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Novel endoscopic findings as visualized by non-magnification endoscopy with linked color imaging are indicative of gastric intestinal metaplasia

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Chinese Medical Journal 2019年第7期132卷 782-788页

作者： Min Min Teng-hui dong Yan Liu Yi-Liang Bi Cui-Yun Ma Department of Gastroenterology and Hepatology Affiliated Hospital of Academy of Military Medical SciencesBeijing 100071China

Background:Gastric intestinal metaplasia(GIM)is generally considered to be the main mucosal background for the develop gastric *** linked color imaging(LCI),we noticed that the color pattern in areas of GIM was purple mixed with white on the epithelium with signs of mist that were detected by the non-magnifying LCI *** have termed this endoscopic finding wPurple in Mist"(PIM).The aim of this study was to investigate whether PIM could be a useful optical sign for predicting ***:We prospectively evaluated consecutive patients undergoing endoscopy for various *** endoscopist used the LCI system to carefully observe the gastric antrum,body and *** a PIM was identified in the surface layer,targeted biopsies were subsequently taken from this *** the suspected area had no PIM on the surface,targeted biopsies were also ***:Sixty-three consecutive patients were included in this *** prevalence of intestinal metaplasia(IM)was 29/63(46%).In PIM-positive patients,the prevalence of IM was 23/26(89%).Of these patients,146 biopsy specimens were included in this *** the diagnosis of IM,compared to histological assessment,the LCI finding had an accuracy of 91.1%(95%CI:86.5%-95.7%),a sensitivity of 89.8%(95%CI:81.3%-98.3%),a specificity of 91.8%(95%CI:86.3%-97.2%),a positive predictive value of 84.6%(95%CI:74.8%-94.4%),and a negative predictive value of 94.7%(95%CI:90.1%-99.2%).Conclusions:A positive PIM finding in a suspicious lesion on LCI would complement LCI diagnosis of possible IM because of the positive predictive value of *** could be a novel endoscopic marker for IM.

关键词： Gastric intestinal metaplasia Linked color imaging Non-magnification endoscopy

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碳纳米管/金刚石复合材料的场发射特性

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发光学报 2010年第4期31卷 595-598页

作者：董建会单云中北大学理学院物理系山西太原030051 昆山国力真空电器有限公司 215316

采用微波烧结方法制备了碳纳米管/金刚石复合材料。将碳纳米管和纳米金刚石粉末混合后研磨压片,然后在微波等离子气相沉积系统中采用微波烧结。利用扫描电镜对复合材料的表面形貌和微观结构进行了分析,结果显示碳纳米管比较均匀地分散... 详细信息

采用微波烧结方法制备了碳纳米管/金刚石复合材料。将碳纳米管和纳米金刚石粉末混合后研磨压片,然后在微波等离子气相沉积系统中采用微波烧结。利用扫描电镜对复合材料的表面形貌和微观结构进行了分析,结果显示碳纳米管比较均匀地分散于复合材料中,并在表面形成了发射微尖。利用二极管结构在动态真空室中对复合材料的场发射特性进行了研究,复合材料有较好的场发射特性,电流密度接近15mA/cm^2。

关键词：碳纳米管金刚石复合材料微波烧结场发射

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The Protective Effect of Electroacupuncturing Zusanli Points on Hemorrhagic Shock Rats through Cholinergic Anti-inflammatory Pathway

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生物医学工程学杂志 2005年第S1期22卷 151-152页

作者： Zhao-hui DU Jian-Guo LI Yan-Lin WANG Zhou-quan PENG, Xiao-Feng YE(Department of ICU, Zhongnan Hospital, Wuhan University,Wuhan 430071,China) Department of ICU Zhongnan Hospital Wuhan University Wuhan 430071 China

1 IntroductionIn conditions of circulatory shock, systemic inflammatory response (SIRS) plays a funda mental pathogenetic role, with activation of transcription nuclear factors(mainly NF- kB) and markedly increased production of cytokines (mainly TNF-a), which trigger the inflammatory cascade active ation. Recent research have identified a basic neural pathway that reflexively monitors and adjusts such response. It is through the rapid activation (in 'real-time') of efferent vagus nerve fibres(the recentlyrecognized 'brain cholinergic antiinflammatory pathway' ) [1].There are show that the rapid activation cholinergic antiinflammatory pathway can protect against the hemorrhagic shock[2,3].

