检索结果-南通市图书馆

Biocompatibility and characteristics of chitosan/cellulose acetate microspheres for drug delivery

在线全文

学校读者我要写书评

暂无评论

Frontiers of Materials Science 2011年第4期5卷 367-378页

作者： Hui-Yun ZHOU dong-ju ZHOU Wei-Fen ZHANG Ling-juan JIANG jun-Bo LI Xi-Guang CHEN Chemical Engineering and Pharmaceutics College Henan University of Science and Technology Luoyang 471003 China College of Marine Life Science Ocean University of China Qingdao 266003 China Department of Pharmaceutics Weifang Medical College Weifang 261042 China

In this work, chitosan/cellulose acetate microspheres （CCAM） were prepared by the method of WlO/W emulsion with no toxic reagents. The microspheres were spherical, free flowing, and non-aggregated, which had a narrow size distribution. More than 90% of the microspheres had the diameter ranging from 200 to 280 pm. The hemolytic analysis indicated that CCAM was safe and had no hemolytic effect. The implanted CCAM did not produce any significant changes in the hematology of Sprague- Dawley （SD） rats, such as white blood cell, red blood cell, platelet, and the volume of hemoglobin. In addition, the levels of serum alanine aminotransferase, blood urea nitrogen, and creatinine had no obvious changes in SD rats implanted with CCAM, surger thread, or normal SD rats without any implantation. Thus, the CCAM had good blood compatibility and had no hepatotoxicity or renal toxicity to SD rats. Furthermore, CCAM with or without the model drug had good tissue compatibility with respect to the inflammatory reaction in SD rats and showed no significant difference from that of SD rats implanted with surgery thread. CCAM shows promise as a long-acting delivery system, which had good biocompatibility and biodegradability.

关键词： chitosan cellulose acetate CCAM blood compatibility tissue compatibility

Primary liver cancer spectrum:current knowledge and the next steps

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2024年第1期13卷 157-160页

作者： Mohammad Saeid Rezaee-Zavareh Ekaterina K.Koltsova Yujin Hoshida ju dong Yang Middle East Liver Diseases Center TehranIran Cedars-Sinai Cancer Smidt Heart InstituteCedars-Sinai Medical CenterLos AngelesCAUSA Division of Digestive and Liver Diseases Department of Internal MedicineUniversity of Texas Southwestern Medical CenterDallasTXUSA Karsh Division of Gastroenterology and Hepatology Cedars-Sinai Medical CenterLos AngelesCAUSA Comprehensive Transplant Center Cedars-Sinai Medical CenterLos AngelesCAUSA Samuel Oschin Comprehensive Cancer Institute Cedars-Sinai Medical CenterLos AngelesCAUSA

Hepatocellular carcinoma(HCC)and intrahepatic cholangiocarcinoma(iCCA)constitute the main subtypes of primary liver cancers(PLCs)as a major cause of cancer-related mortality and *** emerge from varying quantities and levels of differentiation among major liver cells,comprising hepatocytes,mucin-or non-mucin-producing cholangiocytes,and hepatic progenitor cells(HPCs)with the capability to differentiate into either hepatocytes or cholangiocytes.

关键词： Liver cancer spectrum hepatocellular carcinoma(HCC) cholangiocarcinoma(CCA) integrated analysis

Bacterial Community Structure in a Mollisol Under Long-Term Natural Restoration, Cropping, and Bare Fallow History Estimated by PCR-DGGE

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pedosphere 2009年第2期19卷 156-165页

作者： WANG Guang-Hua JIN Jian LIU jun-Jie CHEN Xue-Li LIU ju-dong LIU Xiao-Bing Key Laboratory of Black Soil Ecology Northeast Institute of Geography and Agroecology Chinese Academy of Sciences Harbin 150081 China

Soil microbial biomass and community structures are commonly used as indicators for soil quality and fertility. A investigation was performed to study the effects of long-term natural restoration, cropping, and bare fallow managements on the soil microbial biomass and bacterial community structures in depths of 0-10, 20 30, and 40-50 cm in a black soil （Mollisol）. Microbial biomass was estimated from chloroform fumigation-extraction, and bacterial community structures were determined by analysis of 16S rDNA using polymerase chain reaction-denaturing gradient gel electrophoresis （PCR- DGGE）. Experimental results showed that microbial biomass significantly declined with soil depth in the managements of restoration and cropping, but not in the bare fallow. DGGE profiles indicated that the band number in top 0-10 cm soils was less than that in depth of 20-30 or 40-50 cm. These suggested that the microbial population was high but the bacterial community structure was simple in the topsoil. Cluster and principle component analysis based on DGGE banding patterns showed that the bacterial community structure was affected by soil depth more primarily than by managements, and the succession of bacterial community as increase of soil depth has a similar tendency in the three managements. Fourteen predominating DGGE bands were excised and sequenced, in which 6 bands were identified as the taxa of Verrueomicrobia, 2 bands as Actinobacteria, 2 bands as α-Proteobacteria, and the other 4 bands as 8-Proteobacteria, Aeidobacteria, Nitrospira, and unclassified bacteria. In addition, the sequences of 11 DGGE bands were closely related to uncultured bacteria. Thus, the bacterial community structure in black soil was stable, and the predominating bacterial groups were uncultured.

