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Food Science and Human Wellness 2023年第4期12卷 1287-1299页

作者： Sujin Park YoonA kim Jaewang Lee Hyunsoo Seo Sang-Jip Nam dong-Gyu Jo dong-Hoon Hyun Department of Life Science Ewha Womans UniversitySeoul 03760South Korea Department of Chemistry and Nano Science Ewha Womans UniversitySeoul 03760South Korea School of Pharmacy Sungkyunkwan UniversitySuwon 16419South Korea

Many approaches to neurodegenerative diseases that focus on amyloid-βclearance and gene therapy have not been *** therapeutic applications focus on enhancing neuronal cell survival during the pathogenesis of neurodegenerative diseases,including mitochondrial *** membrane(PM)redox enzymes are crucial in maintaining cellular physiology and redox homeostasis in response to mitochondrial *** phytochemicals are known to induce the expression of detoxifying enzymes under stress *** this study,mechanisms of neuroprotective effects of 4-hydroxycinnamic acid(HCA)were examined by analyzing cell survival,levels of abnormal proteins,and mitochondrial functions in two different neuronal *** protected two neuronal cells exhibited high expression of PM redox enzymes and the consequent increase in the NAD^(+)/NADH *** cultured with HCA showed delayed apoptosis and decreased oxidative/nitrative damage accompanied by decreased ROS production in the *** increased the mitochondrial complexes I and II activities and ATP ***,HCA increased mitochondrial fusion and decreased mitochondrial ***,HCA maintains redox homeostasis and energy metabolism under oxidative/metabolic stress *** findings suggest that HCA could be a promising therapeutic approach for neurodegenerative diseases.

关键词： NADH-quinone oxidoreductase 1(NQO1) Cytochrome b5 reductase 4-Hydroxycinnamic acid Neuroprotection Improved mitochondrial functions

Incidence and Related Risk Factors of Junctional Ectopic Tachycardia in Infants after Cardiac Surgery for Congenital Heart Disease

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Congenital Heart Disease 2022年第5期17卷 569-578页

作者： Jae Hee Seol Se Yong Jung Jae Young Choi Han Ki Park Young Hwan Park Nam kyun kim Department of Pediatrics Congenital Heart Disease CenterDivision of Pediatric CardiologySeverance Cardiovascular HospitalYonsei University College of MedicineSeoulKorea Department of Pediatrics Yonsei University Wonju College of MedicineWonjuKorea Department of Thoracic and Cardiovascular Surgery Division of Cardiovascular SurgeryCongenital Heart Disease CenterSeverance Cardiovascular HospitalYonsei University College of MedicineSeoulKorea Department of Pediatrics and Biomedical Engineering School of MedicineEmory UniversityAtlantaUSA

Objective:Junctional ectopic tachycardia is common after cardiac surgery for congenital heart ***,its incidence and related risk factors in infants after cardiac surgery are not well *** objective of this study was to determine the overall incidence and related risk factors for junctional ectopic tachycardia in neonates and ***:We enrolled a total of 271 patients aged<1 year who underwent open cardiac surgery at Severance Cardiovascular Hospital from January 2018 to December *** criteria were immediate postoperative mortality,other arrhythmias detected in the perioperative period,and ***:The overall incidence of junctional ectopic tachycardia was 12.9%.The logistic regression analysis revealed that longer cardiopulmonary bypass time,surgery involving atrioventricular node stretching,and the presence of early repolarization on preoperative electrocardiography increased the risk of junctional ectopic *** with junctional ectopic tachycardia had longer intubation time and intensive care unit ***:Junctional ectopic tachycardia is a common arrhythmia after cardiac surgery for congenital heart disease in ***,infants developing junctional ectopic tachycardia after cardiac surgery have specific preoperative electrocardiography *** risk factors for junctional ectopic tachycardia were associated not only with surgical procedural factors but also with preoperative electrocardiographic parameters.

关键词： Junctional ectopic tachycardia congenital heart disease early re-polarization

Metastatic pancreatic solitary fibrous tumor: A case report

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World Journal of Clinical Cases 2023年第35期11卷 8416-8424页

作者： Kiyoun Yi Jonghyun Lee dong Uk kim Division of Gastroenterology Department of Internal MedicinePusan National University HospitalBusan 49241South Korea Biomedical Research Institute Pusan National University HospitalBusan 49241South Korea