关键词： EA The Protective Effect of Electroacupuncturing Zusanli Points on Hemorrhagic Shock Rats through Cholinergic Anti-inflammatory Pathway

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Antiviral drug resistance increases hepatocellular carcinoma:A prospective decompensated cirrhosis cohort study

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World Journal of Gastroenterology 2013年第45期19卷 8373-8381页

作者： Lei Li Wei Liu Yu-Han Chen Chun-Lei Fan Pei-Ling dong Fei-Li Wei Bing Li De-Xi Chen hui-Guo Ding Department of Gastroenterology and Hepatology Beijing You’an Hospital Affiliated with Capital Medical University Department of Internal Medicine Beijing Ji Shui Tan HospitalAffiliated with Peking University Viral Laboratory of Liver Diseases Research Institute Capital Medical University

AIM:To study the clinical outcome of antiviral therapy in hepatitis B-related decompensated cirrhotic ***:Three hundred and twelve patients with decompensated hepatitis B cirrhosis were evaluated in a prospective *** two years of follow-up,198patients in the group receiving antiviral therapy with nucleos(t)ide analogues and 39 patients in the control group without antiviral treatment were ***:Among the antiviral treatment patients,162had a complete virological response(CVR),and 36 were drug-resistant(DR).The two-year cumulative incidence of hepatocellular carcinoma(HCC)in the DR patients(30.6%)was significantly higher than that in both the CVR patients(4.3%)and the control group(10.3%)(P<0.001).Among the DR patients in particular,the incidence of HCC was 55.6%(5/9)in those who failed rescue therapy,which was extremely *** rtA181T mutation was closely associated with rescue therapy failure(P=0.006).The Child-Pugh scores of the CVR group were significantly decreased compared with the baseline(8.9±2.3 vs 6.0±1.3,P=0.043).CONCLUSION:This study showed that antiviral drug resistance increased the risk of HCC in decompensated hepatitis B-related cirrhotic patients,especially in those who failed rescue therapy.

关键词： Hepatitis B Decompensated cirrhosis Nucleos(t)ide analogues Hepatocellular carcinoma Drug resistance

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微生物检测技术在动物细菌性疫病诊断中的研究进展

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微生物学杂志 2024年第4期44卷 111-118页

作者：孙志刚刘静王奕凯任晓敏司晓慧吕若一张倩董虹孙英健刘晓晔北京农学院兽医学(中医药)北京市重点实验室北京102206 北京农学院动物科学技术学院北京102206

动物细菌性疾病一直是困扰我国兽医临床和畜禽健康养殖的一大难题,细菌性疾病的传播能力及耐药性变异能力使临床用药举步维艰,而不合理用药导致的药物残留问题,不仅危害动物和人类健康,也给养殖户造成巨大经济损失。动物细菌性疫病的快... 详细信息

动物细菌性疾病一直是困扰我国兽医临床和畜禽健康养殖的一大难题,细菌性疾病的传播能力及耐药性变异能力使临床用药举步维艰,而不合理用药导致的药物残留问题,不仅危害动物和人类健康,也给养殖户造成巨大经济损失。动物细菌性疫病的快速诊断是阻断细菌传播的先决条件之一,也是制定合理用药方案的基础。微生物检测方法是动物细菌性疫病快速诊断的主要技术手段。传统的微生物检测技术仍是现阶段的主流方法。然而,随着细菌不断变异,生存环境不断变化,传统方法不足以应对细菌变异多样、抗菌药物匮乏的当下。不断革新的微生物检测技术也随科技发展产生了许多满足临床需求的新兴技术,不仅可以快速诊断动物细菌性疾病,区分活死细菌数量,也能直观的反应细菌与药物的相互作用。本文从传统的检测手段到基于核酸、蛋白质、细菌光谱特性等更加快速、精确的检测技术进行了系统总结,同时也拓展并提出了宿主导向用药方案的临床微生物检测需求,对于微生物检测技术的综述为临床诊断动物细菌性疫病提供了方法,为兽医临床精准用药提供最佳方案。

