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补脾清肠活血汤对溃疡性结肠炎患者淋巴细胞功能的影响

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世界华人消化杂志 2006年第11期14卷 1124-1127页

作者：董文毅胡刚正郑长青中国医科大学附属第二医院(盛京医院)中医科辽宁省沈阳市110004 中国医科大学附属第二医院(盛京医院)消化内科辽宁省沈阳市110004

目的:探讨补脾清肠活血汤、复合灌肠液及环孢素A对溃疡性结肠炎的治疗作用是否通过影响淋巴细胞的增殖或细胞因子表达谱来实现．方法:体外培养中用植物凝集素刺激溃疡性结肠炎患者外周血淋巴细胞,分组加入一定剂量的补脾清肠活血汤、复... 详细信息

目的:探讨补脾清肠活血汤、复合灌肠液及环孢素A对溃疡性结肠炎的治疗作用是否通过影响淋巴细胞的增殖或细胞因子表达谱来实现．方法:体外培养中用植物凝集素刺激溃疡性结肠炎患者外周血淋巴细胞,分组加入一定剂量的补脾清肠活血汤、复合灌肠液、环孢素A及空白对照剂,检测增殖程度及细胞因子表达谱．结果:复合灌肠液和环孢素A能显著抑制淋巴细胞的增殖及细胞因子IL-2、IL-4及IFN-γ的分泌,同时也抑制了免疫抑制性细胞因子 IL-10的分泌,而补脾清肠活血汤抑制增殖及促炎细胞因子的作用较弱,但能促进IL-10的分泌．结论:补脾清肠活血汤、复合灌肠液及环孢素A均可通过影响T细胞来促进免疫耐受的形成,但其作用的具体途径有差别,这些途径很可能产生协同作用．

关键词：溃疡性结肠炎中药淋巴细胞免疫耐受 IL-2 IFN-γ IL-10 IL-4

不同丘脑神经环路分别调控组织损伤和抑郁样状态引起的机械痛敏

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中国疼痛医学杂志 2021年第7期27卷 515-515页

作者： Zhu X Tang HD dong wy 王佳昕(译) 刘风雨(校) 不详北京大学神经科学研究所

丘脑是疼痛传导通路中重要的脑区之一,疼痛的上行传导与下行调控通路中均有丘脑参与调节。组织损伤和负面情绪(如抑郁)都能引起痛觉敏化,但是否由不同的丘脑环路调控尚不清楚。目的:探讨丘脑调控组织损伤引起的痛敏和抑郁情绪产生痛敏... 详细信息

丘脑是疼痛传导通路中重要的脑区之一,疼痛的上行传导与下行调控通路中均有丘脑参与调节。组织损伤和负面情绪(如抑郁)都能引起痛觉敏化,但是否由不同的丘脑环路调控尚不清楚。目的:探讨丘脑调控组织损伤引起的痛敏和抑郁情绪产生痛敏的机制。方法:(1)动物模型:注射完全弗氏佐剂(CFA)建立小鼠慢性炎症痛模型或通过保留性神经损伤(SNI)建立小鼠神经病理性疼痛模型;采用慢性束缚应激(CRS)或慢性不可预测应激(CUS)诱导小鼠出现抑郁样行为的同时引起痛敏;(2)行为学实验:采用von Frey hair纤维丝检测机械痛敏;采用社交行为、悬尾实验和强迫游泳检测抑郁样情绪。

关键词：完全弗氏佐剂机械痛敏组织损伤悬尾实验负面情绪神经病理性疼痛神经环路动物模型

Oomycete Nudix effectors display wy-Nudix conformation and mRNA decapping activity

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Journal of Integrative Plant Biology 2024年第8期66卷 1548-1552页

作者： Baodian Guo Qinli Hu Bangwei Wang Deqiang Yao Haonan Wang Guanghui Kong Chenyang Han Suomeng dong Fengquan Liu Weiman Xing Yuanchao Wang Department of Plant Pathology Nanjing Agricultural UniversityNanjing 210095China Institute of Plant Protection Jiangsu Academy of Agricultural SciencesNanjing 210014China Department of Molecular Genetics University of Texas Southwestern Medical CenterDallasTexas 75390USA Institute of Aging&Tissue Regeneration Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China College of Horticulture Nanjing Agricultural UniversityNanjing 210095China College of Agriculture Guizhou UniversityGuiyang 550025China College of Life Sciences Shanghai Normal UniversityShanghai 200234China

Phytopathogens secrete effectors to promote colonization of their host *** effectors modulate host immune responses by interfering with various pathways,but little is known about their biochemical *** recent reports indicate that some phytopathogen effectors have Nudix hydrolase activity,including Avr3b from Phytophthora sojae(dong et al.,2011),AvrM14 from Melampsora lini (McCombe et al.,2023),and RipN from Ralstonia solanacearum (Sun et al.,2019).