关键词： bacterial community black soil denaturing gradient gel electrophoresis (DGGE) polymerase chain reaction (PCR) soil depth

Simulation of critical cooling rate and process conditions for metallic glasses in vertical type twin-roll casting

在线全文

学校读者我要写书评

暂无评论

Transactions of Nonferrous Metals Society of China 2017年第11期27卷 2406-2414页

作者： Zhi-pu PEI dong-ying ju Xue LI Graduate School of Saitama Institute of Technology Fusaiji 1690 Fukaya Saitama 369-0293 Japan Department of Material Science and Engineering Saitama Institute of TechnologyFusaiji 1690 Fukaya Saitama 369-0293 Japan School of Materials and Metallurgy University of Science and Technology Liaoning Anshan 114051 China

Critical cooling rates for producing metallic glasses were evaluated based on a calculated continuous cooling transformation(CCT)*** distributions of the melt in molten pool in the vertical type twin-roll casting(VTRC)process of metallic glasses were simulated,and cooling rates under different casting conditions were calculated with the simulated *** comparing the results obtained by CCT diagrams and simulation,the possibility of producing metallic glasses by the VTRC method and influences of casting conditions on cooling rate were *** results reveal that cooling rate with3or4orders of magnitude by the VTRC process can be attained in producing Mg-based metallic glasses,which is faster than the critical cooling rate calculated by the CCT *** side pouring mode can improve the temperature distributions of casting *** process has a good ability in continuous casting metallic glassy thin strips.

关键词： metallic glass critical cooling rate twin-roll casting simulation

Invasion, expansion, and control of Bactrocera dorsalis(Hendel) in China

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2019年第4期18卷 771-787页

作者： LIU Huan ZHANG dong-ju XU Yi-juan WANG Lei CHENG Dai-feng QI Yi-xiang ZENG Ling LU Yong-yue Department of Entomology South China Agricultural University

The Oriental fruit fly, Bactrocera dorsalis(Hendel), is among the most destructive fruit/vegetable-eating agricultural pests in the world, particularly in Asian countries such as China. Because of its widespread distribution, invasive ability, pest status, and economic losses to fruit and vegetable crops, this insect species is viewed as an organism warranting severe quarantine restrictions by many countries in the world. To understand the characteristics and potential for expansion of this pest, this article assembled current knowledge on the occurrence and comprehensive control of the Oriental fruit fly in China concerning the following key aspects: invasion and expansion process, biological and ecological characteristics, dynamic monitoring, chemical ecology, function of symbionts, mechanism of insecticide resistance, control index, and comprehensive control and countermeasures. Some suggestions for the further control and study of this pest are also proposed.

关键词： Oriental fruit fly invasion biology ecology management China

Deep learning in hepatocellular carcinoma:Current status and future perspectives

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2021年第12期13卷 2039-2051页

作者： Joseph C Ahn Touseef Ahmad Qureshi Amit G Singal Debiao Li ju-dong Yang Gastroenterology and Hepatology Mayo ClinicRochesterMN 55904United States Biomedical Imaging Research Institute Cedars-Sinai Medical CenterLos AngelesCA 90048United States Internal Medicine University of Texas Southwestern Medical CenterDallasTX 75390United States Karsh Division of Gastroenterology and Hepatology Cedars-Sinai Medical CenterLos AngelesCA 90048United States

Hepatocellular carcinoma(HCC)is among the leading causes of cancer incidence and *** decades of research and development of new treatment options,the overall outcomes of patients with HCC continue to remain *** are areas of unmet need in risk prediction,early diagnosis,accurate prognostication,and individualized treatments for patients with *** years have seen an explosive growth in the application of artificial intelligence(AI)technology in medical research,with the field of HCC being no *** the various AI-based machine learning algorithms,deep learning algorithms are considered state-of-the-art techniques for handling and processing complex multimodal data ranging from routine clinical variables to high-resolution medical *** article will provide a comprehensive review of the recently published studies that have applied deep learning for risk prediction,diagnosis,prognostication,and treatment planning for patients with HCC.

