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Clinical implications of neutrophil-to-lymphocyte ratio and MDSC kinetics in gastric cancer patients treated with ramucirumab plus paclitaxel

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Chinese Journal of Cancer Research 2020年第5期32卷 621-630页

作者： Hyung-Don Kim Min-hee ryu Sangsoon Yoon Young-Soon Na Meesun Moon Hyungeun Lee Hyung Geun Song Yoon-Koo Kang Department of Oncology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea Asan Institute for Life Science Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea DiNonA Inc Seoul 05505Korea

Objective: We aimed to investigate the prognostic value of neutrophil-to-lymphocyte ratio(NLR) and myeloidderived suppressor cells(MDSCs) in gastric cancer patients treated with second-line ramucirumab plus ***: A total of 116 patients with advanced or metastatic gastric cancer who receive ramucirumab plus paclitaxel were prospectively enrolled. Fresh blood samples were collected before and after treatment, and flow cytometry was performed to assess the proportions of monocytic(m MDSCs) and granulocytic MDSCs(g MDSCs).Results: Median age was 58 years and 71(61.2%) patients were male. A baseline NLR≥2.94 was associated with significantly poorer progression-free survival(PFS) and overall survival(OS) vs. an NLR<2.94(P=0.011 and P=0.002, respectively). In multivariate analysis, an NLR≥2.94 was independently associated with poorer PFS[hazard ratio(HR)=1.58;95% confidence interval(95% CI): 1.01-2.49, P=0.046] and OS(HR=1.77;95% CI:1.04-3.04, P=0.036). While m MDSC counts did not significantly change following two cycles of therapy(P=0.530),g MDSC counts decreased significantly after two treatment cycles(P=0.025) but tended to increase in patients with progressive disease after two treatment cycles(P=0.098). A progressive increase in g MDSC counts(≥44%) was associated with a significantly shorter PFS and OS vs. a g MDSC count increase <44%(P=0.001 and P=0.003,respectively).Conclusions: The baseline NLR may help guide clinical decisions during ramucirumab plus paclitaxel therapy for gastric cancer. Our g MDSC kinetics data warrant further clinical validation and mechanistic investigation.

关键词： Gastric cancer ramucirumab plus paclitaxel neutrophil-to-lymphocyte ratio myeloid-derived suppressor cells

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Carbon monoxide decreases interleukin-1β levels in the lung through the induction of pyrin

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Cellular & Molecular Immunology 2017年第4期14卷 349-359页

作者： Seul-Ki Kim Yeonsoo Joe Yingqing Chen Jinhyun ryu Jeong-hee Lee Gyeong Jae Cho Stefan W. Ryter Hun Taeg Chung Department of Biological Sciences University of Ulsan Ulsan 680-749 Republic of Korea Department of Anatomy School of Medicine and Institute of Health Sciences Gyeongsang National University Jinju 660-701 Republic of Korea Department of Pathology School of Medicine and Institute of Health Sciences Gyeongsang National University Jinju 660-701 Republic of Korea Joan and Sanford I. Weill Department of Medicine New York-Presbyterian Hospital Division of Pulmonary and Critical Care Medicine Weill Cornell Medical Center New York NY USA

Carbon monoxide （CO） can act as an anti-inflammatory effector in mouse models of lung injury and disease, through the downregulation of pro-inflammatory cytokines production, though the underlying mechanisms remain unclear. The nucleotide-binding oligomerization domain-, leucine-rich region-, and pyrin domain-containing-3 （NLRP3） inflammasome is a protein complex that regulates the maturation and secretion of pro-inflammatory cytokines, including interleukin-1β （IL-1β）. In this report, we show that the CO-releasing molecule （CORM-2） can stimulate the expression of pyrin, a negative regulator of the NLRP3 inflammasome. CORM-2 increased the transcription of pyrin in the human leukemic cell line （THP-1） in the absence and presence of lipopolysaccharide （LPS）. In THP-1 cells, CORM-2 treatment dose-dependently reduced the activation of caspase-1 and the secretion of IL-lp, and increased the levels of IL-IO, in response to LPS and adenosine 5＇-triphosphate （ATP）, an NLRP3 inflammasome activation model. Genetic interference of IL-10 by small interfering RNA （siRNA） reduced the effectiveness of CORM-2 in inhibiting IL-1β production and in inducing pyrin expression. Genetic interference of pyrin by siRNA increased IL-lp production in response to LPS and ATP, and reversed CORM-2-dependent inhibition of caspase-1 activation. CO inhalation （250 ppm） in vivo increased the expression of pyrin and IL-10 in lung and spleen, and decreased the levels of IL-1β induced by LPS. Consistent with the induction of pyrin and IL-10, and the downregulation of lung IL-1β production, CO provided protection in a model of acute lung injury induced by intranasal LPS administration. These results provide a novel mechanism underlying the anti-inflammatory effects of CO, involving the IL-10-dependent upregulation of pyrin expression.