关键词： plants Phytophthora biochemical

Provenance of upper Permian-lowermost Triassic sandstones, Wutonggou low-order cycle, Bogda Mountains, NW China:implications on the unroofing history of the Eastern North Tianshan Suture

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Journal of Palaeogeography 2020年第3期9卷 314-334页

作者： dong-Yu Zheng Wan Yang Geology and Geophysics Program Missouri University of Science and TechnologyRollaMO 65409USA

This study investigates the provenance of sedimentary rocks in Bogda Mountains, NW China, and reconstructs the lithology and unroofing history of the Eastern North Tianshan Suture. Petrographic point counting data of sandstones and compositions of conglomerates of upper Permian-lowermost Triassic Wutonggou low-order cycle from Zhaobishan, North Tarlong, Taodonggou, and Dalongkou sections in the southern and northern foothills of Bogda Mountains were used to interpret the temporal and spatial variations of lithology of the Eastern North Tianshan Suture, which is the sediment source area. Three compositional trends were identified. A trend of upwardincreasing quartz content and granitic pebbles in Zhaobishan section suggests a change from the undissected volcanic arc, accretionary wedge and trench setting to predominantly transitional volcanic arc and subordinate accretionary wedge and trench, in the eastern part of the Eastern North Tianshan Suture. In North Tarlong and Taodonggou sections, however, the lithic content decreases and the contents of quartz and granitic pebbles increase up sections. These trends indicate that the western part of the Eastern North Tianshan Suture changed from an undissected volcanic arc to the transitional volcanic arc, accretionary wedge and trench. No clear trend in the lithic-rich sandstones of the Dalongkou section indicates that sediments were derived from the undissected volcanic arc in the Eastern North Tianshan Suture and local rift shoulders. Compositional variations of studied rocks suggest that the Eastern North Tianshan Suture was an amalgamated complex with great spatial and temporal heterogeneities in lithology and experienced persistent unroofing during late Permian-earliest Triassic. This study reconstructs a key element of the Chinese Tianshan Suture and serves as an example to understand the unroofing processes of ancient sutures.

关键词： Provenance Wutonggou low-order cycle Bogda Mountains Unroofing Eastern North Tianshan Suture NW China

Preparation and characterization of m PEG grafted chitosan micelles as 5-fluorouracil carriers for effective anti-tumor activity

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Chinese Chemical Letters 2014年第11期25卷 1435-1440页

作者： dong-Jun Fu Yu Jin Mu-Qing Xie Ya-Jing Ye dong-dong Qin Kai-Yan Lou Yan-Zuo Chen Feng Gao Department of Pharmaceutics School of Pharmacy East China University of Science and Technology Shanghai Key Laboratory of Functional Materials Chemistry East China University of Science and Technology Shanghai Key Laboratory of New Drug Design East China University of Science and Technology

The objective of this study was to investigate the potential of methoxy polyethylene glycol（m PEG）grafted chitosan（m PEG-g-CS） to be used as a drug carrier. m PEG-g-CS was successfully synthesized by one-step method with formaldehyde. The substitution degree of m PEG on chitosan was calculated by elemental analysis and was found to be（3.23 0.25）%. m PEG-g-CS self-assembled micelles were prepared by ultrasonic method with the controlled size of 178.5–195.1 nm and spherical morphology. Stable dispersion of the micelles was formed with the zeta potential of 2.3–30.2 m V. 5-Fluorouracil（5-FU）, an anticancer chemotherapy drug, was used as a model drug to evaluate the efficiency of the new drug delivery carrier. The loading efficiency of 5-FU was（4.01 0.03）%, and the drug-loaded m PEG-g-CS self-assembled micelle showed a controlled-release effect. In summary, the m PEG-g-CS self-assembled micelle is proved to be a promising carrier with controlled particle size and controlled-release effect. Therefore, it has great potential for the application as 5-FU carriers for effective anti-tumor activity.

