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Long-term clinical outcome between beta-blocker with ACEI or ARB in patients with NSTEMI who underwent PCI with drug-eluting stents

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Journal of Geriatric Cardiology 2019年第3期16卷 280-290页

作者： Yong hoon Kim Ae-Young Her Eun-Seok shin Myung Ho Jeong Division of Cardiology Department of Internal MedicineKangwon National University School of MedicineChuncheonSouth Korea Division of Cardiology Department of Internal MedicineUlsan Medical CenterUlsan HospitalUlsanSouth Korea Chonnam National University Hospital GwangjuSouth Korea

Background Because limited comparative data are available,we decided to compare 2-year major clinical outcomes between beta-blockers (BB) with angiotensin converting enzyme inhibitors (ACEI) and BB with angiotensin receptor blockers (ARB) therapy in patients with non-ST-segment elevation myocardial infarction (NSTEMI) after percutaneous coronary intervention (PCI) with drug-eluting stents (DES).Methods A total 11,288 NSTEMI patients who underwent PCI with DES were enrolled and they were divided into two groups,the BB with ACEI group (n = 7600) and the BB with ARB group (n = 3688).The major clinical endpoint was the occurrence of major adverse cardiac events (MACE) defined as all-cause death,recurrent myocardial infarction (re-MI),total revascularization [target lesion revascularization (TLR),target vessel revascularization (TVR),non-TVR] rate during the 2-year follow-up *** After propensity score-matched (PSM) analysis,two PSM groups (3317 pairs,n = 6634,C-statistic = 0.695) were *** the cumulative incidences of all-cause death,cardiac death,TLR,and non-TVR were similar between the two groups,MACE (HR = 0.832,95% CI: 0.704?0.982,P = 0.030),total revascularization rate (HR = 0.767,95% CI: 0.598?0.984,P = 0.037),and TVR rate (HR = 0.646,95% CI: 0.470?0.888,P = 0.007) were significantly lower in the BB with ACEI group after *** In this study,we suggest that the combination of BB with ACEI may be beneficial for reducing the cumulative incidences of MACE,total revascularization rate,and TVR rather than the BB with ARB after PCI with DES in NSTEMI patients.

关键词： Angiotensin converting enzyme inhibitor Angiotensin receptor blocker Beta-blocker Myocardial infarction

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Quantitative volumetric analysis of the optic radiation in the normal human brain using diffusion tensor magnetic resonance imaging-based tractography

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Neural Regeneration Research 2014年第3期9卷 280-284页

作者： dong-hoon Lee Ji-Won Park Cheol-Pyo Hong Center for Medical Metrology Division of Convergence Technology Korea Research Institute of Standards and Science (KRISS) Department of Radiological Science College of Health Science Yonsei University Department of Physical Therapy College of Medical Science Catholic University of Daegu

To attain the volumetric information of the optic radiation in normal human brains, we per- formed diffusion tensor imaging examination in 13 healthy volunteers. Simultaneously, we used a brain normalization method to reduce individual brain variation and increase the accuracy of volumetric information analysis. In addition, tractography-based group mapping method was also used to investigate the probability and distribution of the optic radiation pathways. Our results showed that the measured optic radiation fiber tract volume was a range of about 0.16% and that the fractional anisotropy value was about 0.53. Moreover, the optic radiation probability fiber pathway that was determined with diffusion tensor tractography-based group mapping was able to detect the location relatively accurately. We believe that our methods and results are help- ful in the study of optic radiation fiber tract information.

关键词： nerve regeneration optic radiation diffusion tensor imaging diffusion tensor tractogra-phy magnetic resonance imaging volumetric analysis probability map group mapping visualiza-tion individual variation neural regeneration

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Strategy of photo-protection in phytoplankton assemblages in the Kongsfjorden, Svalbard, Arctic

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Chinese Journal of Oceanology and Limnology 2016年第1期34卷 1-12页

作者： Sun-Yong HA Doo Byoul LEE Sung-Ho KANG Kyung-hoon shin Korea Polar Research Institute 26 Songdomirae-ro Yeonsu-gu Incheon 406-840 Republic of Korea Hanyang University Marine Environmental Science Department 1271 Sa-3 dong Sangnok-gu Ansan Kyeonggi-do 425-791 Republic of Korea

Photo-protective functions were investigated in phytoplankton assemblages at Kongsfjorden,Svalbard in spring,using their UV-absorbing compounds(mycosporine-like amino acids(MAAs)),xanthophyll pigments(diadinoxanthin(DD) and diatoxanthin(DT)) and - dimethylsulphoniopropionate(- DMSP). The dominant phytoplankton species in the inner bay were dominated by Phaeocystis spp. and nanoflagellates,while the offshore waters were dominated by Thalassiosira spp. In the inner bay,UVabsorbing compounds and xanthophyll pigments exhibited higher ratios of MAA to chlorophyll a(MAA:chl a ratio),and both DD and DT to chlorophyll a(DD:chl a ratio and DT:chl a ratio),***,the photoprotective-pigments such as DD and DT appear to complement MAAs in the natural phytoplankton assemblage. However,the ratio of- DMSP to chlorophyll a(-DMSP:chl a ratio) did not show a distinct spatial distribution according to environmental factors or interspecies differences. In this study,we found that photoprotective compounds occurred in a manner dependent on the phytoplankton species composition in Kongsfjorden Bay,where Phaeocystis is the dominant species.

