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Milk fat globule membrane supplementation protects againstβ-lactoglobul-ininduced food allergy in mice via upregulation of regulatory T cells and enhancement of intestinal barrier in a microbiota-derived short-chain fatty acids manner

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Food Science and Human Wellness 2024年第1期13卷 124-136页

作者： Han Gong Tiange Li dong Liang Jingxin Gao Xiaohan Liu Xueying Mao Key Laboratory of Functional Dairy Ministry of EducationCollege of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China Henan Engineering Technology Research Center of Food Processing and Circulation Safety Control College of Food Science and TechnologyHenan Agricultural UniversityZhengzhou 450002China Applied Nutrition I China National Center for Food Safety Risk AssessmentBeijing 100022China

Milk fat globule membrane(MFGM),which contains abundant glycoproteins and phospholipids,exerts beneficial effects on intestinal health and *** aim of this study was to evaluate the protective effects and possible underlying mechanisms of MFGM on cow’s milk allergy(CMA)in aβ-lactoglobulin(BLG)-induced allergic mice *** was supplemented to allergic mice induced by BLG at a dose of 400 mg/kg body *** demonstrated that MFGM alleviated food allergy symptoms,decreased serum levels of lipopolysaccharide,pro-inflammatory cytokines,immunoglobulin(Ig)E,Ig G1,and Th2 cytokines including interleukin(il)-4,while increased serum levels of Th1 cytokines including interferon-γand regulatory T cells(Tregs)cytokines including il-10 and transforming growth factor-β.MFGM modulated gut microbiota and enhanced intestinal barrier of BLG-allergic mice,as evidenced by decreased relative abundance of Desulfobacterota,Rikenellaceae,Lachnospiraceae,and Desulfovibrionaceae,while increased relative abundance of Bacteroidetes,Lactobacillaceae and Muribaculaceae,and enhanced expressions of tight junction proteins including Occludin,Claudin-1 and zonula ***,MFGM increased fecal short-chain fatty acids(SCFAs)levels,which elevated G protein-coupled receptor(GPR)43 and GPR109A *** increased expressions of GPR43 and GPR109A induced CD103+dendritic cells accumulation and promoted Tregs differentiation in mesenteric lymph node to a certain *** summary,MFGM alleviated CMA in a BLG-induced allergic mice model through enhancing intestinal barrier and promoting Tregs differentiation,which may be correlated with SCFAs-mediated activation of *** findings suggest that MFGM may be useful as a promising functional ingredient against CMA.

关键词： Cow’s milk allergy Milk fat globule membrane Gut microbiota Short-chain fatty acid G protein-coupled receptor Regulatory T cell

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特厚煤层底板断层破坏与顶板垮断联动效应的CFDEM模拟研究

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煤炭学报 2024年第6期49卷 2615-2629页

作者：李浩唐世斌康志勤杨栋马立强太原理工大学原位改性采矿教育部重点实验室山西太原030000 大连理工大学土木工程学院岩石破裂与失稳研究所辽宁大连116024 中国矿业大学矿业工程学院江苏徐州211116

特厚煤层采场空间大、覆岩扰动范围广,顶板垮断产生的强扰动加卸荷载易导致底板断层破坏加剧。通过数值模拟研究特厚煤层底板断层突水与顶板垮断联动效应机理规律是开展水害防治的基础,关键在于掌握加卸载下岩体渐进破坏与裂隙流耦合特... 详细信息

