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Antibiofilm and antithrombotic hydrogel coating based on superhydrophilic zwitterionic carboxymethyl chitosan for blood-contacting devices

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Bioactive Materials 2024年第4期34卷 112-124页

作者： dong uk lee Mukhammad Kayumov Junghun Park Se Kye Park Yeongkwon Kang Yejin Ahn Woojin Kim Seung Hwa Yoo Jun-Kyu Park Bong-Gi Kim Yong Suk Oh In-Seok Jeong dong Yun Choi Biomedical Manufacturing Technology Center Korea Institute of Industrial TechnologyYeongcheon38822Republic of Korea Department of Thoracic and Cardiovascular Surgery Chonnam National University Hospital and Medical SchoolGwangju61469Republic of Korea Research Institute of Advanced Materials Seoul National UniversitySeoul08826Republic of Korea Department of Organic and Nano System Engineering Konkuk UniversitySeoul05029Republic of Korea Department of Quantum System Engineering Jeonbuk National UniversityJeonju-si54896Republic of Korea IMT Inc. Gwangju61086Republic of Korea Department of Mechanical Engineering Changwon National UniversityChangwon51140Republic of Korea

Blood-contacting devices must be designed to minimize the risk of bloodstream-associated infections,thrombosis,and intimal lesions caused by surface ***,achieving effective prevention of both bloodstream-associated infections and thrombosis poses a challenge due to the conflicting nature of antibacterial and antithrombotic activities,specifically regarding electrostatic *** study introduced a novel biocompatible hydrogel of sodium alginate and zwitterionic carboxymethyl chitosan(ZW@CMC)with antibacterial and antithrombotic activities for use in *** ZW@CMC hydrogel demonstrates a superhydrophilic surface and good hygroscopic properties,which facilitate the formation of a stable hydration layer with low *** zwitterionic-functionalized CMC incorporates an additional negative sulfone group and increased negative charge density in the carboxyl *** augmentation enhances electrostatic repulsion and facilitates the formation of hydration *** leads to exceptional prevention of blood clotting factor adhesion and inhibition of biofilm ***,the ZW@CMC hydrogel exhibited biocompatibility with tests of in vitro cytotoxicity,hemolysis,and catheter ***,in vivo tests of antithrombotic and systemic inflammation models with catheterization indicated that ZW@CMC has significant advantages for practical applications in cardiovascular-related and sepsis *** study opens a new avenue for the development of chitosan-based multifunctional hydrogel for applications in blood-contacting devices.

关键词： Zwitterionic Hydrogel Blood-clotting Antimicrobial Sepsis

“数邦相合”的天朝:西方联邦观念的引进对晚清藩属观念的影响

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四川大学学报（哲学社会科学版） 2018年第3期 100-111页

作者：李动旭北京大学历史学系

在晚清接受西方国际体系的过程中,"联邦"等新概念的引入影响到了时人对藩属问题的认知,部分士人及外交官员将清朝与周边属国的关系比拟为《万国公法》中的"数邦相合"体制,并试图援引西例改变清朝藩属体制,还出现了将清朝与仅存的外藩、... 详细信息

在晚清接受西方国际体系的过程中,"联邦"等新概念的引入影响到了时人对藩属问题的认知,部分士人及外交官员将清朝与周边属国的关系比拟为《万国公法》中的"数邦相合"体制,并试图援引西例改变清朝藩属体制,还出现了将清朝与仅存的外藩、属国结合起来视作一个"联邦"的思虑。这种现象反映了两种国际体系的遭遇所产生的丰富内涵。对这一问题的探讨,不仅可以丰富我们对晚清士人国际观念的理解,也有助于理解现代民族国家的认同如何在众多可能性中最终浮现出来。

关键词：藩属体制宗藩关系《万国公法》国际法西学东渐

Aligned Ion Conduction Pathway of Polyrotaxane‑Based Electrolyte with Dispersed Hydrophobic Chains for Solid‑State Lithium–Oxygen Batteries

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Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram Kim Myeong‑Chang Sung Gwang‑Hee lee Byoungjoon Hwang Sojung Seo Ji‑Hun Seo dong‑Wan Kim Department of Materials Science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea School of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials Science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves ***-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： Solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity Hydrophobic chain

Metastatic pancreatic solitary fibrous tumor: A case report

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World Journal of Clinical Cases 2023年第35期11卷 8416-8424页

作者： Kiyoun Yi Jonghyun lee dong uk Kim Division of Gastroenterology Department of Internal MedicinePusan National University HospitalBusan 49241South Korea Biomedical Research Institute Pusan National University HospitalBusan 49241South Korea