关键词： Self-assembled micelles Methoxy polyethylene glycol grafted chitosan 5-Fluorouracil Controlled-release

A new die-cast magnesium alloy for applications at higher elevated temperatures of 200-300℃

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Journal of Magnesium and Alloys 2021年第1期9卷 90-101页

作者： Xixi dong Lingyun Feng Shihao Wang Eric A.Nyberg Shouxun Ji Brunel Centre for Advanced Solidification Technology(BCAST) Brunel University LondonUxbridge UB83PHUnited Kingdom Tungsten Parts wyoming LaramieWY 82072USA

The development of lightweight magnesium(Mg)alloys capable of operating at elevated temperatures of 200-300℃and the ability of using high pressure die casting for high-volume manufacturing are the most advanced developments in manufacturing critical parts for internal combustion engines used in power *** we report the microstructure and mechanical properties of a newly developed die-cast Mg-RE(La,Ce,Nd,Gd)-Al alloy capable of working at higher elevated temperatures of 200-300℃.The new alloy delivers the yield strength of 94 MPa at 300℃,which demonstrates a 42%increase over the benchmark AE44 high temperature die-cast Mg *** new alloy also has good stiffness at elevated temperatures with its modulus only decreasing linearly by 13%from room temperature up to 300℃.Thermal analysis shows a minor peak at 364.7℃in the specific heat curve of the new alloy,indicating a good phase stability of the alloy up to 300℃.Nd and Gd have more affinity to Al for the formation of the minority of divorced Al-RE(Nd,Gd)based compounds,and the stable Al-poor Mg_(12)RE(La_(0.22)Ce_(0.13)Nd_(0.31)Gd_(0.31))Zn_(0.39)Al_(0.13)compound acts as the continuous inter-dendritic network,which contribute to the high mechanical performance and stability of the new die-cast Mg alloy at 200-300℃.

关键词： Magnesium alloys High pressure die casting Elevated temperatures Microstructure Mechanical properties

维持性血液透析患者外周血miR-125b-5p与冠状动脉钙化相关性研究

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中国分子心脏病学杂志 2024年第1期24卷 5844-5852页

作者：董莉萍刘松徐琦杜兴国李承旭李华董骏武田明武汉市第四医院肾病内科武汉430033 武汉市第四医院临床营养科武汉430033 武汉市第四医院影像科武汉430033 武汉市第四医院超声科武汉430033

目的分析外周血miR-125b-5p水平与尿毒症患者冠状动脉钙化严重程度的相关性,并对机制进行探讨。方法选取2021年1月至2023年5月于武汉市第四医院古田院区接受维持性血液透析的患者为研究对象。所有入选者均接受胸部心脏CT检查,并检测... 详细信息

目的分析外周血miR-125b-5p水平与尿毒症患者冠状动脉钙化严重程度的相关性,并对机制进行探讨。方法选取2021年1月至2023年5月于武汉市第四医院古田院区接受维持性血液透析的患者为研究对象。所有入选者均接受胸部心脏CT检查,并检测外周血miR-125b-5p水平。在小鼠胸主动脉平滑肌细胞中,探索高磷及miR-125b-5p表达对细胞钙化沉积和炎症蛋白表达的影响。结果共有117例患者纳入研究,男性69例(59%),女性48例(41%),平均年龄62岁。依据冠状动脉钙化积分将纳入患者分组:轻度冠状动脉钙化(积分<400分)组(71例),严重冠状动脉钙化(积分≥400分)组(46例)。多因素二元logistic回归分析表明外周血miR-125b-5p水平(OR=0.325,95%CI:0.205~0.517,P<0.001)与冠状动脉钙化严重程度独立相关。受试者操作特征曲线分析miR-125b-5p对严重冠状动脉钙化的预测价值,曲线下面积为0.831(95%CI:0.750~0.894,P<0.001)。细胞实验结果显示,相较于对照组,高磷干预下胸主动脉平滑肌细胞钙化沉积明显增加,且炎症蛋白TLR4及NF-κB p65蛋白同时上调(P<0.05);而相较于高磷组,过表达miR-125b-5p可显著减少高磷诱导的钙化沉积及减轻炎症蛋白TLR4及NF-κB p65蛋白表达的上调(P<0.05)。结论外周血miR-125b-5p的相对表达水平与维持性血液透析患者冠状动脉钙化严重程度呈显著负相关,其机制可能是通过减轻炎性反应而减轻血管钙化。