BACKGROUND Solitary fibrous tumor(SFT)is a rare mesenchymal tumor that is most commonly found in the pleura but can also originate from non-pleural *** the nonpleural localizations,the pancreas is extremely *** particular,metastasis to the pancreas from the central nervous system(CNS)is extremely rare,with only two cases reported so *** report a case of recurrence in the pancreas 14 years after the initial complete surgical removal of a tumor in the *** SUMMARY A 68-year-old man with a past medical history of recurrent meningeal hemangiopericytoma,currently referred to as SFT,presented to the hospital with *** patient was first diagnosed with an 8cm-sized meningeal hemangiopericytoma fourteen years ago and underwent osteoplastic *** 16 mo,imaging showed recurrence and he underwent gamma knife radiosurgery(GKRS).2 years later,imaging showed recurrence again leading to a second GKRS.5 years later,recurrence was again suspected leading to a second *** then 3 years had passed,and imaging showed a 3.5cm-sized mass lesion on the pancreatic head with obstruction of the pancreatic and bile *** with fine-needle aspiration biopsy was done preoperatively and aided in the diagnosis of *** patient underwent pyloruspreserving *** findings of the resected pancreatic specimen,consistent with the previously resected brain specimen,confirmed the diagnosis of *** The rarity and lack of knowledge about SFTs make suspecting and diagnosing this disease *** believe that a report of metastatic pancreatic SFT from the CNS will contribute to a better understanding of this rare disease.

关键词： Solitary fibrous tumor Hemangiopericytoma Pancreas Metastasis Central nervous system Case report

Locked nucleic acid real-time polymerase chain reaction method identifying two polymorphisms of hepatitis B virus genotype C2 infections,rt269L and rt269I

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World Journal of Gastroenterology 2023年第11期29卷 1721-1734页

作者： Kijeong kim Yu-Min Choi dong Hyun kim Junghwa Jang Won Hyeok Choe Bum-Joon kim Department of Microbiology College of MedicineChung-Ang UniversitySeoul 06974South Korea Department of Microbiology and Immunology College of MedicineSeoul National UniversitySeoul 03080South Korea Department of Internal Medicine Konkuk University School of MedicineSeoul 05030South Korea Department of Biomedical Sciences College of MedicineSeoul National UniversitySeoul 03080South Korea Liver Research Institute College of MedicineSeoul National UniversitySeoul 03080South Korea Seoul National University Medical Research Center Seoul 03080South Korea

BACKGROUND The presence of two distinct hepatitis B virus(HBV)Pol RT polymorphisms,rt269L and rt269I,could contribute to the unique clinical or virological phenotype of HBV genotype ***,a simple and sensitive method capable of identifying both types in chronic hepatitis B(CHB)patients infected with genotype C2 should be *** To develop a novel simple and sensitive locked nucleic acid(LNA)-real timepolymerase chain reaction(RT-PCR)method capable of identifying two rt269 types in CHB genotype C2 *** We designed proper primer and probe sets for LNA-RT-PCR for the separation of rt269 *** synthesized DNAs of the wild type and variant forms,melting temperature analysis,detection sensitivity,and endpoint genotyping for LNA-RT-PCR were *** developed LNA-RT-PCR method was applied to a total of 94 CHB patients of genotype C2 for the identification of two rt269 polymorphisms,and these results were compared with those obtained by a direct sequencing *** The LNA-RT-PCR method could identify two rt269L and rt269I polymorphisms of three genotypes,two rt269L types[‘L1’(WT)and‘L2’]and one rt269I type(‘I’)in single(63 samples,72.4%)or mixed forms(24 samples,27.6%)in 87(92.6%sensitivity)of 94 samples from Korean CHB *** the results were compared with those obtained by the direct sequencing protocol,the LNA-RT-PCR method showed the same results in all but one of 87 positive detected samples(98.9%specificity).CONCLUSION The newly developed LNA-RT-PCR method could identify two rt269 polymorphisms,rt269L and rt269I,in CHB patients with genotype C2 *** method could be effectively used for the understanding of disease progression in genotype C2 endemic areas.

关键词： Hepatitis B virus Genotype C2 Polymerase rt269 Locked nucleic acid-real time-polymerase chain reaction Chronic hepatitis B

Milk protein-shelled gold nanoparticles with gastrointestinally active absorption for aurotherapy to brain tumor

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Bioactive Materials 2022年第2期7卷 35-48页

作者： Hyung Shik kim Seung Jae Lee dong Yun Lee Department of Bioengineering College of Engineeringand BK FOUR Biopharmaceutical Innovation Leader for Education and Research GroupHanyang UniversitySeoul04763Republic of Korea Institute of Nano Science and Technology Hanyang UniversitySeoul04763Republic of Korea

Orally absorbable gold nanoparticles(AuNP)having cancer ablation therapy is strongly demanded to treat glioblastoma multiforme(GBM)for patients with its highest incidence ***,we develop a milk protein lactoferrin-conjugated AuNP for its oral absorption and targeting to the GBM through the interaction between lactoferrin(Lf)and lactoferrin receptor(LfR)that is highly expressed in the intestine,blood-brain barrier and *** stability and long circulation of AuNP,glutathione and polyethylene glycol(PEG)is introduced,which is called to *** Lf-PEG-AuNP are orally administered to orthotopic GBM-bearing mice,11-fold and 8-fold higher concentrations of AuNP are measured in bloodstreams and GBM in the brain,respectively,compared with ***,orally administered Lf-PEG-AuNP exhibit an outstanding temperature rise in GBM by irradiating laser and significantly reduce tumor ***,we suggest that the Lf-PEG-AuNP can fundamentally target GBM in the brain through oral absorption,and that its efficient photothermal therapy is possible.