BACKGROUND Solitary fibrous tumor(SFT)is a rare mesenchymal tumor that is most commonly found in the pleura but can also originate from non-pleural *** the nonpleural localizations,the pancreas is extremely *** particular,metastasis to the pancreas from the central nervous system(CNS)is extremely rare,with only two cases reported so *** report a case of recurrence in the pancreas 14 years after the initial complete surgical removal of a tumor in the *** SUMMARY A 68-year-old man with a past medical history of recurrent meningeal hemangiopericytoma,currently referred to as SFT,presented to the hospital with *** patient was first diagnosed with an 8cm-sized meningeal hemangiopericytoma fourteen years ago and underwent osteoplastic *** 16 mo,imaging showed recurrence and he underwent gamma knife radiosurgery(GKRS).2 years later,imaging showed recurrence again leading to a second GKRS.5 years later,recurrence was again suspected leading to a second *** then 3 years had passed,and imaging showed a 3.5cm-sized mass lesion on the pancreatic head with obstruction of the pancreatic and bile *** with fine-needle aspiration biopsy was done preoperatively and aided in the diagnosis of *** patient underwent pyloruspreserving *** findings of the resected pancreatic specimen,consistent with the previously resected brain specimen,confirmed the diagnosis of *** The rarity and lack of knowledge about SFTs make suspecting and diagnosing this disease *** believe that a report of metastatic pancreatic SFT from the CNS will contribute to a better understanding of this rare disease.

关键词： Solitary fibrous tumor Hemangiopericytoma Pancreas Metastasis Central nervous system Case report

Microglia lactylation in relation to central nervous system diseases

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Neural Regeneration Research 2025年第1期20卷 29-40页

作者： Hui Yang Nan Mo Le Tong Jianhong dong Ziwei Fan Mengxian Jia Juanqing Yue Ying Wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

Missing Value Imputation Model Based on Adversarial Autoencoder Using Spatiotemporal Feature Extraction

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Intelligent Automation & Soft Computing 2023年第8期37卷 1925-1940页

作者： dong-Hoon Shin Seo-El lee Byeong-uk Jeon Kyungyong Chung Department of Computer Science Kyonggi UniversitySuwon-siGyeonggi-do16227Korea Department of Public Safety Bigdata Kyonggi UniversitySuwon-siGyeonggi-do16227Korea Division of AI Computer Science and Engineering Kyonggi UniversitySuwon-siGyeonggi-do16227Korea

Recently,the importance of data analysis has increased significantly due to the rapid data *** particular,vehicle communication data,considered a significant challenge in Intelligent Transportation Systems(ITS),has spatiotemporal characteristics and many missing *** missing values in data lead to the decreased predictive performance of *** missing value imputation models ignore the topology of transportation net-works due to the structural connection of road networks,although physical distances are close in spatiotemporal image ***,the learning process of missing value imputation models requires complete data,but there are limitations in securing complete vehicle communication *** study proposes a missing value imputation model based on adversarial autoencoder using spatiotemporal feature extraction to address these *** proposed method replaces missing values by reflecting spatiotemporal characteristics of transportation data using temporal convolution and spatial *** results show that the proposed model has the lowest error rate of 5.92%,demonstrating excellent predictive *** this,it is possible to solve the data sparsity problem and improve traffic safety by showing superior predictive performance.

关键词： Missing value adversarial autoencoder spatiotemporal feature extraction

Removal of intrahepatic bile duct stone could reduce the risk of cholangiocarcinoma: A single-center retrospective study in South Korea

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World Journal of Clinical Cases 2024年第5期12卷 913-921页

作者： Tae In Kim Sung Yong Han Jonghyun lee dong uk Kim Division of Gastroenterology Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Internal Medicine Pusan National UniversityCollege of MedicineYangsan 50612South Korea

BACKGROUND Intrahepatic duct(IHD)stones are among the most important risk factors for cholangiocarcinoma(CCC).Approximately 10%of patients with IHD stones develop CCC;however,there are limited studies regarding the effect of IHD stone removal on CCC *** To investigate the association between IHD stone removal and CCC *** We retrospectively analyzed 397 patients with IHD stones at a tertiary referral center between January 2011 and December *** CCC occurred in 36 of the 397 enrolled *** univariate analysis,chronic hepatitis B infection(11.1%vs 3.0%,P=0.03),carbohydrate antigen 19-9(CA19-9,176.00 vs 11.96 II/mL,P=0.010),stone located in left or both lobes(86.1%vs 70.1%,P=0.042),focal atrophy(52.8%vs 26.9%,P=0.001),duct stricture(47.2%vs 24.9%,P=0.004),and removal status of IHD stone(33.3%vs 63.2%,Pupper normal limit,carcinoembryonic antigen>upper normal limit,stones located in the left or both lobes,focal atrophy,and complete removal of IHD stones without recurrence were independent factors influencing CCC ***,the type of removal method was not associated with CCC *** Complete removal of IHD stones without recurrence could reduce CCC risk.