关键词： anti-inflammatory effects carbon monoxide (CO) IL-1β inflammasome pyrin

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Variations in microstructure and bending formability of extruded Mg–Al–Zn–Ca–Y–MM alloy with precompression and subsequent annealing treatment conditions

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Journal of Magnesium and Alloys 2022年第9期10卷 2475-2490页

作者： Jong Un Lee Sang-Hoon Kim dong hee Lee Hyun Ji Kim Young Min Kim Sung Hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Agency for Defense Development Daejeon 34186Republic of Korea Implementation Research Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea

In this study, the bending formability of an extruded Mg–9Al–1Zn–0.3Mn–0.9Ca–0.6Y–0.5 MM(AZXWMM91100, wt%) alloy at room temperature is significantly improved through application of a combined precompression and subsequent annealing(PCA) treatment. As the amount of precompression applied along the extrusion direction(ED)(i.e., the total strain) increases from 4% to 6%, the area fraction of ED-oriented grains of the PCA-treated alloy increases, which consequently causes an improvement in its bending formability because these grains accommodate larger tensile strain along the ED during bending. As the temperature of the subsequent annealing treatment increases from 350 ℃ to 450 ℃, both the area fraction of the ED-oriented grains and the average grain size increase, and the residual dislocation density decreases owing to the promotion of boundary migration and occurrence of the recovery process at higher ***, the bending formability of both the 4%-precompressed and the 6%-precompressed samples increases with an increase in the annealing temperature. However, when the precompressed samples are annealed at 300 ℃, their bending formability is lower than that of the extruded alloy because the dislocations formed by precompression remain even after the subsequent annealing at this temperature.

关键词： Magnesium Extrusion Bending Formability Texture

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Effects of electrochemical synthetic conditions on surface property and photocatalytic performance of copper and iron-mixed p-type oxide electrodes

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Journal of Materials Science & Technology 2018年第9期34卷 1503-1510页

作者： Sun hee Yoon dong Suk Han Unseock Kang Seung Yo Choi Wubulikasimu Yiming Ahmed Abdel-Wahab Hyunwoong Park Chemical Engineering Program Texas A&M University at Qatar School of Energy Engineering Kyungpook National University Department of Mechanical Engineering Texas A&M University at Qatar

Earth-abundant copper and iron-mixed oxide（CuO/CuFeO_2; CFO） film electrodes are synthesized using an electrochemical deposition（ED） technique at two different ED potentials（-0.36 and-0.66 V vs saturated calomel electrode（SCE）; denoted as ED-1 and ED-2, respectively）. Then, their surface morphologies are compared, and the photo（electro）catalytic activities for the reduction of Cr（VI） are examined in aqueous solutions at pH 7 under simulated sunlight（AM 1.5 G; 100 mW cm（-2））. The degree of the electrical potential applied to the ED process significantly affects the thickness of the synthesized electrode film and the intensity ratio of the diffraction peaks of CuO（111） and CuFeO_2（012）. A 200 μm thick ED-2 sample with a distinct stacking of CuO on CuFeO_2 exhibits a larger broadband absorption spectrum than the 50-μm thick ED-1 with less separate stacking. Furthermore, the ED-2 sample has a higher intensity ratio of the diffraction peaks of CuO（111） and CuFe02（012） than ED-1. As-synthesized ED-2 samples produce larger photocurrents, leading to faster Cr（VI） reduction on the surface under given potential bias（-0.5 V vs SCE）or bias-free conditions. The energy levels（i.e., flatband potential） for the two samples are almost the same（only 10 mV difference）, presumably supposing that the enhanced photoactivity of the ED-2 sample for Cr（VI） reduction is due to the facilitated charge transfer. The time-resolved photoluminescence emission spectra analysis reveal that the lifetime（r） of the charge carriers in the ED-1 sample is 0.103 ns, which decreases to 0.0876 ns in the ED-2. The ED-2 sample synthesized at a high negative potential is expected to contribute greatly to the application of other solar-to-fuel energy conversion fields as a highly efficient electrode material.