关键词： intestine absorption gastrointestinal

Anomaly Detection Based on Discrete Wavelet Transformation for Insider Threat Classification

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Computer Systems Science & Engineering 2023年第7期46卷 153-164页

作者： dong-Wook kim Gun-Yoon Shin Myung-Mook Han Department of Computer Engineering Gachon UniversitySeongnam-si13120Korea Department of AI Software Gachon UniversitySeongnam-si13120Korea

Unlike external attacks,insider threats arise from legitimate users who belong to the *** individuals may be a potential threat for hostile behavior depending on their *** insider detection,many intrusion detection systems learn and prevent known scenarios,but because malicious behavior has similar patterns to normal behavior,in reality,these systems can be ***,because insider threats share a feature space similar to normal behavior,identifying them by detecting anomalies has *** study proposes an improved anomaly detection methodology for insider threats that occur in cybersecurity in which a discrete wavelet transformation technique is applied to classify normal *** *** discrete wavelet transformation technique easily discovers new patterns or decomposes synthesized data,making it possible to distinguish between shared *** verify the efficacy of the proposed methodology,experiments were conducted in which normal users and malicious users were classified based on insider threat scenarios provided in Carnegie Mellon University’s Computer Emergency Response Team(CERT)*** experimental results indicate that the proposed methodology with discrete wavelet transformation reduced the false-positive rate by 82%to 98%compared to the case with no wavelet ***,the proposed methodology has high potential for application to similar feature spaces.

关键词： Anomaly detection cybersecurity discrete wavelet transformation insider threat classification

Nanostructured hafnium-doped strontium oxide film for homeotropic/homogeneous convertible liquid crystal alignment depending on the curing temperature

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International Journal of Smart and Nano Materials 2022年第4期13卷 597-611页

作者： dong Hyun kim dong Wook Lee Jin Young Oh Jonghoon Won Hae-Chang Jeong Dae-Shik Seo IT Nano Electronic Device Laboratory Department of Electrical and Electronic EngineeringYonsei UniversitySeoulRepublic of Korea Department of Smart Manufacturing Engineering Changwon National UniversityChangwonGyeongnamRepublic of Korea Department of Electrical Electronic and Control Engineering Changwon National UniversityChangwonGyeongnamRepublic of Korea

A hafnium strontium oxide(HfSrO)liquid crystal(LC)alignment film was efficiently created through brush coating,and its ability to change the LC alignment direction was confirmed.A brush was applied to HfSrO sol coated on an indium-tin oxide substrate,after which the coating was solidified at var-ious curing *** was confirmed that a directional micro/nanostructure was formed above 280°C due to the shear stresses caused by the movement of the brush *** chemical changes were analyzed by using X-ray photoelectron spectroscopy and contact angle *** the curing temperature increased,the prevalence of oxygen bonds increased and the contact angle decreased,thereby increasing the surface *** anisotropic boundary of the micro-grooves and the van der Waals forces due to an increase in surface energy changed the alignment direction of LC mole-cules from vertical to horizontal,as verified through polarized optical microscopy and pretilt angle ***,the efficiency of the brush-coating method,which dramatically simplifies the LC alignment film process,was *** homeotropic/homogeneous LC alignment property of the HfSrO film produced through brush coating depending on the curing temperature provides an innovative approach for LC alignment.

关键词： Brush coating nanostructure solution process liquid crystal alignment

Outlier Behavior Detection for Indoor Environment Based on t-SNE Clustering

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Computers, Materials & Continua 2021年第9期68卷 3725-3736页

作者： Shinjin Kang Soo kyun kim School of Games Hongik UniversitySejong30016Korea Department of Computer Engineering Jeju National UniversityJeju63243Korea

In this study,we propose a low-cost system that can detect the space outlier utilization of residents in an indoor *** focus on the users’app usage to analyze unusual behavior,especially in indoor *** is reflected in the behavioral analysis in that the frequency of using smartphones in personal spaces has recently *** system facilitates autonomous data collection from mobile app logs and Google app servers and generates a high-dimensional dataset that can detect outlier *** density-based spatial clustering of applications with noise(DBSCAN)algorithm was applied for effective singular movement *** analyze high-level mobile phone usage,the t-distributed stochastic neighbor embedding(t-SNE)algorithm was *** two clustering algorithms can effectively detect outlier behaviors in terms of movement and app usage in indoor *** experimental results showed that our system enables effective spatial behavioral analysis at a low cost when applied to logs collected in actual living ***,large volumes of data required for outlier detection can be easily *** system can automatically detect the unusual behavior of a user in an indoor *** particular,this study aims to reflect the recent trend of the increasing use of smartphones in indoor spaces to the behavioral analysis.