特厚煤层采场空间大、覆岩扰动范围广,顶板垮断产生的强扰动加卸荷载易导致底板断层破坏加剧。通过数值模拟研究特厚煤层底板断层突水与顶板垮断联动效应机理规律是开展水害防治的基础,关键在于掌握加卸载下岩体渐进破坏与裂隙流耦合特征。构建加卸载下拉、剪损伤演化方程,结合有效偏/球应力为基本变量的屈服准则与塑性势函数,得到完整岩块的塑性损伤本构;建立拉/剪、混合型加卸载过程中塑性位移与强度劣化关系,以平方拉剪应力与B-K准则为初始、完全断裂准则,形成非贯通裂隙断裂本构;提出岩块分离、压缩、剪切判据,结合实验数据建立离散块体间挤压、剪切摩擦本构与剪胀方程。基于质量/动量守恒、状态方程,并结合流体体积与浸没边界方法,形成裂隙岩体气−水二相流模拟理论。由此形成CFDEM数值计算程序,并将加卸载下塑性损伤、断裂、挤压/摩擦、流体属性分别赋予实体单元(岩块)、黏聚力单元(非贯通裂隙)、接触对(贯通裂隙)、欧拉单元(水和气)。根据宁武煤田北部矿区工程地质条件,建立特厚煤层底板断层突水与顶板垮断联动效应数值计算模型。结果表明:①CFDEM耦合程序及相应的理论模型可数值实现特厚煤层覆岩及底板断层从(准)连续体到离散体转化,以及地下水在裂隙中运移;②模拟条件下特厚煤层含断层底板的采动裂隙包络线呈w形,最深处超过55 m位于断层及其上盘,最浅处23 m位于断层下盘,而无构造底板处的破坏深度为24~36 m,已导通奥灰含水层;③特厚煤层底板普遍出现二次破坏现象。表现为无构造底板在超前工作面处破坏深度为24.0~29.3 m,但在采空区内普遍增加至31.5~36.0 m;断层及其上盘在超前工作面处裂隙总开度为0.34~0.86 m,但在采空区内迅速增加至3.6 m,形成突水优势通道。④底板断层突水与顶板垮断联动效应的根源在于覆岩高位关键岩层垮断失稳、砌体梁下沉与二次断裂,并导致底板二次破坏,突水风险加剧。

关键词：特厚煤层底板断层突水顶底板联动效应 CFDEM程序微震实验

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强制对流对高压套管油介质中乙炔分子传质过程的影响

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电机与控制学报 2024年第4期28卷 31-40页

作者：陈图南李康邱宗甲韩冬张国强中国科学院电工研究所北京100190 中国科学院大学北京100049

为优化对高压套管进行油中溶解气体分析时的取样质量,提升分析结果的代表性和准确性,提出一种对高压套管中的绝缘油施加强制对流的方法,通过向绝缘油施加速度场促进油中溶解气体的传质过程,进而改善油中溶解气体分析的取样质量。从仿真... 详细信息

为优化对高压套管进行油中溶解气体分析时的取样质量,提升分析结果的代表性和准确性,提出一种对高压套管中的绝缘油施加强制对流的方法,通过向绝缘油施加速度场促进油中溶解气体的传质过程,进而改善油中溶解气体分析的取样质量。从仿真计算和实验验证2个方面对绝缘油中溶解乙炔气体传质过程进行研究。首先分析无强制对流情况下气体的传质过程,并测量气体从故障源到取样口的时间;然后分析在强制对流情况下气体的传质过程并测量了传质时间,在此基础上讨论气体传质时间缩短的原因;最后探究不同强制对流动作周期对传质过程影响的程度。研究成果能够为高压套管在线监测装置的研发提供参考。

关键词：高压套管油中溶解气体分析乙炔传质强制对流

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Calculation of the energy dependence of fission fragments yields and kinetic energy distributions for neutron-induced ^(235)U fission

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Chinese Physics C 2024年第8期48卷 159-169页

作者： Ya-Ning Han Zheng Wei Yi-Xuan Wang dong-Ying Huo Peng-Qi Zhang Ming Li Jun Ma kang Wu Yong-Guang Zheng Yuan He Zhi-Yong Deng Tian-Zhi Jiang Xiang-Lin Zhuo Jin Li Yun Zhang Yu Zhang Jun-Run Wang Xiao-dong Su Ze-En Yao School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China Engineering Research Center for Neutron Application Technology Ministry of EducationLanzhou UniversityLanzhou 730000China MOE Frontiers Science Center for Rare Isotopes Lanzhou UniversityLanzhou 730000China School of Mathematics and Statistics Lanzhou UniversityLanzhou 730000China Nuclear Power Institute of China Chengdu 610000China