关键词：尿毒症血液透析冠状动脉钙化 miR-125b-5p

Effects of wy14643 on hepatic ischemia reperfusion injury in rats

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World Journal of Gastroenterology 2008年第45期14卷 6936-6942页

作者： Si-Qi Xu Yuan-Hai Li Sheng-Hong Hu Ke Chen Liu-Yi dong Department of Anesthesiology First Affiliated Hospital of Anhui Medical University Hefei 230022 Anhui Province China Department of Pharmacology Anhui Medical University Hefei 230032 Anhui Province China

AIM: To investigate the effects and possible mechanisms of wy14643 on hepatic ischemia-reperfusion (I/R) injury in ***: Thirty male Sprague-Dawley rats weighing 220-280 g were randomly divided into five experimental groups: sham group (G1, n = 6): a sham operation was performed (except for liver I/R); I/R-untreated group (G2, n = 6): rats underwent liver ischemia for 90 min followed by reperfusion for 4 h; and I/R + wy14643 groups (G3, G4, G5; n = 6): after the same surgical procedure as in group 2, animals were pretreated with wy14643 at the dose of 1, 5 and 10 mg/kg 1 h before ischemia, respectively. Hepatic ischemia-reperfusion (I/R) was induced by clamping blood supply to the left lateral and median lobes of the liver for 90 min, and atraumatic clamp was removed for 4 h reperfusion. Blood samples and liver tissues were obtained at the end of reperfusion to assess serum and hepatic tissue homogenate aminotransferase (ALT), aspartate aminotransferase (AST), myeloperoxidase (MPO), serum interleukin-1β (IL-1β) and tumor necrosis factor alpha (TNF-α), as well as activity of superoxide dismutase (SOD) and content of malondialdehyde (MDA) in the hepatic tissue homogenate. RESULTS: Hepatic I/R induced a significant increase in the serum levels of ALT, AST, TNF-α, IL-1β and MPO, as well as the levels of ALT, AST and MDA in the liver tissue homogenate, which were reduced bypretreatment with wy14643 at the dose of 1, 5 and 10 mg/kg, respectively. The activity of SOD in the liver tissue homogenate was decreased after hepatic I/R, which was enhanced by wy14643 pretreatment. In addition, serum and liver tissue homogenate ALT and AST in the wy14643 10 mg/kg group were lower than in the wy14643 1 mg/kg and 5 mg/kg groups, ***: wy14643 pretreatment exerts significant protection against hepatic I/R injury in rats. The protective effects are possibly associated with enhancement of anti-oxidant and inhibition inflammation response.

关键词： wy14643 Liver Ischemia-reperfusion Effects

How high can fracture porosity become in the ultra-deep subsurface?

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Geoscience Frontiers 2023年第5期14卷 233-240页

作者： Jin Lai Fei Zhao Mei Zhang Tianyu Bai Yuyue Huang dong Li Guiwen Wang Ziqiang Qin State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing 102249China College of Geosciences China University of Petroleum(Beijing)102249China Department of Petroleum Engineering University of WyomingLaramieWY 82071USA

Knowledge of how high can fracture porosity become in the ultra-deep burial conditions is important but remains *** aperture and porosity are measured using X-ray computed tomography(CT)at atmospheric pressure and then calculated by image *** attention is paid to how high fracture porosity can become in ultra-deep(>6000 m)settings,and which situations will result in high fracture *** situ stress magnitudes,which can be calculated using well logs,control fracture performances,and dissolution along fracture improve fracture porosity at ultra-deep burial *** horizontal stress difference(Dr45 MPa),a high degree of dissolution along the fracture dramatically increases fracture *** will result in the vuggy fracture planes and improve fracture porosity up to 2.0%.The results provide insights into the detection,characterization,and modeling of subsurface fractures.

关键词： Fracture porosity Image log Ultra-deep In-situ stress Dissolution