关键词： Outlier detection trajectory clustering behavior analysis app data smartphone

Enhancing the efficiency and scalability of perovskite solar cells through pseudo-halide salt addition

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Journal of Materials Science & Technology 2023年第34期165卷 161-169页

作者： Dohun Baek Geon Yeong Park Jeongbeom Cha Hyemi Na dong Seok Ham Min kim School of Chemical Engineering Future Energy Research CenterJeonbuk National UniversityJeonju 54896Republic of Korea Graduate School of Integrated Energy-AI Jeonbuk National UniversityJeonju 54896Republic of Korea Chemical Materials Solutions Center Korea Research Institute of Chemical Technology(KRICT)Daejeon 34114Republic of Korea

Organic-inorganic halide perovskites have significant potential for application in next-generation solar ***,their applications are limited by challenges associated with large-area processability and long-term stability owing to the presence of pinholes and defect ***,we incorporated cesium formate in a perovskite active layer using a sequential perovskite fabrication process to eliminate the defect sites of perovskites and improve the film processability via roll-to-roll(R2R)*** addition of cesium formate salt to the PbI2 layer influences the perovskite crystal formation behavior as well as increases the perovskite crystallinity and decreases the defect ***,cesium formate addition eliminated small PbI2 grains and smoothed the perovskite surface,resulting in a large crystal grain *** formate ions interact with the PbI2 component and passivate halide vacancy defects,reducing nonradiative recombination and improving charge ***,the treated perovskite films were highly stable in air,exhibiting improved efficiency retention over time and achieving a power conversion efficiency(PCE)of>22%compared to the ***,the additive-treated perovskite film was processed using the R2R method,achieving a high PCE of>14%with minimal hysteresis.

关键词： Perovskite Solar Cells Pseudo-halide ion Stability Roll-to-roll process

Study of engineering electronic structure modulated non-noble metal oxides for scaled-up alkaline blend seawater splitting

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Journal of Energy Chemistry 2023年第11期86卷 167-179,I0004页

作者： Natarajan Logeshwaran Subramanian Vijayapradeep Ae Rhan kim Prabhakaran Sampath Shanmugam Ramakrishnan Milan Babu Poudel Do Hwan kim dong Jin Yoo Graduate School Department of Energy Storage/Conversion Engineering(BK21 FOUR)Hydrogen and Fuel Cell Research CenterJeonbuk National University567-Baekje-daeroDeokjin-guJeonju-siJeollabuk-do 54896Republic of Korea Department of Life Science Jeonbuk National University567-Baekje-daeroDeokjin-guJeonju-siJeollabuk-do 54896Republic of Korea Division of Science Education and Institute of Fusion Science Jeonbuk National University567-Baekje-daeroDeokjin-guJeonju-siJeollabuk-do 54896Republic of Korea Department of Nano Convergence Engineering Jeonbuk National University567-Baekje-daeroDeokjin-guJeonju-siJeollabuk-do 54896Republic of Korea School of Engineering Merz CourtNewcastle UniversityNE17RUUnited Kingdom

Scaled-up industrial water electrolysis equipment that can be used with abundant seawater is key for affordable hydrogen *** search for highly stable,dynamic,and economical electrocatalysts could have a significant impact on hydrogen ***,we prepared energy-efficient,scalable,and engineering electronic structure modulated Mn-Ni bimetal oxides(Mn_(0.25)Ni_(0.75)O)through simple hydrothermal followed by calcination ***-optimized Mn_(0.25)Ni_(0.75)O displayed enhanced oxygen and hydrogen evolution reaction(OER and HER)performance with overpotentials of 266 and115 mV at current densities of 10 mA cm^(-2)in alkaline KOH added seawater electrolyte ***,Mn-Ni oxide catalytic benefits were attributed to the calculated electronic configurations and Gibbs free energy for OER,and HER values were estimated using first principles *** real-time practical application,we mimicked industrial operating conditions with modified seawater electrolysis using Mn_(0.25)Ni_(0.75)O‖Mn_(0.25)Ni_(0.75)O under various temperature conditions,which performs superior to the commercial IrO_(2)‖Pt-C *** findings demonstrate an inexpensive and facile technique for feasible large-scale hydrogen production.

关键词： Waterel ectrolysis Mn-Ni oxide complex Chlorine evolution reaction Industrial seawater operations Density functional theory calculations