关键词： Artificial photosynthesis Solar fuel Delafossites Morphology Charge transfer

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Electrochemical behavior of Nd in its pyrometallurgical recovery from waste magnet

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Rare Metals 2015年第2期34卷 111-117页

作者： Hong-Youl ryu Jong-Hyeon Lee Wan-Gou Kim Hayk H.Nersisyan Go-Gi Lee Sung-Koo Jo Huk-hee Lee Il-Soon Hwang Graduate School of Green Energy Technology Chungnam National University Department of Nano Materials Engineering Chungnam National University Rapidly Solidified Materials Research Institute Chungnam National University Research Institute of Industrial Science and Technology Korea Research Institute of Chemical Technology School of Energy Systems Engineering Seoul National University

High-purity Nd metal was recovered from waste Nd–Fe–B magnet by the molten salt electrowinning process with chemical pretreatment. X-ray diffraction（XRD）, scanning electron microscopy（SEM）, energy dispersive spectroscopy（EDS）, cyclic voltammetry（CV）,chronopotentiometry（CP）, and inductively coupled plasma-atomic emission spectrometer（ICP/AES） were used to characterize the deposit and electrochemical behaviors. The results show that NdF_3 is effectively synthesized from the Nd–Fe–B magnet using HCl solution and NH4F. During the chemical treatment of the waste magnet,iron impurity is eliminated as a soluble [NH4]3[FeF6]complex. Electrowinning using NdF_3 in LiF molten salt shows that Nd metal is deposited from the electrolyte onthe cathode at the reduction potentials ranging from-1.48to-1.35 V（vs. W） with the concentration change of NdF_*** final purity of Nd metal deposit is higher than99.78 %.

关键词： Electrowinning Neodymium Nd-Fe-Bmagnet Rare earth recycling

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Bioprinted Vascularized Mature Adipose Tissue with Collagen Microfibers for Soft Tissue Regeneration

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Cyborg and Bionic Systems 2021年第1期2021卷 1-15页

作者： Fiona Louis Marie Piantino Hao Liu dong-hee Kang Yoshihiro Sowa Shiro Kitano Michiya Matsusaki Joint Research Laboratory(TOPPAN)for Advanced Cell Regulatory Chemistry Graduate School of EngineeringOsaka UniversityJapan Department of Applied Chemistry Graduate School of EngineeringOsaka UniversityJapan Department of Plastic and Reconstructive Surgery Graduate School of Medical SciencesKyoto Prefectural University of MedicineJapan Toppan Printing Co. Ltd.TokyoJapan

The development of soft tissue regeneration has recently gained importance due to safety concerns about artificial breast *** autologous fat graft implantations can result in up to 90%of volume loss in long-term outcomes due to their limited *** tissue has a highly vascularized structure which enables its proper homeostasis as well as its endocrine *** adipocytes surrounded by a dense vascular network are the specific features required for efficient regeneration of the adipose tissue to perform host anastomosis after its ***,bioprinting has been introduced as a promising solution to recreate in vitro this architecture in large-scale ***,the in vitro induction of both the angiogenesis and adipogenesis differentiations from stem cells yields limited maturation states for these two *** overcome these issues,we report a novel method for obtaining a fully vascularized adipose tissue reconstruction using supporting bath *** the first time,directly isolated mature adipocytes encapsulated in a bioink containing physiological collagen microfibers(CMF)were bioprinted in a gellan gum supporting *** multilayered bioprinted tissues retained high viability even after 7 days of ***,the functionality was also confirmed by the maintenance of fatty acid uptake from mature ***,this method of constructing fully functional adipose tissue regeneration holds promise for future clinical applications.

关键词： supporting printing fibers

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TT virus and hepatitis G virus infections in Korean blood donors and patients with chronic liver disease

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World Journal of Gastroenterology 2003年第4期9卷 741-744页

作者： Mee Juhng Jeon Jong hee Shin Soon Pal Suh Young Chai Lim dong Wook Ryang Division of Medical Research Kwangju-Chonnan Red Cross Blood CenterChonnam National UniversityKwangju Republic of Korea Department of Clinical Pathology Chonnam National UniversityKwangju Republic of Korea Research Institute of Medical SciencesChonnam Nationa UniversityKwangjuRepublic of Korea Department of Pharmacology Medical SchoolChonnam National UniversityKwangjuRepublic of Korea Research Institute of Medical SciencesChonnam National UniversityKwangjuRepublic of Korea Department of Clinical Pathology Chonnam National UniversityKwangjuRepublic of Korea Research Institute of Medical Scienceschonnam National UniversityKwangjuRepublic of Korea

