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NON C^0 NONCONFORMING ELEMENTS FOR ELLIPTIC FOURTH ORDER SINGULAR PERTURBATION PROBLEM

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Journal of Computational Mathematics 2005年第2期23卷 185-198页

作者： shao-chunchen Yong-chengZhao dong-yangShi DepartmentofMathematics ZhengzhouUniversityZhengzhou450052China

In this paper we give a convergence theorem for non C^0 nonconforming finite element to solve the elliptic fourth order singular perturbation problem. Two such kind of elements, a nine parameter triangular element and a twelve parameter rectangular element both with double set parameters, are presented. The convergence and numerical results of the two elements are given.

关键词： Singular perturbation problem Nonconforming element Double set parameter method

Predictive Zone Control of Pressure Management for Water Supply Network Systems

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International Journal of Automation and computing 2016年第6期13卷 607-614页

作者： dong-Ming Liu shao-Yuan Li Department of Automation Shanghai Jiao Tong University Shanghai 200240 China Key Laboratory of System Control and Information Processing Ministry of Education Shanghai 200240 China Changzhou Institute of Light Industry Technology Jiangsu 213164 China

In this paper we address the problem of pressure management in water supply system （WSS） network. The model-based predictive control （MPC） strategies have some important features to deal with WSS. By hydraulic analysis of WSS, the predictive model is derived from the dynamic model and static model of WSS. Through WSS, the consumers＇ demands are required to be met at all times according to some operational constraints that must be satisfied. The constraints of flow through actuators, the water level of reservoirs and the consumer areas＇ pressure demand are determined by a specific system. In this work, we develop a constrained MPC controller that considers the zone control of the pressure outputs and incorporates steady state economic targets in the control cost function. The designed management strategies are applied to a case study and simulation results, covering different aspects, are provided. The output nodal pressure can be controlled in the desired zone by optimal scheduling the actuators of the WSS. If the variation range of reservoir＇s water level is broader, the rate of flow through the actuators is gentle, and vice versa.

关键词： Water supply system (WSS) network mathematical modelling zone control pressure control model predictive control(MPC).

Cheeger's cut, maxcut and the spectral theory of1-Laplacian on graphs

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Science China Mathematics 2017年第11期60卷 1963-1980页

作者： CHANG KungChing shao SiHong ZHANG dong LMAM and School of Mathematical Sciences Peking University

This is primarily an expository paper surveying up-to-date known results on the spectral theory of1-Laplacian on graphs and its applications to the Cheeger cut, maxcut and multi-cut problems. The structure of eigenspa... 详细信息

关键词： spectral graph theory Laplacian graph cut optimization critical point theory

Lithiated Nafion-garnet ceramic composite electrolyte membrane for solid-state lithium metal battery

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Journal of Energy Chemistry 2020年第7期29卷 237-247,I0008页

作者： Jing Gao Qinjun shao Jian chen Advanced Rechargeable Battery Laboratory Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China

Single-ion conducting solid polymer electrolytes are expected to play a vital role in the realization of solid-state Li metal *** this work,a lithiated Nafion(Li-Nafion)-garnet ceramic Li6.25La3 Zr2 Al0.25O12(LLZAO)composite solid electrolyte(CSE)membrane with 30μm thickness was prepared for the first *** employing X-ray photoelectron spectroscopy and transmission electron microscope,the interaction between LLZAO and Li-Nafion was *** is found that the LLZAO interacts with the Li-Nafion to form a space charge layer at the interface between LLZAO and *** space charge layer reduces the migration barrier of Li-ions and improves the ionic conductivity of the CSE *** CSE membrane containing 10 wt%LLZAO exhibits the highest ionic conductivity of2.26×10-4 S cm-1 at 30℃among the pristine Li-Nafion membrane,the membrane containing 5 wt%,20 wt%,and 30 wt%LLZAO,*** also exhibits a high Li-ion transference number of 0.92,and a broader electrochemical window of 0-+4.8 V ***+/Li than that of 0-+4.0 V ***+/Li for the pristine Li-Nafion *** is observed that the CSE membrane not only inhibits the growth of Li dendrites but also keeps excellent electrochemical stability with the Li *** from the above merits,the solid-state LiFePO4/Li cell fabricated with the CSE membrane was practically charged and discharged at 30℃.The cell exhibits an initial reversible discharge specific capacity of 160 mAh g-1 with 97%capacity retention after 100 cycles at 0.2 C,and maintains discharge specific capacity of 126 mAh g-1 after500 cycles at 1 *** CSE membrane prepared with Li-Nafion and LLZAO is proved to be a promising solid electrolyte for advanced solid-state Li metal batteries.