关键词：浮游植物群落保护策略群岛叶绿素a 北极 MAAS 紫外吸收棕囊藻属

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Spectral Properties and Photochromic Characteristics of Spiropyran Dyes

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Chemical Research in Chinese Universities 2006年第4期22卷 505-509页

作者： SHEN Kai-hua HAN Jian-guo ZHANG Gang CHOI dong-hoon The State Key Laboratory of Fine Chemicals Dalian University of Technology Dalian 116012 P. R. China The Key Laboratory of Cellulose and Lignocellulosics Chemistry Guangzhou Institute of Chemistry Chinese Academy of Sciences Guangzhou 510650 P. R. China Polymer and Fiber Material Engineering Kyunghee University Kyong Kido 449-701 Korea

A bis-benzospiropyran（BBSP） and nitro-substituted indoline spirobenzopyrans（SBP） were prepared by following a simple procedure. The reaction mechanism of synthesizing bis-benzospiropyran is discussed. A comparative analysis of the spectral and photochromic properties between SBP and BBSP was carried out with the aid of a PMMA film. The results indicate that chemical structures and UV irradiation played an important role in the spectral and photochromic properties of SBP and BBSP, which would readily affect λmax of the colored forms and the reversibility. The IR spectra and ^1H NMR spectra of these compounds are used to interpret the photochromic phenomena under different UV irradiation and determine the configurations of SBP and BBSP.

关键词： Photochromism Spiropyran UV radiation Protonation

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Design,fabrication,and structural safety validation of 3D-printable biporous bone augments

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Bio-Design and Manufacturing 2023年第1期6卷 26-37页

作者： Yeokyung Kang Dasol Lim Doo-hoon Sun Jong-Chul Park Jungsung Kim Central Research&Development Center Corentec Company Ltd.33-2Banpo-daero 20-gilSeocho-guSeoulRepublic of Korea Cellbiocontrol Laboratory Department of Medical EngineeringYonsei University College of Medicine50-1 Yonsei-roSinchon-dongSeodaemun-guSeoulRepublic of Korea Department of Orthopaedic Surgery Daejeon Sun Hospital10-7 Mok-dongJung-guDaejeonRepublic of Korea

The use of commercial products such as a cup and liner for total hip arthroplasty for patients with severe bone defects has a high probability of *** these patients the cup alone cannot cover the bone defect,and thus,an additional augment or cage is *** this study,we designed three-dimensional(3D)printable bone augments as an alternative to surgeries using reinforcement ***-five sharp-edged bone augments of various sizes were 3D printed.A biporous structure was designed to reduce the weight of the augment and to facilitate bone *** types of frames were used to prevent damage to the augment’s porous structure and maintain its stability during ***,two types of holes were provided for easy augment fixation at various *** tests were performed on a combination of worst-case sizes derived using finite element *** test results confirmed the structural stability of the specimens at a load of 5340 *** the porosity of the specimens was measured to be 63.70%,it cannot be said that the porous nature was uniformly distributed because porosity tests were performed locally and *** summary,3D-printable biporous bone augments capable of bonding from various angles and bidirectionally through angulation and bottom-plane screw holes are *** mechanical results with bone augments indicate good structural safety in ***,further research is necessary to study the clinical applications of the proposed bone augment.

关键词： Bone augment 3D printing Biporous structure Total hip arthroplasty Metal implant

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The American Joint Committee on Cancer 8th edition staging system for the pancreatic ductal adenocarcinoma: is it better than the 7th edition?

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Hepatobiliary Surgery and Nutrition 2020年第1期9卷 98-100页

作者： dong Woo shin Jaihwan Kim Division of Gastroenterology Department of Internal MedicineSeoul National University College of MedicineSeoul National University Bundang HospitalSeongnamKorea