AIM:To determine the prevalences of TTV and HGV infections among blood donors and patients with chronic liver disease in Korea,to investigate the association of TTV and HGV infections with blood transfusion,and to assess the correlation between TTV and HGV viremia and hepatic damage. METHODS:A total of 391 serum samples were examined in this *** were obtained from healthy blood donors(n=110),hepatitis B surface antigen(HBsAg)-positive donors(n=112),anti-hepatitis C virus(anti-HCV)-positive donors(n=69),patients with type B chronic liver disease (n=81),and patients with type C chronic liver disease(n=19). Trv DNA was detected using the hemi-nested *** RNA was tested using RT-PCR.A history of blood transfusion and serum levels of alanine aminotransferase(ALT)and aspartate aminotransferase(AST)were also determined. RESULTS:TTV DNA was detected in 8.2%of healthy blood donors,16.1%of HBsAg-positive donors,20.3%of anti- HCV-positive donors,21.0%of patients with type B chronic liver disease,and 21.1%of patients with type C chronic liver *** RNA was detected in 1.8%of healthy blood donors,1.8%of HBsAg-positive donors,17.4%of anti-HCV-positive donors,13.6%of patients with type B chronic liver disease,and 10.5%of patients with type C chronic liver *** prevalence of TTV and HGV infections in HBV- or HCV-positive donors and patients was significantly higher than in healthy blood donors(P<0.05), except for the detection rate of HGV in HBsAg-positive donors which was the same as for healthy *** was a history of transfusion in 66.7%of TTV DNA-positive patients and 76.9%of HGV RNA-positive patients(P<0.05).No significant increase in serum ALT and AST was detected in the TTV or HGV-positive donors and patients. CONCLUSION:TTV and HGV infections are more frequently found in donors and patients infected with HBV or HCV than in healthy blood ***,there is no significant association between TTV or HGV infections and liver injury.

关键词： Blood Donors Blood Transfusion Chronic Disease DNA Virus Infections DNA, Viral Flaviviridae Infections GB virus C purification Hepatitis B Surface Antigens Hepatitis, Viral, Human Korea Liver Diseases Polymerase Chain Reaction Reference Values Reverse Transcriptase Polymerase Chain Reaction Torque teno virus

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Combined 23-gauge sutureless vitrectomy and clear corneal phacoemulsification for rhegmatogenous retinal detachment repair

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International Journal of Ophthalmology(English edition) 2015年第1期8卷 122-127页

作者： Hoseok Moon hee Jin Sohn Dea Yeong Lee Jong Yeon Lee dong Heun Nam Department of Ophthalmology Gachon University Gil Hospital Department of Ophthalmology Hongik Hospital

AIM: To assess the outcomes of combined 23-gauge sutureless vitrectomy and clear corneal phacoemulsification with intraocular lens implantation for rhegmatogenous retinal detachment(RRD) ***: This was a retrospective, consecutive,noncomparative, interventional case series of 30 eyes of30 patients who underwent combined sutureless vitrectomy and clear corneal cataract surgery for the repair of RRD. The principal outcome measures were primary anatomical success rate, reasons for redetachment, final visual acuity, and surgical ***: Primary reattachment was achieved in 27eyes(90.0%). The reasons for redetachment(3 eyes, 10%)were incomplete laser retinopexy, persistent chronic subretinal fluid, and proliferative vitreoretinopathy,respectively. The logarithm of the minimum angle of resolution visual acuity(mean±SD) improved from 0.76±0.74 preoperatively to 0. 21 ± 0. 37 6 months’ postoperatively(P <0.0001). Postoperative hypotony was not detected,but 1 eye( 3. 3 %) had increased intraocular pressure(30 mm Hg) with spontaneous resolution. No endophthalmitis developed during follow-up. Macular pucker was detected in 3 eyes(10.0%).· CONCLUSION: Combined 23-gauge sutureless vitrectomy and clear corneal phacoemulsification with intraocular lens implantation for RRD repair was proven safe and effective. It may provide not only the known advantages of conventional combined surgery, but also additional advantages such as less conjunctival fibrosis and the maintenance of stable intraocular pressure with low risks of postoperative hypotony and intraocular pressure elevation.