关键词：微生物检测技术药物残留动物细菌性疫病临床诊断精准用药

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两相区热处理对不同初始组态钢板组织性能的影响

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东北大学学报（自然科学版） 2008年第3期29卷 339-342页

作者：韩会全刘彦春张驰王国栋东北大学轧制技术及连轧自动化国家重点实验室辽宁沈阳110004

采用0.08C-1.2Mn-0.15Si成分钢,研究了γ+α两相区退火+淬火工艺对不同初始组态钢板组织及力学性能的影响.在相同热处理制度下,初始晶粒越细,马氏体体积分数越多;同一初始组态钢板.保温时间在2～30 min内,随着保温时间延长,马氏体体积... 详细信息

采用0.08C-1.2Mn-0.15Si成分钢,研究了γ+α两相区退火+淬火工艺对不同初始组态钢板组织及力学性能的影响.在相同热处理制度下,初始晶粒越细,马氏体体积分数越多;同一初始组态钢板.保温时间在2～30 min内,随着保温时间延长,马氏体体积分数缓慢增长;经热处理后,得到铁素体+马氏体双相钢的力学性能:抗拉强度600 MPa级,加工硬化指数n值为0.17～0.22,屈强比0.50～O.60,延伸率大于20%.

关键词： γ+α两相区退火淬火组织性能双相钢

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Application of blunt dissection in ESD of a gastric submucosal tumor

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World Journal of Gastroenterology 2014年第21期20卷 6698-6700页

作者： Zong-quan Wen Guang-Yao Wu Shao-Ping Yu Xiao-dong Lin Song-Hu Li Xian-Guang Huang Fu Zhang Xiao-Yu Zeng Hai-Yan Huang Ai-Mei Li Department of Gastroenterology Dongguan Kanghua Hospital Department of Endoscopy Centre Dongguan Kanghua Hospital

We performed endoscopic submucosal dissection of a gastric fundus *** was difficult to strip the tumor completely due to space limitation,and we used blunt dissection to remove the tumor quickly and ***,the basal area of the 2.5 cm submucosal tumor located in the gastric fundus was cut open,and the mucosa was *** tumor was difficult to peel,therefore,a snare was used and the tumor was pulled and tightened *** electronic coagulation was used during the *** tumor was then bluntly *** method ensured rapid and complete removal of the tumor.

关键词： Blunt dissection Endoscopic submucosal dissection Gastric fundus submucosal tumor

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A scanning distortion correction method based on Ⅹ-Y galvanometer Lidar system

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Chinese Physics B 2021年第4期30卷 257-263页

作者： Bao-Ling Qi Chun-hui Wang dong-Bing Guo Bin Zhang Key Laboratory of Tunable Laser Technology Harbin Institute of TechnologyHarbin 150001China

Aiming at the problem of scanning distortion in X-Y galvanometer light detecting and ranging(Lidar) scanning system,we propose a method of image scanning distortion correction with controllable driving voltage ***,the geometrical optics vectors model is established to explain the principle of pincushion distortion in the galvanometer scanning system,and the simulation result of scanning trajectory is consistent with *** linear relationship between the driving voltage and the scanning angle of the galvanometer is ***,the relationship between the deflection angle of the galvanometer and the scanning trajectory and the driving voltage is deduced respectively,and an image scanning correction algorithm with controllable driving voltage compensation is *** simulation experiment results of the proposed method show that the root-mean-square error(RMSE) and the corresponding curve between the scan value and the actual value at different distances,have a good correction effect for the pincushion ***,the X-Y galvanometer scanning Lidar system is established to obtain undistorted two-dimensional scanned image and it can be applied to the three-dimensional Lidar scanning system in the actual experiments,which further demonstrates the feasibility and practicability of our method.