关键词： Intrahepatic bile duct stone Cholangiocarcinoma Percutaneous transhepatic cholangioscopy Endoscopic retrograde cholangiopancreatography Carbohydrate antigen 19-9

Natural maternal transmission of H pylori in Mongolian gerbils

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World Journal of Gastroenterology 2006年第35期12卷 5663-5667页

作者： Jin-uk lee Okjin Kim Department of Laboratory Animal Sciences College of Medicine Seoul National University Seoul 110-799 South Korea Animal Disease Research Unit College of Life Science and Natural Resources Wonkwang University Iksan 570-749 South Korea

AIM: To investigate maternal H pylori infection status to determine the potential of maternal transmission. METHODS: In the present study, we examined these issues in an experimental murine model, which is a Mongolian gerbil model that has been reported as an optimal laboratory animal model to study H pylori . Pregnant Mongolian gerbils, infected experimentally with H pylori, were divided into as four groups. Following the experimental design, the stomachs of the mother and litters were isolated and assessed for transmission of H pylori at the prenatal period, parturition day, 1-wk old and 3-wk old respectively. Bacterial culture and polymerase chain reaction (PCR) were used to examine the presence of transmitted H pylori. RESULTS: All litters showed no transmission of H pylori during pregnancy and at parturition day. However, they revealed 33.3% and 69.6% at 1-wk and 3-wk of age respectively by PCR. CONCLUSION: These results suggested that vertical infection during the prenatal period or delivery procedure is unlikely as a route of mother-to-child H pylori infection. It may be that H pylori is acquired through breast- feeding, contaminated saliva and fecal-oral transmission during co-habitation.

关键词： H pylori Vertical Maternal Transmission

Effect of molybdenum on interfacial properties of titanium carbide reinforced Fe composite

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Journal of Materials Science & Technology 2022年第12期107卷 252-258页

作者： Seungchan Cho Junghwan Kim Ilguk Jo Jae Hyun Park Jaekwang lee Hyun-uk Hong Bong Ho lee Wook Ryol Hwang dong-Woo Suh Sang-Kwan lee Sang-Bok lee Composites Research Division Korea Institute of Materials Science(KIMS)Changwon 51508South Korea Advanced Materials Engineering Dong-Eui UniversityBusan 47340South Korea Department of Aerospace and Software Engineering Gyeongsang National UniversityJinju 52828South Korea Department of Physics Pusan National UniversityBusan 46241South Korea Department of Materials Convergence and System Engineering Changwon National UniversityChangwon 51140South Korea Center for Core Research Facilities Daegu Gyeongbuk Institute of Science and TechnologyDaegu 42988South Korea School of Mechanical Engineering Gyeongsang National UniversityJinju 52828South Korea Graduate Institute of Ferrous Technology Pohang University of Science and TechnologyGyeongbuk 37673South Korea

This study shows that the mechanical strength of the composite of Fe matrix and titanium carbide(Ti C)ceramic particles is significantly enhanced with addition of molybdenum(Mo) atoms. Ti C reinforced Fe(Fe-0.2C-7Mn) composites with and without Mo were fabricated by a liquid pressing infiltration(LPI)process and the effect of Mo on interfacial properties of TiC–Fe composite was investigated using atomic probe tomography(APT) analysis, molecular dynamics(MD) simulations, first-principle density functional theory(DFT), and thermodynamic calculations. First, DFT calculations showed that total energies of the Mo-doped Ti C–Fe superlattices strongly depend on the position of Mo defects, and are minimized when the Mo atom is located at the TiC/Fe interface, supporting the probable formation of MoC-like interphase at the TiC/Fe interface region. Then, APT analysis confirmed the DFT predictions by finding that about6.5 wt.% Mo is incorporated in the Ti C–Fe(Mo) composite and that sub-micrometer thick(Ti,Mo)C interphase is indeed formed near the interface. The MD simulations show that Mo atoms migrate to the Mo-free TiC–Fe interface at elevated temperatures and the mechanical strength of the interface is considerably enhanced, which is in good agreement with experimental observations.

关键词： Metal matrix composites(MMCs) Titanium carbide Fe matrix composite Infiltration Molybdenum Interfacial property