关键词： Hepatocellular carcinoma Artificial intelligence Deep learning

Heat Treatment Simulation for Low Pressure Hyper Carburizing Process

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mechanics Engineering and Automation 2019年第1期9卷 33-39页

作者： Tsuyoshi Sugimoto dong-Ying ju Nissan Motor Co. Ltd.AtsugiKanagawaJapan Saitama Institute of Technology FukayaSaitamaJapan

Carburizing heat treatment is well used to increase the strength of gears and automobile drivetrain *** very high contact fatigue strength is required,hyper carburizing or carbonitriding is well used to improve the surface hardness and tempering softening *** saturate carburizing as called hyper carburizing can be used in a conventional ordinary carburizing furnace and investment of new gas supply equipment is unnecessary,while there are problems such as controlling precipitation of cementite and securing hardenability of the surface,***,problems such as secondary precipitation to control the material micro structure,its quality prediction method becomes *** recent years the low pressure carburizing method has been widely used and the possibility of making hyper carburizing in low cost has been ***,when hyper carburizing is performed by low pressure carburizng,reticulated cementite occurs at the edge of the part,there is a problem such as local increase of carbon concentration distribution and *** this study,we tried to formulate precipitation when super carburizing was performed on steel parts using a low pressure carburizing furnace,formulated the surface hardness distribution,and tried to calculate the hardness and cementite precipitation size *** method is used to obtain the physical property values,graphite of an intermediate product was precipitated from the low pressure carburizing atmosphere on the surface layer,and it was assumed that carburization occurred *** supersaturated carbon precipitates as cementite,the growth amount of the precipitate is *** deposition rate was estimated by comparing the actual measurement with the calculated *** hardness is determined by the sum of the hardness of the precipitate and the hardness of the parent phase part,the hardness distribution was *** a result,the hardness distribution at the time of high c

关键词： Heat treatment simulation low pressure carburizing hyper carburizing cementite precipitation

Nitrogen application affects maize grain filling by regulating grain water relations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2022年第4期21卷 977-994页

作者： WU Ya-wei ZHAO Bo LI Xiao-long LIU Qin-lin FENG dong-ju LAN Tian-qiong KONG Fan-lei LI Qiang YUAN Ji-chao College of Agriculture Sichuan Agricultural UniversityChengdu 611130P.R.China Chongqing Key Laboratory of Economic Plant Biotechnology/Collaborative Innovation Center of Special Plant Industry in Chongqing/Institute of Special Plants Chongqing University of Arts and SciencesChongqing 402160P.R.China Crop Ecophysiology and Cultivation Key Laboratory of Sichuan Province Chengdu 611130P.R.China

Grain water relations play an important role in grain filling in maize. The study aimed to gain a clear understanding of the changes in grain dry weight and water relations in maize grains by using hybrids with contrasting nitrogen efficiencies under differing nitrogen levels. The objectives were: 1) to understand the changes in dry matter and percent moisture content(MC) during grain development in response to different nitrogen application rates and 2) to determine whether nitrogen application affects grain filling by regulating grain water relations. Two maize hybrids, high N-efficient Zhenghong 311(ZH311) and low N-efficient Xianyu 508(XY508), were grown in the field under four levels of N fertilizer: 0, 150, 300, and 450 kg N ha;during three growing seasons. Dry weight, percent MC and water content(WC) of basal-middle and apical grains were investigated. The difference in the maximum WC and filling duration of basal-middle and apical grains in maize ears resulted in a significant difference in final grain weight. Grain position markedly influenced grain drying down;specifically, the drying down rate of apical grains was faster than that of basal-middle grains. Genotype and grain position both influenced the impact of nitrogen application rate on grain filling and drying down. Nitrogen rate determined the maximum grain WC and percent MC loss rate in the middle and the late grain-filling stages, thus affecting final grain weight. The use of high N-efficient hybrids, combined with the reduction of nitrogen application rate, can coordinate basal-middle and apical grain drying down to ensure yield. This management strategy could lead to a win-win situation in which the maximum maize yield, efficient mechanical harvest and environmental safety are all achieved.

关键词： maize grain filling grain drying down nitrogen maximum water content

在线全文

学校读者我要写书评

暂无评论

热处理虚拟系统在制造业技术革新中的作用

金属热处理 2008年第1期33卷 21-25页

作者：巨东英日本埼玉工业大学先端科学研究所

着重介绍国际上热处理制造业特别是发达国家的热处理制造业在基于信息化技术领域的发展趋势,针对热处理虚拟系统的发展和在制造业中的技术革新作用和重要性进行概要性的阐述,并以实例介绍了国际上热处理制造业中的信息化技术发展动态。

关键词：热处理数值模拟变形控制虚拟系统数据库