Fission fragments yields and average total kinetic energy are fundamental nuclear data for nuclear energy applications and the study of nuclear *** fission products,such as ^(95)Zr,^(99)Mo,^(140)Ba,^(144)Ce,and ^(147)Nd,serve as burnup monitors,assessing the number of fissions induced by neutrons on ^(235)***,current experimental data for these fission products worldwide are inconsistent,introducing significant uncertainty into related scientific *** this study,we employed the Potential-driving Model to calculate the independent yields of ^(235)U and evaluate its advantages in such ***,we investigated the energy dependence of independent yields to select important ***,we calculated the cumulative yields of ^(95)Zr,^(99)Mo,^(140)Ba,^(144)Ce,and ^(147)Nd,and compared them with existing literature data to explore the energy dependence of fission products for ^(235)*** the lack of fission product yield data above 14.8 MeV,we extended our calculated incident neutron energy to 20 MeV,aiming to support future scientific *** Geant4 physical model does not consider the influence of incident neutron energy on the average total kinetic energy of fission fragments;thus,we introduced the excitation function of the total kinetic energy of fission fragments recommended by Madland et al.,which effectively describes the experimental data of the average total kinetic energy of fragments formed in ^(235)U *** this paper,we comprehensively discuss the energy dependence of fission product yields and average total kinetic energy.

关键词： ^(235)U(n f) potential-driving model fission yields kinetic energies energy dependence

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Research on groundwater ecological environment mapping based on ecological service function:A case study of five Central Asian countries and neighboring regions of China

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Journal of Groundwater Science and Engineering 2024年第3期12卷 339-346页

作者： Li-qiang Ge Yan-pei Cheng Qing Yi Xue-ru Wen Hua dong Kun Liu Jian-kang Zhang National Research Center for Geoanalysis Beijing 100037China Institute of Hydrogeologv and Environimental Geology Chinese Academy of Geological SciencesShijiazhuang 050061China

The groundwater system is a unique ecosystem that serves both resource and ecological *** have conducted extensive theoretical research and practical work on groundwater ecological *** paper,based on the study of groundwater resources and surface ecology in the five Central Asian countries and adjacent areas of China,introduces the concept of ecosystem service *** establishes a groundwater ecological zoning index system and conducts research of ecological mapping using the five Central Asian countries and adjacent areas of China as *** this process,the ecosystem service functions of groundwater can be more comprehensively reflected,which can better guide regional geological environment protection and industrial *** approach helps coordinate the relationship between socio-economic development and water resource protection,maintain the health of the groundwater ecological environment,enhance the value of groundwater ecological services,and promote the sustainable development of regional economies and societies.

关键词： Groundwater ecosystem Groundwater ecological service Ecological zoning of groundwater Five Central Asian countries

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侧栅晶体管太赫兹探测器的物理模型、结构制备与直流测试

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红外与毫米波学报 2024年第4期43卷 526-532页

作者：康亚茹董慧刘晶黄镇李兆峰颜伟王晓东中国科学院大学集成电路学院北京100049 中国科学院大学材料与光电研究中心北京100049 中国科学院半导体研究所半导体集成技术工程研究中心北京100083 中国科学技术大学微电子学院安徽合肥230026 湖北九峰山实验室研究中心湖北武汉430074

针对侧栅结构高电子迁移率晶体管(High Electron Mobility Transistors,HEMTs)太赫兹探测器,构建了器件的直流输运和太赫兹探测的物理模型。运用自对准工艺,成功制备了形态良好、接触可靠的侧栅结构,有效地解决了器件双侧栅与台面间的... 详细信息