关键词： Lidar laser scanning optical vector model image scanning

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Tomato lycopene prevention of alcoholic fatty liver disease and hepatocellular carcinoma development

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慢性疾病与转化医学(英文) 2018年第4期04卷 211-224页

作者： Stice Camilla P. Xia hui Wang Xiang-dong Nutrition and Cancer Biology Laboratory Jean-Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University Boston MA USA

Alcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. The incidence of hepatocellular carcinoma (HCC) is increasing in the United States, and chronic, excessive alcohol consumption is responsible for 32%-45% of all the liver cancer cases in the United States. Avoidance of chronic or excessive alcohol intake is the best protection against alcohol-related liver injury; however, the social presence and addictive power of alcohol are strong. Induction of the cytochrome P450 2E1 (CYP2E1) enzyme by chronic and excessive alcohol intake is known to play a role in the pathogenesis of ALD. High intake of tomatoes, rich in the carotenoid lycopene, is associated with a decreased risk of chronic disease. The review will overview the prevention of ALD and HCC through dietary tomato rich in lycopene as an effective intervention strategy and the crucial role of CYP2E1 induction as a molecular target. The review also indicates a need for caution among individuals consuming both alcohol and high dose lycopene as a dietary supplement.

关键词： Tomato Lycopene Alcoholic liver disease Liver cancer CYP2E1

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Integration of genome-wide association study and selection signatures reveals genetic determinants for skeletal muscle production traits in an F2 chicken population

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Journal of Integrative Agriculture 2022年第7期21卷 2065-2075页

作者： LI Yu-dong BAI Xue LIU Xin WANG Wei-jia LI Zi-wei WANG Ning XIAO Fan GAO Hai-he GUO Huai-shun LI hui WANG Shou-zhi Key Laboratory of Chicken Genetics and Breeding Ministry of Agriculture and Rural AffairsHarbin 150030P.R.China Key Laboratory of Animal Genetics Breeding and ReproductionEducation Department of Heilongjiang ProvinceHarbin 150030P.R.Chin a 3 School of Animal Sciences and Technology Northeast Agricultural UniversityHarbin 150030P.R.China Fujian Sunnzer Biotechnology Development Co. Ltd.Guangze 354100P.R.China

Improving the production of broiler chicken meat has been a goal of broiler breeding programs worldwide for many years. However, the genetic architectures of skeletal muscle production traits in chickens have not yet been fully elucidated. In the present study, a total of 519 F_(2) birds, derived from a cross of Arbor Acres broiler and Baier layer, were re-sequenced(26 F_(0) individuals were re-sequenced at a 10-fold depth;519 F_(2) individuals were re-sequenced at a 3-fold depth) and the coupling of genome-wide association study(GWAS) and selection signatures(FST(fixation index) and θπ(nucleotide diversity)) was carried out to pinpoint the associated loci and genes that contribute to pectoral muscle weight(PMW) and thigh muscle weight(TMW). A total of 7 890 258 single nucleotide polymorphisms(SNPs) remained to be analyzed after quality control and imputation. The integration of GWAS and selection signature analyses revealed that genetic determinants responsible for skeletal muscle production traits were mainly localized on chromosomes 1(168.95–172.43 Mb) and 4(74.37–75.23 Mb). A total of 17 positional candidate genes(PCGs)(LRCH1, CDADC1, CAB39 L, LOC112531568, LOC112531569, FAM124 A, FOXO1, NBEA, GPALPP1, RUBCNL, ARL11, KPNA3, LHFP, GBA3, LOC112532426, KCNIP4, and SLIT2) were identified in these regions. In particular, KPNA3 and FOXO1 were the most promising candidates for meat production in chickens. These findings will help enhance our understanding of the genetic architecture of chicken muscle production traits, and the significant SNPs identified could be promising candidates for integration into practical breeding programs such as genome-wide selection(GS) to improve the meat yield of chickens.

关键词： chicken muscle growth and development GWAS selection signature

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