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Gene-activated dermal equivalents to accelerate healing of diabetic chronic wounds by regulating inflammation and promoting angiogenesis

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Bioactive Materials 2020年第3期5卷 667-679页

作者： dong lou Yu Luo Qian Pang Wei-Qiang Tan Lie Ma MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027PR China Department of Plastic Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou310016PR China

Diabetic chronic wound,characterized by prolonged inflammation and impaired angiogenesis,has become one of the most serious challenges in clinic and pose a significant healthcare burden *** a great variety of wound dressings have been developed,few of encouraged achievements were obtained so *** this study,the gene-activated strategy was applied to enhance sustained expression of vascular endothelial growth factor(VEGF)and achieve better healing outcomes by regulating inflammation and promoting *** gene-activated bilayer dermal equivalents(Ga-BDEs),which has good biocompatibility,were fabricated by loading the nano-sized complexes of Lipofectamine 2000/plasmid DNA-encoding VEGF into a collagen-chitosan scaffold/silicone membrane bilayer dermal *** DNA complexes were released in a sustained manner and showed the effective transfection capacities to up-regulate the expression of VEGF in *** overcome cutaneous contraction of rodents and mimic the wound healing mechanisms of the human,a reformative rat model of full-thickness diabetic chronic wound was *** the treatment of Ga-BDEs,speeding wound healing was observed,which is accompanied by the accelerated infiltration and phenotype shift of macrophages and enhanced angiogenesis in early and late healing phases,*** proved that Ga-BDEs possess the functions of immunomodulation and pro-angiogenesis ***,the better regeneration outcomes,including deposition of oriented collagen and fast reepithelialization,were *** these results indicated that,being different from traditional pro-angiogenic concept,the up-regulated expression of VEGF by Ga-BDEs in a sustained manner shows versatile potentials for promoting the healing of diabetic chronic wounds.

关键词： Gene-activated dermal equivalent Vascular endothelial growth factor Inflammation Angiogenesis Diabetic chronic wounds

Preparation and Properties of a Novel Water Soluble Core Material

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Journal of Materials Science & Technology 2010年第3期26卷 270-275页

作者： Weiguo Jiang,Jiasheng dong,Langhong lou,Ming Liu and Zhuangqi Hu Institute of Metal Research,Chinese Academy of Sciences,Shenyang 110016,China Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

A novel water-soluble core material composed of polyethylene glycol,sodium chloride,mica powder and plasticizer was *** compressive strength,bend strength,hygroscopic coefficient and the material solubility in water were *** results show that the compressive yield strength of the soluble core can reach 1 MPa and the highest compressive strength can reach 4 MPa,the bend strength is as high as 6.65 MPa,the hygroscopic coefficient is lower than 0.22%/month and the solubility of suitable core material is 35.7-55.75 g/（min·m 2）.The wax pattern with undercuts was prepared successfully by using the novel water-soluble core material.

关键词： Investment cast Core materials Mechanical properties Microstructure

Photosynthetic biomaterials: applications of photosynthesis in algae as oxygenerator in biomedical therapies

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Bio-Design and Manufacturing 2021年第3期4卷 596-611页

作者： Yong Wang Yanan Xue Tao Zhang Qingqing Fang Mingyuan Jin Xiaofeng Wang Zhengcai Wang Yanyan Hu Wanyi Zhao dong lou Wei-Qiang Tan Department of Plastic Surgery Sir Run Run Shaw HospitalZhejiang University School of Medicine3 East Qingchun RoadHangzhou 310016China Department of Plastic Surgery The Fourth Affiliated HospitalZhejiang University School of MedicineN1 Shangcheng RoadYiwu 322000China

For most organisms,molecular oxygen is indispensable for normal physiological metabolism;in humans,prolonged hypoxia in tissues can induce many diseases,exemplified by cardiovascular disease,chronic wounds,and tissue ***,the oxygen in our environment is vital for *** a main source of oxygen in the natural world that transforms light energy into chemical energy and oxygen,photosynthesis has been widely studied in scientific research and used in production of food,fuel,and *** recent years,photosynthesis has become more closely involved in biomedicine and has been widely used in photodynamic therapy,tissue regeneration,transplantation,and in treatment of specific *** review summarizes innovative applications of photosynthesis in biomedical research and highlights the theory and implications of clinical treatment for specific diseases.