关键词： Single-ion conductor Composite solid electrolyte Lithiated Nafion Garnet ceramic Solid-state Li metal battery

Hot Deformation Behavior of Vanadium-microalloyed Medium-carbon Steel for Fracture Splitting Connecting Rod

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Journal of Iron and Steel Research International 2015年第7期22卷 615-621页

作者： Wei-jun HUI Si-lian chen cheng-wei shao Yong-jian ZHANG Han dong School of Mechanical Electronic and Control EngineeringBeijing Jiaotong University Central Iron and Steel Research Institute

Single compression tests were carried out with a Gleeble-3800 thermal simulator to investigate hot deform- ation behavior of two vanadium-microalloyed medium-carbon steels for fracture splitting connecting rod. The tests were performed to a total true strain of 0.92 at true strain rates ranging from 10-2 to 10 s-1 and deformation temper- ature of 900--1 150 ℃, The results show that hot deformation behavior of the tested steels is similar to that of con- ventional medium-carbon microalloyed steels and dynamic recrystallization is easier to occur at higher deformation temperature and lower strain rate. The austenite deformation resistance and activation energy of deformation increase with increasing vanadium content from 0.15% to 0. 28% and thus the starting time of dynamic recrystallization was delayed. Finer recrystallized austenite grain could he obtained at higher strain rate, lower deformation temperature and higher vanadium content. TEM observation of the specimens quenched just before and after deformation reveals that vanadium is mainly in dissolved solute condition in austenite and thus affects the dynamic recrystallization behavior of the tested steels mainly through solute-drag effect.

关键词： vanadium microalloyed medium-carbon steel hot deformation dynamic recrystallization fracture splitting connected rod

Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian Xin Hua Jianhong dong Zheyu Fang Yuqing Liu Sibing chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

Molecular characterization and expression analysis of Patched 1 gene in the half-smooth tongue sole(Cynoglossus semilaevis)

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Acta Oceanologica Sinica 2016年第6期35卷 19-28页

作者： dong Zhongdian QI Qian ZHANG Ning shao Changwei ZHANG Liyan WEN Haishen chen Songlin Fisheries College Ocean University of China Yellow Sea Fisheries Research Institute Chinese Academy of Fishery Sciences Function Laboratory for Marine Fisheries Science and Food Production Processes National Laboratory for Marine Science and Technology

The signaling molecule hedgehog（Hh） is essential for cellular signaling required for body pattern formation in embryonic and individual development in vertebrate and *** 1（Ptc1）,a receptor of Hh,mediates the activity of Hh by binging the Hh *** this study,the Ptc1 of half-smooth tongue sole Cynoglossus semilaevis（CsPtc1） was cloned and *** full-length of CsPtc1 cDNA is 5 212 nucleotides（nt）,and encodes a protein with 1 543 amino acid ***1 shared many features with Ptc1 of other telesot ***-time quantitative PCR revealed CsPtc1 mRNA expressed in brain,liver,heart,gill,intestines,spleen,gonad and kidney,with expression level in testis significantly higher than in *** testis,hybridization signals were mainly detected in primary spermatocytes,secondary spermatocytes,and sertoli cells,while weak signals were found in ***,the degree of methylation is higher in female than in male and *** indicate that CsPtc1 may be involved in Desert Hedgehog（DHH） maintenance of the male and pseudo-male germ line and spermatogenesis.

关键词： half-smooth tongue sole male and female Patched 1 RACE qRT-PCR methylation

Evidence of coal combustion contribution to ambient VOCs during winter in Beijing

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Chinese Chemical Letters 2013年第9期24卷 829-832页

作者： Ming Wang Min shao Si-Hua Lu Yu-dong Yang Wen-Tai chen State Joint Key Laboratory of Environmental Simulation and Pollution Control College of Environmental Sciences and Engineering Peking University

Volatile organic compounds （VOCs） play ,an important role in ozone and secondary organic aerosol （SOA） formation, but VOCs sources during winter are not fully understood. To investigate VOCs sources during winter, mixing ratios of C2-C12 VOCs were measured at an urban site in Beijing from December 29, 2011 to January 17, 2012. Correlation analysis of toluene to benzene and i-pentane to n-pentane suggest that coal combustion could also be an important source for VOCs besides vehicular emissions. Source apportionment results show that coal combustion and vehicular emissions contributed 28%-39% and 31%-45% to ambient VOCs during winter, respectively. Backward trajectory analyses demonstrated that contributions from the burning of coal were higher when air masses came from southern regions outside Beijing. Close attention should be paid to VOCs emissions from coal combustion in Beijing city and the vicinity to the South.

关键词： VOC Source apportionment Coal combustion Transport

Deubiquitinases as pivotal regulators of T cell functions

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Frontiers of Medicine 2018年第4期12卷 451-462页

作者： Xiao-dong Yang shao-Cong Sun Shanghai Institute of Immunology Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Immunology The University of Texas MD Anderson Cancer Center 7455 Fannin Street Box 902 Houston TX 77030 USA The University of Texas Graduate School of Biomedical Sciences at Houston Houston TX 77030 USA

T cells efficiently respond to foreign antigens to mediate immune responses against infections but are tolerant to self-tissues. Defect in T cell activation is associated with severe immune deficiencies, whereas aberrant T cell activation contributes to the pathogenesis of diverse autoimmune and inflammatory diseases. An emerging mechanism that regulates T cell activation and tolerance is ubiquitination, a reversible process of protein modification that is counter-regulated by ubiquitinating enzymes and deubiquitinases （DUBs）. DUBs are isopeptidases that cleave polyubiquitin chains and remove ubiquitin from target proteins, thereby controlling the magnitude and duration of ubiquitin signaling. It is now well recognized that DUBs are crucial regulators of T cell responses and serve as potential therapeutic targets for manipulating immune responses in the treatment of immunological disorders and cancer. This review will discuss the recent progresses regarding the functions of DUBs in T cells.

关键词： deubiquitinase ubiquitination T cell activation T cell differentiation T cell tolerance