Pancreatic ductal adenocarcinoma (PDA) is the fourth leading cause of cancer-related death and has a poor prognosis with a 5-year survival rate of 9%. In 2019, 56,770 new PDAs and 45,750 deaths are projected to occur in the United States (1). Because of the dismal prognosis, it is important to predict the course of the disease precisely. The TNM staging system is a widely used not only for predicting prognosis but also for collecting and exchanging cancer information. The American Joint Committee on Cancer (AJCC) Cancer Staging Manual, 8th edition was introduced in October 2016 and there were many changes in the staging of PDA compared with the previous one. Of the several controversies related with the previous edition, the most important one was the reproducibility of the T-category. In the 7th edition, there were discrepancies in opinion among pathologists about pT3 (extension beyond the pancreas). Because the pancreas does not have a capsule, it is difficult to determine if there is an extra-pancreatic extension in the presence of inflammation or desmoplasia. Therefore, in the revised staging system, T-category was classified by size, regardless of the extra-pancreatic invasion: pT1, ≤2 cm in maximal diameter;pT2,>2 cm but ≤4 cm;pT3, >4 cm;pT4, locally unresectable due to involvement of major arteries (the celiac axis or the superior mesenteric artery). Another controversy in the 7th edition was that the N-category is simply divided into pN0 and pN1. It has been suggested that the N-category should be subdivided because the number of metastatic lymph nodes (LNs) affects prognosis (2).

关键词： staging Cancer invasion

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Analysis of Feature Importance and Interpretation for Malware Classification

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Computers, Materials & Continua 2020年第12期65卷 1891-1904页

作者： dong-Wook Kim Gun-Yoon shin Myung-Mook Han Department of Computer Engineering Gachon UniversitySungnam-si13120Korea Department of Software Gachon UniversitySungnam-si13120Korea

This study was conducted to enable prompt classification of malware,which was becoming increasingly *** do this,we analyzed the important features of malware and the relative importance of selected features according to a learning model to assess how those important features were ***,the analysis features were extracted using Cuckoo Sandbox,an open-source malware analysis tool,then the features were divided into five categories using the extracted *** 804 extracted features were reduced by 70%after selecting only the most suitable ones for malware classification using a learning model-based feature selection method called the recursive feature ***,these important features were *** level of contribution from each one was assessed by the Random Forest classifier *** results showed that System call features were mostly *** the end,it was possible to accurately identify the malware type using only 36 to 76 features for each of the four types of malware with the most analysis samples *** were the Trojan,Adware,Downloader,and Backdoor malware.

关键词： Recursive feature elimination model interpretability feature importance malware classification

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A Computational Study of Thrust Vectoring Control Using Dual Throat Nozzle

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Journal of Thermal Science 2010年第6期19卷 486-490页

作者： Choon Sik shin Heuy dong Kim Toshiaki Setoguchi Shigeru Matsuo Department of Mechanical Engineering Andong National University Department of Mechanical Engineering Saga University

Dual throat nozzle (DTN) is fast becoming a popular technique for thrust vectoring. The DTN is designed with two throats, an upstream minimum and a downstream minimum at the nozzle exit, with a cavity in between the upstream throat and exit. In the present study, a computational work has been carried out to analyze the performance of a dual throat nozzle at various mass flow rates of secondary flow and nozzle pressure ratios (NPR). Two-dimensional, steady, compressible Navier-Stokes equations were solved using a fully implicit finite volume scheme. The present computational results were validated with available experimental data. Based on the present results, the control effectiveness of thrust-vectoring is discussed in terms of the thrust coefficient and the coefficient of discharge.

关键词：推力矢量控制计算结果双喷嘴 Stokes方程推力矢量技术有限体积格式服务机构实验数据

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Cryptanalysis of the obfuscated round boundary technique for whitebox cryptography

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Science China(Information Sciences) 2020年第3期63卷 257-265页

作者： Yongjin YEOM dong-Chan KIM Chung Hun BAEK Junbum shin Department of Information Security Cryptology and Mathematics Kookmin University Samsung Research Samsung Electronics

Dear editor,The security of cryptographic techniques heavily relies on the confidentiality of the key, and everything except keys can be made open to public without affecting security. When working with cryptographic services, we must protect the keys from a variety of attackers, including eavesdroppers and malware. A whitebox adversary is an attacker

关键词： II Cryptanalysis of the obfuscated round boundary technique for whitebox cryptography

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Effects of China＇s Structural Change on the Exports of East Asian Economies

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China & World Economy 2017年第3期25卷 1-30页

作者： Hyun-hoon Lee donghyun Park Kwanho shin Professor International Trade and Business Kangwon National UniversityKorea Principal Economist Economic Research and Regional Cooperation Department Asian Development Bank. Professor Economics Department Korea University

The Chinese economy is slowing down and is in the midst of a structural transJormattonfrom export-led and investment-led growth to domestic demand-led and consumption-ledgrowth. While there are widespread concerns among China＇s trading partners about theeffect of the slowdown in China＇s growth on their exports, China＇s structural changes arealso likely to have a significant impact：for example, China will import fewer machinesand more cosmetics. The central objective of the present paper is to empirically examinethe effect of China＇s structural transformation on the exports of East Asian economies,which have close trade linkages with China. We find that economies that have failed toincrease the share of consumption goods in their exports to China have suffered largerdeclines in their quantities of exports to China. In addition, economies that have sufferedlosses in their shares of China＇s parts and components imports have faced reductions intheir shares in China ＂s total imports.

关键词： China, East Asia, export, global value chain, structural change

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