vs.82.76%),but with no significant difference in AUC(0.91 vs.0.83,P=0.347).Conclusions:CT-based ASGE guideline showed superior diagnostic performance than US for predicting *** diagnostic options,EUS or MRCP,with negative CT finding showed comparable ***,the diagnostic modality should be selected based on availability,experience,cost,and contraindications.

关键词： Choledocholithiasis ASGE guideline Accuracy Endoscopic ultrasound Magnetic resonance cholangiopancreatography

面向Web论坛的网络信息获取技术及系统实现

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计算机工程与科学 2011年第1期33卷 157-160页

作者：彭冬蔡皖东西北工业大学计算机学院陕西西安710072

网络爬虫技术是网络信息获取的重要手段,面向Web论坛的信息获取则是网络爬虫技术所面临的新课题。在分析和研究面向Web论坛信息获取技术的基础上,本文设计和实现了一种用于Web论坛信息获取的主题网络爬虫系统,根据Web论坛信息组织结构,... 详细信息

网络爬虫技术是网络信息获取的重要手段,面向Web论坛的信息获取则是网络爬虫技术所面临的新课题。在分析和研究面向Web论坛信息获取技术的基础上,本文设计和实现了一种用于Web论坛信息获取的主题网络爬虫系统,根据Web论坛信息组织结构,提出了基于遍历策略的信息搜索技术;根据正文信息分布及论坛自身特点,提出了基于DOM与分块算法相结合的正文提取技术。实验结果表明,遍历策略比传统的网络爬虫遍历策略具有更高的效率,能够采集到更多主题相关度高的网页;经过噪声清洗处理后,有效提取网页正文,提高了信息采集精度。

关键词：网络爬虫 Web论坛正文提取主题相关度