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Expression Analysis of Proline Metabolism-related Genes From Halophyte Arabis stelleri under Osmotic Stress Conditions

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Journal of Integrative Plant Biology 2010年第10期52卷 891-903页

作者： Yuchul Jung Jungan Park Yunjung Choi Jin-Gweon Yang donggiun Kim Beom-Gi Kim Kyunghee Roh dong-Hee Lee chung-Kyoon Auh Sukchan Lee Department of Genetic Engineering Sungkyunkwan University Institute of Life Science and Technology Sungkyunkwan University National Academy of Agricultural Science Rural Development Administration Department of Life Science Ewha Womans University Department of Biological Sciences Mokpo National University

Arabis stelleri var. japonica evidenced stronger osmotic stress tolerance than Arabidopsis thaliana. Using an A. thaliana microarray chip, we determined changes in the expression of approximately 2 800 genes between A. stelleri plants treated with 0.2 M mannitol versus mock-treated plants. The most significant changes in the gene expression patterns were in genes defining cellular components or in genes associated with the endomembrane system, stimulus response, stress response, chemical stimulus response, and defense response. The expression patterns of three de novo proline biosynthesis enzymes were evaluated in A. stelleri var. japonica seedlings treated with 0.2 M mannitol, 0.2 M sorbitol, and 0.2 M NaCI. The expression of At-pyrroline-5-carboxylate synthetase was not affected by NaCI stress but was similarly induced by mannitol and sorbitol. The proline dehydrogenase gene, which is known to be repressed by dehydration stress and induced by free L-proline, was induced at an early stage by mannitol treatment, but the level of proline dehydrogenase was increased later by treatment with both mannitol and NaCI. The level of free L-proline accumulation increased progressively in response to treatments with mannitol, sorbitol, and NaCI. Mannitol induced L-proline accumulation more rapidly than NaCI or sorbitol. These findings demonstrate that the osmotic tolerance of the novel halophyte, Arabis stelleri, is associated with the accumulation of L-proline.

关键词： Expression Analysis of Proline Metabolism-related Genes From Halophyte Arabis stelleri under Osmotic Stress Conditions

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Acoustic Nonlinearity of a Laser-Generated Surface Wave in a Plastically Deformed Aluminum Alloy

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Chinese Physics Letters 2012年第12期29卷 39-43页

作者： KIM chung-Seok JHANG Kyung-Young Metallurgy and Materials Engineering Chosun UniversitySeosuk-dongGwangju501-759South Korea Mechanical Engineering Hanyang UniversityHangdang-dongSeongdong-guSeoul133-791South Korea

The acoustic nonlinearity of surface waves is studied to evaluate plastic deformation in aluminum alloys.A narrow-band surface wave is successfully generated by a pulsed Nd-YAG laser system consisting of a beam expander and a slit *** degrees of tensile deformation are induced by interrupting the tensile tests so as to obtain aluminum specimens with different degrees of plastic *** normalized acoustic nonlinearity increases as a function of tensile *** experimental results show that the acoustic nonlinearity of a laser-generated surface wave has a good correlation with the level of tensile deformation and has a potential to evaluate microdamage induced by dislocation microplasticity.

关键词： deformation nonlinearity Deform

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Endoscopic bilateral stent-in-stent placement for malignant hilar obstruction using a large cell type stent

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Hepatobiliary & Pancreatic Diseases International 2016年第6期15卷 633-639页

作者： Jin Myung Park Sang Hyub Lee Kwang Hyun chung dong Kee Jang Ji Kon Ryu Yong-Tae Kim Jae Min Lee Woo Hyun Paik Department of Internal Medicine and Liver Research Institute Seoul National University HospitalSeoul National University College of Medicine Department of Internal Medicine Kangwon National University HospitalKangwon National University School of Medicine Department of Internal Medicine Gyeongsang National University HospitalGyeongsang National University College of Medicine Department of Internal Medicine Inje University Ilsan Paik Hospital