关键词： clear corneal phacoemulsification combined 23-guage sutureless vitrectomy rhegmatogenous retinal detachment

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Gastrosplenic fistula occurring in lymphoma patients: Systematic review with a new case of extranodal NK/T-cell lymphoma

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World Journal of Gastroenterology 2017年第35期23卷 6491-6499页

作者： dong Hyeok Kang Jimi Huh Jong Hwa Lee Yoong Ki Jeong hee Jeong Cha Department of Radiology Ulsan University HospitalUniversity of Ulsan College of Medicine Department of Pathology Ulsan University HospitalUniversity of Ulsan College of Medicine

AIM To provide the overall spectrum of gastrosplenic fistula(GSF) occurring in lymphomas through a systematic review including a patient at our *** A comprehensive literature search was performed in the MEDLINE database to identify studies of GSF occurring in lymphomas. A computerized search of our institutional database was also performed. In all cases, we analyzed the clinicopathologic/radiologic features, treatment and outcome of GSF occurring in lymphomas. RESULTS A literature search identified 25 relevant studies with 26 patients. Our institutional data search added 1 patient. Systematic review of the total 27 cases revealed that GSF occurred mainly in diffuse, large B-cell lymphoma(n = 23), but also in diffuse, histiocytic lymphoma(n = 1), Hodgkin's lymphoma(n = 2), and NK/T-cell lymphoma(n = 1, our patient). The common clinical presentations are constitutional symptoms(n = 20) and abdominal pain(n = 17), although acute gastrointestinal bleeding(n = 6) and infection symptoms due to splenic abscess(n = 3) are also noted. In all patients, computed tomography scanning was very helpful for diagnosing GSF and for evaluating the lymphoma extent. GSF could occur either post-chemotherapy(n = 10) or spontaneously(n = 17). Surgical resection has been the most common treatment. Once patients have recovered from the acute illness status after undergoing surgery, their long-term outcome has been favorable. CONCLUSION This systematic review provides an overview of GSF occurring in lymphomas, and will be helpful in making physicians aware of this rare disease entity.

关键词： Gastrosplenic fistula Lymphoma NK/T-cell lymphoma Systematic review

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Rapid species identification of pathogenic bacteria from a minute quantity exploiting three-dimensional quantitative phase imaging and artificial neural network

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Light(Science & Applications) 2022年第7期11卷 1595-1606页

作者： Geon Kim Daewoong Ahn Minhee Kang Jinho Park dongHun ryu YoungJu Jo Jinyeop Song Jea Sung ryu Gunho Choi Hyun Jung Chung Kyuseok Kim Doo Ryeon Chung In Young Yoo hee Jae Huh Hyun-seok Min Nam Yong Lee YongKeun Park Department of Physics Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea KAIST Institute for Health Science and Technology KAISTDaejeon 34141Republic of Korea Tomocube Inc. Daejeon 34109Republic of Korea Smart Healthcare&Device Research Center Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Graduate School of Nanoscience and Technology Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Department of Biological Sciences Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Department of Emergency Medicine Bundang CHA HospitalSeongnam-siGyeonggi-Do 13496Korea Division of Infectious Diseases Department of Internal MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Department of Laboratory Medicine Seoul St.Mary's HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea Department of Laboratory Medicine and Genetics Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Department of Applied Physics Stanford UniversityStanfordCA 94305USA Department of Physics Massachusetts Institute of TechnologyCambridgeMA 02139USA

The healthcare industry is in dire need of rapid microbial identification techniques for treating microbial *** infections are a major healthcare issue worldwide,as these widespread diseases often develop into deadly *** studies have shown that an early appropriate antibiotic treatment significantly reduces the mortality of an infection,this effective treatment is difficult to *** main obstacle to early appropriate antibiotic treatments is the long turnaround time of the routine microbial identification,which includes time-consuming sample ***,we propose a microscopy-based framework that identifies the pathogen from single to few *** framework obtains and exploits the morphology of the limited sample by incorporating three-dimensional quantitative phase imaging and an artificial neural *** demonstrate the identification of 19 bacterial species that cause bloodstream infections,achieving an accuracy of 82.5%from an individual bacterial cell or *** performance,comparable to that of the gold standard mass spectroscopy under a sufficient amount of sample,underpins the effectiveness of our framework in clinical ***,our accuracy increases with multiple measurements,reaching 99.9%with seven different measurements of cells or *** believe that our framework can serve as a beneficial advisory tool for clinicians during the initial treatment of infections.

关键词： artificial neural exploit

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