关键词： Biomaterials Photosynthesis Hypoxia Myocardial infarction Photodynamic therapy Tissue engineering

On Income Distribution Mechanism of Farmer Cooperatives in the Context of Membership Heterogeneity

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Asian Agricultural Research 2015年第11期7卷 82-88页

作者： Xiangzhi KONG dong lou Chanjuan FANG School of Agricultural Economics and Rural Development Renmin University of China Wuyi University Wuyishan

With reference to several possible solutions to the issue of two subject allocation,using the Accumulation Point analysis method in Game Theory,this paper analyzed the income distribution mechanism between large farmers and small farmers in farmer cooperatives in the context of membership heterogeneity. It found that,in the practice of the income distribution in farmer cooperatives,there possibly exists equalization solution,pure utility solution,Nash solution and Kalai-Smorodinsky solution and it will be affected by social conventions. Finally,it made an empirical analysis using five cases of farmer cooperatives.

关键词： Farmer cooperatives Membership heterogeneity Income distribution Social conventions

Effects of histamine on spontaneous neuropathic pain induced by peripheral axotomy

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Neuroscience Bulletin 2013年第3期29卷 261-269页

作者： Jie Yu Guo-dong lou Jia-Xing Yue Ying-Ying Tang Wei-Wei Hou Wen-Ting Shou Hiroshi Ohtsu Shi-Hong Zhang Zhong Chen Department of Pharmacology School of Basic Medical Sciences College of Pharmaceutical Sciences Zhejiang University School of Pharmaceutical Sciences Wenzhou Medical College Department of Engineering School of Medicine Tohoku University

The present study was designed to investigate the effects of histamine on spontaneous neuropathic pain （NP） induced by peripheral axotomy. Rats and mice were subjected to complete transection of the left sciatic and saphenous nerves to induce spontaneous NP （the neuroma model）. Rats were then treated with drugs once daily for 30 days （histidine and Ioratadine, i.p.） or 21 days （histamine, i.c.v.）. Autotomy behavior was scored daily until day 50 postoperation （PO）. On days 14 to 21 PO, some rats in the control group were subjected to singlefiber recording. Autotomy behavior was also monitored daily in histidine decarboxylase （the key enzyme for histamine synthesis） knockout （HDC/） and wildtype mice for 42 days. We found that both histidine （500 mg/kg）（a precursor of histamine that increases histamine levels in the tissues） and histamine （50 pg/5 pL） significantly suppressed autotomy behavior in rats. HDC mice lacking endogenous histamine showed higher levels of autotomy than the wildtype. In addition, the analgesic effect of histidine was not antagonized by Ioratadine （a peripherallyacting H1 receptor antago nist）, while Ioratadine alone significantly suppressed autotomy. Electrophysiological recording showed that ectopic spontaneous discharges from the neuromawere blocked by systemic diphenhydramine （an H receptor antagonist）. Our results suggest that hista mine plays an important role in spontaneous NP. It is likely that histamine in the central nervous system is analgesic, while in the periphery, via H receptors, it is algesic. This study justifies the avoidance of a histaminerich diet and the use of peripherallyacting H receptor antagonists as well as agents that improve histamine action in the central nervous system in pa tients with spontaneous NP.

关键词： histamine Ioratadine H1 receptor neuropathic pain

基于解释结构模型的老年人信息需求影响因素分析

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图书情报工作 2018年第7期62卷 88-95页

作者：娄冬娄策群华中师范大学信息管理学院武汉430079 华中师范大学湖北省电子商务研究中心武汉430079

[目的／意义]建立老年人信息需求影响因素解释结构模型，并对影响因素的层级关系及其对老年人信息需求的影响进行分析。[方法／过程]借鉴老年人信息需求影响因素已有科研成果，通过第一轮专家调查，确定影响老年人信息需求的20个因素，... 详细信息