BACKGROUND： Bilateral stent-in-stent （SIS） self-expandable metal stent placement is technically chghallenging for palliation of unresectable malignant hilar obstruction. In the SIS technique, the uniform large cell type biliary stent facilitates contralateral stent deployment through the mesh of the first metallic stent. This study aimed to assess the technical success and clinical effectiveness of this technique with a uniform large cell type biliary stent. METHODS： Thirty-one patients who underwentlbilateral SIS placement using a large cell type stent were reviewed retrospectively. All patients showed malignant hilarl obstruction （Bismuth types Ⅱ, Ⅲ, Ⅳ） with different etiologies. RESULTS： Sixteen （51.6%） patients were male. The mean age of the patients was 67.0±14.0 years. Most patients were diagnosed as having hilar cholangiocarcinoma （58.1%） and gallbladder cancer （29.0%）. Technical success rate was 83.9%. Success was achieved more frequently in patients without masses obstructing the biliary confluence （MOC） than those with MOC （95.2% vs 60.0%, P=0.03）. Functional success rate was 77.4%. Complications occurred in 29.0% of the patients. These tended to occur more frequently in patients with MOC （50.0% vs 19.0%, P=0.11）. Median time to recurrent biliary obstruction was 188 days and median survival was 175 days. CONCLUSIONS： The large cell type stent can be used efficiently for bilateral SIS placement in malignant hilar obstruction. However, the risk of technical failure increases in patients with MOC, and caution is needed to prevent complications for these patients.

关键词： biliary tract disease cholangiocarcinoma endoscopic biliary drainage stent insertion

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Fatigue-Induced Micro-damage Characterization of Austenitic Stainless Steel 316 Using Innovative Nonlinear Acoustics

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Chinese Physics Letters 2012年第6期29卷 82-85页

作者： chung-Seok KIM Kyung-Young JHANG Automotive Engineering Hanyang UniversityHangdang-dongSeongdong-guSeoul133-791South Korea Mechanical Engineering Hanyang UniversityHangdang-dongSeongdong-guSeoul133-791South Korea

We present innovative nonlinear acoustics for characterizing fatigue-induced micro-damage of austenitic stainless steel 316 subjected to high-cycle *** fatigue-driven deformations are accumulated at several positions near the middle of hourglass-shaped specimens.A bell-shaped curve of acoustic nonlinearity as a function of position is observed,and the variation in acoustic nonlinearity is attributed to the evolution of a lattice defect (dislocation) and stress-induced martensite based on transmission electron microscopy (TEM) *** oblique incidence technique using a longitudinal waveform is a potentially viable method for characterizing the high-cycle fatigue deformation of austenitic stainless steel 316 alloys.

关键词： fatigue steel martensite

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Investigation of the genetic etiology in male infertility with apparently balanced chromosomal structural rearrangements by genome sequencing

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Asian Journal of Andrology 2022年第3期24卷 248-254页

作者： Matthew Hoi Kin Chau Ying Li Peng Dai Mengmeng Shi Xiaofan Zhu Jacqueline Pui Wah chung Yvonne K Kwok Kwong Wai Choy Xiangdong Kong Zirui dong Department of Obstetrics and Gynaecology The Chinese University of Hong KongHong KongChina Shenzhen Research Institute The Chinese University of Hong KongShenzhen 518057China Hong Kong Hub of Paediatric Excellence The Chinese University of Hong KongHong KongChina Genetics and Prenatal Diagnosis Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China The Chinese University of Hong Kong-Baylor College of Medicine Joint Center for Medical Genetics Hong KongChina

Apparently balanced chromosomal structural rearrangements are known to cause male infertility and account for approximately 1%of azoospermia or severe ***,the underlying mechanisms of pathogenesis and etiologies are still largely ***,we investigated apparently balanced interchromosomal structural rearrangements in six cases with azoospermia/severe oligospermia to comprehensively identify and delineate cryptic structural rearrangements and the related copy number *** addition,high read-depth genome sequencing(GS)(30-fold)was performed to investigate point mutations causative of male ***-pair GS(4-fold)revealed additional structural rearrangements and/or copy number changes in 5 of 6 cases and detected a total of 48 ***,the breakpoints caused truncations of 30 RefSeq genes,five of which were associated with ***,the breakpoints disrupted 43 topological-associated *** disruptions or potential dysregulations of genes,which play potential roles in male germ cell development,apoptosis,and spermatogenesis,were found in all cases(n=6).In addition,high read-depth GS detected dual molecular findings in case MI6,involving a complex rearrangement and two point mutations in the gene ***,our study provided the molecular characteristics of apparently balanced interchromosomal structural rearrangements in patients with male *** demonstrated the complexity of chromosomal structural rearrangements,potential gene disruptions/dysregulation and single-gene mutations could be the contributing mechanisms underlie male infertility.