针对侧栅结构高电子迁移率晶体管(High Electron Mobility Transistors,HEMTs)太赫兹探测器,构建了器件的直流输运和太赫兹探测的物理模型。运用自对准工艺,成功制备了形态良好、接触可靠的侧栅结构,有效地解决了器件双侧栅与台面间的接触问题,最终获得了不同栅宽(200 nm、800 nm和1400 nm)的侧栅GaN/AlGaN HEMT太赫兹探测器。通过直流测试表征发现,不同器件的栅宽与其阈值电压之间呈现出明显的线性关系,验证了侧栅结构HEMT太赫兹探测器的直流输运模型。上述结果为完整的侧栅HEMT太赫兹探测器的理论模型提供了实验验证和指导,为侧栅HEMT太赫兹探测器的发展提供了重要支持。

关键词：氮化镓太赫兹探测器侧栅高电子迁移率晶体管

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基于土地覆盖变化与遥感生态指数的奇台绿洲生态环境质量监测

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环境科学 2024年第10期45卷 5890-5899页

作者：邵志东张芳彭康张飞飞新疆大学地理与遥感学科学院乌鲁木齐830017 新疆大学新疆绿洲生态重点实验室乌鲁木齐830017

基于Landsat遥感影像,利用遥感生态指数(RSEI)结合土地利用/覆被变化(LUCC)定量评价了人类活动影响下新疆天山北麓奇台绿洲2001~2022年生态环境质量时空变化,通过空间自相关分析生态环境质量的空间分布特征,采用地理探测器探究生态环境... 详细信息

基于Landsat遥感影像,利用遥感生态指数(RSEI)结合土地利用/覆被变化(LUCC)定量评价了人类活动影响下新疆天山北麓奇台绿洲2001~2022年生态环境质量时空变化,通过空间自相关分析生态环境质量的空间分布特征,采用地理探测器探究生态环境质量空间分布的影响因素.结果显示:①奇台绿洲2001年、2007年、2014年和2022年RSEI均值分别为0.392、0.423、0.452和0.438,生态环境质量整体处于较差水平,空间分布特征表现为南北差中部好,时间变化呈现出先升后降,整体上升的趋势;②奇台绿洲生态环境质量存在正的空间自相关性,低-低聚类主要集中分布于绿洲北部靠近古尔班通古特沙漠的区域,高-高聚类表现为由散布向绿洲中部耕地区域明显集聚;③自然因素对奇台绿洲RSEI空间分布影响不大,影响奇台绿洲RSEI变化的主要因素是LUCC;④RSEI能较好地反映奇台绿洲的生态环境质量现状,草地、裸地等天然生态系统的RSEI变化对干旱区生态环境质量变化具有很好的指向性.

关键词：生态环境质量土地利用/覆被变化(LUCC) 遥感生态指数(RSEI) Moran's I指数地理探测器奇台绿洲

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考虑资源稀缺性的路面养护措施综合效益全寿命周期费用评估

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北京工业大学学报 2024年第4期50卷 417-430页

作者：董侨姚康黄梦雨倪富健东南大学交通学院南京211189 东南大学道路交通工程国家级实验教学示范中心南京211189

为提高道路工程中不可再生资源利用的合理性,建立养护措施综合效益的全寿命周期费用评价方法,推动交通运输基础设施的可持续发展,基于全寿命周期费用评价(life-cycle cost assessment,LCCA)理论,引入了资源稀缺性的评价指标,并基于存量... 详细信息