[目的／意义]建立老年人信息需求影响因素解释结构模型，并对影响因素的层级关系及其对老年人信息需求的影响进行分析。[方法／过程]借鉴老年人信息需求影响因素已有科研成果，通过第一轮专家调查，确定影响老年人信息需求的20个因素，并将其归类。在此基础上，通过第二轮专家调查，确定老年人信息需求影响因素的相互关系，建立邻接矩阵；对邻接矩阵进行运算，得到可达矩阵；分解可达矩阵，将老年人信息需求影响因素划分为5个层级，建立老年人信息需求影响因素解释结构模型，并对影响因素的层级关系及其对老年人信息需求的影响进行分析。[结果／结论]老年人信息需求影响因素可分为表层因素、中层因素和深层因素。表层因素是影响老年人信息需求最为直接的因素；中层因素是影响老年人信息需求较为直接的因素；深层因素是影响老年人信息需求的根本因素。

关键词：老年人信息需求信息需求影响因素解释结构模型

A new guaiane-type sesquiterpene lactone from the Chinese liverwort Porella acutifolia subsp, tosana

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中国天然药物 2013年第1期11卷 74-76页

作者： LI Rui-Juan GUO dong-Xiao lou Hong-Xiang Department of Natural Products Chemistry School of Pharmaceutical Sciences Shandong University Jinan 250012 China

试图学习中国地钱 Porella acutifolia subsp 的化学成分。tosana。混合物与列层析和他们的结构被孤立并且净化的方法根据 1D-NMR 和 2D-NMR 分析被决定。结果三混合物作为 guaian-3-en-2 被获得并且识别， 14-6， 12-diolide (1 ) ，(2... 详细信息

试图学习中国地钱 Porella acutifolia subsp 的化学成分。tosana。混合物与列层析和他们的结构被孤立并且净化的方法根据 1D-NMR 和 2D-NMR 分析被决定。结果三混合物作为 guaian-3-en-2 被获得并且识别， 14-6， 12-diolide (1 ) ，(20R )-6-hydroxystigmasta-4, 22-dien-3-one (2 ) ，并且(20R )-3-hydroxystigmasta-5, 22-dien-7-one (3 ) 。结论化合物 1 是新 guaiane 类型 sesquiterpene 内酯。加重 2 和 3 被知道类固醇。

关键词：苔纲植物尖瓣光萼苔(东亚亚种) 愈创木烷型倍半萜内酯

Flexible electrical stimulation device with Chitosan-Vaseline®dressing accelerates wound healing in diabetes

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Bioactive Materials 2021年第1期6卷 230-243页

作者： Xiao-Feng Wang Meng-Lu Li Qing-Qing Fang Wan-Yi Zhao dong lou Yan-Yan Hu Jun Chen Xiao-Zhi Wang Wei-Qiang Tan Department of Plastic Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou310016Zhejiang ProvincePR China Key Laboratory of Micro-Nano Electronic Devices and Smart Systems of Zhejiang Province College of Information Science&Electronic EngineeringZhejiang UniversityHangzhou310027Zhejiang ProvincePR China Innovation Center for Signaling Network College of Life SciencesZhejiang UniversityHangzhou310058Zhejiang ProvincePR China

The healing process of diabetic wounds is typically disordered and prolonged and requires both angiogenesis and *** of the endogenous electric fields(EFs)may lead to disordered cell *** stimulation(ES)that mimics endogenous EFs is a promising method in treating diabetic wounds;however,a microenvironment that facilitates cell migration and a convenient means that can be used to apply ES are also ***-Vaseline■gauze(CVG)has been identified to facilitate wound healing;it also promotes moisture retention and immune regulation and has antibacterial *** this study,we created a wound dressing using CVG together with a flexible ES device and further evaluated its potential as a treatment for diabetic *** found that high voltage monophasic pulsed current(HVMPC)promoted healing of diabetic wounds in *** studies carried out in vitro,we found that HVMPC promoted the proliferation and migration of human umbilical vein endothelial cells(HUVECs)by activating PI3K/Akt and ERK1/2 ***,we determined that the flexible ES-chitosan dressing may promoted healing of diabetic wounds by accelerating angiogenesis,enhancing epithelialization,and inhibiting scar *** findings provide support for the ongoing development of this multidisciplinary product for the care and treatment of diabetic wounds.

关键词： Diabetic wounds Flexible electronic device Electrical stimulation Chitosan-vaseline■gauze Wound healing

The Frequency Stability Analysis of IGS final clock products

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The Frequency Stability Analysis of IGS final clock products