关键词： azoospermia balanced structural rearrangements genome sequencing male infertility severe oligospermia

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Nontarget screening using passive air and water sampling with a level Ⅱ fugacity model to identify unregulated environmental contaminants

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Journal of Environmental Sciences 2017年第12期29卷 84-91页

作者： In-Young chung Yu-Mi Park Hyun-Jeoung Lee Hyuk Kim dong-Hoon Kim Il-Gyu Kim Sang-Min Kim Young-Sun Do Kwang-Seol Seok Jung-Hwan Kwon Chemical Research Division Environmental Health Research Department National Institute of Environmental ResearchIncheon Division of Environmental Science and Ecological Engineering Korea University

It is thought that there are many unregulated anthropogenic chemicals in the *** risk assessment of chemicals, it is essential to estimate the predicted environmental concentrations. As an effort of identifying residual organic contaminants in air and water in Korea, nontarget screening using two-dimensional gas chromatography time-of-flight mass spectrometry（GC × GC-TOFMS） was conducted at 10 sites using polyurethane foam passive air sampler and at 6 sites using polydimethyl siloxane（PDMS） passive water sampler in three different seasons in 2014. More than 600 chemical peaks were identified satisfying the identification criteria in air and water samples, respectively, providing a list for further investigation. Chemical substances with reported national emission rates in2014（n = 149） were also screened for potential existence in the environment using a level Ⅱ fugacity model. Most of chemical substances classified as not detectable were not identified with detection frequency greater than 20% by nontarget screening, indicating that a simple equilibrium model has a strong potential to be used to exclude chemicals that are not likely to remain in the environment after emissions from targeted monitoring.

关键词： Nontarget screening GC × GC-TOFMS Passive sampling Pollutant release and transfer register(PRTR) Fugacity model

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Intravitreal long-term sustained ranibizumab delivery using injectable microgel-embedded hydrogel

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Asian Journal of Pharmaceutical Sciences 2024年第5期19卷 126-138页

作者： Simin Lee Jun Young Park Hye Kyoung Hong Joo Young Son Byungwook Kim Jae Yong chung Se Joon Woo Ki dong Park Department of Molecular Science and Technology Ajou UniversitySuwon 16499Republic of Korea Department of Ophthalmology Seoul National University College of MedicineSeoul National University Bundang HospitalSeongnam 13620Republic of Korea Department of Ophthalmology Eulji University School of MedicineUijeongbu Eulji Medical CenterUijeongbu11759Republic of Korea Seoul National University Hospital Seoul 03080Republic of Korea Department of Clinical Pharmacology and Therapeutics Seoul National University College of MedicineSeoul National University Bundang HospitalSeongnam 13620Republic of Korea

Retinal vascular disease is the leading cause of visual *** intravitreal drug injections are the most suitable approach for addressing retinal disorders,existing clinical treatments necessitate repeated administration,imposing a substantial burden on patients with various intraocular *** study introduces an injectable and biodegradable hyaluronan microgel(Hm)-embedded gelatin-PEG-tyramine hydrogel(HmGh)designed for sustained intravitreal ranibizumab(RBZ)delivery to reduce patient burden and minimize the side effects associated with frequent *** exhibited a controlled RBZ loading capacity and release *** effectively controlled the initial burst release and overall release *** and cellular drug efficacy were also *** an animal study,HmGh maintained RBZ concentrations in the vitreous and retina for>120 *** studies showed that the half-life of RBZ-loaded HmGh in the vitreous and retina was 2.55 and 2.05 times longer than that of RBZ-loaded Hm and 9.58 and 38.46 times longer than that of RBZ ***,the initial RBZ elimination from HmGh to the aqueous humor was significantly reduced compared to that from Hm and RBZ *** degradation and safety were comprehensively evaluated using fundus imaging and histological *** conclusion,this injectable hydrogel is a promising prolonged drug delivery system for treating various posterior segment eye diseases.