为提高道路工程中不可再生资源利用的合理性,建立养护措施综合效益的全寿命周期费用评价方法,推动交通运输基础设施的可持续发展,基于全寿命周期费用评价(life-cycle cost assessment,LCCA)理论,引入了资源稀缺性的评价指标,并基于存量稀缺、进口稀缺和技术稀缺3个评价维度,建立了适用于路用材料的项目级资源稀缺性评价体系,同时,将该指标量化为货币当量计入成本清单中。依托江苏省路面养护管理系统数据,将资源稀缺性、经济效益、性能发展3个维度统一,定量分析了再生类、铣刨重铺类和罩面类共3类、12个常见养护措施的综合效益。研究结果表明:考虑资源稀缺性,再生类养护措施旧料利用率较高,具有极佳的资源合理性;EC A-10薄层罩面处治厚度薄、耗材量小,与普通罩面相比能节省50%左右的资源;铣刨料直接废弃、石料来源选择不当将导致额外支出10%~20%的当量成本。考虑综合效益,各养护方案与施工特性(如施工工期、施工水平、工艺先进性等)相关的成本效益接近60%,其中用户间接的经济损失占比超过30%,直接由施工工期决定。因此,建议谨慎选择材料来源及去向以减少不可再生资源浪费,优化养护施工流程以降低用户的间接经济损失,提高施工水平以降低用户的直接油耗开支,开展科学养护决策以降低政府投入成本。

关键词：路面工程全寿命周期费用评价(life-cycle cost assessment,LCCA) 资源稀缺性成本评估养护措施养护决策

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Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui Jiang Hui-Li kang Yi Jiang Hua-Wei Zhang Xiao-Mei Song Yu-Ze Li Wen-Li Huang dong-dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

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Solar Driven 15.7% Hydrogen Conversion by Harmony of Light Harvesting,Electron Transporting Bridge,and S-Defection in a Self-Assembled Microscale CuS/rGO/CP Photoanode

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Energy & Environmental Materials 2024年第3期7卷 190-201页

作者： Sujeong Kim Boseok Seo Hyerim Park Younghwan Im Jeong Yeon Do Byung Sub Kwak Namgyu Son Minkyu Kim Misook kang Department of Chemistry College of Natural SciencesYeungnam UniversityGyeongsan Gyeongbuk 38541Korea School of Chemical Engineering Yeungnam UniversityGyeongsan Gyeongbuk 38541Korea Department of Energy and Hydrocarbon Chemistry Graduate School of EngineeringKyoto UniversityKyoto 615-8510Japan Korea Evaluation Institute of Industrial Technology(Keit) Cheomdan-Ro 8-GilDong-GuDaegu 41069Korea Korea Electric Power Research Institute(KEPRI)105 Munji-ro Yooseong-guDaejeon 34056Korea

CuS is an encouraging photoelectrode candidate that meets the essential requirements for efficient solar-to-hydrogen production,but it has not been thoroughly studied.A CuS light absorber layer is grown by the self-assembly of copper and sulfur precursors on a carbon paper(CP)***,rGO is introduced as a buffer layer to control the optical and electrical properties of the *** well-ordered microstructural arrangement suppresses the recombination loss of electrons and holes owing to enhanced charge-carrier generation,separation,and *** potential reaching 10 mA cm^(-2)in 1.0 M KOH solution is significantly lowered to 0.87 V,and the photocurrent density at 1.23 V is 94.7 mA cm^(-2).The computational result reveals that the potential-determining step is sensitive to O^(*)stability;the lower stability of O^(*)in the thin layer of CuS/rGO decreases the free-energy gap between the initial and final states of the potential-determining step,resulting in a lowering of the onset *** faradaic efficiency for the photoelectrochemical oxygen evolution reaction in the optimized 2CuS/1rGO/CP photoanode is 98.60%,and the applied bias photon-to-current and the solar-to-hydrogen efficiencies are 11.2%and 15.7%,respectively,and its ultra-high performance is maintained for 250 *** record-breaking achievement indices may be a trigger for establishing a green hydrogen economy.

关键词： 15.7%-solar to hydrogen density functional theory lower photopotential p-CuS/rGO/CP photoanode photoelectrochemical oxygen evolution

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