关键词： Age-related macular degeneration Ranibizumab Microgel-embedded hydrogel Long-term drug delivery Pharmacokinetics Biodegradation

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Laparoscopic resection of gastric gastrointestinal stromal tumors presenting as left adrenal tumors

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World Journal of Gastroenterology 2012年第1期18卷 96-98页

作者： Shiu-dong chung Jeff Shih-chieh Chueh Hong-Jeng Yu Division of Urology Department of Surgery Far Eastern Memorial Hospital Department of Urology National Taiwan University Hospital Cleveland Clinic Urology Charleston Office Glickman Urological and Kidney Institute Cleveland Clinic Cleveland Clinic Lerner College of Medicine Case Western Reserve University

Gastrointestinal stromal tumors (GISTs) are rare gastrointestinal malignancies. They are rarely seen near the urinary tract. In a literature review, only one case of GIST presenting as a left adrenal tumor was reported. We report two documented cases of gastric GISTs mimicking left adrenal tumors which were successfully treated with pure laparoscopic adrenalectomy and wedge resection of the stomach by excising the tumor from the stomach with serial fi ring of endoscopic gastrointestinal staplers. The surgical margins were clear, and the patients recovered smoothly. No adjuvant therapy with imatinib was prescribed. During the surveillance for 9 mo and 44 mo respectively, no tumor recurrence and metastasis were documented. Laparoscopic tumor excision, when adhering to the principles of surgical oncology, seems feasible and the prognosisis favorable for such tumors.

关键词： Gastrointestinal stromal tumor Stomach Laparoscopy

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The associated evolution of raptorial foreleg and mantispid diversification during 200 million years

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National Science Review 2023年第12期10卷 49-52页

作者： Dahang Lai Peichao Chen Shumin Li Xianzhe Xiang Haohong Ou Nuoyao Kang Jingtao Yang Hong Pang chung Kun Shih Conrad C.Labandeira dong Ren Qiang Yang Chaofan Shi School of Earth Sciences and Engineering Guangdong Provincial Key Lab of Geological Processes and Mineral Resources Sun Yat-sen University School of Life Sciences Key Laboratory of Conservation and Application in Biodiversity of South China Guangzhou University School of Ecology Sun Yat-sen University College of Life Sciences Capital Normal University Department of Paleobiology National Museum of Natural HistorySmithsonian Institution Department of Entomology University of Maryland College Park

Adaptive evolution of predatory structure grants carnivores selective advantages[1], which evokes questions regarding the mechanism of functional adaptation via morphological variation and their potential impact on lineage diversification. Raptorial foreleg, as a key predatory structure in insects, is typically characterized by elongate coxae and stout femora possessing spines, and has evolved independently in many lineages [2].

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Unconventional assemblies of bisacylhydrazones:The role of water for circularly polarized luminescence

Aggregate

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Aggregate 2022年第5期3卷 185-193页

作者： Hye Jin Cho dong Yeun Jeong Hwihyun Moon Taewoo Kim You Kyoung chung Yeongdong Lee Zonghoon Lee Joonsuk Huh Youngmin You Changsik Song Department of Chemistry Sungkyunkwan UniversitySuwonGyeonggi 16419Republic of Korea Division of Chemical Engineering and Materials Science Graduate Program in System Health Science and EngineeringEwha Womans UniversitySeoul 03760Republic of Korea Center for Multidimensional Carbon Materials Institute for Basic Science(IBS)Department of Materials Science and EngineeringUlsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea

Understanding the precise molecular arrangement of chiral supramolecular polymers is essential not only to comprehend complex superstructures like proteins and DNA but also for the development of next-generation optoelectronic materials,including materials displaying high-performance circularly polarized luminescence(CPL).Herein,we report the first chiral supramolecular polymer systems based on hydrazone–pyridinium conjugates comprising alkyl chains of different lengths,which afforded control of the apparent supramolecular *** supramolecular chirality is governed basically by the remote chiral centers of alkyl chains,helicity inversion was achieved by controlling the conditions under which the hydrazone building blocks underwent aggregation(i.e.,solvent compositions or temperature).More importantly,the addition of water to the system led to aggregationinduced hydrazone deprotonation,which resulted in a completely different selfassembly *** water molecules played an essential role,forming the assembly’s channel-like backbone,around which hydrazone molecules gathered as a result of hydrogen bonding *** co-assembly of an achiral hydrazone luminophore with the given supramolecular polymer system allowed the fabrication of a novel CPL-active hydrazone-based material exhibiting a high maximum value for the photoluminescence dissymmetry factor of -2.6×10^(-2).

关键词： circularly polarized luminescence(CPL) helicity control hydrazone self-assembly structural water supramolecular polymerization

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